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45 results

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Novel Ultrasound-Induced Thermal Strain Imaging

05695

Ultrasound-induced thermal strain imaging (US-TSI) rapidly heats tissue to reveal lipid-rich atherosclerotic plaques for safer diagnosis.

Technology Type: Medical Device
Technology Subtype: Monitoring Medical Device
Therapeutic Areas: Other
Tags: Diagnostic Imaging
Life Science
Lead Inventor: Kang Kim
Department: Bioengineering
All Tech Innovators: Mengyue Chen
Qiyang Chen
Xuecang Geng
Date Submitted: 2021-05-18

Software for De-Identifying Medical Narrative Documents

05144

Automates HIPAA-compliant de-identification of free-text medical narratives, enabling large-scale privacy-safe data sharing for research.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Other
Lead Inventor: Melissa Saul
Department: All Temps
All Tech Innovators: Gregory F. Cooper
John D. Levander
Melissa Irene Saul
Date Submitted: 2019-10-25

Humanized Animal Models for Advanced Antibody Production

04301

Humanized mice cultivate human immune responses to produce monoclonal antibodies, enabling safer, more efficacious human antibody therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Moses Bility
Department: GSPH-Infectious Diseases & Microbiology
All Tech Innovators: Moses Turkle Bility
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2017-06-21

Stimulation of Exosome Secretion

04959

A potent stimulator boosts exosome secretion up to 24-fold, enabling rapid, scalable exosome production for therapies and research.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Theresa Whiteside
Department: Med-Pathology
All Tech Innovators: Edwin Kerry Jackson
Nils Ludwig
Theresa L. Whiteside
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-05-19

Boronic Acid Mediated Cellular Delivery of Therapies

06367

Boronic acid–mediated cell delivery enhances nucleic acid therapies by boosting oligonucleotide penetration and efficacy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Lead Inventor: Kabirul Islam
Department: Chemistry
All Tech Innovators: Kirsten Deprey
Kabirul Islam
Joshua Kritzer
Date Submitted: 2023-04-10

Novel Biosensor to Detect Fentanyl Exposure

06287

Ultra-sensitive sc-SWCNT FET biosensor detects norfentanyl in biofluids within minutes, enabling rapid, portable fentanyl exposure screening.

Technology Type: Diagnostic/Assay
Therapeutic Areas: Other
Lead Inventor: Alexander Star
Department: Chemistry
All Tech Innovators: Wenting Shao
Alexander Star
Date Submitted: 2023-02-09

High Field of View High Frame Rate 3D Ultrasound

05980

Gives real-time, high-frame-rate 3D ultrasound with wide field of view using AI-optimized beamforming and reduced channels.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Other
Tags: Artificial intelligence (AI)
Algorithm
Lead Inventor: Kang Kim
Department: Bioengineering
All Tech Innovators: Kang Kim
Zhiyu Sheng
Date Submitted: 2022-03-08
Collections: Healthcare AI

SENSEIWheel to Measure Pushrim Dynamics

06227

A lightweight, modular sensor attaches to wheelchairs to measure pushrim dynamics, enabling personalized design and biomechanical analysis.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Other
Tags: Human performance
Lead Inventor: Rory Cooper
Department: Med-Physical Medicine & Rehabilitation
All Tech Innovators: Joshua D. Brown
Jorge Luis Candiotti
Rory A. Cooper Ph.D.
Date Submitted: 2022-11-23

A New Information System for Community Engagement Tracking

05930

A web-based system automates collection, analysis, and visualization of community engagement data for multiple user roles.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Other
Lead Inventor: Leming Zhou
Department: SHRS-Health Information Management
All Tech Innovators: Bambang Parmanto
Andi Saptono
Leming Zhou
Date Submitted: 2021-12-28

Innovative Online Learning Modules: Design and Authoring for Beginners

05794

Open-licensed, beginner-friendly online course guiding design and authoring of effective online learning modules for faculty.

Technology Type: Digital Health
Technology Subtype: Other Digital Health
Therapeutic Areas: Other
Tags: Education Technology
Lead Inventor: Seraphim Thornton
Department: Falk Library
All Tech Innovators: Seraphim R. Thornton
Date Submitted: 2021-08-27

Microfluidic System Rapidly Isolates Extracellular Vesicles from Biological Fluids

05658

Automated microfluidic device rapidly, fractionally isolating all extracellular vesicle sizes and large cells from fluids in seconds.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Kambez Hajipouran Benam
Department: Med-Medicine
All Tech Innovators: Kambez Hajipouran Benam
Alexander Joseph Kaiser
Date Submitted: 2021-04-04

Steeltown Retractor

03966

Motorized base with disposable, adjustable retractor arm enables rapid, precise abdominal exposures, reducing OR time and sterilization.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Other
Tags: Minimally invasive
Lead Inventor: Jeffrey Vipperman
Department: Mechanical Engineering and Materials Science
All Tech Innovators: Peter David Allen MD
Christopher Michael Dumm
Garth Abraham Elias
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2016-06-20

Depth-Resolved Low-Coherence Phase Microscopy for Quantitative 3D Imaging of Stained and Unstained Tissues

03378

Depth-resolved, label-free 3D tissue imaging with tunable white-light phase microscopy; integrates staining, autofocus, and automated nuclear segmentation.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Other
Lead Inventor: Yang Liu
Department: Med-Medicine
All Tech Innovators: Yang Liu
Hoa Vinh Pham
Shikhar Uttam
Date Submitted: 2014-08-12

Remote and Controllable Drug Release System

05191

Acoustically driven, power-free microtube system enables remote, pulsatile drug release via bubble oscillation and mass transfer.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Implantable Medical Device
Life Science
Therapeutic Medical Device
Lead Inventor: Sung Kwon Cho
Department: Mechanical Engineering and Materials Science
All Tech Innovators: Sung Kwon Cho
Fang-Wei Liu
Date Submitted: 2019-12-05

Nano Seeding Tools to generate nanometer size crystallization seeds

03160

Precise, bead-dissected nanoseeds standardize protein crystallization, boosting reproducibility, crystal quality, and throughput for challenging targets.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Other
Lead Inventor: Guillermo Calero Velazquez
Department: Med-Structural Biology
All Tech Innovators: Guillermo Calero Velazquez
Date Submitted: 2013-10-28

Using Nanoparticles to Stabilize and Preserve the Bioactivity of Proteins and Peptides

04961

Silica nanoparticle textures stabilize surface-bound proteins, enabling dry storage, broader biosensor and implant applications.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Other
Tags: Biomaterial
Coating
Platform Technology
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Xinyan Cui
Kevin M. Woeppel
Date Submitted: 2019-04-17

Novel Pipette Tip Design Encapsulates Cells to Co-Culture 96 or 384

04138

BioActivator: encapsulated hepatocytes on pipette tips enable on-demand bioactivation for HTS/co-culture in 96–1536-well plates.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Other
Lead Inventor: Lawrence Vernetti
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Lawrence A. Vernetti
Date Submitted: 2017-01-27

Boryl Ethers as Oxidatively-Triggered Drug Delivery Vehicles

03939

Oxidation-triggered boryl-ether prodrugs release non-toxic carbonyl cargos selectively in oxidative-stress disease sites.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Paul Floreancig
Department: Chemistry
All Tech Innovators: Alexander Deiters
Paul Edward Floreancig
Ramsey D. Hanna
Date Submitted: 2016-05-13

Smart Cannula Technology: Tissue Sensing for Safer Gluteal Fat Grafting Surgery

04679

Smart cannula with tissue sensing alerts surgeons to muscle or blood contact during gluteal fat grafting, enhancing safety.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Other
Lead Inventor: William Clark
Department: Engr-Dept Chairperson's Office
All Tech Innovators: William W. Clark
Cameron Dezfulian
April Marie Lawrence
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2018-07-09

Ultrasound-Guided Rete Testis Injection/Aspiration Device

04016

Ultrasound-guided, non-surgical rete testis injection/aspiration device enables targeted delivery of therapies with single, minimal procedures.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Other
Reproductive Health
Therapeutic Indications: Male genitourinary
Infertility
Tags: Minimally invasive
Regenerative medicine
Lead Inventor: Kyle Orwig
Department: Med-OB-Gyn & Reproductive Science
All Tech Innovators: Brian Peter Hermann
Kyle E. Orwig
Date Submitted: 2016-08-29
Collections: Women's & Reproductive Health

Protection and Delivery of Multiple Therapeutic Proteins

03836

Coacervate delivery system extends protein half-lives to weeks using platelet-rich plasma, enhancing wound healing and tissue repair.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Daniel Long
Department: Bioengineering
All Tech Innovators: Eric M. Jeffries
Noah R. Johnson
Daniel Ward Long
Date Submitted: 2016-02-25
Collections: Regenerative Medicine

Light-Activated CRISPR/Cas9: Precise Control over Gene Editing

03547

Light-activated CRISPR/Cas9 enables spatially, temporally precise gene editing, reducing off-target effects with light control.

Technology Type: Life Science Research Tool
Technology Subtype: Nucleic Acid
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Alexander Deiters
Department: Distinguished Faculty-Dietrich School of Arts and Sciences
All Tech Innovators: Aravind Asokan
Erin Borchardt
Alexander Deiters
Date Submitted: 2015-03-11

Targeted Protein Degradation through Site-Specific Recruitment of Ubiquitin Ligase

06399

Site-specific E3 ligase recruitment enables PROTAC-like protein degradation without a small-molecule ligand, advancing targetability.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Other
Lead Inventor: Alexander Deiters
Department: Distinguished Faculty-Dietrich School of Arts and Sciences
All Tech Innovators: Alexander Deiters
Olivia Hanson Shade
Technology Readiness Level: 1. Research idea
Date Submitted: 2023-05-08

SafeStep: A stair navigation assist device

06049

SafeStep modular stair aid uses a cable-driven moving handrail to help upright, active aging and home mobility without lifts.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Other
Tags: Aging
Lead Inventor: Jonathan Pearlman
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: MD Rayhan Afsar
David M. Brienza Ph.D.
Alexandra Marie Delazio
Technology Readiness Level: 3. Prototype development
Date Submitted: 2022-06-08

Novel Aptamers for Selective Protein Targeting

05575

Novel covalent aptamers selectively modify and label target proteins, enabling drug delivery, detection, and degradation without antibody costs.

Technology Type: Engineering Technology
Technology Subtype: Chemical
Therapeutic Areas: Other
Lead Inventor: Alexander Deiters
Department: Distinguished Faculty-Dietrich School of Arts and Sciences
All Tech Innovators: Alexander Deiters
Yaniv Tivon
Date Submitted: 2020-12-21

Monopolar Smart Cannula: Simpler and More Accurate Tissue Sensing for Safer Gluteal Fat Grafting Surgery

05019

Smart, impedance-based cannula guides fat grafting by tissue type, reducing injury risk with audible/visual alerts and simpler design.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Other
Tags: Plastic Surgery
Lead Inventor: Joseph Rubin
Department: Med-Plastic Surgery
All Tech Innovators: William W. Clark
Cameron Dezfulian
April Marie Lawrence
Technology Readiness Level: 3. Prototype development
Date Submitted: 2019-06-21

Low-Coherence Interferometric Microscopy for Depth-Resolved Nanoscale Cellular Architecture Quantification

03176

Depth-resolved nanoscale nuclear architecture on stained slides via low-coherence interferometric microscopy for label-free pathology.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Other
Lead Inventor: Yang Liu
Department: Med-Medicine
All Tech Innovators: Randall E. Brand
Yang Liu
Hoa Vinh Pham
Date Submitted: 2013-11-26

Pittsburgh DOULA-AC Program: End of Life Care Reimagined for the Black Community

05730

Culturally tailored end‑of‑life doula program providing companions, practical support, legacy work, and bereavement care for Black patients.

Technology Type: Other
Therapeutic Areas: Other
Tags: Aging
Lead Inventor: Margaret Rosenzweig
Department: Nurs-Acute and Tertiary Care
All Tech Innovators: Margaret Quinn Rosenzweig
Date Submitted: 2021-06-17

Hydractinia RNA as a Research Tool

04833

Extraction of Hydractinia RNA enables new stem cell and regenerative research tools, linking animal-wide gene toolkit to human disease studies.

Technology Type: Life Science Research Tool
Technology Subtype: Nucleic Acid
Therapeutic Areas: Other
Lead Inventor: Matthew Nicotra
Department: Med-Surgery
All Tech Innovators: Matthew L. Nicotra
Steven M. Sanders
Date Submitted: 2018-12-07

Preserving Harvested Fat Between Grafting Procedures

04358

A on-site, closed-system fat graft preservation vessel enables cryo-storage for repeat grafting, reducing procedures and costs.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Other
Tags: Plastic Surgery
Lead Inventor: Joseph Rubin
Department: Med-Plastic Surgery
All Tech Innovators: Joseph Peter Rubin
Technology Readiness Level: 3. Prototype development
Date Submitted: 2017-08-25
Collections: Regenerative Medicine

Label-Free Differential Mass Spectrometry Workflow for Identifying Ligand-Stabilized Protein Targets

03917

A label-free, single-temperature proteome-wide MS workflow detects ligand-stabilized targets by quantitative full-scan data and cloud-based ranking.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Other
Lead Inventor: Nathan Yates
Department: Med-Cell Biology
All Tech Innovators: Harris B. Bell-Temin
Steven James Mullett
Nathan A. Yates
Date Submitted: 2016-04-25

Synthetic Enveloped Virus as a Systemically Deliverable Therapy

03499

Biomimetic synthetic enveloped virus delivers targeted, systemic viral therapies with pH-triggered release and enhanced persistence.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Stephen Thorne
Department: Med-Cell Biology
All Tech Innovators: Song Li
Stephen Howard Thorne
Date Submitted: 2015-01-26

Low-Coherence Quantitative Phase Microscope for Multispectral Imaging and Precise Sample Registration

03192

Multispectral quantitative phase microscopy integrates precise optics and registration for high-resolution, unstained tissue analysis.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Other
Lead Inventor: Yang Liu
Department: Med-Medicine
All Tech Innovators: Yang Liu
Hoa Vinh Pham
Date Submitted: 2013-12-08

ProtWeaver: Advanced Coevolutionary Analysis for Protein Function Prediction

06479

ProtWeaver predicts gene functional associations via multi-evidence coevolution scores, boosting speed, accuracy, and open-source accessibility.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Therapeutic Areas: Other
Lead Inventor: Aidan Lakshman
Department: Med-Biomedical Informatics
All Tech Innovators: Aidan H. Lakshman
Technology Readiness Level: 1. Concept development
Date Submitted: 2023-08-10

Fade-to-Clear Sutures

04276

Fade-to-clear sutures: visible during use, fade to clear within 24 hours, reducing eyestrain and patient-visible scarring.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Other
Tags: Polymer
Material Science
Lead Inventor: Eric Beckman
Department: Chem/Petroleum Engineering
All Tech Innovators: Eric J. Beckman
Stephen Douglas Cummings
Joseph Peter Rubin
Technology Readiness Level: 3. Prototype development
Date Submitted: 2017-06-04

Data Analysis Software for Extracting Nanoscale Details from Biological Samples

03191

Transforms low-coherence interferometric data into high‑contrast quantitative phase maps revealing nanoscale cellular structure.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Therapeutic Areas: Other
Lead Inventor: Shikhar Uttam
Department: Med-Computational and Systems Biology
All Tech Innovators: Yang Liu
Hoa Vinh Pham
Shikhar Uttam
Date Submitted: 2013-12-08

Novel Lighting Solution for Surgical Operating Rooms

05454

Adjustable, sterile, fiberoptic surgical lighting that clips to the bed, collaborating with existing lights for better visibility.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Other
Tags: Surgery
Lead Inventor: Alexandra Delazio
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: David M. Brienza Ph.D.
William W. Clark
Alexandra Marie Delazio
Technology Readiness Level: 3. Prototype development
Date Submitted: 2020-07-21

Tele-Clinical Trial Platform: Revolutionizing Rare Disease Research and Beyond

04562

A tele-clinical trial platform enables remote enrollment, at-home trial management, and data collection to broaden rare-disease research.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Other
Tags: Rare disease
Lead Inventor: Rohit Aggarwal
Department: Med-Medicine
All Tech Innovators: Rohit Aggarwal
Technology Readiness Level: 3. Prototype development
Date Submitted: 2018-03-24

Reflective-shell Photoacoustic Probe for Redirecting Scattered Light to Enhance Imaging Depth and Contrast

02650

Reflective-shell probe recycles light to deepen photoacoustic imaging, boost contrast, and enable unified imaging-guided therapy.

Technology Type: Engineering Technology
Technology Subtype: Other Engineering Technology
Therapeutic Areas: Other
Lead Inventor: Kang Kim
Department: Bioengineering
All Tech Innovators: Seung Han Ha
Kang Kim
Zhaohui Hui Wang
Date Submitted: 2011-12-15

DataDigger: A Quick, Flexible Search Engine for Biomarker Data

04527

DataDigger: flexible, cloud-capable tool for multi-file biomarker data search and SNP-based patient subset querying.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Therapeutic Areas: Other
Oncology
Tags: Platform Technology
Lead Inventor: Yoram Vodovotz
Department: Med-Surgery
All Tech Innovators: Fayten Kathryn El-Dehaibi
Qi Mi
Yoram Vodovotz
Date Submitted: 2018-02-23

Innovative 3D Bioprinting for Primary and iPSC-Derived Organoids

06820

3D bioprinting platform creates functional primary and iPSC-derived organoids in alginate-methylcellulose hydrogel for personalized tissue applications.

Technology Type: Engineering Technology
Technology Subtype: Other Engineering Technology
Therapeutic Areas: Other
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Miranda Poklar
Department: Chem/Petroleum Engineering
All Tech Innovators: Ipsita Banerjee
Yong Fan
Prashant N. Kumta
Date Submitted: 2024-07-24

Fiber Optic Light Cable Safety Cover

03693

Protects patients and staff by insulating and shielding fiber optic cables after use, reducing burns, fires, and liability.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Other
Tags: Minimally invasive
Material Science
Lead Inventor: Steven Docimo
Department: Med-Urology
All Tech Innovators: William W. Clark
Alexandra Marie Delazio
Steven Gerard Docimo
Technology Readiness Level: 3. Prototype development
Date Submitted: 2015-08-02

Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells

04531

Magnetic-assisted hydrogel fixation delivers adipose-derived stem cells to target sites, enabling minimally invasive, localized therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: David Vorp
Department: Bioengineering
All Tech Innovators: Yogev Baruch
Kory James Blose
Timothy K. Chung
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2018-03-05

A Variable Pressure Device to Improve Decellularization of Biological Tissues

03142

A programmable, cyclical pressure decellularization method preserves extracellular matrix across diverse tissues for robust regenerative scaffolds.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Other
Lead Inventor: Thomas Gilbert
Department: Bioengineering
All Tech Innovators: Thomas W. Gilbert
Christopher Michael Hobson
Ethan Napat Ungchusri
Date Submitted: 2013-10-07

Safer Seat: Assisting Safe Transfers to and from Vehicles

05990

Compact remote-controlled vehicle seat assist with lift-tilt and turn for safer, independent transfers in/out of cars.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Other
Lead Inventor: Julie Faieta
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Julie Marie Faieta
Technology Readiness Level: 3. Prototype development
Date Submitted: 2022-03-22