Technology Subtype

Diagnostic Imaging

Heterocyclic Compounds for Imaging Aggregated Tau

06319

New indole-based PET radiotracers selectively image 4R-tau tauopathies (PSP, CBD), aiding early diagnosis and therapy monitoring.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Tags: Diagnostic Imaging
Life Science
Lead Inventor: Jeffrey Stehouwer
Department: Med-Radiology
All Tech Innovators: Thomas Graham
Robert H. Mach
Chester A. Mathis Jr., Ph.D.
Date Submitted: 2023-02-28

Automated 3D OCT Vessel Segmentation Framework for Precise Retinal Blood Vessel Mapping

01998

Automated 3D SD-OCT vessel segmentation fuses 2D fundus and 3D OCT cues for robust retinal vessel mapping and early disease detection.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Tags: Microscopy
Lead Inventor: Juan Xu
Department: Med-Ophthalmology
All Tech Innovators: Hiroshi Ishikawa
Joel Steven Schuman
David Tolliver
Date Submitted: 2009-05-11

AROSE Adjustment of the Rotation and Saturation Effects of CEST MRI Imaging

05589

AROSE sharpens CEST MRI specificity by adjusting rotation/saturation, filtering non-specific signals for precise biomarker imaging.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Lead Inventor: Tao Jin
Department: Med-Radiology
All Tech Innovators: Julius Chung
Tao Jin
Date Submitted: 2021-01-14

4D Oxy-Wavelet MRI for Monitoring Mitochondrial Function

06288

Non-invasive 4D Oxy-wavelet MRI tracks mitochondrial function via BOLD, revealing oxygen balance and tissue health in vivo.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Endocrinology and Metabolic Diseases
Therapeutic Indications: Other
Mitochondrial Disease
Tags: Pediatrics
Rare disease
Diagnostic Imaging
Lead Inventor: Yijen Wu
Department: Med-Pediatrics
All Tech Innovators: Anthony G. Christodoulou
Devin Raine Everaldo Cortes
Yijen Wu
Date Submitted: 2023-02-13
Collections: Rare Diseases
Cardiometabolic

High Field of View High Frame Rate 3D Ultrasound

05980

Gives real-time, high-frame-rate 3D ultrasound with wide field of view using AI-optimized beamforming and reduced channels.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Other
Tags: Artificial intelligence (AI)
Algorithm
Lead Inventor: Kang Kim
Department: Bioengineering
All Tech Innovators: Kang Kim
Zhiyu Sheng
Date Submitted: 2022-03-08
Collections: Healthcare AI

MePhys: Mesoscopic Electrophysiology

06557

MePhys images whole primate brains with 992 intracranial and 32 skull electrodes, enabling ultra-fast, high-resolution brain connectome mapping.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Tags: Diagnostic Imaging
Life Science
Lead Inventor: Tobias Teichert
Department: Med-Psychiatry
All Tech Innovators: Tobias Teichert
Date Submitted: 2023-11-03

Novel Structural and Functional Imaging of Bladder Diseases

06472

Intravesical MRI emulsion enhances bladder imaging by direct contrast instillation, improving cancer staging and permeability assessment.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Urology
Oncology
Therapeutic Indications: Overactive Bladder
Bladder
Urothelial carcinoma (Bladder cancer)
Tags: Diagnostic Imaging
Life Science
MR Contrast Agents
Lead Inventor: Pradeep Tyagi
Department: Med-Urology
All Tech Innovators: Chan-Hong Moon
Pradeep Tyagi
Date Submitted: 2023-08-02

Novel Technique to Obtain 3D Kinematics

06054

Innovative dynamic-filter radiography enables 3D kinematics capture by moving with the subject, enhancing spinal biomechanics imaging.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Musculoskeletal
Lead Inventor: Tom Gale
Department: Med-Orthopedic Surgery
All Tech Innovators: William J. Anderst
Tom Gale
Date Submitted: 2022-06-14

Comparing OCT Scans from Baseline and Follow Up

06320

New OCT/OCTA 3D change-mapping algorithm compares baseline vs. follow-up scans without layer segmentation, enabling earlier retinal disease insight.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Lead Inventor: Shaohua Pi
Department: Med-Ophthalmology
All Tech Innovators: Shaohua Pi
Bingjie Wang
Date Submitted: 2023-02-28

Novel 4D MRI Method for In Utero Imaging

05257

Innovative 4D MRI combines high-frame-rate cMRI and fMRI with reconstruction software to image fetal and placental development in utero.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Reproductive Health
Therapeutic Indications: Obstetrics
Tags: Diagnostic Imaging
Life Science
Lead Inventor: Yijen Wu
Department: Med-Pediatrics
All Tech Innovators: Anthony G. Christodoulou
Yijen Wu
Date Submitted: 2020-02-25
Collections: Women's & Reproductive Health

PET Imaging Agents for Aggregated Tau in the Brain

06483

Novel 4R-tau PET radiotracers: photostable, high affinity to 4R-tau, enabling early PSP/CBD diagnosis and progression tracking.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Therapeutic Indications: Other
Progressive supranuclear palsy
Alzheimer's Disease
Lead Inventor: Chester Mathis
Department: Med-Radiology
All Tech Innovators: Chester A. Mathis Jr., Ph.D.
Jeffrey S. Stehouwer
Date Submitted: 2023-08-16

Method for Monitoring Tissue Parameter by Magnetic Resonance Imaging

03250

Spin-lock MRI isolates chemical-exchange signals to quantify proteoglycan content linearly, robust to T1/T2 variations, aiding tissue health assessment.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Musculoskeletal
Therapeutic Indications: Pain
Osteoporosis
Lead Inventor: Wen Ling
Department: Med-Radiology
All Tech Innovators: Kyong Tae Bae
Tao Jin
Wen Ling
Date Submitted: 2014-02-19
Collections: Women's & Reproductive Health

Smart MRI: New methodology provides MRI results 6 Times Faster Than Current Exams for Adult and Pediatric Populations

04962

Ultra-fast MRI method speeds brain exams 6x+, cutting scans to under 10 minutes and reducing need for pediatric sedation.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Pediatrics/Neonatology
Neuroscience
Therapeutic Indications: Pain
Tags: Pediatrics
Lead Inventor: Vanessa Schmithorst
Department: Med-Radiology
All Tech Innovators: Vanessa Jean Schmithorst
Technology Readiness Level: 3. Prototype development
Date Submitted: 2019-04-17

An integrated ultrasound and mechanical testing system for mapping 3D tissue mechanics and fiber architecture.

02986

Integrated ultrasound-mechanical tester maps 3D tissue mechanics and fiber architecture in opaque, thick samples without extensive prep.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Cardiovascular
Tags: Cardiovascular Disease
Diagnostic Imaging
Lead Inventor: Kang Kim
Department: Bioengineering
All Tech Innovators: Kang Kim
Choon Hwai Yap
Date Submitted: 2013-02-18
Collections: Cardiometabolic

A New Methodology for Computing Phase-Locking Value for Dynamic Functional Connectivity

02754

A real-time PLV method links phase synchrony to per-time-point SNR, enabling instantaneous dynamic functional connectivity.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Lead Inventor: Tianhu Lei
Department: Med-Radiology
All Tech Innovators: Kyong Tae Bae
Tianhu Lei
Timothy Roberts
Date Submitted: 2012-04-24

Magnetic Resonance Imaging Sequence for Efficient Simultaneous T1 and T2 Imaging with CSF Suppression

04601

Efficient, CSF-suppressing MRI binds T1/T2 imaging in one high-field, multi-block sequence with self-correcting IPN.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Tags: Algorithm
Lead Inventor: Jullie Pan
Department: Med-Radiology
All Tech Innovators: Hoby Hetherington
Chan-Hong Moon
Jullie W. Pan
Date Submitted: 2018-04-23

Selective Zero-Quantum Coherence Transfer (Sel-ZQC) for High-Resolution Metabolite Imaging at Ultrahigh Field without Inhomogeneous Line Broadening

02457

Sel-ZQC enables high-resolution metabolite MRI at ultrahigh fields without hardware stabilization, boosting SNR and lipid separation.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Qiuhong He
Department: Med-Radiology
All Tech Innovators: Jeffrey W. Barker
Song Chen
Qiuhong He
Date Submitted: 2011-04-08
Collections: Women's & Reproductive Health

Optical Coherence Tomography (OCT) Image Enhancement

03534

Virtual averaging accelerates OCT scanning by 80%, producing frame-averaged-quality images from rapid, nonframe-averaged data.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Lead Inventor: Hiroshi Ishikawa
Department: Med-Ophthalmology
All Tech Innovators: Chieh-Li Chen
Hiroshi Ishikawa
Joel Steven Schuman
Date Submitted: 2015-03-04

Novel System for Glucose Transport by Spin-Lock Magnetic Resonance

03252

A non-radioactive MRI method using spin-locks to map glucose transport/metabolism with high sensitivity and rapid quantification.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Lead Inventor: Tao Jin
Department: Med-Radiology
All Tech Innovators: Kristy S. Hendrich
Tao Jin
Seonggi Kim
Date Submitted: 2014-02-26

Signal Normalization Among Multiple Optical Coherence Tomography Devices

03384

Device-independent OCT normalization standardizes cross-device images via resampling, denoising, histogram-based scaling for consistent comparisons.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Lead Inventor: Chieh-Li Chen
Department: Bioengineering
All Tech Innovators: Chieh-Li Chen
Hiroshi Ishikawa
Joel Steven Schuman
Date Submitted: 2014-08-18

Precision PET Image Enhancement

07314

Precision PET denoising software enhances early lesion visibility and diagnostic clarity without extra hardware, enabling retrospective and clinical use.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Neuroscience
Therapeutic Indications: Alzheimer's Disease
Tags: Platform Technology
Algorithm
Software
Lead Inventor: Vinicius Paranaiba Campos
Department: Med-Neurobiology
All Tech Innovators: Vinicius Paranaiba Paranaiba Campos
Afonso Costa E Silva
Diego Szczupak
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-08-28

AI Assisted Diagnosis of Thrombotic Syndrome

06193

AI-driven non-invasive tool predicts DVT severity and PTS risk via vein biomechanics, enabling early personalized prevention.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Hematology
Cardiovascular
Therapeutic Indications: Thrombosis
Tags: Artificial intelligence (AI)
Lead Inventor: Timothy Chung
All Tech Innovators: Timothy K. Chung
Cyrus J. Darvish
Pete Gueldner
Technology Readiness Level: 2. Initial proof-of-concept (PoC)
Date Submitted: 2022-10-21
Collections: Cardiometabolic
Healthcare AI

Quantification of Disease Severity Using 2D X-Ray

05478

Novel CNN method quantifies thoracic disease extent from 2D X-rays, using 3D CT ground truth for accuracy.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Respiratory
Infectious Disease
Therapeutic Indications: Emphysema
Pneumococcal
Chronic Obstructive Pulmonary Disease (COPD)
Lead Inventor: Jiantao Pu
Department: Med-Radiology
All Tech Innovators: Jiantao Pu
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2020-08-12

Non-contact OCT Imaging and Analysis System for 3D Visualization and Monitoring of Limbal Palisades

02412

Non-contact 3D OCT maps Palisades of Vogt for limbal stem cell niche profiling, disease monitoring, and donor assessment.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Lead Inventor: Kira Lathrop
Department: Med-Ophthalmology
All Tech Innovators: Lawrence E. Kagemann Jr
Kira L. Lathrop
Joel Steven Schuman
Date Submitted: 2011-02-22

Method and Apparatus to Standardize the Strains in Ultrasound Elasticity Imaging

02350

New ultrasound elasticity method standardizes tissue strain to detect subtle stiffness changes from inflammation and fibrosis.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Lead Inventor: Kang Kim
Department: Bioengineering
All Tech Innovators: Kang Kim
Jonathan M. Rubin
Jingping Xu
Date Submitted: 2010-12-01

AWSOS: Fast Ultrashort Echo Time MRI

01336

AWSOS enables ultra-short echo time MRI with 2D spiral readouts, 1 mm resolution, 3-minute scans, visualizing hard-to-image tissues.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Musculoskeletal
Oncology
Lead Inventor: Yongxian Qian
Department: Med-Radiology
All Tech Innovators: Fernando E. Boada
Yongxian Qian
Date Submitted: 2006-08-28

Use of Ultrasound for Non-Invasive Lipid Detection

02764

A non-invasive ultrasound method using temperature-controlled lipid-specific thermal strain imaging maps to quantify tissue fat in real time.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Hepatology
Lead Inventor: Kang Kim
Department: Bioengineering
All Tech Innovators: Debaditya Dutta
Kang Kim
Ahmed Mohamed Ehab Ahmed Mahmoud
Date Submitted: 2012-05-03

Intravascular Ultrasound for Enhanced Microbubble Contrast and Vascular Imaging

02356

Catheter IVUS using dual-frequency radial modulation of microbubbles for high-contrast, high-resolution plaque and microvascular imaging.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Cardiovascular
Tags: Cardiology
Cardiovascular Disease
Diagnostic Imaging
Lead Inventor: Xucai Chen
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Flordeliza S. Villanueva M.D.
Francois Tchi Ho Yu
Date Submitted: 2010-12-07
Collections: Cardiometabolic

Low-coherence Common-path Phase Microscopy for Nanoscale Detection of Malignancy in Stained Tissue Slides

02125

New reflectance-phase microscope uses common-path, nanoscale quantitative phase maps for malignant changes in stained slides, with seamless workflow.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Yang Liu
Department: Med-Medicine
All Tech Innovators: Randall E. Brand
Yang Liu
Pin Wang
Date Submitted: 2009-12-18

Combined Structural and Chemical Imaging for Breast Cancer Diagnosis

01543

Integrated MRI-MRSI breast detector boosts cancer specificity/sensitivity without radiation, profiling biomarkers like PUFA, lactate, choline.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Reproductive Health
Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Qiuhong He
Department: Med-Radiology
All Tech Innovators: Brendan Patrick Clifford
Doudou Gao
Qiuhong He
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2007-07-25
Collections: Women's & Reproductive Health

Innovative Short-T2 Sodium MRI for Accurate Intracellular Sodium Measurement

03055

Short-T2 sodium MRI enables noninvasive intracellular Na+ measurement with lower SAR, higher SNR, aiding brain tumor and neurological disease assessment.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Oncology
Therapeutic Indications: Parkinson's Disease
Multiple Sclerosis (MS)
Epilepsy
Lead Inventor: Yongxian Qian
Department: Med-Radiology
All Tech Innovators: James Michael Mountz
Ashok Panigrahy
Yongxian Qian
Date Submitted: 2013-05-15

Multinuclear-selective MR Spectroscopy Imaging Platform for Single-scan Lipid/water Suppression and Metabolite Mapping

01965

Simultaneous lipid/water suppression and multi-metabolite mapping in a single scan using selective multiple-quantum coherence MRI spectroscopy.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Qiuhong He
Department: Med-Radiology
All Tech Innovators: Qiuhong He
Date Submitted: 2009-03-26
Collections: Women's & Reproductive Health

Novel MRI Pulse Sequence based on QSPACE Trajectory Technique

02716

Novel MRI pulse sequence speeds High-Definition Fiber Tracking by angular oversampling, halving scan time without compromising resolution.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Surgery
Neuroscience
Lead Inventor: Fernando Boada
Department: Med-Radiology
All Tech Innovators: Fernando E. Boada
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2012-03-13

Advanced Respiratory Motion Prediction and Correction for Enhanced MRI Imaging

03114

Advanced respiratory motion prediction corrects MRI in real time, enabling 1 mm accuracy across full volumes without breath-holds.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Lead Inventor: H Gach
Department: Med-Radiology
All Tech Innovators: H Michael Gach
Dan Ruan
Hao Song
Date Submitted: 2013-08-24

Directional Diffusion Fiber Tracking

02376

Directional diffusion MRI quantifies axonal connectivity volumetrically, robust to crossings, improving tractography and cortical boundary accuracy.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Lead Inventor: Walter Schneider
Department: Psychology
All Tech Innovators: Sudhir Kumar Pathak
Walter Schneider
Date Submitted: 2011-01-06

Expanded Phase-encoding EPI Sequence for Recovering Susceptibility-induced Signal Loss

01631

Expanded phase-encoding EPI enlarges encoding window to recover susceptibility-induced signal loss with minimal time, seamless integration.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Kwan-Jin Jung
Department: Office of Administration-Health Sciences
All Tech Innovators: Kwan-Jin Jung
Hua Peng
Date Submitted: 2008-01-29

Automated Segmentation of Kidneys from MR Images in Subjects with Autosomal Dominant Polycystic Kidney Disease

03602

Automated, robust MRI kidney segmentation for ADPKD: precise left/right delineation, TV regularization, and reliable volume measurement.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Nephrology
Therapeutic Indications: Polycystic Kidney Disease (PKD)
Lead Inventor: Kyong Bae
Department: Med-Radiology
All Tech Innovators: Kyong Tae Bae
Youngwoo Kim
Date Submitted: 2015-05-07

Light Refraction Imaging to Measure Liquid Volume

02316

Light refraction imaging enables noninvasive, high-throughput airway liquid volume measurement using standard lab cameras, matching confocal accuracy.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Respiratory
Lead Inventor: Michael Myerburg
Department: Med-Medicine
All Tech Innovators: Michael M. Myerburg
Date Submitted: 2010-10-06

TPI-SENSE for Efficient 3D Proton/Non-Proton MR Imaging

01479

TPI-SENSE enables fast, 3D proton/non-proton MRI with higher SNR for short-T2 tissues, improving stroke/cancer diagnostics.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Cardiovascular
Oncology
Therapeutic Indications: Stroke
Solid tumor
Lead Inventor: Fernando Boada
Department: Med-Radiology
All Tech Innovators: Fernando E. Boada
Yongxian Qian
Date Submitted: 2007-04-13
Collections: Cardiometabolic

Dual-Echo MRI Method for Simultaneous MR Angiography and MR Venography

01780

Dual-echo MRI enables simultaneous high-quality MRA and MRV in one scan, matching separate scans without extra time.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Cardiovascular
Lead Inventor: Sung-Hong Park
Department: Med-Radiology
All Tech Innovators: Kyong Tae Bae
Sung-Hong Park
Date Submitted: 2008-07-09
Collections: Cardiometabolic

Cross-dimensional OCT Registration for Aligning 2D Scans with 3D Volumes across Devices

01633

Cross-Device OCT alignment enables 2D-3D registration across time and platforms, preserving history and reducing variability.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Lead Inventor: Hiroshi Ishikawa
Department: Med-Ophthalmology
All Tech Innovators: Hiroshi Ishikawa
Jongsick S. Kim
Joel Steven Schuman
Date Submitted: 2008-02-04

Apparatus and Method for Positioning Patients

00286

Noninvasive head-motion control via real-time optical tracking enhances radiotherapy precision and diagnostic image clarity.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Oncology
Lead Inventor: Donald Sashin
Department: Med-Radiology
All Tech Innovators: Donald Sashin
Date Submitted: 1998-09-10

Novel Method for Safer Lung Cancer Screening

06213

Personalized LDCT risk tool tailors lung cancer screening, reducing unnecessary tests and targeting high-risk patients.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Therapeutic Indications: Lung cancer - other
Lung Cancer - Non-Small Cell
Lead Inventor: Jiantao Pu
Department: Med-Radiology
All Tech Innovators: Jiantao Pu
Date Submitted: 2022-11-11