A flipping mirror directs illumination into a reflection-mode module—where backscattered tissue waves interfere with reference waves across ~230 wavelengths using a right-angle prism to prevent double transmission—or into a trans-illumination module employing a transmission grating to separate DC and first-order beams for quantitative phase imaging. - Label-free tissue pathology imaging. - Label-free, depth-resolved quantitative phase imaging of unstained tissue with nanoscale sensitivity.
High-throughput optical monitoring is a commonly used research technique in drug screening and monitoring cell morphology in response to stimuli (e. Commercially available 96-well plates used in high-throughputscreening typically require sample volumes between 40–280 µL. With the possibility to modify the dimensions of these wells and arrange into arrays of various size, these optically transparent wells allow for monitoring of high-throughput samples to improve research.
Contrast-enhanced molecular imaging. High-efficiency coatings and acoustic-matching media reduce energy losses, while the reflective shell improves signal‐to‐noise ratio and imaging depth without added external optics. The present invention is a novel device that can enhance the effective intensity and diffusivity of a light source to illuminate a target imaging area at depth.