The technology involves a genetically engineered MCF-7 breast cancer cell line that has been modified to overexpress the Pin1 protein, a key peptidyl-prolyl cis/trans isomerase important for cell cycle regulation. These cells have been created using established genetic engineering techniques and are maintained as authenticated stocks to ensure consistent behavior in laboratory studies. This cell model facilitates detailed investigations into the cellular mechanisms governing breast cancer progression and provides a platform for screening compounds that might affect cell cycle dynamics.
Description
What differentiates this technology is its specialized focus on Pin1 overexpression, making it a unique tool for understanding cell cycle regulation in cancer biology. By specifically amplifying a protein known to impact cancer progression, this system offers enhanced sensitivity in detecting the effects of therapeutic compounds. The approach stands apart from conventional cell models by enabling more precise and reliable studies.
Applications
- Cancer drug screening tool
- Preclinical assay platform
- Target validation studies
- Breast cancer research tool
Advantages
- Provides a reliable in vitro model to study the role of Pin1 in breast cancer and cell cycle regulation.
- Facilitates the screening and evaluation of compounds that target cell cycle progression in cancer research.
IP Status
Research Tool
