This technology employs an en-bloc surgical resection technique that preserves both the tumor and adjacent brain tissue in an intact specimen. The tissue is maintained outside the body using vessel cannulation and continuous perfusion, which ensures controlled oxygenation, pH levels, and overall tissue viability. This setup retains the original histology and stroma, accurately modeling the blood–brain barrier in a laboratory environment. It is specially designed for high-throughput pre-clinical studies, allowing for detailed analysis of personalized drug responses and tumor behavior in conditions that closely mimic the human brain.

Description

What sets this approach apart is its ability to maintain an entirely human context by preserving the complete anatomical structure post-resection. Unlike traditional models, it keeps both cancerous and normal brain tissue viable, providing an unmatched representation of the in vivo state. The method’s unique combination of controlled perfusion and continuous monitoring not only simulates the natural environment but also facilitates rapid, cost-efficient, and personalized testing. This results in a highly accurate and versatile platform for both clinical research and drug development.

Applications

- Personalized treatment selection
- Co-clinical trial simulations
- Drug development testing
- Blood-brain barrier testing
- Cancer biology research

Advantages

- Preserves both tumor and normal brain tissue in an intact, viable state for accurate human tissue analysis.
- Maintains continuous perfusion with controlled oxygenation and pH, ensuring faithful tumor histology and blood–brain barrier representation.
- Enables high-throughput pre-clinical studies for personalized drug response testing and co-clinical trials.
- Facilitates rapid, cost-efficient research and development in drug testing and basic cancer biology.
- Supports patient-specific modeling, advancing personalized treatment selection and targeted therapeutic strategies.

IP Status

Research Tool

Personalized Ex-Vivo Brain Tumor Model