Inhibition of p97 ATPase activity triggers downstream cellular effects, including the suppression of cellular proliferation that makes cancer such a dangerous disease. And because these compounds specifically inhibit p97, they offer the possibility of treating a wide array of ailments with fewer side effects than drugs acting on broader pathways; neurodegenerative diseases, for example, display dysregulation of protein homeostasis via p97 and have the potential to be treated with these inhibitors.
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