Technology Subtype

Drug Delivery / Formulation

Regenerative Topical Therapy for Cold-Induced Skin Injury: A Field-Ready Solution to Prevent Necrosis and Amputation

07296

Hydrogel HA-Metformin topical therapy regenerates frostbitten skin, restores architecture, reduces necrosis risk, deployable field-ready.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Dermatology
Tags: Biomaterial
Polymer
Regenerative medicine
Lead Inventor: James Wang
Department: Med-Orthopedic Surgery
All Tech Innovators: James Huicong Wang
Jianying Zhang
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2025-08-19
Collections: Regenerative Medicine

Lung-Targeting Peptide to Deliver Diagnostic and Therapeutic Targets to the Lung

05084

Lung-targeting cell-penetrating peptides enable higher-transduction delivery of diagnostics and therapies directly to lung tissue.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Therapeutic Indications: Chronic Obstructive Pulmonary Disease (COPD)
Asthma
Acute respiratory failure
Tags: Platform Technology
Lead Inventor: Maliha Zahid
All Tech Innovators: Maliha Zahid
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-08-07

Novel Use of Metformin to Treat Musculoskeletal Injury

06416

Metformin advances tendon healing by reducing fibrosis and inflammation, promoting angiogenesis for safer, cost-effective tendinopathy treatment.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Neuroscience
Musculoskeletal
Lead Inventor: James Wang
Department: Med-Orthopedic Surgery
All Tech Innovators: James Huicong Wang
Jianying Zhang
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-05-23
Collections: Regenerative Medicine

Biodegradable Poly(Ester Amide) Elastomers

03590

Biodegradable poly(ester amide) elastomers: solvent-free, tunable, biocompatible scaffolds for soft tissue engineering and drug delivery.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Tags: Polymer
Platform Technology
Lead Inventor: Shilpa Sant
Department: Department of Pharmaceutical Sciences
All Tech Innovators: Shilpa Sant
Vinayak Sant
Date Submitted: 2015-04-20
Collections: Regenerative Medicine

A Novel Platform for Enhanced Inner Ear Drug Delivery and Gene Therapy

07230

Exosome-based inner ear drug delivery platform enhances RWM traversal, enabling sustained, versatile loading of drugs and gene therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Otolaryngology
Therapeutic Indications: Hearing Loss
Tags: Regenerative medicine
Platform Technology
Lead Inventor: Adele Moatti
Department: Med-Otolaryngology
All Tech Innovators: Adele Moatti
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-06-23
Collections: Regenerative Medicine

Enhanced Antitumor Efficacy of Ultrasound-mediated Doxorubicin Delivery by Microbubble-liposome Complex

05168

Ultrasound-triggered microbubble-liposome delivery of doxorubicin enhances tumor kill, reduces cardiotoxicity, boosting soft-tissue sarcoma therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Flordeliza Villanueva
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Mingyu He
Flordeliza S. Villanueva M.D.
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-11-14

Stimulation of Exosome Secretion

04959

A potent stimulator boosts exosome secretion up to 24-fold, enabling rapid, scalable exosome production for therapies and research.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Theresa Whiteside
Department: Med-Pathology
All Tech Innovators: Edwin Kerry Jackson
Nils Ludwig
Theresa L. Whiteside
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-05-19

A Mechanistic Approach for the Development and Use of Surfactants Containing Drug-Interactive Domains

02645

Tailored surfactants with drug-interactive interfaces enable stable, efficient delivery of moderately hydrophobic drugs.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Tags: Coating
Platform Technology
Lead Inventor: Xiang Gao
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Michael W. Epperly Ph.D.
Xiang Gao
Joel S. Greenberger M.D.
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2011-12-06

Delivery of Antagonists and Agonists for Immune Modulation

06543

Controlled microparticle release delivers ATP antagonists and adenosine receptor agonists to suppress inflammation long-term.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Dermatology
Immunology
Therapeutic Indications: Dermatitis
Lead Inventor: Elizabeth Bentley
Department: Bioengineering
All Tech Innovators: Stephen C. Balmert
Elizabeth Bentley
Julie Kobyra
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-10-17

Endosomal Lysis for mRNA Induced Protein Expression

06986

Next-gen mRNA therapy: a modified GSDMC peptide enhances endosome escape, boosting mRNA delivery and protein production.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Infectious Disease
Tags: Life Science
Lead Inventor: Yi-Nan Gong
Department: Med-Immunology
All Tech Innovators: Yi-Nan Gong
Reinhard Hinterleitner
Donghui Yang
Date Submitted: 2024-11-27

Boronic Acid Mediated Cellular Delivery of Therapies

06367

Boronic acids enable cellular delivery of oligonucleotide therapies, boosting cytosolic penetration and potential drug efficacy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Lead Inventor: Kabirul Islam
Department: Chemistry
All Tech Innovators: Kirsten Deprey
Kabirul Islam
Joshua Kritzer
Date Submitted: 2023-04-10

Amphiphilic Polymer Carriers for Targeted Cancer Treatment

05348

Amphiphilic polymer carriers co-deliver chemo and COX inhibitors, targeting cancer stem cells for enhanced immunotherapy synergy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Lead Inventor: Song Li
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Yixian Huang
Haozhe Huang
Song Li
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-05-08
Collections: Women's & Reproductive Health

CyteSolutions Lens: Drug-Eluting Contact Lens Technology

04712

CyteSolutions Lens enables days-long, low-dose, sustained drug delivery via a smart contact lens to treat dry eye inflammation.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Lead Inventor: Alexis Nolfi
Department: Office of the SVC and Provost
All Tech Innovators: Bryan Nicklaus Brown
Vishal Jhanji
Alexis Lauren Nolfi
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2018-08-17

Novel Genetically Encoded Nanoparticles

05910

Genetically encoded nanoparticles target and protect cells, enabling precision antibacterial, anticancer therapies and radiation shielding.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Infectious Disease
Oncology
Lead Inventor: Or Shemesh
Department: Med-Ophthalmology
All Tech Innovators: Or Shemesh
Date Submitted: 2021-12-06

Enema-Based Prophylaxis for HIV and Other STIs

05760

Enema-delivered TFV and Q-Griffithsin offer topical PrEP for HIV/STI prevention, aiming to improve adherence among MSM.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Infectious Disease
Therapeutic Indications: HIV
Lead Inventor: Lisa Rohan
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Lisa Cencia Rohan
Xin Tong
Date Submitted: 2021-07-14
Collections: Women's & Reproductive Health

Prevention of DED Utilizing a Histone/Protein Deacetylase Inhibitor (HDACi)

04403

HDAC inhibitor-loaded PLGA microspheres deliver targeted, long-term anti-inflammatory therapy for dry eye by boosting regulatory T cells.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Conjunctivitis
Dry eye syndrome
Uveitic macular edema (UME)
Lead Inventor: Steven Little
Department: Engr-Dept Chairperson's Office
All Tech Innovators: Steven R. Little
Michelle Lynn Ratay
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2017-10-09

Microbubble-Based Sonosensitizer Delivery Systems for Ultrasound-Triggered Reactive Oxygen Species Generation and Cancer Therapy

04132

Ultrasound-triggered lipid microbubbles deliver hydrophobic sonosensitizers for targeted ROS-based cancer therapy with theranostic imaging.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Xucai Chen
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Bin Qin
Flordeliza S. Villanueva M.D.
Date Submitted: 2017-01-19

Novel Nitro-Fatty Acid Microbubbles for Targeted Therapy

05003

Targeted ultrasound-triggered nitro-fatty acid microbubbles enable localized, enhanced delivery for cardiovascular therapy and imaging.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Intensive Care
Cardiovascular
Lead Inventor: Gary Yu
Department: Bioengineering
All Tech Innovators: Xucai Chen
Marco Fazzari
Bruce A. Freeman
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-06-14
Collections: Cardiometabolic

Nanoparticles to Treat Coronary Arterial Calcification

06198

Nanoparticle-delivered sodium thiosulfate selectively dissolves arterial plaque calcium, reducing rupture risk and side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Atherosclerotic disease
Lead Inventor: Brittany Rodriguez
Department: Graduate Studies-Dietrich School of Arts and Sciences
All Tech Innovators: Brittany Renee Rodriguez
David A. Vorp Ph.D.
Justin Sol Weinbaum
Date Submitted: 2022-10-26
Collections: Cardiometabolic

Easier, Faster Oligosaccharide Synthesis

04225

A fast, one-pot glycosylation method yields oligosaccharides with 93%+ yields at room temperature, enabling automated synthesis.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Intensive Care
Gastroenterology
Lead Inventor: Xinyu Liu
Department: Chemistry
All Tech Innovators: Xinyu Liu
Aniruddha Sasmal
Date Submitted: 2017-04-28

Targeted Treatment of Inflammatory Bowel Disease

05417

Orally delivered, targeted PLGA microparticles deliver IL-2, TGF-β, and rapamycin to inflamed gut tissue, reducing IBD activity.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Gastroenterology
Immunology
Therapeutic Indications: Chrohn's Disease
Lead Inventor: Roger Sands
Department: Med-Medicine
All Tech Innovators: Steven R. Little
Roger Warren Sands
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-06-11

Thermogel-extended Release Microsphere Based Delivery to the Paranasal Sinuses

05299

Thermogel-PLGA microspheres deliver four-week, localized mometasone furoate to paranasal sinuses post-surgery.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Infectious Disease
Lead Inventor: Andrea Schilling
Department: Chemical and Petroleum Engineering
All Tech Innovators: Stella Lee
Steven R. Little
Andrea Leigh Schilling
Date Submitted: 2020-04-10

Complex Coacervate for Controlled Release

03713

Versatile complex coacervate enables customizable, localized, sustained biomolecule delivery (up to 400 targets) for cancer and heart therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Lead Inventor: Yadong Wang
Department: Bioengineering
All Tech Innovators: Eric M. Jeffries
Yadong Wang
Date Submitted: 2015-09-04

Slow Drug Release for Ophthalmic Treatments

05610

Coacervate gel delivers CXCL10p peptide to the eye for slow, tunable dry eye treatment, reducing goblet cell loss.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Dry eye syndrome
Tags: Life Science
Lead Inventor: Alan Wells
Department: Med-Pathology
All Tech Innovators: Shivalingappa Kottur Swamynathan
Yadong Wang
Alan H. Wells
Date Submitted: 2021-02-08

Novel Cu(I)-Catalyzed Azide-Alkyne Cycloadditions (CuAAC) Ligands for Application in the Radiometal-based Pharmaceuticals and the Use Thereof

03303

Cu(I) three-component CuAAC ligands enable rapid, high-purity radiometal labeling with reduced copper toxicity for PET imaging.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Lead Inventor: Dexing Zeng
All Tech Innovators: Dexing Zeng
Date Submitted: 2014-04-23

Controlled Release Microparticle Platform for Localized Prevention of Tissue Calcification and Ossification

03248

PLGA microparticles deliver BMP receptor inhibitor locally to prevent tissue calcification with sustained, customizable release.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Sports medicine
Tissue engineering
Lead Inventor: Riccardo Gottardi
All Tech Innovators: Peter Alexander
Patrick A. Bianconi
Riccardo Luca Gottardi
Date Submitted: 2014-02-17
Collections: Regenerative Medicine

A Novel Vaginal Film Platform for Sustained Drug Delivery

05770

Sustained-release vaginal film co-delivers HIV prevention and contraception, enabling monthly dosing and multi-actives compatibility.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Infectious Disease
Reproductive Health
Therapeutic Indications: HIV
Obstetrics
Gynecological disorder
Lead Inventor: Lisa Rohan
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Prithivirajan Durairajan
Sravan Kumar Patel
Lisa Cencia Rohan
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-07-23
Collections: Women's & Reproductive Health

Ultrasound-Mediated Treatment of Microvascular Obstruction Using tPA-Labeled Microbubbles

04611

Ultrasound-triggered tPA-labeled microbubbles disrupt microthrombi, enhancing thrombolysis to improve microvascular patency in CAD.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Lead Inventor: John Pacella
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Stephen D'Auria
John J. Pacella
Date Submitted: 2018-04-30
Collections: Cardiometabolic

Boryl Ethers as Oxidatively-Triggered Drug Delivery Vehicles

03939

Oxidative-stress-triggered α-boryl ether prodrugs release non-toxic ketone/aldehyde cargos selectively in diseased cells.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Paul Floreancig
Department: Chemistry
All Tech Innovators: Alexander Deiters
Paul Edward Floreancig
Ramsey D. Hanna
Date Submitted: 2016-05-13

Noninvasive & Long-Acting Thermoresponsive Hydrogel for Sustained Ocular Drug Delivery

02867

Noninvasive, thermoresponsive ocular gel with drug-loaded microparticles enables month-long, drop-free sustained eye treatment.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Other
Glaucoma
Dry eye syndrome
Lead Inventor: Morgan Dileo
Department: Med-Ophthalmology
All Tech Innovators: Anthony Cugini
Morgan Virginia Dileo
Steven R. Little
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2012-08-14

Selective Targeting of Cardiomyocytes

06346

Cardiomyocyte-targeted AAV-PKG1 therapy boosts heart function, promising selective treatment for heart failure with reduced off-target effects.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Heart failure
Dialated cardiomyopathy
Lead Inventor: Jason Becker
Department: Med-Medicine
All Tech Innovators: Jason Robert Becker
Soumojit Pal
Date Submitted: 2023-03-07
Collections: Cardiometabolic

Remote and Controllable Drug Release System

05191

Acoustically driven microtube system enables remote, dose-controllable, pulsatile drug release without implanted power, via bubble mechanics.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Implantable Medical Device
Life Science
Therapeutic Medical Device
Lead Inventor: Sung Kwon Cho
Department: Mechanical Engineering and Materials Science
All Tech Innovators: Sung Kwon Cho
Fang-Wei Liu
Date Submitted: 2019-12-05

Easier, Faster Oligosaccharide Synthesis

02720

Efficient one-pot glycosylation enables fast, high-yield oligosaccharide assembly for food, pharma, and research via a robust, operable method.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Gastroenterology
Lead Inventor: Xinyu Liu
Department: Chemistry
All Tech Innovators: Xinyu Liu
Date Submitted: 2012-03-14

Protection and Delivery of Multiple Therapeutic Proteins

03836

Coacervate delivery system extends protein half-lives to weeks using platelet-rich plasma, enhancing wound healing and tissue repair.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Daniel Long
Department: Bioengineering
All Tech Innovators: Eric M. Jeffries
Noah R. Johnson
Daniel Ward Long
Date Submitted: 2016-02-25
Collections: Regenerative Medicine

Tenofovir Spray Drying Sachet Enema Powder Formulation for HIV Prevention

05906

Spray-dried tenofovir sachet enema powder improves HIV prevention accessibility, manufacturability, and user acceptance over liquid formulations.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Infectious Disease
Therapeutic Indications: HIV
Lead Inventor: Lisa Rohan
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Christina Bagia
Craig Hendrix
Lisa Cencia Rohan
Date Submitted: 2021-12-03
Collections: Women's & Reproductive Health

pH-Sensitive Linkers for Advanced Biomedical Delivery

07192

Acid-cleavable beta-diketone/triketone linkers enable bioorthogonal delivery systems for mRNA, gene therapy, and targeted cancer therapeutics.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Immunology
Therapeutic Indications: Solid tumor
Tags: Polymer
Platform Technology
Lead Inventor: Song Li
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Yixian Huang
Song Li
Huatian Li
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2025-05-23

Ovarian ECM Derivatives for Fertility and Endocrine Function Restoration

03824

Ovarian ECM hydrogel enables rapid, targeted follicle delivery to restore fertility and endocrine function after chemotherapy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Reproductive Health
Therapeutic Indications: Infertility
Gynecological disorder
Lead Inventor: Michael Buckenmeyer
Department: Bioengineering
All Tech Innovators: Bryan Nicklaus Brown
Michael Joseph Buckenmeyer
Aleksandar Rajkovic
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2016-02-09
Collections: Women's & Reproductive Health

Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells

04531

Magnetic delivery and hydrogel fixation of adipose-derived stem cells enable minimally invasive, localized AAA treatment and broader applications.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: David Vorp
Department: Bioengineering
All Tech Innovators: Yogev Baruch
Kory James Blose
Timothy K. Chung
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2018-03-05
Collections: Regenerative Medicine

A Novel Multifunctional Drug Delivery System for Chemo-Gene Combination Therapy

04453

Polymeric micelles co-deliver chemotherapy drugs and plasmid DNA, enhancing stability and enabling synergistic chemo-gene cancer therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Lead Inventor: Song Li
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Yichao Chen
Yixian Huang
Song Li
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2017-12-07
Collections: Women's & Reproductive Health

Repurposing Existing Drugs May Offer Novel Treatment for Neurodegenerative Diseases

04236

Repurposed drugs show synergistic neuroprotection for Huntington’s, potentially slowing degeneration and aiding other incurable neurodegenerative diseases.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Neuroscience
Lead Inventor: Mark Schurdak
Department: Med-Computational and Systems Biology
All Tech Innovators: Mark E. Schurdak
Andrew Michael Stern
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2017-05-09

Small-molecule Scaffolds for HIV Nef Drug Development

03422

Small-molecule HIV Nef inhibitors block viral protein–host kinase signaling, boosting immune recognition and aiding combination therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Infectious Disease
Therapeutic Indications: HIV
Lead Inventor: Thomas Smithgall
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Thomas E. Smithgall
Date Submitted: 2014-10-17
Collections: Women's & Reproductive Health

Treatment for Pediatric Bronchopulmonary Dysplasia

06694

Oral vamorolone may treat infant bronchopulmonary dysplasia safely, reducing long-term corticosteroid side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Therapeutic Indications: Other
Tags: Pediatrics
Life Science
Lead Inventor: Donald DeFranco
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Timothy Cole
Donald B. DeFranco
Nathalie El Khoury Juri
Date Submitted: 2024-03-19

Silk-Iron Packaged Extracellular Vesicles

06360

Silk-iron packaged extracellular vesicles guide regenerative, cell-free therapy for abdominal aortic aneurysm by delivering elastin/collagen factors.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Tags: Biomaterial
Regenerative medicine
Lead Inventor: Ande Marini
Department: Bioengineering
All Tech Innovators: Mostafa M. Bedewy
Ande Xiaojie Marini
Golnaz Najaf Tomaraei
Date Submitted: 2023-03-23
Collections: Regenerative Medicine
Cardiometabolic

Oncolytic Viruses Expressing Cytokine IL-36γ for Cancer Therapy

04566

IL-36γ-armed oncolytic vaccinia enhances immune-driven tumor destruction, boosting efficacy across colon, pancreatic, and melanoma models.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Lead Inventor: Zongsheng Guo
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: David L. Bartlett MD
Zongsheng Sheng Guo
Binfeng Lu
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2018-03-27

Injectable Thermoresponsive Hydrogel For Sustained Drug Release and Enhanced Cell therapy

03044

Thermoresponsive injectable hydrogel enables sustained protein/drug release, antioxidative cell support, and tissue regeneration scaffolds.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Neuroscience
Tags: Biomaterial
Lead Inventor: Yadong Wang
Department: Bioengineering
All Tech Innovators: Martin Oudega
Yadong Wang
Date Submitted: 2013-05-02

Targeted Immune Cell Therapy Using CCL22 Muteins for Enhanced Precision

06493

Precise immune cell targeting via CCL22 muteins and engineered CCR4 receptors, boosting therapy localization and reducing off-target effects.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Lead Inventor: Heth Turnquist
Department: Med-Surgery
All Tech Innovators: Stephen C. Balmert
Matthew Andrew Borrelli
Steven R. Little
Date Submitted: 2023-08-24

Novel Treatment for Dry Eye Disease

05988

IL-4 eye drops target inflammation and goblet cell dysfunction in dry eye disease, aiming for lasting tear film stability.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Immunology
Ophthalmology
Tags: Biomaterial
Lead Inventor: Alexis Nolfi
Department: Office of the SVC and Provost
All Tech Innovators: Bryan Nicklaus Brown
Vishal Jhanji
Mangesh Kulkarni
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-03-18

Delivery of Biological Drugs to Epithelia

04508

Anchoring domains bind wet epithelia to prevent washout, enabling extended delivery of biologics to eyes, lungs, and mucosal tissues.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Ophthalmology
Therapeutic Indications: Chronic Obstructive Pulmonary Disease (COPD)
Asthma
Dry eye syndrome
Lead Inventor: Robert Shanks
Department: Med-Ophthalmology
All Tech Innovators: Jes K. Klarlund
Robert Michael Queen Shanks
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2018-02-15
Collections: Women's & Reproductive Health

Thermoresponsive Hydrogel Containing Polymer Microparticles for Controlled Drug Delivery to the Ear

03810

Single-dose, thermoresponsive ear gel with PLGA microspheres for 14-day ciprofloxacin release and lidocaine.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Otolaryngology
Tags: Polymer
Platform Technology
Lead Inventor: Morgan Dileo
Department: Med-Ophthalmology
All Tech Innovators: Liza Anna Bruk
Morgan Virginia Dileo
Steven R. Little
Date Submitted: 2016-01-26

Synthetic Enveloped Virus as a Systemically Deliverable Therapy

03499

Biomimetic synthetic enveloped virus delivers targeted, systemic viral therapies with pH-triggered release and enhanced persistence.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Stephen Thorne
Department: Med-Cell Biology
All Tech Innovators: Song Li
Stephen Howard Thorne
Date Submitted: 2015-01-26