The approach allows for controlled spheroid formation, providing a robust platform for cellular reprogramming and advancing regenerative medicine protocols. - Induces key endothelial markers and modulates cadherin and integrin profiles, supporting advancements in tissue engineering.
In a murine non-ischemic dilated cardiomyopathy model, injection of AAV9-cTnT-mycPKG1WT improved left ventricular function. Human iPS cell derived cardiomyocytes were transduced using AAV6-cTnT-mycPKG1 leading to an amplification of CNP-induced SERCA2a SUMOylation, a known pathway in maintaining the cardiac cycle.
Nampt is a rate-limiting enzyme in the Nicotinamide adenine dinucleotide (NAD+) salvage pathway that converts nicotinamide to nicotinamide mononucleotide in mammals.
