3D Printed Interlocked Platform to Study the Microbial Exometabolome

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- Unbiased proteome-wide target identification using label-free full-scan mass spectrometry.
Peptide mixtures undergo high-frequency full-scan nano-LC-MS, generating mass-to-charge, retention time, and intensity features.
These features are uploaded to a cloud-based analysis platform, where isotope grouping, alignment across replicates, and statistical plus practical filters rank signals by differential intensity.
Based upon an optical configuration of Total Internal Reflection Fluorescence (TIRF) microscopy and the inclusion of an ultra-large field of view, high-density exosome detection, molecular-counting based multiplex quantitative analysis of biomarkers and super-resolved imaging capabilities, this novel platform will allow for significantly higher throughput, multiplicity, and accuracy, all vital for single exosome analysis.
This novel platform could overcome existing challenges in exosome analysis improving the use of single exosome analysis in both research and clinical settings.
Researchers from the University of Pittsburgh have developed a platform technology for hyper-throughput biomarker detection with single molecule sensitivity.
These wells can be used as either a single well, or arranged into larger arrays, with lids and bases easily assembled using clip-in connections and screws to allow for use in high-throughput analysis.
With the possibility to modify the dimensions of these wells and arrange into arrays of various size, these optically transparent wells allow for monitoring of high-throughput samples to improve research.
High-throughput optical monitoring is a commonly used research technique in drug screening and monitoring cell morphology in response to stimuli (e.
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        Tissue engineering
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    • Lead Inventor
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        Riccardo Gottardi
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        Vaughn Cooper
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        Alexander Star
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        Antonio DAmore
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        Douglass Taylor
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        Med-Computational and Systems Biology
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    • All Tech Innovators
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        Riccardo Luca Gottardi
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        Rocky Sung Chi Tuan
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        Yang Liu
      • 2
        Hoa Vinh Pham
      • 2
        Peter Alexander
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