Related Technologies - University of Pittsburgh

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Gene Therapy for Management of Chronic Pain

03200

These novel antagonists, produced using Herpes Simplex Virus (HSV)-based gene therapy vectors, can reduce pain response through regulating TRPTV1 activity, providing a novel approach to the treatment of chronic pain to improve the quality of life of millions of patients.

Current Gene Therapy using Viral Vectors for Chronic Pain.

University of Pittsburgh researchers have identified novel genes capable of producing antagonists to a key regulator of pain response, TRPTV1, with the potential to revolutionize the treatment of chronic pain.

Therapeutic Modality

Other Therapeutic Modality

Musculoskeletal Neuroscience

Other Pain

William Goins

Med-Microbiology and Molecular Genetics

2013-12-13

Advanced HSV Mutant Virus d109for Gene Therapy Applications

04311

The d109 virus offers a unique approach to studying HSV biology and developing therapeutic strategies.

- Vaccine development for HSV and other pathogens.

The virus's ability to express the HSV genome in the absence of these proteins provides a unique tool for studying HSV biology and developing new therapeutic strategies.

Life Science Research Tool

Other Life Science Research Tool

Neal DeLuca

Med-Microbiology and Molecular Genetics

2017-07-11

Novel Glycine Receptor Modulators for Analgesia

04250

• Reducing the necessary dose of opioids for chronic pain management.

ZINC08 is even more effective than THC at enhancing human glycine receptor function in vitro and reduced the effects of inflammatory pain and boosted the efficacy of a sub-therapeutic does of morphine.

THC, the main chemical component of marijuana, has gained popularity as an alternative analgesic for treating chronic pain, but psychoactive side effects and political controversy have stymied widespread adoption.

Med-Anesthesiology and Perioperative Medicine

2017-05-17

Novel Targeted Gene-Therapy for Neuropathic Pain