Therapeutic Indications

Diabetes

EVOLV-Rx: Automated Decision Support for Eliminating Low-Value Clinical Practices

07182

Automated, cross-source detection of low-value prescribing to reduce harm; scalable decision support for providers, payers, and hospitals.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Endocrinology and Metabolic Diseases
Respiratory
Therapeutic Indications: Diabetes
Chronic Obstructive Pulmonary Disease (COPD)
Tags: Aging
Algorithm
Personalized Medicine
Lead Inventor: Thomas Radomski
Department: Med-Medicine
All Tech Innovators: Thomas R. Radomski
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-05-12
Collections: Cardiometabolic

Vasculogenic Reprogramming for Diabetic Wound Healing and Ischemic Tissue Regeneration

06874

Vasculogenic reprogramming via Tissue Nanotransfection induces vasculogenic fibroblasts, boosting diabetic wound healing and ischemic tissue regeneration.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - DNA
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Lead Inventor: Chandan Sen
Department: Med-Surgery
All Tech Innovators: Sujit Kumar Mohanty
Sashwati Roy
Chandan Sen
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2024-09-16
Collections: Cell & Gene Therapy
Regenerative Medicine
Cardiometabolic

Microsphere-Based Therapy for Reversing New-Onset Autoimmune Diabetes

01703

Innovative antisense-loaded microspheres reverses new-onset autoimmune diabetes by downregulating CD40/CD80/CD86, modulating dendritic cells.

Technology Type: Therapeutic Modality
Technology Subtype: Vaccine - subunit, recombinant, polysaccharide, or conjugate
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Lead Inventor: Nick Giannoukakis
Department: Med-Pathology
All Tech Innovators: Nick Giannoukakis
Massimo M. Trucco
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2008-04-17
Collections: Cardiometabolic

New Approach to Combat Lithium-Induced Diabetes Insipidus

04699

Nrf2 activation via Bardoxolone methyl offers a novel Li-NDI therapy, reducing polyuria/polydipsia and protecting kidney health.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Nephrology
Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Chronic Kidney Disease (CKD)
Lead Inventor: Francisco Schopfer
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Soma Jobbagy
Francisco Jose Schopfer PhD
Dario A. Vitturi Iglesias
Date Submitted: 2018-08-02
Collections: Cardiometabolic

Virtual Health Coach Bridges Rural Cardiovascular Care Gaps

06539

A rural-focused virtual health coach delivers empathic, personalized cardiovascular coaching with home monitoring integration for chronic disease.

Technology Type: Digital Health
Technology Subtype: Other Digital Health
Therapeutic Areas: Cardiovascular
Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Pulmonary arterial hypertension (PAH)
Lead Inventor: Jared Magnani
Department: Med-Medicine
All Tech Innovators: Brian Kaleida
Jared William Magnani
Date Submitted: 2023-10-10
Collections: Cardiometabolic

MPowerHub

06448

A device-agnostic mobile platform blending real-time glucose, activity, and adherence data with actionable, evidence-based behavior goals.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Tags: Consumer
Lead Inventor: Ann-Marie Rosland
Department: Med-Medicine
All Tech Innovators: Carissa Ann Low
Ann-Marie Rosland
Date Submitted: 2023-07-05
Collections: Cardiometabolic

Gene Therapy Targeting Type 2 Diabetes

05593

Gene therapy silences smad2 to boost insulin secretion and β-cell function, potentially reversing diet-induced diabetes.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Lead Inventor: George Gittes
Department: Med-Surgery
All Tech Innovators: George K. Gittes
Krishna Prasadan
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-01-15
Collections: Cell & Gene Therapy
Cardiometabolic

Osteoprotegerin Enhances Beta Cell Survival and Proliferation to Treat Diabetes

02495

Osteoprotegerin promotes human beta cell survival and growth, potentially reducing insulin dependence for diabetes treatment.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Lead Inventor: Rupangi Vasavada
Department: Med-Medicine
All Tech Innovators: Rupangi Vasavada
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2011-06-03
Collections: Cardiometabolic

Mixed Radiographic Contrast Agent and Acetic Acid for Pancreatic Infusion

06417

Novel infusion blends acetic acid with radiographic contrast to ablate exocrine pancreas while preserving islets, enabling targeted therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Hepatology
Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Lead Inventor: George Gittes
Department: Med-Surgery
All Tech Innovators: George K. Gittes
Hannah Rinehardt MD
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-05-25
Collections: Cardiometabolic

TightRate: New Mobile App Offers Remote Insulin Titration to Achieve Lasting Targeted Glucose Levels with Patients

05546

Remote insulin titration app TightRate adjusts doses via provider-directed algorithms to achieve stable, personalized glucose targets.

Technology Type: Medical Device
Technology Subtype: Monitoring Medical Device
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Tags: Autoimmune
Lead Inventor: David Rometo
Department: Med-Medicine
All Tech Innovators: David A. Rometo
Sandra Indacochea Sobel
Date Submitted: 2020-11-05
Collections: Cardiometabolic
Women's & Reproductive Health

Cox4i1: A Novel Target for Diabetes Treatment

03958

Cox4i1 as metformin target reveals new diabetes therapies; enables screening for selective, first-in-class antidiabetic drugs.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Lead Inventor: Nathan Yates
Department: Med-Cell Biology
All Tech Innovators: Harris B. Bell-Temin
Steven James Mullett
Nathan A. Yates
Date Submitted: 2016-06-13
Collections: Cardiometabolic

Virtual Patient Simulation of Diabetic Ketoacidosis

02575

Interactive web-based VPsim trains clinical decision-making for diabetic ketoacidosis using virtual patient scenarios and tailored feedback.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Tags: Education Technology
Lead Inventor: Gary Tabas
Department: Med-Medicine
All Tech Innovators: Gary Howard Tabas
Date Submitted: 2011-09-28
Collections: Cardiometabolic

Nitrated-fatty Acids Modulation of Type II Diabetes

01545

Nitrated fatty acids improve type 2 diabetes by PPAR-γ modulation, boosting insulin sensitivity without typical TZD side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Lead Inventor: Bruce Freeman
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Bruce A. Freeman
Date Submitted: 2007-08-01
Collections: Cardiometabolic

Live Cell Imaging of Insulin

01663

A live-cell insulin tracking method uses mcTimer fluorescent probes to monitor insulin synthesis, trafficking, and secretion over 24 hours.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Tags: Microscopy
Lead Inventor: Peter Drain
Department: Med-Cell Biology
All Tech Innovators: Peter Francis Drain
Date Submitted: 2008-03-03
Collections: Cardiometabolic