University of Pittsburgh and Cedars-Sinai Medical Center scientists have developed a novel MRI (magnetic resonance imaging) method, 4D Oxy-wavelet MRI, to monitor mitochondrial function in live tissue (e.

A University of Pittsburgh researcher is developing gene therapy for Prader-Willi syndrome (PWS).

This antioxidant therapy reduces reactive oxygen levels in cells to treat propionic and methylmalonic acidemia.

This pioneering mouse model replicates the key characteristics of hypoplastic left heart syndrome by exhibiting an underdeveloped aorta and left ventricle, along with defective aortic and mitral valves.

Inborn errors of metabolism (IEMs) disrupt biochemical pathways through deficiency of a particular enzyme.

This invention introduces a novel organotypic human kidney culture system designed to model nephrotic syndrome treatment.

The development of preclinical models amenable to live animal bioactive compound screening is an attractive approach to discovering effective pharmacological therapies for disorders caused by misfolded and aggregation-prone proteins.