Extracellular Matrix of Primitive Animal Species03728Zebrafish heart ECM promotes mammalian heart repair via NRG1-ErbB2 signaling, improving function and reducing infarct size.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasCardiovascularTherapeutic IndicationsMyocardial infarctionLead InventorYadong WangDepartmentBioengineeringAll Tech InnovatorsWilliam ChenYadong WangDate Submitted2015-09-19CollectionsRegenerative MedicineCardiometabolic
Complex Coacervate for Controlled Release03713Versatile complex coacervate enables customizable, localized, sustained biomolecule delivery (up to 400 targets) for cancer and heart therapy.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationLead InventorYadong WangDepartmentBioengineeringAll Tech InnovatorsEric M. JeffriesYadong WangDate Submitted2015-09-04
Hybrid Additive Manufacturing and Electrospinning for Fabricating Vascularized Biodegradable Tissue Scaffolds03187Hybrid 3D printing and electrospinning create biodegradable, porous, vascularized tissue scaffolds with programmable microchannels.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTagsRegenerative medicineTissue engineeringLead InventorYadong WangDepartmentBioengineeringAll Tech InnovatorsJames Henry Clampffer IIIEric M. JeffriesYadong WangDate Submitted2013-12-04CollectionsRegenerative Medicine
Slow Drug Release for Ophthalmic Treatments05610Coacervate gel delivers CXCL10p peptide to the eye for slow, tunable dry eye treatment, reducing goblet cell loss.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOphthalmologyTherapeutic IndicationsDry eye syndromeTagsLife ScienceLead InventorAlan WellsDepartmentMed-PathologyAll Tech InnovatorsShivalingappa Kottur SwamynathanYadong WangAlan H. WellsDate Submitted2021-02-08
Protection and Delivery of Multiple Therapeutic Proteins03836Coacervate delivery system extends protein half-lives to weeks using platelet-rich plasma, enhancing wound healing and tissue repair.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsPlatform TechnologyLead InventorDaniel LongDepartmentBioengineeringAll Tech InnovatorsEric M. JeffriesNoah R. JohnsonDaniel Ward LongDate Submitted2016-02-25CollectionsRegenerative Medicine
Advanced Electrospinning for Regenerative Biomaterials02919New PGS electrospun fibers blended with carriers yield suturable, strong, tunable, ECM-mimicking vascular grafts and nerve guides.Technology TypeEngineering TechnologyTechnology SubtypeMaterial ScienceTagsBiomaterialRegenerative medicineTissue engineeringLead InventorEric JeffriesDepartmentBioengineeringAll Tech InnovatorsEric M. JeffriesYadong WangTechnology Readiness Level4. Prototype testing and refinementDate Submitted2012-10-23CollectionsRegenerative Medicine
Novel Regeneration of the Articular Surfaces in the Temporomandibular Joint03909Biodegradable polymer-magnesium scaffold enables acellular TMJ regeneration, promoting bone and cartilage growth with native cells.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasDentalLead InventorAlejandro AlmarzaDepartmentDent Med-Oral and Craniofacial SciencesAll Tech InnovatorsAlejandro Jose AlmarzaAdam Richard ChinJuan M. TaboasDate Submitted2016-04-14CollectionsRegenerative Medicine
Compound Would Healing Technology Platform04661Decorin-based slow-release therapy reduces scarring and improves wound healing in preclinical mouse models via ECM/regulatory pathways.Technology TypeLife Science Research ToolTechnology SubtypeProteinTherapeutic AreasMusculoskeletalLead InventorAlan WellsDepartmentMed-PathologyAll Tech InnovatorsYadong WangAlan H. WellsTechnology Readiness Level4. Prototype testing and refinementDate Submitted2018-06-14CollectionsRegenerative Medicine
Injectable Thermoresponsive Hydrogel For Sustained Drug Release and Enhanced Cell therapy03044Thermoresponsive injectable hydrogel enables sustained protein/drug release, antioxidative cell support, and tissue regeneration scaffolds.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasNeuroscienceTagsBiomaterialLead InventorYadong WangDepartmentBioengineeringAll Tech InnovatorsMartin OudegaYadong WangDate Submitted2013-05-02
A Shear-thinning Hydrogel That Extends In Vivo Bioactivity of Therapeutic Proteins03988Injectable, shear-thinning hydrogel using silicate nanoplatelets and heparin enables rapid, tunable, Bioactive protein delivery and biodegrades in 8 weeks.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTagsBiomaterialRegenerative medicineTissue engineeringLead InventorYadong WangDepartmentBioengineeringAll Tech InnovatorsXiaochu DingJin GaoYadong WangDate Submitted2016-07-07CollectionsRegenerative Medicine
Novel Resorbable Vascular Grafts03518Resorbable, cell-free vascular grafts remodel into native arteries, offering cheaper, faster production and reduced immunogenic risk.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasCardiovascularTagsImplantable Medical DeviceLife ScienceLead InventorYadong WangDepartmentBioengineeringAll Tech InnovatorsRobert Andrew AllenChelsea Elizabeth StowellYadong WangDate Submitted2015-02-11CollectionsCardiometabolic
Reverse Thermal Gels for Ocular Drug Delivery02138Thermo-responsive, biodegradable reverse-thermal gel self-assembles at body temperature for targeted ocular drug delivery and tissue engineering.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOphthalmologyLead InventorDaewon ParkDepartmentBioengineeringAll Tech InnovatorsThomas R. Friberg M.S.,M.D.Daewon ParkYadong WangDate Submitted2010-01-21CollectionsRegenerative Medicine
Bone Generation in Compromised Wounds04646Injectable or implantable hydrogel–scaffold device regenerates large bone volumes using autologous MSCs, scaffolds, and cytokines.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasMusculoskeletalLead InventorJuan TaboasDepartmentDent Med-Oral and Craniofacial SciencesAll Tech InnovatorsAlejandro Jose AlmarzaJingming ChenAdam Richard ChinDate Submitted2018-06-04
