University of Pittsburgh researchers have developed an innovative 3D bioprinting platform capable of generating functional primary and induced pluripotent stem cell (iPSC)-derived organoids within hydrogel constructs.
PCO results from a wound-healing response that elevates levels of TGFฮฒ in the eye, leading to EMT. However, disruption of the integrity of the eye during surgery and the associated healing process can lead to the regrowth of residual epithelial cells migrating to the posterior capsule instead of differentiation into normal fiber cells, resulting in PCO.
Additionally, metformin promotes angiogenesis which can reduce healing time and lead to enhanced tissue healing with high-quality tissue regeneration. In vivo studies in mice with Achilles tendon injuries treated with intraperitoneal injections of metformin demonstrated that the treatment increased and activated AMPK while suppressing TGF-ฮฒ1 levels within the healing tendon in acute injuries. University of Pittsburgh researchers have discovered that metformin (Met), a commonly used medicine to treat type 2 diabetes, to promote soft tissue healing and prevent the development of fibrosis and resulting tendinopathy.
The stents' ability to generate electrical signals from mechanical deformations enhances their functionality as both diagnostic tools and potential therapeutic devices for accelerating wound healing.
Researchers from the University of Pittsburgh have established a novel approach to tackle the current challenge of bone regeneration through harnessing the power of skeletal stem cells (SSCs).
By identifying the most relevant indicators of CSSC quality, this technology ensures the selection of cells with high healing potential, paving the way for more successful clinical trials and treatments. This technology provides a reliable method to select CSSCs with optimal healing and regenerative capabilities, reducing variability in treatment outcomes.
Scientists from the University of Pittsburgh have discovered the ability of corneal stromal stem cell (CSSC)-derived secretome to promote corneal wound healing without producing scarring and so prevents damage to corneal sensory nerves. The cause is the activation of growth factors and cytokines to promote wound healing but which can lead to inflammation-induced corneal cell death and sensory neuron death. This novel approach would promote scarless wound healing, reducing the risk of life-changing vision loss through dampening of the inflammation pathway post-injury to the cornea and rescuing corneal sensory nerves.
Firstly, while initially occluding the aneurysm, the fatty amide-based polyurethane urea (PHEUU) elastomer used to fabricate the Mg-alloy coil not only protects the coil from corrosion but could also promote healing.
A team of University of Pittsburgh researchers have identified the role of estrogen receptor-a (ERa) in osteoarthritis (OA), a debilitating and painful joint disease.
Platelet-rich plasma (PRP) is an emerging biological tool for musculoskeletal tissue healing. Variations within PRP itself, including differences between preparation protocols, number of platelets, use of anticoagulants and activators, and inclusion of leukocytes are variables that may influence the effects of PRP therapy, and while PRP is rich in concentrated growth factors that accelerate tissue healing, it also contains high amounts of deleterious cytokines and growth factors that could exacerbate or increase tissue damage. ยท Next generation PRP product for tissue healing.
This fast-acting probe has enabled real-time imaging of H2O2 produced in endothelial cells and in a zebrafish wound healing model, providing an accurate platform for endogenous H2O2 detection in real time with chemical probes. Hydrogen peroxide mediates various biological processes such as wound healing, apoptosis, and inflammation. The fast kinetics enabled real-time imaging of H2O2 produced in endothelial cells in 8 seconds (much earlier than previously shown) and H2O2 in a zebrafish wound healing model.
