Researchers at the University of Pittsburgh and the University of Pennsylvania have identified Profilin1 (Pfn1) as a novel therapeutic target for atherosclerosis.
University of Pittsburgh researchers have developed a novel infusion solution combining acetic acid with a radiographic contrast agent for the treatment of pancreatic disorders.
University of Pittsburgh researchers have developed a novel treatment for treating disease conditions that result from deficiency of succinyl-CoA including propionic acidemia and fatty acid disorders.
University of Pittsburgh researchers have discovered a way to stop calcification using STAT5 inhibitors for the treatment or prevention of cardiovascular calcification.
Nicotinamide phosphoribosyltransferase (NAMPT) is an enzyme that helps to regulate and reprogram cellular metabolism, and control the activity of NAD-dependent enzymes.
Parathyroid hormone (PTH) type 1 receptor (PTHR) is an indispensable G protein-coupled receptor (GPCR) of class B that functions to regulate blood levels of vitamin D, calcium, and phosphate ions in the body, as well as bone turnover.
University of Pittsburgh researchers have developed novel nitroxide-based lipid peroxidation mitigators designed to prevent ferroptotic cell death, a regulated form of non-apoptotic cell death.
University of Pittsburgh researchers have identified a library of small molecules found to promote activity of AMP-activated Protein Kinase (AMPK), a key regulator of several metabolic pathways.
Therapeutic hypothermia is currently the only clinically approved therapy to treat neurological injury across the central nervous system in the setting of cardiac arrest and other similar conditions, but it comes with a risk of adverse side effects.
One out of every 20 deaths in the United States is caused by stroke. If administered quickly, surgery or clot-dissolving agents can improve the odds of survival.
University of Pittsburgh researchers have identified new small molecules to promote AMP-activated Protein Kinase (AMPK) activity, a key regulator of several metabolic pathways.
