Enhanced Molecular Detection: Size-Selective Nanostructure-Based Sensor Platform07151Size-selective MOF-SWCNT sensor boosts targeted analyte detection with polymer-stabilized, scalable, high-sensitivity transduction.Technology TypeDiagnostic/AssayTechnology SubtypeIn vitro DiagnosticTagsPlatform TechnologyBiomaterialLead InventorZidao ZengDepartmentChemistryAll Tech InnovatorsAlexander StarZidao ZengTechnology Readiness Level4. Proof of conceptDate Submitted2025-04-15
A Novel Platform for Enhanced Inner Ear Drug Delivery and Gene Therapy07230Exosome-based inner ear drug delivery platform enhances RWM traversal, enabling sustained, versatile loading of drugs and gene therapies.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtolaryngologyTherapeutic IndicationsHearing LossTagsPlatform TechnologyRegenerative medicineLead InventorAdele MoattiDepartmentMed-OtolaryngologyAll Tech InnovatorsAdele MoattiTechnology Readiness Level4. Pre-clinical developmentDate Submitted2025-06-23CollectionsRegenerative Medicine
Biomimetic 3D-Printed Platform for Personalized Mechanotransduction and Disease Modeling in Glaucoma07146Biomimetic 3D-printed lamina cribrosa model for patient-specific glaucoma mechanotransduction, genomic shifts, and drug screening.Technology TypeLife Science Research ToolTherapeutic AreasOphthalmologyTherapeutic IndicationsGlaucomaTagsPlatform TechnologyBiomaterialTissue engineeringLead InventorJonathan Vande GeestDepartmentBioengineeringAll Tech InnovatorsIan P. ConnerSusana Isabel Morgado Mendes Antunes da>VFRemi Jessica ShittuTechnology Readiness Level3. Prototype developmentDate Submitted2025-04-10
The Goalistic™ Health Platform: Revolutionizing Healthcare by Centering Care Around Patient Goals07013AI-driven Goalistic Health Platform centers patient goals in care, aligning with guidelines to boost adherence and outcomes.Technology TypeDigital HealthTechnology SubtypeClinical Decision SupportTagsPlatform TechnologyArtificial intelligence (AI)SoftwareLead InventorSteven ReisDepartmentMed-MedicineAll Tech InnovatorsDavid R. MathiasKacy QuaSteven E. ReisTechnology Readiness Level2. Initial proof-of-concept (PoC)Date Submitted2024-12-20CollectionsHealthcare AI
AAV-Based Mitochondrial Gene Therapy: A Novel Approach to Slowing Neurodegeneration07363AAV-PHP.eB–delivered TIM coexpression restores neuronal mitochondrial import, slowing Huntington's progression and broadly addressing neurodegeneration.Technology TypeTherapeutic ModalityTechnology SubtypeGene Therapy - AAVTherapeutic AreasNeuroscienceTherapeutic IndicationsParkinson's DiseaseHuntington's DiseaseAmyotrophic lateral sclerosis (ALS)TagsPlatform TechnologyGeneticsRare diseaseLead InventorRobert FriedlanderDepartmentMed-Neurological SurgeryAll Tech InnovatorsSergei Victorovich BaranovDiane L. CarlisleRobert Max FriedlanderTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2025-10-06CollectionsCell & Gene Therapy
Novel Animal Model for High-Throughput Screening of Anti-Aging and Metabolic Disease Drugs07337 luciferase-based live model quantifies methionine flux, enabling semi-high-throughput anti-aging/drug discovery via MetR mimetics.Technology TypeLife Science Research ToolTechnology SubtypeAnimal ModelTherapeutic AreasEndocrinology and Metabolic DiseasesTherapeutic IndicationsOtherTagsPlatform TechnologyAgingDrug RepurposingLead InventorSudipta PathakDepartmentMed-Aging InstituteAll Tech InnovatorsAndrey ParkhitkoSudipta PathakTechnology Readiness Level4. Prototype testing and refinementDate Submitted2025-09-14CollectionsCardiometabolic
Targeted Anodal Stimulation for Spinal Grey Matter: Precision Motor Recovery07374Targeted intra-spinal anodal stimulation activates motor neuron somata for precise hand and limb recovery, compatible with neuroprosthetics.Technology TypeTherapeutic ModalityTechnology SubtypeOther Therapeutic ModalityTherapeutic AreasNeuroscienceTherapeutic IndicationsMultiple Sclerosis (MS)TagsPlatform TechnologyLead InventorEvan RogersDepartmentMed-Neurological SurgeryAll Tech InnovatorsMarco CapogrossoEvan R. RogersTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2025-10-20
Advanced Temporal Breast Tissue Dynamics for Precise Cancer Risk Prediction07270A dynamic breast density analysis using velocity and acceleration over time to improve personalized, early cancer risk prediction.Technology TypeDigital HealthTechnology SubtypeClinical Decision SupportTherapeutic AreasOncologyTherapeutic IndicationsDuctal carcinoma (Breast cancer)TagsPlatform TechnologyMachine learningAlgorithmLead InventorJu Hun LeeDepartmentMed-RadiologyAll Tech InnovatorsAndriy BandosJu Hun LeeRobert Mark NishikawaTechnology Readiness Level4. Prototype testing and refinementDate Submitted2025-07-30CollectionsWomen's & Reproductive Health
Precision Synthetic Populations: A Scalable Framework for High-Resolution Demographic Modeling07467A scalable, privacy-preserving synthetic population model matching Census marginals with high spatial precision for policy, health, and planning.Technology TypeDigital HealthTechnology SubtypeHealthcare DataTagsPlatform TechnologyAgingLead InventorNatalie SumetskyDepartmentGSPH-Behavioral & Community Health SciencesAll Tech InnovatorsJeanine Marie BuchanichNatalie Michaela SumetskyTechnology Readiness Level4. Prototype testing and refinementDate Submitted2026-01-30
Intelligent Situational Awareness: A Semantically Aware Audio Agent for Personalized Noise Management07361Intelligent audio agent customizes real-time noise filtering, alerting only user-defined sounds while maintaining ANC.Technology TypeEngineering TechnologyTechnology SubtypeComputing, AI & QuantumTagsPlatform TechnologyArtificial intelligence (AI)Human performanceLead InventorLongfei ShangguanDepartmentSCI-Computer ScienceAll Tech InnovatorsZhiwei RenLongfei ShangguanYongjie YangTechnology Readiness Level3. Prototype developmentDate Submitted2025-10-05CollectionsHealthcare AI
Precision PET Image Enhancement07314Improves PET image clarity by denoising for early disease feature visualization; compatible, protocol-agnostic, retrospective analysis.Technology TypeMedical DeviceTechnology SubtypeDiagnostic ImagingTherapeutic AreasOncologyNeuroscienceTherapeutic IndicationsAlzheimer's DiseaseTagsPlatform TechnologyAlgorithmSoftwareLead InventorVinicius Paranaiba CamposDepartmentMed-NeurobiologyAll Tech InnovatorsVinicius Paranaiba Paranaiba CamposAfonso Costa E SilvaDiego SzczupakTechnology Readiness Level4. Prototype testing and refinementDate Submitted2025-08-28
Portable Real-Time Therapeutic Heating System for Cold Injury Care07281Portable, battery-powered warming system for frostbite with closed-loop temperature control, integrated drug infusion, and mobile deployment.Technology TypeMedical DeviceTechnology SubtypeTherapeutic Medical DeviceTagsPlatform TechnologyHuman performanceSports medicineLead InventorFrancesco EgroDepartmentMed-Plastic SurgeryAll Tech InnovatorsFrancesco Maria EgroTechnology Readiness Level4. Prototype testing and refinementDate Submitted2025-08-08
AAV Potentiator Polypeptides: Unlocking Deeper Tissue Penetration for Next-Generation Gene Therapy07037Potentiator polypeptides enhance AAV tissue penetration, enabling lower doses and broader gene therapy targets across tissues.Technology TypeTherapeutic ModalityTechnology SubtypeGene Therapy - AAVTherapeutic AreasOncologyOphthalmologyTherapeutic IndicationsOtherRetinitis pigmentosa (RP)Age-related macular degenerationTagsPlatform TechnologyGeneticsLead InventorMiguel BetegonDepartmentMed-OphthalmologyAll Tech InnovatorsMiguel BetegonLeah Caroline Thomas ByrneTechnology Readiness Level4. Pre-clinical developmentDate Submitted2025-01-20CollectionsCell & Gene Therapy
pH-Sensitive Linkers for Advanced Biomedical Delivery07192pH-triggered beta-diketone/triketone linkers enable acid-labile, stable delivery systems (LNPs, polymers) for mRNA, cancer, gene therapies.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOncologyImmunologyTherapeutic IndicationsSolid tumorTagsPlatform TechnologyPolymerLead InventorSong LiDepartmentPharm-Pharmaceutical ScienceAll Tech InnovatorsYixian HuangSong LiHuatian LiTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2025-05-23
3D-Printed Anatomical Guides for High-Precision Needle Placement and Drug Delivery07194Custom 3D-printed, patient-specific needle guides enable precise, safe multi-depth drug delivery and biopsies with robotic aid.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasOncologyTherapeutic IndicationsSolid tumorTagsPlatform TechnologyMinimally invasiveSurgeryLead InventorJose ZevallosDepartmentMed-OtolaryngologyAll Tech InnovatorsJose P. ZevallosTechnology Readiness Level4. Prototype testing and refinementDate Submitted2025-05-23CollectionsWomen's & Reproductive Health
Advanced Closed-Loop Neurostimulation System with Real-Time Impedance Monitoring for Enhanced Electrode Longevity07176Real-time impedance-driven closed-loop neurostimulation with asymmetric biphasic pulses enhances electrode longevity and safety.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasNeuroscienceTherapeutic IndicationsParkinson's DiseasePainTagsPlatform TechnologyAlgorithmLead InventorKangni LiuDepartmentElectrical and Computer EngineeringAll Tech InnovatorsGuangzong ChenRajkumar Chinnakonda KubendranXinyan CuiTechnology Readiness Level4. Prototype testing and refinementDate Submitted2025-05-06
High-Performance Fiber Optic Carbon Dioxide Sensor for Elevated Temperature and Distributed Monitoring07143High-temperature fiber-optic CO2 sensor with Lewis acid-base polymer film enables 50–100°C detection, distributed sensing, and strong signal.Technology TypeEngineering TechnologyTechnology SubtypeMaterial ScienceTagsPlatform TechnologyCoatingPolymerLead InventorPaul OhodnickiDepartmentMechanical Engineering and Materials ScienceAll Tech InnovatorsTulika KhanikarPaul Richard OhodnickiYang-Duan SuTechnology Readiness Level5. Advanced prototype validationDate Submitted2025-04-08
Targeting Cardiomyocyte Endoreplication to Prevent Hypertrophic Cardiomyopathy07132Inhibits PCNA-POLD1 interactions via p21 to curb cardiomyocyte endoreplication, preventing hypertrophic cardiomyopathy progression.Technology TypeTherapeutic ModalityTechnology SubtypeGene Therapy - RNATherapeutic AreasCardiovascularTherapeutic IndicationsHypertrophic cardiomyopathyTagsPlatform TechnologyGeneticsRegenerative medicineLead InventorJason BeckerDepartmentMed-MedicineAll Tech InnovatorsJason Robert BeckerSoumojit PalTechnology Readiness Level4. Pre-clinical developmentDate Submitted2025-03-30CollectionsCell & Gene TherapyCardiometabolic
A Novel Approach to Treating Autoimmune Diseases by Modulating Immune Cell Proliferation07129Inhibits PIKFYVE to boost Treg cells, lowering Th17-driven autoimmunity and restoring immune balance.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Discovery - TargetTherapeutic AreasNeuroscienceImmunologyTherapeutic IndicationsMultiple Sclerosis (MS)Autoimmune encephalitis (AIE)TagsPlatform TechnologyAutoimmunePersonalized MedicineLead InventorWilliam HawseDepartmentMed-ImmunologyAll Tech InnovatorsWilliam F. HawseTechnology Readiness Level4. Pre-clinical developmentDate Submitted2025-03-27
Novel Patient-Derived Assembloid Model Accelerates Immunotherapy Development for Difficult-to-Treat Cancers06922Patient-derived assembloid with tumor-immune co-cultures accelerates immunotherapy/vaccine development for hard-to-treat head and neck cancers.Technology TypeLife Science Research ToolTechnology SubtypeCell LineTherapeutic AreasImmunologyOncologyTherapeutic IndicationsSolid tumorTagsPlatform TechnologyImmuno-oncologyTissue engineeringLead InventorRiyue BaoDepartmentMed-MedicineAll Tech InnovatorsRiyue BaoJason J. LukeTechnology Readiness Level3. Prototype developmentDate Submitted2024-10-16
Novel Mouse Model for Immune-Related Adverse Events06884Non-genetic mouse model mimics immunotherapy irAEs across gut, liver, skin via diet/microbiome changes; versatile, human-relevant, safe for KO systems.Technology TypeLife Science Research ToolTechnology SubtypeAnimal ModelTherapeutic AreasImmunologyTherapeutic IndicationsInflammation - GeneralTagsPlatform TechnologyAutoimmuneImmuno-oncologyLead InventorAbigail OveracreDepartmentMed-ImmunologyAll Tech InnovatorsGreg M. DelgoffeAbigail Elise OveracreDipyaman PatraTechnology Readiness Level4. Prototype testing and refinementDate Submitted2024-09-19
Automated OCT-Based Tissue Screening System06669Automated OCT tissue screening with deep learning for label-free, high-throughput, quantitative 3-D tissue analysis and drug screening.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasOphthalmologyTagsPlatform TechnologyMicroscopyMachine learningLead InventorShaohua PiDepartmentMed-OphthalmologyAll Tech InnovatorsYuanyuan ChenShaohua PiJose Alain SahelTechnology Readiness Level4. Prototype testing and refinementDate Submitted2024-03-06
Telehealth Usability Questionnaire (TUQ)06620Validated questionnaire measuring telehealth usability across usefulness, ease, reliability, and satisfaction for design and evaluation.Technology TypeDigital HealthTechnology SubtypeHealthcare DeliveryTagsPlatform TechnologyLead InventorBambang ParmantoDepartmentSHRS-Health Information ManagementAll Tech InnovatorsBambang ParmantoDate Submitted2024-01-29
Deep Learning System for Noise-Free Optical Coherence Tomography (OCT) Imaging without Clean Training Data06607Dual-scan, noise-free OCT denoising via Sub2Full: train on two noisy scans to reveal fine retinal structures without clean data.Technology TypeDigital HealthTechnology SubtypeHealthcare DataTherapeutic AreasOphthalmologyTherapeutic IndicationsDiabetic retinopathyTagsPlatform TechnologyArtificial intelligence (AI)MicroscopyLead InventorShaohua PiDepartmentMed-OphthalmologyAll Tech InnovatorsShaohua PiLingyun WangTechnology Readiness Level5. Advanced prototype validationDate Submitted2024-01-10CollectionsHealthcare AI
MAUQ: The First Comprehensive Standard for Measuring Mobile Health App Usability06596MAUQ standardizes mobile health app usability testing with four targeted versions, global validation, and actionable metrics.Technology TypeDigital HealthTechnology SubtypeHealthcare DeliveryTagsPlatform TechnologyConsumerLead InventorLeming ZhouDepartmentSHRS-Health Information ManagementAll Tech InnovatorsBambang ParmantoLeming ZhouDate Submitted2023-12-13
AI-Driven Bioreactor for Long-Term Ex Vivo Human Tissue Perfusion and Research06260AI-driven bioreactor extends ex vivo human tissue viability to weeks, enabling AI-monitored, high-fidelity drug testing and research.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasDermatologyOncologyTagsPlatform TechnologyArtificial intelligence (AI)BiomaterialLead InventorAsim EjazDepartmentMed-Plastic SurgeryAll Tech InnovatorsJose ArellanoAsim EjazYusuf SurucuTechnology Readiness Level4. Prototype testing and refinementDate Submitted2023-01-08CollectionsHealthcare AI
Gene Therapy for Prader-Willi Syndrome06241A multi-gene Prader-Willi gene therapy using a minigene AAV vector to encode up to eight PWS genes for potential treatment.Technology TypeTherapeutic ModalityTechnology SubtypeGene Therapy - AAVTherapeutic AreasEndocrinology and Metabolic DiseasesTherapeutic IndicationsPrader-Willi SyndromeTagsPlatform TechnologyLead InventorRobert NichollsDepartmentMed-PediatricsAll Tech InnovatorsRobert David NichollsDate Submitted2022-12-06CollectionsCell & Gene TherapyCardiometabolic
Novel Therapy to Prevent Transplanted Organ Rejection (DCreg)05684DCreg therapy from donor liver perfusate induces immune tolerance, enabling immunosuppression withdrawal and reduced rejection risk.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - NK CellTherapeutic AreasNeuroscienceTagsPlatform TechnologySurgeryLife ScienceLead InventorAngus ThomsonDepartmentMed-SurgeryAll Tech InnovatorsEster BadamiPier Giulio ConaldiFadi G. Lakkis M.D.Technology Readiness Level6. IND-enabling studiesDate Submitted2021-04-30CollectionsCell & Gene Therapy
Microfluidic System Rapidly Isolates Extracellular Vesicles from Biological Fluids05658Automated microfluidic device rapidly, fractionally isolating all extracellular vesicle sizes and large cells from fluids in seconds.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasOtherTagsPlatform TechnologyLead InventorKambez Hajipouran BenamDepartmentMed-MedicineAll Tech InnovatorsKambez Hajipouran BenamAlexander Joseph KaiserDate Submitted2021-04-04
Enhanced Small Diameter Optical Fiber with Integrated Gratings05612Integrated gratings form in protected, tiny-diameter fiber via UV exposure; boosts speed, reliability, and sensing in DOFS.Technology TypeEngineering TechnologyTechnology SubtypeSensorTagsPlatform TechnologyCoatingMinimally invasiveLead InventorPeng ChenDepartmentElectrical and Computer EngineeringAll Tech InnovatorsPeng Kevin ChenMing-Jun LiJingyu WuTechnology Readiness Level4. Prototype testing and refinementDate Submitted2021-02-09
Profilin1-actin Interaction Inhibitor as a Novel Anti-Angiogenic Compound05290Profilin1–actin interaction inhibitor blocks ccRCC angiogenesis, offering a resistance-evading, low-toxicity anti-angiogenic cancer therapy.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasOncologyOphthalmologyTherapeutic IndicationsDiabetic retinopathyAge-related macular degenerationTagsPlatform TechnologyLead InventorPartha RoyDepartmentBioengineeringAll Tech InnovatorsPaul G. FrancoeurDavid Martin GauAbigail GondringerTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2020-04-09
Lung-Targeting Peptide to Deliver Diagnostic and Therapeutic Targets to the Lung05084Lung-targeting cell-penetrating peptides enable higher-transduction delivery of diagnostics and therapies directly to lung tissue.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasRespiratoryTherapeutic IndicationsChronic Obstructive Pulmonary Disease (COPD)AsthmaAcute respiratory failureTagsPlatform TechnologyLead InventorMaliha ZahidAll Tech InnovatorsMaliha ZahidTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2019-08-07
Stimulation of Exosome Secretion04959A potent stimulator boosts exosome secretion up to 24-fold, enabling rapid, scalable exosome production for therapies and research.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsPlatform TechnologyLead InventorTheresa WhitesideDepartmentMed-PathologyAll Tech InnovatorsEdwin Kerry JacksonNils LudwigTheresa L. WhitesideTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2019-05-19
Nanoparticle Dopants for Conducting Polymers04941Nanoparticle-doped PEDOT lowers impedance, boosts charge injection and drug loading for improved neural interfaces.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasCardiovascularNeuroscienceTagsPlatform TechnologyBiomaterialCoatingLead InventorXinyan CuiDepartmentBioengineeringAll Tech InnovatorsXinyan CuiKevin M. WoeppelDate Submitted2019-04-03CollectionsCardiometabolic
Using Nanoparticles to Stabilize and Preserve the Bioactivity of Proteins and Peptides04961Silica nanoparticle textures stabilize surface-bound proteins, enabling dry storage, broader biosensor and implant applications.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasOtherTagsPlatform TechnologyBiomaterialCoatingLead InventorXinyan CuiDepartmentBioengineeringAll Tech InnovatorsXinyan CuiKevin M. WoeppelDate Submitted2019-04-17
Functional Poly(Hydrosiloxane)-Based Microbial Nanoculture Systems04723Functional PDMS-based microbial nanocultures enhance permeability and mechanical strength for safer, in-situ microbial studies.Technology TypeEngineering TechnologyTechnology SubtypeMaterial ScienceTherapeutic AreasImmunologyTagsPlatform TechnologyBiomaterialLead InventorTagbo NiepaDepartmentChem/Petroleum EngineeringAll Tech InnovatorsShanna-Leigh DavidsonTagbo Herman Roland NiepaDate Submitted2018-08-29
Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells04531Magnetic-assisted hydrogel fixation delivers adipose-derived stem cells to target sites, enabling minimally invasive, localized therapy.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsPlatform TechnologyBiomaterialRegenerative medicineLead InventorDavid VorpDepartmentBioengineeringAll Tech InnovatorsYogev BaruchKory James BloseTimothy K. ChungTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2018-03-05
DataDigger: A Quick, Flexible Search Engine for Biomarker Data04527DataDigger: flexible, cloud-capable tool for multi-file biomarker data search and SNP-based patient subset querying.Technology TypeLife Science Research ToolTechnology SubtypeBioinformaticsTherapeutic AreasOncologyOtherTagsPlatform TechnologyLead InventorYoram VodovotzDepartmentMed-SurgeryAll Tech InnovatorsFayten Kathryn El-DehaibiQi MiYoram VodovotzDate Submitted2018-02-23
Humanized Animal Models for Advanced Antibody Production04301Humanized mice cultivate human immune responses to produce monoclonal antibodies, enabling safer, more efficacious human antibody therapies.Technology TypeTherapeutic ModalityTechnology SubtypeAntibody - mAbTherapeutic AreasOtherTagsPlatform TechnologyLead InventorMoses BilityDepartmentGSPH-Infectious Diseases & MicrobiologyAll Tech InnovatorsMoses Turkle BilityTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2017-06-21
Ultra-Stable Distributed Fiber Optic Sensor for High-Resolution, High-Temperature Monitoring04137Ultra-stable, high-temperature distributed fiber sensor with nanograting-enhanced Rayleigh scattering for 1 mm resolution.Technology TypeEngineering TechnologyTechnology SubtypeSensorTagsPlatform TechnologySustainabilityLead InventorPeng ChenDepartmentElectrical and Computer EngineeringAll Tech InnovatorsMichael Paul BuricPeng Kevin ChenRongzhang ChenTechnology Readiness Level5. Advanced prototype validationDate Submitted2017-01-25
Optogenetic Induction of Neurodegenerative Disease Pathologies04130Blue-light induced fusion proteins trigger controllable TDP-43/alpha-synuclein/Tau aggregation, modeling neurodegeneration for high-throughput screening.Technology TypeLife Science Research ToolTechnology SubtypeNucleic AcidTherapeutic AreasNeuroscienceTherapeutic IndicationsAmyotrophic lateral sclerosis (ALS)Alzheimer's DiseaseTagsPlatform TechnologyAgingGeneticsLead InventorChristopher DonnellyDepartmentMed-NeurobiologyAll Tech InnovatorsChristopher James DonnellyJacob R. MannDate Submitted2017-01-15
VitaCapsule: A Synthetic Hydrogel for Supporting Human Stem Cells04045VitaCapsule: a low-cost, animal-free hydrogel that enhances single-cell hPSC viability for 2D/3D expansion and scalable biomanufacturing.Technology TypeEngineering TechnologyTechnology SubtypeIndustrial BiotechTagsPlatform TechnologyBiomaterialRegenerative medicineLead InventorThomas RichardsonDepartmentAll TempsAll Tech InnovatorsIpsita BanerjeePrashant N. KumtaThomas Charles RichardsonDate Submitted2016-10-12
Boryl Ethers as Oxidatively-Triggered Drug Delivery Vehicles03939Oxidation-triggered boryl-ether prodrugs release non-toxic carbonyl cargos selectively in oxidative-stress disease sites.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsPlatform TechnologyLead InventorPaul FloreancigDepartmentChemistryAll Tech InnovatorsAlexander DeitersPaul Edward FloreancigRamsey D. HannaDate Submitted2016-05-13
Protection and Delivery of Multiple Therapeutic Proteins03836Coacervate delivery system extends protein half-lives to weeks using platelet-rich plasma, enhancing wound healing and tissue repair.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsPlatform TechnologyLead InventorDaniel LongDepartmentBioengineeringAll Tech InnovatorsEric M. JeffriesNoah R. JohnsonDaniel Ward LongDate Submitted2016-02-25CollectionsRegenerative Medicine
Thermoresponsive Hydrogel Containing Polymer Microparticles for Controlled Drug Delivery to the Ear03810Single-dose, thermoresponsive ear gel with PLGA microspheres for 14-day ciprofloxacin release and lidocaine.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtolaryngologyTagsPlatform TechnologyPolymerLead InventorMorgan DileoDepartmentMed-OphthalmologyAll Tech InnovatorsLiza Anna BrukMorgan Virginia DileoSteven R. LittleDate Submitted2016-01-26
Layer Up: Drug-Eluting Coating for Implantable Devices and Biomaterials03741Layer Up coats implants with drug-eluting anti-inflammatory mesh coatings to reduce rejection and enhance tissue integration.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTagsPlatform TechnologyBiomaterialCoatingLead InventorDaniel HachimDepartmentBioengineering DepartmentAll Tech InnovatorsBryan Nicklaus BrownDaniel HachimDate Submitted2015-10-05
Biodegradable Poly(Ester Amide) Elastomers03590Biodegradable poly(ester amide) elastomers: solvent-free, tunable, biocompatible scaffolds for soft tissue engineering and drug delivery.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTagsPlatform TechnologyPolymerLead InventorShilpa SantDepartmentDepartment of Pharmaceutical SciencesAll Tech InnovatorsShilpa SantVinayak SantDate Submitted2015-04-20CollectionsRegenerative Medicine
Light-Activated CRISPR/Cas9: Precise Control over Gene Editing03547Light-activated CRISPR/Cas9 enables spatially, temporally precise gene editing, reducing off-target effects with light control.Technology TypeLife Science Research ToolTechnology SubtypeNucleic AcidTherapeutic AreasOtherTagsPlatform TechnologyLead InventorAlexander DeitersDepartmentDistinguished Faculty-Dietrich School of Arts and SciencesAll Tech InnovatorsAravind AsokanErin BorchardtAlexander DeitersDate Submitted2015-03-11
Synthetic Enveloped Virus as a Systemically Deliverable Therapy03499Biomimetic synthetic enveloped virus delivers targeted, systemic viral therapies with pH-triggered release and enhanced persistence.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsPlatform TechnologyLead InventorStephen ThorneDepartmentMed-Cell BiologyAll Tech InnovatorsSong LiStephen Howard ThorneDate Submitted2015-01-26
Pittsburgh Fatigability Scale (PFS)03429A validated, self-administered 10-item scale measuring physical and mental fatigability in older adults to predict mobility risk.Technology TypeDiagnostic/AssayTechnology SubtypeOther Diagnostic/AssayTherapeutic AreasEndocrinology and Metabolic DiseasesTagsPlatform TechnologyAgingHuman performanceLead InventorNancy GlynnDepartmentGSPH-EpidemiologyAll Tech InnovatorsScott Richard BeachRobert M. BoudreauNancy W. GlynnDate Submitted2014-10-22CollectionsCardiometabolic
