Cardiometabolic
Includes cardiometabolic-related technologies including indications like NASH, Cirrhosis, CKD, nephrosis, and diabetic kidney disease.
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This technology utilizes three-dimensional spheroid culture techniques to transform human pericytes isolated from the aortic adventitia into pluripotent cells.
University of Pittsburgh researchers have developed a novel in vitro model of metabolic dysfunction-associated steatotic liver disease (MASLD) in patients with genetic mutations (TM6SF2-167K).
A pioneering approach harnesses human-induced pluripotent stem cells (hiPSCs) to create functional, three-dimensional heart valves grown on heart organoids entirely in vitro.
University of Pittsburgh researchers have used the CRISPR technology to create a new mouse model for a rare, recessive metabolic disorder.
This pioneering mouse model replicates the key characteristics of hypoplastic left heart syndrome by exhibiting an underdeveloped aorta and left ventricle, along with defective aortic and mitral valves.
The technology employs extracellular matrix (ECM) extracted from zebrafish hearts as a substrate to promote cardiac tissue repair in mammals, particularly after myocardial infarction.
This live-cell dual biosensor technology employs fluorescent tagging of proinsulin and proglucagon using fusion protein constructs under native promoters.
University of Pittsburgh researchers have developed an invention, related to the field of imaging intracellular proteins, which uses fluorescent probes capable of changing color over time to identify and track the synthesis, trafficking, and secretion of intracellular proteins.
The development of preclinical models amenable to live animal bioactive compound screening is an attractive approach to discovering effective pharmacological therapies for disorders caused by misfolded and aggregation-prone proteins.
University of Pittsburgh researchers have identified a novel mutation in the endogenous Drosophila mitochondrial ATP6 gene which conferes neuromuscular impairment.