During the corneal wound healing process an immune response is mounted.
University of Pittsburgh researchers have developed an ocular live biotherapeutic product (LBP) by engineering eye-colonizing bacteria to continuously deliver therapeutic agents to eye wounds and promote healing.
This first-of-a-kind bacterium can promote corneal wound healing and offers a novel therapeutic approach to deliver ocular therapeutics.
Researchers from the University of Pittsburgh have established a novel approach to tackle the current challenge of bone regeneration through harnessing the power of skeletal stem cells (SSCs).
Scientists from the University of Pittsburgh have discovered the ability of corneal stromal stem cell (CSSC)-derived secretome to promote corneal wound healing without producing scarring and so prevents damage to corneal sensory nerves.
The cause is the activation of growth factors and cytokines to promote wound healing but which can lead to inflammation-induced corneal cell death and sensory neuron death.
This novel approach would promote scarless wound healing, reducing the risk of life-changing vision loss through dampening of the inflammation pathway post-injury to the cornea and rescuing corneal sensory nerves.
This fast-acting probe has enabled real-time imaging of H2O2 produced in endothelial cells and in a zebrafish wound healing model, providing an accurate platform for endogenous H2O2 detection in real time with chemical probes.
Hydrogen peroxide mediates various biological processes such as wound healing, apoptosis, and inflammation.
The fast kinetics enabled real-time imaging of H2O2 produced in endothelial cells in 8 seconds (much earlier than previously shown) and H2O2 in a zebrafish wound healing model.
- Drug-eluting bone healing devices.
A novel injectable hydrogel system is designed for soft tissue repair and reconstruction.
The formulation incorporates extracellular matrix material extracted from decellularized porcine bladder, maintaining bioactive cues that promote healing.
Extensive in vivo evaluations have confirmed its capacity to drive favorable tissue regeneration, positioning it as a transformative approach in regenerative medicine. Applications. - Injectable soft tissue repair. - Adipose tissue regeneration scaffold. - Minimally invasive reconstruction.
University of Pittsburgh researchers have developed a novel laser surface texturing technology that fabricates defined micro grid patterns on endovascular metallic materials, such as Cobalt-Chromium (CoCr).
By targeting the epigenetic silencing of key endothelial genes, this technology enhances the efficacy of VEGF therapy, improving blood flow and wound healing in diabetic ischemic tissues.
• Enhancing VEGF therapy for diabetic wound healing.
It combines epigenetic editing with VEGF therapy to enhance revascularization and wound healing.
PCO results from a wound-healing response that elevates levels of TGFβ in the eye, leading to EMT.
However, disruption of the integrity of the eye during surgery and the associated healing process can lead to the regrowth of residual epithelial cells migrating to the posterior capsule instead of differentiation into normal fiber cells, resulting in PCO.
Researchers from the University of Pittsburgh have developed a novel device for coating medical conduits with solid state micro/nano particles.
Firstly, while initially occluding the aneurysm, the fatty amide-based polyurethane urea (PHEUU) elastomer used to fabricate the Mg-alloy coil not only protects the coil from corrosion but could also promote healing.
Additionally, metformin promotes angiogenesis which can reduce healing time and lead to enhanced tissue healing with high-quality tissue regeneration.
In vivo studies in mice with Achilles tendon injuries treated with intraperitoneal injections of metformin demonstrated that the treatment increased and activated AMPK while suppressing TGF-β1 levels within the healing tendon in acute injuries.
University of Pittsburgh researchers have discovered that metformin (Met), a commonly used medicine to treat type 2 diabetes, to promote soft tissue healing and prevent the development of fibrosis and resulting tendinopathy.
This innovative approach holds significant promise for diabetic wound healing and ischemic tissue regeneration.
• Diabetic Wound Healing: Promotes the formation of new blood vessels to improve tissue perfusion and accelerate healing.
• Diabetic Wound Healing: Promotes the formation of new blood vessels to improve tissue perfusion and accelerate healing.
Facial nerve defects can result from trauma, tumor ablation, and iatrogenic surgical injury.
This technology employs a hybrid process that combines additive manufacturing and electrospinning to fabricate biodegradable, porous fibrous scaffolds with built-in microchannels.
