Therapeutic Indications

Solid tumor

AI-Driven Precision Dosing and Survival Analytics for Personalized Brain Radiosurgery

07224

AI-driven personalized brain radiosurgery doses with survival analytics; real-time guardrails, offline decision support, rapid prognostic predictions.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Neuroscience
Oncology
Therapeutic Indications: Solid tumor
Brain cancer - Other
Glioblastoma
Tags: Artificial intelligence (AI)
Machine learning
Surgery
Lead Inventor: Jheremy S. Reyes
All Tech Innovators: Constantinos George Hadjipanayis
L Dade Lunsford
Ajay Niranjan
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-06-16
Collections: Healthcare AI

Highly Accurate Serological Biomarker for Early Detection of Nasopharyngeal Carcinoma

05923

A serological panel detects EBV EBNA1 IgA with 100% sensitivity/specificity, enabling pre-diagnostic NPC risk screening.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Nasopharyngeal carcinoma (NPC)
Lead Inventor: Kathy Ho Yen Shair
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Kathy Ho Yen Shair
Jian-Min Yuan
Date Submitted: 2021-12-20

AI-Powered Single-Cell Analysis from Standard H&E Slides for Personalized Cancer Therapy Prediction

06923

AI-driven single-cell typing from standard H&E slides enables personalized cancer therapy predictions, increasing accessibility and speed.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Hepatocellular carcinoma (HCC)
Tags: Artificial intelligence (AI)
Biomarker
Algorithm
Lead Inventor: Riyue Bao
Department: Med-Medicine
All Tech Innovators: Riyue Bao
Jason J. Luke
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2024-10-16
Collections: Healthcare AI

Fluid Removal Algorithm for Acute Kidney Injury

05831

A standardized, data-driven fluid removal tool for ICU dialysis in AKI, aiming to reduce hypotension and complications.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - scFV
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Leukemia
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dimiter Stanchev Dimitrov
John W. Mellors
Zehua Sun
Date Submitted: 2021-10-06

Enhanced Antitumor Efficacy of Ultrasound-mediated Doxorubicin Delivery by Microbubble-liposome Complex

05168

Ultrasound-triggered microbubble-liposome delivery of doxorubicin enhances tumor kill, reduces cardiotoxicity, boosting soft-tissue sarcoma therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Flordeliza Villanueva
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Mingyu He
Flordeliza S. Villanueva M.D.
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-11-14

Novel EGFR Tumor-Associated Antigens and Enhanced Agonist Epitopes

01638

Novel EGFR tumor antigens and potent agonist epitopes enable enhanced immunotherapy and vaccines for EGFR-expressing cancers.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Nasopharyngeal carcinoma (NPC)
Other
Tags: Immuno-oncology
Lead Inventor: Robert Ferris
Department: Med-Otolaryngology
All Tech Innovators: Pedro Alcantara Andrade
Robert Louis Ferris
Andres Lopez Albaitero
Technology Readiness Level: 6. IND-enabling studies
Date Submitted: 2008-02-11

Novel Patient-Derived Assembloid Model Accelerates Immunotherapy Development for Difficult-to-Treat Cancers

06922

Patient-derived assembloid with tumor-immune co-cultures accelerates immunotherapy/vaccine development for hard-to-treat head and neck cancers.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Immunology
Oncology
Therapeutic Indications: Solid tumor
Tags: Immuno-oncology
Tissue engineering
Platform Technology
Lead Inventor: Riyue Bao
Department: Med-Medicine
All Tech Innovators: Riyue Bao
Jason J. Luke
Technology Readiness Level: 3. Prototype development
Date Submitted: 2024-10-16

Enhancing the Activity of Cancer-targeting Immune Cells

06446

AMPK agonist c991 boosts oxidative T cell metabolism during CAR T preparation, enhancing anti-leukemia efficacy in vivo.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Chronic Myeloid Leukemia (CML)
Chronic Lymphocytic Leukemia (CLL)
Lead Inventor: Craig Byersdorfer
Department: Med-Pediatrics
All Tech Innovators: Erica Braverman
Craig Alan Byersdorfer
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-07-02

Identification of Fully Human Antibodies

05676

Fully human PSCA-targeting antibodies enable potent ADCC and ADCs against PSCA+ cancers, including prostate tumors.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - Fab
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Prostate cancer / adenocarcinoma
Renal cell carcinoma (RCC)
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Dimiter Stanchev Dimitrov
Dontcho V. Jelev
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-04-21

Microbubble-Based Sonosensitizer Delivery Systems for Ultrasound-Triggered Reactive Oxygen Species Generation and Cancer Therapy

04132

Ultrasound-triggered lipid microbubbles deliver hydrophobic sonosensitizers for targeted ROS-based cancer therapy with theranostic imaging.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Xucai Chen
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Bin Qin
Flordeliza S. Villanueva M.D.
Date Submitted: 2017-01-19

Novel Human Antibodies Targeting ENPP1

05859

Novel fully human anti-ENPP1 antibodies offer targeted cancer immunotherapy potential, compatible with BiTE, CAR-T, and ADC strategies.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Immunology
Oncology
Therapeutic Indications: Solid tumor
Ductal carcinoma (Breast cancer)
Lung cancer - other
Tags: Immuno-oncology
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Xiaojie Chu
Dimiter Stanchev Dimitrov
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-10-30
Collections: Women's & Reproductive Health

Genetic Re-engineering of Immune Cells to Improve Metabolic Fitness for Immunotherapy

03881

Engineered CAR T cells boosted by mitochondrial biogenesis genes to enhance metabolic resilience for solid-tumor immunotherapy.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Immunology
Oncology
Therapeutic Indications: Solid tumor
Tags: Immuno-oncology
Lead Inventor: Greg Delgoffe
Department: Med-Immunology
All Tech Innovators: Greg M. Delgoffe
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2016-03-30
Collections: Cell & Gene Therapy

Next-Generation Precision Oncolytic HSV: Dual-Targeted Viral Therapy for Enhanced Safety and Potency

02144

Dual-targeted oncolytic HSV with miRNA safety regulation and tumor-specific entry, boosting glioma therapy while reducing neurotoxicity.

Technology Type: Therapeutic Modality
Technology Subtype: Oncolytic Virus
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Brain cancer - Other
Tags: Genetics
Immuno-oncology
Precision medicine
Lead Inventor: Joseph Glorioso
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Justus Bernard Cohen
Joseph C. Glorioso III
Hiroaki Uchida
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2010-02-19

pH-Sensitive Linkers for Advanced Biomedical Delivery

07192

Acid-cleavable beta-diketone/triketone linkers enable bioorthogonal delivery systems for mRNA, gene therapy, and targeted cancer therapeutics.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Immunology
Therapeutic Indications: Solid tumor
Tags: Polymer
Platform Technology
Lead Inventor: Song Li
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Yixian Huang
Song Li
Huatian Li
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2025-05-23

Engineered Dendritic Cell Platform for Ligand-Controlled Local IL-12 Antitumor Activation

01540

Ligand-controlled dendritic cells locally activate IL-12 for targeted tumor immunotherapy with tunable dosing and reduced systemic toxicity.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Walter Storkus
Department: Med-Dermatology
All Tech Innovators: Hideo Komita
Walter J. Storkus Ph.D.
Cynthia Zhao
Date Submitted: 2007-07-19
Collections: Cell & Gene Therapy

Human Antibody Domains and Fragments to CD276

04890

Fully human antibody domains and fragments target CD276 (B7-H3) to enhance solid tumor immunotherapy and tumor penetration.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - Bispecific
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dimiter Stanchev Dimitrov
Wei Li
John W. Mellors
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-02-11

Targeting Chromosomal Rearrangements for Cancer Treatment

03641

Targeting fusion gene-driven cancers with genome-editing therapies for precise, breakpoint-specific treatment and improved outcomes.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Hodgkin Lymphoma
Chronic Myeloid Leukemia (CML)
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Zhanghui Chen
Jianhua Luo
George Michalopoulos
Date Submitted: 2015-06-09
Collections: Women's & Reproductive Health

Chemical Synthesis and Antitumor Activity of FR901464 and Its Analogs

01313

Easier synthesis of potent FR901464 analogs with picomolar antiproliferative activity against resistant cancer cells.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Kazunori Koide
Department: Chemistry
All Tech Innovators: Brian J. Albert
Kazunori Koide
Ananthapadmanabhan Sivaramakrishnan
Date Submitted: 2006-08-11

Human Antibody Domains and Fragments to CD276

06094

engineered fully human single-domain antibodies and Fabs targeting CD276 (B7-H3) for potent, broadly applicable cancer immunotherapy.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Melanoma
Prostate cancer / adenocarcinoma
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dimiter Stanchev Dimitrov
Dontcho V. Jelev
John W. Mellors
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2022-07-06

Enhancing Cancer Immunotherapy by Silencing MCT11 to Overcome T-Cell Exhaustion

05632

Silencing MCT11 (Slc16a11) in T cells to prevent lactate-driven exhaustion, boosting CAR-T/TIL therapies against solid tumors.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Melanoma
Colorectal cancer (CRC)
Tags: Genetics
Immuno-oncology
Lead Inventor: Greg Delgoffe
Department: Med-Immunology
All Tech Innovators: Greg M. Delgoffe
Ronal Peralta
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2021-03-09
Collections: Cell & Gene Therapy

Method and Device for Ultrasound-Assisted Therapy

02728

Ultrasound-assisted therapy uses microbubble contrast to target delivery of drugs or genes, enabling safer, image-guided sonoporation.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Xucai Chen
Department: Med-Medicine
All Tech Innovators: Xucai Chen
John J. Pacella
Flordeliza S. Villanueva M.D.
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2012-03-23

Low-coherence Common-path Phase Microscopy for Nanoscale Detection of Malignancy in Stained Tissue Slides

02125

New reflectance-phase microscope uses common-path, nanoscale quantitative phase maps for malignant changes in stained slides, with seamless workflow.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Yang Liu
Department: Med-Medicine
All Tech Innovators: Randall E. Brand
Yang Liu
Pin Wang
Date Submitted: 2009-12-18

Stapled Acid-Sensitive Endosome Disrupting Alginates

03618

Acid-responsive alginoketal nanoparticles release divalent cations and cargo in acidic endosomes, enabling targeted cancer and biofilm therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Neuroscience
Oncology
Therapeutic Indications: Solid tumor
Parkinson's Disease
Alzheimer's Disease
Lead Inventor: Abhinav Acharya
Department: Chem/Petroleum Engineering
All Tech Innovators: Abhinav Prakash Acharya
Steven R. Little
Date Submitted: 2015-05-21

Controlled Release Formulations for Induction and Proliferation of Regulatory T Cells

02616

Controlled release IL-2, TGF-β, and rapamycin formulations induce human regulatory T cells in vitro, enabling targeted in vivo expansion.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Oncology
Immunology
Therapeutic Indications: Solid tumor
Lymphoma
Leukemia
Tags: Autoimmune
Immuno-oncology
Lead Inventor: Steven Little
Department: Engr-Dept Chairperson's Office
All Tech Innovators: Siddharth Jhunjhunwala
Steven R. Little
Giorgio Raimondi
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2011-11-10
Collections: Cell & Gene Therapy

T Cell Receptors Targeting Defective DNA Repair Proteins

04988

Engineered T cells express two TCRs targeting mutated DNA repair proteins, offering mutation-specific cancer immunotherapy.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Immunology
Oncology
Therapeutic Indications: Solid tumor
Tags: Immuno-oncology
Lead Inventor: Udai Kammula
Department: Med-Surgery
All Tech Innovators: Chetana Bhaskarla
Smriti Chaurasia
Udai Shankar Kammula
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2019-05-10
Collections: Cell & Gene Therapy
Women's & Reproductive Health

A Novel Universal Pre-Targeting Strategy for Molecular Imaging and Radionuclide Therapy

03779

A universal pre-targeting method (DRPT) enhances tumor imaging and therapy by boosting uptake, sensitivity, and antibody scope.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Tags: Immuno-oncology
Microscopy
Lead Inventor: Dexing Zeng
All Tech Innovators: Yongkang Gai
Lingyi Sun
Dexing Zeng
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2015-12-03

Expanded Phase-encoding EPI Sequence for Recovering Susceptibility-induced Signal Loss

01631

Expanded phase-encoding EPI enlarges encoding window to recover susceptibility-induced signal loss with minimal time, seamless integration.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Kwan-Jin Jung
Department: Office of Administration-Health Sciences
All Tech Innovators: Kwan-Jin Jung
Hua Peng
Date Submitted: 2008-01-29

Use of Tim-3 Cytoplasmic Tails in Chimeric Antigen Receptors

04970

Tim-3 cytoplasmic tail in CARs may boost T-cell activation, potentially reducing toxicity and cytokine release syndrome.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lymphoma
Leukemia
Lead Inventor: Lawrence Kane
Department: Med-Immunology
All Tech Innovators: Lawrence Patrick Kane
Jason Jakob Lohmueller
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2019-04-26
Collections: Cell & Gene Therapy

A METHOD FOR INTRAOPERATIVE MOLECULAR PROGNOSTIC ANALYSIS OF TUMORS

00536

Single-tube, two-stage RT-PCR enables rapid (<20 min), sensitive multiplex tumor diagnostics with reduced primer titration.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Tony Godfrey
Department: The James P. Wilmot Cancer Center
All Tech Innovators: Sydney David Finkelstein
Tony Edward Godfrey
Lori Ann Kelly
Date Submitted: 2000-10-19

TPI-SENSE for Efficient 3D Proton/Non-Proton MR Imaging

01479

TPI-SENSE enables fast, 3D proton/non-proton MRI with higher SNR for short-T2 tissues, improving stroke/cancer diagnostics.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Cardiovascular
Oncology
Therapeutic Indications: Solid tumor
Stroke
Lead Inventor: Fernando Boada
Department: Med-Radiology
All Tech Innovators: Fernando E. Boada
Yongxian Qian
Date Submitted: 2007-04-13
Collections: Cardiometabolic