This technology is built on a modular platform that integrates customizable components to support advanced 3D tissue culture. Its design features a base plate resembling standard multi-well plates with paired conduits feeding distinct upper and lower compartments, allowing precise fluid control. Tightly fitting well inserts, complete with peripheral sealing flanges and porous walls, create isolated yet dynamically interactive chambers. An interchangeable lid with integrated micro-mechanical actuators and force sensors provides controlled vertical mechanical loading. Additionally, an option with a shell and reciprocating piston offers refined control over fluid communication and mechanical or chemical perturbations, making it highly adaptable for complex tissue experiments.
Description
InterfacePLUS is a drug development tool that can effectively and efficiently test and predict the effects and potential side effects of a candidate compound on human tissue. InterfacePLUS is a platform in which multiple tissues or engineered tissue constructs can be cultured together reproducing the complexity that is present in the human body, offering drug developers a sophisticated assessment tool and the ability to fail early and fail fast screening out ineffective or potentially damaging compounds early in the translation process. The InterfacePLUS platform allows testing of 3D tissue models in a high throughput, streamlined manner, and it can also predict the side effects of candidate drugs. InterfacePLUS can then increase the amount of compounds screened out prior to animal or human testing and predict possible side effects of candidate drugs. InterfacePLUS is a plate with the dimensions and structure of a standard 96 well plate, with additional microfluidics and a chamber where multiple tissues can be cultured together within each chamber reproducing the complexity that is present in the human body, where each organ is composed of multiple tissue types. Each tissue can be cultured in its own specific environment to maintain it under ideal conditions. The different wells are connected by a microfluidic system that allows high throughput and connection between different organ types.
Applications
Modular design allows flexible, customizable configurations for diverse experimental needs.
Compatibility with standard multi-well plate formats facilitates integration with existing lab equipment.
Separate fluidic compartments enable the maintenance of distinct microenvironments for multiple tissue types.
Integrated mechanical actuators and sensors provide precise mechanical stimulation and real-time monitoring.
High-throughput scalability supports efficient drug screening, disease modeling, and tissue engineering applications.
Advantages
Drug screening platform
Disease modeling platform
Tissue engineering research
Multi-tissue culture studies
IP Status
https://patents.google.com/patent/US20240093157A1
