Innovative 3D Bioprinting for Primary and iPSC-Derived Organoids068203D bioprinting platform fabricates viable primary and iPSC-derived organoids in porous hydrogel for drug testing.Technology TypeEngineering TechnologyTechnology SubtypeOther Engineering TechnologyTherapeutic AreasOtherTagsRegenerative medicineTissue engineeringLead InventorMiranda PoklarDepartmentChem/Petroleum EngineeringAll Tech InnovatorsIpsita BanerjeeYong FanPrashant N. KumtaDate Submitted2024-07-24CollectionsRegenerative Medicine
Novel Ultrasound-Induced Thermal Strain Imaging05695Ultra-fast ultrasound thermal imaging to detect lipid-rich atherosclerotic plaques by heat-induced sound-speed changes in tissue.Technology TypeMedical DeviceTechnology SubtypeMonitoring Medical DeviceTherapeutic AreasOtherTagsDiagnostic ImagingLife ScienceLead InventorKang KimDepartmentBioengineeringAll Tech InnovatorsMengyue ChenQiyang ChenXuecang GengDate Submitted2021-05-18
Software for De-Identifying Medical Narrative Documents05144Automates HIPAA-compliant de-identification of free-text medical narratives, enabling large-scale privacy-safe data sharing for research.Technology TypeDigital HealthTechnology SubtypeHealthcare DataTherapeutic AreasOtherLead InventorMelissa SaulDepartmentAll TempsAll Tech InnovatorsGregory F. CooperJohn D. LevanderMelissa Irene SaulDate Submitted2019-10-25
Humanized Animal Models for Advanced Antibody Production04301Humanized mice cultivate human immune responses to produce monoclonal antibodies, enabling safer, more efficacious human antibody therapies.Technology TypeTherapeutic ModalityTechnology SubtypeAntibody - mAbTherapeutic AreasOtherTagsPlatform TechnologyLead InventorMoses BilityDepartmentGSPH-Infectious Diseases & MicrobiologyAll Tech InnovatorsMoses Turkle BilityTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2017-06-21
Stimulation of Exosome Secretion04959A potent stimulator boosts exosome secretion up to 24-fold, enabling rapid, scalable exosome production for therapies and research.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsPlatform TechnologyLead InventorTheresa WhitesideDepartmentMed-PathologyAll Tech InnovatorsEdwin Kerry JacksonNils LudwigTheresa L. WhitesideTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2019-05-19
Boronic Acid Mediated Cellular Delivery of Therapies06367Boronic acids enable cellular delivery of oligonucleotide therapies, boosting cytosolic penetration and potential drug efficacy.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherLead InventorKabirul IslamDepartmentChemistryAll Tech InnovatorsKirsten DepreyKabirul IslamJoshua KritzerDate Submitted2023-04-10
Novel Biosensor to Detect Fentanyl Exposure06287Ultra-sensitive carbon nanotube FET biosensor detects norfentanyl in minutes (fg/mL), enabling rapid point-of-care fentanyl exposure screening.Technology TypeDiagnostic/AssayTherapeutic AreasOtherLead InventorAlexander StarDepartmentChemistryAll Tech InnovatorsWenting ShaoAlexander StarDate Submitted2023-02-09
High Field of View High Frame Rate 3D Ultrasound05980Gives real-time, high-frame-rate 3D ultrasound with wide field of view using AI-optimized beamforming and reduced channels.Technology TypeMedical DeviceTechnology SubtypeDiagnostic ImagingTherapeutic AreasOtherTagsArtificial intelligence (AI)AlgorithmLead InventorKang KimDepartmentBioengineeringAll Tech InnovatorsKang KimZhiyu ShengDate Submitted2022-03-08CollectionsHealthcare AI
SENSEIWheel to Measure Pushrim Dynamics06227A lightweight, modular sensor attaches to wheelchairs to measure pushrim dynamics, enabling personalized design and biomechanical analysis.Technology TypeMedical DeviceTechnology SubtypeRehab or Assistive Medical DeviceTherapeutic AreasOtherTagsHuman performanceLead InventorRory CooperDepartmentMed-Physical Medicine & RehabilitationAll Tech InnovatorsJoshua D. BrownJorge Luis CandiottiRory A. Cooper Ph.D.Date Submitted2022-11-23
A New Information System for Community Engagement Tracking05930A web-based system automates collection, analysis, and visualization of community engagement data for multiple user roles.Technology TypeDigital HealthTechnology SubtypeHealthcare DataTherapeutic AreasOtherLead InventorLeming ZhouDepartmentSHRS-Health Information ManagementAll Tech InnovatorsBambang ParmantoAndi SaptonoLeming ZhouDate Submitted2021-12-28
Innovative Online Learning Modules: Design and Authoring for Beginners05794Open-licensed, beginner-friendly online course guiding design and authoring of effective online learning modules for faculty.Technology TypeDigital HealthTechnology SubtypeOther Digital HealthTherapeutic AreasOtherTagsEducation TechnologyLead InventorSeraphim ThorntonDepartmentFalk LibraryAll Tech InnovatorsSeraphim R. ThorntonDate Submitted2021-08-27
Microfluidic System Rapidly Isolates Extracellular Vesicles from Biological Fluids05658Automated microfluidic device rapidly, fractionally isolating all extracellular vesicle sizes and large cells from fluids in seconds.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasOtherTagsPlatform TechnologyLead InventorKambez Hajipouran BenamDepartmentMed-MedicineAll Tech InnovatorsKambez Hajipouran BenamAlexander Joseph KaiserDate Submitted2021-04-04
Novel Pipette Tip Design Encapsulates Cells to Co-Culture 96 or 38404138BioActivator pipette tips encapsulate hepatocytes for on-demand bioactivation in HTS plates, enabling flexible co-culture and screening.Technology TypeLife Science Research ToolTechnology SubtypeCell LineTherapeutic AreasOtherLead InventorLawrence VernettiDepartmentMed-Computational and Systems BiologyAll Tech InnovatorsLawrence A. VernettiDate Submitted2017-01-27
Steeltown Retractor03966Motorized base with disposable, adjustable retractor arm enables rapid, precise abdominal exposures, reducing OR time and sterilization.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasOtherTagsMinimally invasiveLead InventorJeffrey VippermanDepartmentMechanical Engineering and Materials ScienceAll Tech InnovatorsPeter David Allen MDChristopher Michael DummGarth Abraham EliasTechnology Readiness Level4. Prototype testing and refinementDate Submitted2016-06-20
Depth-Resolved Low-Coherence Phase Microscopy for Quantitative 3D Imaging of Stained and Unstained Tissues03378Depth-resolved, label-free 3D tissue imaging with tunable white-light phase microscopy; integrates staining, autofocus, and automated nuclear segmentation.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasOtherLead InventorYang LiuDepartmentMed-MedicineAll Tech InnovatorsYang LiuHoa Vinh PhamShikhar UttamDate Submitted2014-08-12
Nano Seeding Tools to generate nanometer size crystallization seeds03160Precise, bead-dissected nanoseeds standardize protein crystallization, boosting reproducibility, crystal quality, and throughput for challenging targets.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasOtherLead InventorGuillermo Calero VelazquezDepartmentMed-Structural BiologyAll Tech InnovatorsGuillermo Calero VelazquezDate Submitted2013-10-28
Using Nanoparticles to Stabilize and Preserve the Bioactivity of Proteins and Peptides04961Silica nanoparticle textures stabilize surface-bound proteins, enabling dry storage, broader biosensor and implant applications.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasOtherTagsBiomaterialCoatingPlatform TechnologyLead InventorXinyan CuiDepartmentBioengineeringAll Tech InnovatorsXinyan CuiKevin M. WoeppelDate Submitted2019-04-17
Targeted Protein Degradation through Site-Specific Recruitment of Ubiquitin Ligase06399Site-specific E3 ligase recruitment enables PROTAC-like protein degradation without a small-molecule ligand, advancing targetability.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasOtherLead InventorAlexander DeitersDepartmentDistinguished Faculty-Dietrich School of Arts and SciencesAll Tech InnovatorsAlexander DeitersOlivia Hanson ShadeTechnology Readiness Level1. Research ideaDate Submitted2023-05-08
Boryl Ethers as Oxidatively-Triggered Drug Delivery Vehicles03939Oxidative-stress-triggered α-boryl ether prodrugs release non-toxic ketone/aldehyde cargos selectively in diseased cells.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsPlatform TechnologyLead InventorPaul FloreancigDepartmentChemistryAll Tech InnovatorsAlexander DeitersPaul Edward FloreancigRamsey D. HannaDate Submitted2016-05-13
Remote and Controllable Drug Release System05191Acoustically driven microtube system enables remote, dose-controllable, pulsatile drug release without implanted power, via bubble mechanics.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsImplantable Medical DeviceLife ScienceTherapeutic Medical DeviceLead InventorSung Kwon ChoDepartmentMechanical Engineering and Materials ScienceAll Tech InnovatorsSung Kwon ChoFang-Wei LiuDate Submitted2019-12-05
Smart Cannula Technology: Tissue Sensing for Safer Gluteal Fat Grafting Surgery04679Smart cannula with tissue sensing alerts surgeons to muscle or blood contact during gluteal fat grafting, enhancing safety.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasOtherLead InventorWilliam ClarkDepartmentEngr-Dept Chairperson's OfficeAll Tech InnovatorsWilliam W. ClarkCameron DezfulianApril Marie LawrenceTechnology Readiness Level4. Prototype testing and refinementDate Submitted2018-07-09
Protection and Delivery of Multiple Therapeutic Proteins03836Coacervate delivery system extends protein half-lives to weeks using platelet-rich plasma, enhancing wound healing and tissue repair.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsPlatform TechnologyLead InventorDaniel LongDepartmentBioengineeringAll Tech InnovatorsEric M. JeffriesNoah R. JohnsonDaniel Ward LongDate Submitted2016-02-25CollectionsRegenerative Medicine
Light-Activated CRISPR/Cas9: Precise Control over Gene Editing03547Light-activated CRISPR/Cas9 enables spatially, temporally precise gene editing, reducing off-target effects with light control.Technology TypeLife Science Research ToolTechnology SubtypeNucleic AcidTherapeutic AreasOtherTagsPlatform TechnologyLead InventorAlexander DeitersDepartmentDistinguished Faculty-Dietrich School of Arts and SciencesAll Tech InnovatorsAravind AsokanErin BorchardtAlexander DeitersDate Submitted2015-03-11
Novel Aptamers for Selective Protein Targeting05575Covalent, cleavable-electrophile aptamers selectively target proteins for labeling, modification, or degradation, rivaling antibodies.Technology TypeEngineering TechnologyTechnology SubtypeChemicalTherapeutic AreasOtherLead InventorAlexander DeitersDepartmentDistinguished Faculty-Dietrich School of Arts and SciencesAll Tech InnovatorsAlexander DeitersYaniv TivonDate Submitted2020-12-21
Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells04531Magnetic delivery and hydrogel fixation of adipose-derived stem cells enable minimally invasive, localized AAA treatment and broader applications.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsBiomaterialRegenerative medicineTissue engineeringLead InventorDavid VorpDepartmentBioengineeringAll Tech InnovatorsYogev BaruchKory James BloseTimothy K. ChungTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2018-03-05CollectionsRegenerative Medicine
SafeStep: A stair navigation assist device06049SafeStep is a modular, affordable cable-driven stair assist enabling upright, independent ascent/descent for aging or mobility-impaired users.Technology TypeMedical DeviceTechnology SubtypeRehab or Assistive Medical DeviceTherapeutic AreasOtherTagsAgingLead InventorJonathan PearlmanDepartmentSHRS-Rehab Sci & TechAll Tech InnovatorsMD Rayhan AfsarDavid M. Brienza Ph.D.Alexandra Marie DelazioTechnology Readiness Level3. Prototype developmentDate Submitted2022-06-08
Monopolar Smart Cannula: Simpler and More Accurate Tissue Sensing for Safer Gluteal Fat Grafting Surgery05019Smart, impedance-based cannula guides fat grafting by tissue type, reducing injury risk with audible/visual alerts and simpler design.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasOtherTagsPlastic SurgeryLead InventorJoseph RubinDepartmentMed-Plastic SurgeryAll Tech InnovatorsWilliam W. ClarkCameron DezfulianApril Marie LawrenceTechnology Readiness Level3. Prototype developmentDate Submitted2019-06-21
Low-Coherence Interferometric Microscopy for Depth-Resolved Nanoscale Cellular Architecture Quantification03176Depth-resolved nanoscale nuclear architecture on stained slides via low-coherence interferometric microscopy for label-free pathology.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasOtherLead InventorYang LiuDepartmentMed-MedicineAll Tech InnovatorsRandall E. BrandYang LiuHoa Vinh PhamDate Submitted2013-11-26
Pittsburgh DOULA-AC Program: End of Life Care Reimagined for the Black Community05730Culturally tailored end‑of‑life doula program providing companions, practical support, legacy work, and bereavement care for Black patients.Technology TypeTherapeutic ModalityTechnology SubtypeOther Therapeutic ModalityTherapeutic AreasOtherTagsAgingLead InventorMargaret RosenzweigDepartmentNurs-Acute and Tertiary CareAll Tech InnovatorsMargaret Quinn RosenzweigDate Submitted2021-06-17
Hydractinia RNA as a Research Tool04833RNA from Hydractinia enables new tools for stem cell, developmental, and regenerative research, linking animal genes to human biology.Technology TypeLife Science Research ToolTechnology SubtypeNucleic AcidTherapeutic AreasOtherLead InventorMatthew NicotraDepartmentMed-SurgeryAll Tech InnovatorsMatthew L. NicotraSteven M. SandersDate Submitted2018-12-07
Preserving Harvested Fat Between Grafting Procedures04358A on-site, closed-system fat graft preservation vessel enables cryo-storage for repeat grafting, reducing procedures and costs.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasOtherTagsPlastic SurgeryLead InventorJoseph RubinDepartmentMed-Plastic SurgeryAll Tech InnovatorsJoseph Peter RubinTechnology Readiness Level3. Prototype developmentDate Submitted2017-08-25CollectionsRegenerative Medicine
Label-Free Differential Mass Spectrometry Workflow for Identifying Ligand-Stabilized Protein Targets03917A label-free, single-temperature proteome-wide MS workflow detects ligand-stabilized targets by quantitative full-scan data and cloud-based ranking.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Discovery - TargetTherapeutic AreasOtherLead InventorNathan YatesDepartmentMed-Cell BiologyAll Tech InnovatorsHarris B. Bell-TeminSteven James MullettNathan A. YatesDate Submitted2016-04-25
Synthetic Enveloped Virus as a Systemically Deliverable Therapy03499Biomimetic synthetic enveloped virus delivers targeted, systemic viral therapies with pH-triggered release and enhanced persistence.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsPlatform TechnologyLead InventorStephen ThorneDepartmentMed-Cell BiologyAll Tech InnovatorsSong LiStephen Howard ThorneDate Submitted2015-01-26
Low-Coherence Quantitative Phase Microscope for Multispectral Imaging and Precise Sample Registration03192Multispectral quantitative phase microscopy integrates precise optics and registration for high-resolution, unstained tissue analysis.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasOtherLead InventorYang LiuDepartmentMed-MedicineAll Tech InnovatorsYang LiuHoa Vinh PhamDate Submitted2013-12-08
ProtWeaver: Advanced Coevolutionary Analysis for Protein Function Prediction06479ProtWeaver predicts gene functional associations via multi-evidence coevolution scores, boosting speed, accuracy, and open-source accessibility.Technology TypeLife Science Research ToolTechnology SubtypeBioinformaticsTherapeutic AreasOtherLead InventorAidan LakshmanDepartmentMed-Biomedical InformaticsAll Tech InnovatorsAidan H. LakshmanTechnology Readiness Level1. Concept developmentDate Submitted2023-08-10
Fade-to-Clear Sutures04276Fade-to-clear sutures: visible during use, fade to clear within 24 hours, reducing eyestrain and patient-visible scarring.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasOtherTagsPolymerMaterial ScienceLead InventorEric BeckmanDepartmentChem/Petroleum EngineeringAll Tech InnovatorsEric J. BeckmanStephen Douglas CummingsJoseph Peter RubinTechnology Readiness Level3. Prototype developmentDate Submitted2017-06-04
Data Analysis Software for Extracting Nanoscale Details from Biological Samples03191Transforms low-coherence interferometric data into high‑contrast quantitative phase maps revealing nanoscale cellular structure.Technology TypeLife Science Research ToolTechnology SubtypeBioinformaticsTherapeutic AreasOtherLead InventorShikhar UttamDepartmentMed-Computational and Systems BiologyAll Tech InnovatorsYang LiuHoa Vinh PhamShikhar UttamDate Submitted2013-12-08
Novel Lighting Solution for Surgical Operating Rooms05454Adjustable, sterile, fiberoptic surgical lighting that clips to the bed, collaborating with existing lights for better visibility.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasOtherTagsSurgeryLead InventorAlexandra DelazioDepartmentSHRS-Rehab Sci & TechAll Tech InnovatorsDavid M. Brienza Ph.D.William W. ClarkAlexandra Marie DelazioTechnology Readiness Level3. Prototype developmentDate Submitted2020-07-21
Tele-Clinical Trial Platform: Revolutionizing Rare Disease Research and Beyond04562A tele-clinical trial platform enables remote enrollment, at-home trial management, and data collection to broaden rare-disease research.Technology TypeDigital HealthTechnology SubtypeHealthcare DeliveryTherapeutic AreasOtherTagsRare diseaseLead InventorRohit AggarwalDepartmentMed-MedicineAll Tech InnovatorsRohit AggarwalTechnology Readiness Level3. Prototype developmentDate Submitted2018-03-24CollectionsRare Diseases
Ultrasound-Guided Rete Testis Injection/Aspiration Device04016Ultrasound-guided, non-surgical rete testis access device enables targeted injections/aspirations, reducing biopsies for azoospermia therapy.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasOtherReproductive HealthTherapeutic IndicationsMale genitourinaryInfertilityTagsMinimally invasiveRegenerative medicineLead InventorKyle OrwigDepartmentMed-OB-Gyn & Reproductive ScienceAll Tech InnovatorsBrian Peter HermannKyle E. OrwigDate Submitted2016-08-29CollectionsRegenerative MedicineWomen's & Reproductive Health
Reflective-shell Photoacoustic Probe for Redirecting Scattered Light to Enhance Imaging Depth and Contrast02650Reflective-shell probe recycles light to deepen photoacoustic imaging, boost contrast, and enable unified imaging-guided therapy.Technology TypeEngineering TechnologyTechnology SubtypeOther Engineering TechnologyTherapeutic AreasOtherLead InventorKang KimDepartmentBioengineeringAll Tech InnovatorsSeung Han HaKang KimZhaohui Hui WangDate Submitted2011-12-15
DataDigger: A Quick, Flexible Search Engine for Biomarker Data04527DataDigger: flexible, cloud-capable tool for multi-file biomarker data search and SNP-based patient subset querying.Technology TypeLife Science Research ToolTechnology SubtypeBioinformaticsTherapeutic AreasOtherOncologyTagsPlatform TechnologyLead InventorYoram VodovotzDepartmentMed-SurgeryAll Tech InnovatorsFayten Kathryn El-DehaibiQi MiYoram VodovotzDate Submitted2018-02-23
A Variable Pressure Device to Improve Decellularization of Biological Tissues03142A programmable, cyclical pressure decellularization method preserves extracellular matrix across diverse tissues for robust regenerative scaffolds.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasOtherLead InventorThomas GilbertDepartmentBioengineeringAll Tech InnovatorsThomas W. GilbertChristopher Michael HobsonEthan Napat UngchusriDate Submitted2013-10-07
Fiber Optic Light Cable Safety Cover03693Fiber Optic Safety Cover prevents heat/light hazards when cables disconnect, boosting patient safety and reducing hospital liability.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasOtherTagsMinimally invasiveMaterial ScienceLead InventorSteven DocimoDepartmentMed-UrologyAll Tech InnovatorsWilliam W. ClarkAlexandra Marie DelazioSteven Gerard DocimoTechnology Readiness Level3. Prototype developmentDate Submitted2015-08-02
Safer Seat: Assisting Safe Transfers to and from Vehicles05990Compact remote-controlled vehicle seat assist with lift-tilt and turn for safer, independent transfers in/out of cars.Technology TypeMedical DeviceTechnology SubtypeRehab or Assistive Medical DeviceTherapeutic AreasOtherLead InventorJulie FaietaDepartmentSHRS-Rehab Sci & TechAll Tech InnovatorsJulie Marie FaietaTechnology Readiness Level3. Prototype developmentDate Submitted2022-03-22
