Epigenetic Biomarkers for the Minimally Invasive Diagnosis of Fetal Genetic Disease
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University of Pittsburgh researchers have developed a novel approach to augment VEGF therapy for ischemic tissue revascularization using epigenetic principles. Researchers identified that hyperglycemia leads to DNA methylation-based silencing of the PLCγ2 gene, hindering VEGF therapy. It combines epigenetic editing with VEGF therapy to enhance revascularization and wound healing.
While the expression pattern of C19MC is almost exclusively in the placenta accounting for nearly 40% of miRNAs present in trophoblasts, it is of note that abnormal expression is associated with some uncommon cancers. Transgenic mice were generated following pronuclear microinjection of supercoiled Bacterial Artificial Chromosome (BAC) DNA containing the entire human C19MC locus including an upstream regulatory sequence into mice embryos. `University of Pittsburgh researchers have developed a genetically modified mouse line carrying 46 genes coding for primate specific micro-RNAs (miRNAs), referred to as the chromosome 19 microRNA cluster (C19MC) due to being located on chromosome 19.q13 in humans.
This method leverages the analysis of DNA methylation signatures within cell-free DNA fragments found in plasma or other fluid reservoirs. The technology involves the detection of DNA methylation signatures in cell-free DNA from plasma or other fluid reservoirs of ovarian cancer patients. This approach allows for the accurate prediction of methylation patterns in new plasma samples, enhancing the sensitivity and specificity of ovarian cancer detection.