Mass Immunization Device

Overview
Request Info
More Like This
Search text
Active Filters
No Name Given Kanhaiya
1 result
(0.06 seconds)
Epigenetic Enhancement of VEGF Therapy for Ischemic Tissue Revascularization
06723
University of Pittsburgh researchers have developed a novel approach to augment VEGF therapy for ischemic tissue revascularization using epigenetic principles.
Researchers identified that hyperglycemia leads to DNA methylation-based silencing of the PLCγ2 gene, hindering VEGF therapy.
Using a CRISPR/dCas9-based demethylation cocktail delivered via tissue nano-transfection (TNT) technology, the PLCγ2 promoter is specifically demethylated in endothelial cells during VEGF therapy.
Therapeutic Modality
Drug Discovery - Target
Dermatology
Other
No Name Given Kanhaiya
Med-Surgery
2024-04-18
    • Technology Type
      • 1
        Therapeutic Modality
      • Add ...
    • Technology Subtype
      • 1
        Drug Discovery - Target
      • Add ...
    • Therapeutic Areas
      • 1
        Dermatology
      • Add ...
    • Therapeutic Indications
      • 1
        Other
      • Add ...
    • Tags
      • Add ...
    • Lead Inventor
      • 4
        Mingui Sun
      • 2
        Stephen Weber
      • 2
        Xinyan Cui
      • 2
        Yi Hong
      • 1
        Bing Wang
      • 1
        No Name Given Kanhaiya
      • Add ...
    • Department
      • 1
        Med-Surgery
      • Add ...
    • All Tech Innovators
      • 1
        Chandan Sen
      • 1
        Kanhaiya Singh
      • 1
        Sumit Singh Verma
      • Add ...
    • Date Submitted
This site uses cookies to deliver a better user experience. Learn more.