Synthetic Methodology for Functionalized Bis-Peptides
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AMPs are cationic peptides, typically 12–50 peptides in length, and demonstrate antimicrobial properties against treatment-resistant pathogens. A University of Pittsburgh researcher has developed novel cationic antimicrobial peptides (AMPs) through modification of secondary structure and the associated amphipathic characteristics. Based on peptides in existing AMPs the secondary structure has been scrambled to change the amphipathic from helical to linear.
4D printing, in which printed objects demonstrate functional responses to stimuli, represents the very forefront of additive manufacturing technology. The monomer can be changed between subsequent layers, introducing functional gradations that can elicit dynamic and varied response profiles in the finished structure.
Peptide studies to date are incremental and tailored to a single best peptide. Deciphering the therapeutic code of cationic peptides for the treatment of cancer and infections associated with antibiotic resistant bacteria. Although current treatments include natural antimicrobial peptides (AMPs), they pose several challenges for clinical applications, notably lack of in vivo efficacy and potential toxicity to mammalian cells.
- 15Therapeutic Modality
- 6Engineering Technology
- 2Medical Device
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- 5Drug Delivery / Formulation
- 5Small Molecule
- 4Material Science
- 3Peptide
- 2Chemical
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- 8Oncology
- 4Infectious Disease
- 4Other
- 2Neuroscience
- 1Cardiovascular
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- 1Streptococcus
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- 4Biomaterial
- 3Platform Technology
- 2Coating
- 2Life Science
- 2Small molecule
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- 2Berthony Deslouches
- 2Nathaniel Rosi
- 2Paul Floreancig
- 2Peter Wipf
- 2Song Li
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- 4Chemistry
- 3Bioengineering
- 3Distinguished Faculty-Dietrich School of Arts and Sciences
- 2GSPH-Environmental/Occupational Health
- 2Med-Cell Biology
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- 3Berthony Deslouches
- 3Song Li
- 2Alexander Deiters
- 2Andrea David Merg
- 2Elias Aizenman
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