Platform Technology

A Novel Platform for Enhanced Inner Ear Drug Delivery and Gene Therapy

07230

Exosome-based inner ear drug delivery platform enhances RWM traversal, enabling sustained, versatile loading of drugs and gene therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Otolaryngology
Therapeutic Indications: Hearing Loss
Tags: Platform Technology
Regenerative medicine
Lead Inventor: Adele Moatti
Department: Med-Otolaryngology
All Tech Innovators: Adele Moatti
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-06-23
Collections: Regenerative Medicine

The Goalistic™ Health Platform: Revolutionizing Healthcare by Centering Care Around Patient Goals

07013

AI-driven Goalistic Health Platform centers patient goals in care, aligning with guidelines to boost adherence and outcomes.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Tags: Platform Technology
Artificial intelligence (AI)
Software
Lead Inventor: Steven Reis
Department: Med-Medicine
All Tech Innovators: David R. Mathias
Kacy Qua
Steven E. Reis
Technology Readiness Level: 2. Initial proof-of-concept (PoC)
Date Submitted: 2024-12-20
Collections: Healthcare AI

Novel Animal Model for High-Throughput Screening of Anti-Aging and Metabolic Disease Drugs

07337

luciferase-based live model quantifies methionine flux, enabling semi-high-throughput anti-aging/drug discovery via MetR mimetics.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Other
Tags: Platform Technology
Aging
Drug Repurposing
Lead Inventor: Sudipta Pathak
Department: Med-Aging Institute
All Tech Innovators: Andrey Parkhitko
Sudipta Pathak
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-09-14
Collections: Cardiometabolic

Advanced Temporal Breast Tissue Dynamics for Precise Cancer Risk Prediction

07270

A dynamic breast density analysis using velocity and acceleration over time to improve personalized, early cancer risk prediction.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Tags: Platform Technology
Machine learning
Algorithm
Lead Inventor: Ju Hun Lee
Department: Med-Radiology
All Tech Innovators: Andriy Bandos
Ju Hun Lee
Robert Mark Nishikawa
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-07-30
Collections: Women's & Reproductive Health

Precision Synthetic Populations: A Scalable Framework for High-Resolution Demographic Modeling

07467

Graph-driven, privacy-preserving synthetic US population framework harmonizes Census data to block-group precision, enabling hyper-local planning.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Tags: Platform Technology
Aging
Lead Inventor: Natalie Sumetsky
Department: GSPH-Behavioral & Community Health Sciences
All Tech Innovators: Jeanine Marie Buchanich
Natalie Michaela Sumetsky
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2026-01-30

Intelligent Situational Awareness: A Semantically Aware Audio Agent for Personalized Noise Management

07361

Intelligent audio agent customizes real-time noise filtering, alerting only user-defined sounds while maintaining ANC.

Technology Type: Engineering Technology
Technology Subtype: Computing, AI & Quantum
Tags: Platform Technology
Artificial intelligence (AI)
Human performance
Lead Inventor: Longfei Shangguan
Department: SCI-Computer Science
All Tech Innovators: Zhiwei Ren
Longfei Shangguan
Yongjie Yang
Technology Readiness Level: 3. Prototype development
Date Submitted: 2025-10-05
Collections: Healthcare AI

Precision PET Image Enhancement

07314

Precision PET denoising software enhances early lesion visibility and diagnostic clarity without extra hardware, enabling retrospective and clinical use.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Neuroscience
Therapeutic Indications: Alzheimer's Disease
Tags: Platform Technology
Algorithm
Software
Lead Inventor: Vinicius Paranaiba Campos
Department: Med-Neurobiology
All Tech Innovators: Vinicius Paranaiba Paranaiba Campos
Afonso Costa E Silva
Diego Szczupak
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-08-28

pH-Sensitive Linkers for Advanced Biomedical Delivery

07192

Acid-cleavable beta-diketone/triketone linkers enable bioorthogonal delivery systems for mRNA, gene therapy, and targeted cancer therapeutics.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Immunology
Therapeutic Indications: Solid tumor
Tags: Platform Technology
Polymer
Lead Inventor: Song Li
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Yixian Huang
Song Li
Huatian Li
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2025-05-23

High-Performance Fiber Optic Carbon Dioxide Sensor for Elevated Temperature and Distributed Monitoring

07143

High-temperature fiber-optic CO2 sensor with Lewis acid-base polymer film enables 50–100°C detection, distributed sensing, and strong signal.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Tags: Platform Technology
Coating
Polymer
Lead Inventor: Paul Ohodnicki
Department: Mechanical Engineering and Materials Science
All Tech Innovators: Tulika Khanikar
Paul Richard Ohodnicki
Yang-Duan Su
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2025-04-08

Targeting Cardiomyocyte Endoreplication to Prevent Hypertrophic Cardiomyopathy

07132

Inhibits PCNA-POLD1 interactions via p21 to curb cardiomyocyte endoreplication, preventing hypertrophic cardiomyopathy progression.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Hypertrophic cardiomyopathy
Tags: Platform Technology
Genetics
Regenerative medicine
Lead Inventor: Jason Becker
Department: Med-Medicine
All Tech Innovators: Jason Robert Becker
Soumojit Pal
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-03-30
Collections: Cell & Gene Therapy
Regenerative Medicine
Cardiometabolic

A Novel Approach to Treating Autoimmune Diseases by Modulating Immune Cell Proliferation

07129

Inhibits PIKFYVE to boost Treg cells, lowering Th17-driven autoimmunity and restoring immune balance.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Immunology
Therapeutic Indications: Multiple Sclerosis (MS)
Autoimmune encephalitis (AIE)
Tags: Platform Technology
Autoimmune
Personalized Medicine
Lead Inventor: William Hawse
Department: Med-Immunology
All Tech Innovators: William F. Hawse
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-03-27

Novel Patient-Derived Assembloid Model Accelerates Immunotherapy Development for Difficult-to-Treat Cancers

06922

Patient-derived assembloid with tumor-immune co-cultures accelerates immunotherapy/vaccine development for hard-to-treat head and neck cancers.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Immunology
Oncology
Therapeutic Indications: Solid tumor
Tags: Platform Technology
Immuno-oncology
Tissue engineering
Lead Inventor: Riyue Bao
Department: Med-Medicine
All Tech Innovators: Riyue Bao
Jason J. Luke
Technology Readiness Level: 3. Prototype development
Date Submitted: 2024-10-16

Novel Mouse Model for Immune-Related Adverse Events

06884

Non-genetic mouse model mimics immunotherapy irAEs across gut, liver, skin via diet/microbiome changes; versatile, human-relevant, safe for KO systems.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Immunology
Therapeutic Indications: Inflammation - General
Tags: Platform Technology
Autoimmune
Immuno-oncology
Lead Inventor: Abigail Overacre
Department: Med-Immunology
All Tech Innovators: Greg M. Delgoffe
Abigail Elise Overacre
Dipyaman Patra
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2024-09-19

Automated OCT-Based Tissue Screening System

06669

Automated OCT tissue screening with deep learning for label-free, high-throughput, quantitative 3-D tissue analysis and drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Ophthalmology
Tags: Platform Technology
Microscopy
Machine learning
Lead Inventor: Shaohua Pi
Department: Med-Ophthalmology
All Tech Innovators: Yuanyuan Chen
Shaohua Pi
Jose Alain Sahel
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2024-03-06

Deep Learning System for Noise-Free Optical Coherence Tomography (OCT) Imaging without Clean Training Data

06607

Dual-scan, noise-free OCT denoising via Sub2Full: train on two noisy scans to reveal fine retinal structures without clean data.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Diabetic retinopathy
Tags: Platform Technology
Artificial intelligence (AI)
Microscopy
Lead Inventor: Shaohua Pi
Department: Med-Ophthalmology
All Tech Innovators: Shaohua Pi
Lingyun Wang
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2024-01-10
Collections: Healthcare AI

AI-Driven Bioreactor for Long-Term Ex Vivo Human Tissue Perfusion and Research

06260

AI-driven bioreactor extends ex vivo human tissue viability to weeks, enabling AI-monitored, high-fidelity drug testing and research.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Dermatology
Oncology
Tags: Platform Technology
Artificial intelligence (AI)
Biomaterial
Lead Inventor: Asim Ejaz
Department: Med-Plastic Surgery
All Tech Innovators: Jose Arellano
Asim Ejaz
Yusuf Surucu
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2023-01-08
Collections: Healthcare AI

Gene Therapy for Prader-Willi Syndrome

06241

A multi-gene Prader-Willi gene therapy using a minigene AAV vector to encode up to eight PWS genes for potential treatment.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - AAV
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Prader-Willi Syndrome
Tags: Platform Technology
Lead Inventor: Robert Nicholls
Department: Med-Pediatrics
All Tech Innovators: Robert David Nicholls
Date Submitted: 2022-12-06
Collections: Cell & Gene Therapy
Cardiometabolic

Novel Therapy to Prevent Transplanted Organ Rejection (DCreg)

05684

Regulatory dendritic cells from donor liver perfusate enable immunosuppression withdrawal, reducing organ rejection risk.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - NK Cell
Therapeutic Areas: Neuroscience
Tags: Platform Technology
Surgery
Life Science
Lead Inventor: Angus Thomson
Department: Med-Surgery
All Tech Innovators: Ester Badami
Pier Giulio Conaldi
Fadi G. Lakkis M.D.
Technology Readiness Level: 6. IND-enabling studies
Date Submitted: 2021-04-30
Collections: Cell & Gene Therapy

Microfluidic System Rapidly Isolates Extracellular Vesicles from Biological Fluids

05658

Automated microfluidic device rapidly, fractionally isolating all extracellular vesicle sizes and large cells from fluids in seconds.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Kambez Hajipouran Benam
Department: Med-Medicine
All Tech Innovators: Kambez Hajipouran Benam
Alexander Joseph Kaiser
Date Submitted: 2021-04-04

Enhanced Small Diameter Optical Fiber with Integrated Gratings

05612

Integrated gratings form in protected, tiny-diameter fiber via UV exposure; boosts speed, reliability, and sensing in DOFS.

Technology Type: Engineering Technology
Technology Subtype: Sensor
Tags: Platform Technology
Coating
Minimally invasive
Lead Inventor: Peng Chen
Department: Electrical and Computer Engineering
All Tech Innovators: Peng Kevin Chen
Ming-Jun Li
Jingyu Wu
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2021-02-09

Profilin1-actin Interaction Inhibitor as a Novel Anti-Angiogenic Compound

05290

Profilin1–actin interaction inhibitor blocks ccRCC angiogenesis, offering a resistance-evading, low-toxicity anti-angiogenic cancer therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Oncology
Ophthalmology
Therapeutic Indications: Diabetic retinopathy
Age-related macular degeneration
Tags: Platform Technology
Lead Inventor: Partha Roy
Department: Bioengineering
All Tech Innovators: Paul G. Francoeur
David Martin Gau
Abigail Gondringer
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-04-09

Lung-Targeting Peptide to Deliver Diagnostic and Therapeutic Targets to the Lung

05084

Lung-targeting cell-penetrating peptides enable higher-transduction delivery of diagnostics and therapies directly to lung tissue.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Therapeutic Indications: Chronic Obstructive Pulmonary Disease (COPD)
Asthma
Acute respiratory failure
Tags: Platform Technology
Lead Inventor: Maliha Zahid
All Tech Innovators: Maliha Zahid
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-08-07

Stimulation of Exosome Secretion

04959

A potent stimulator boosts exosome secretion up to 24-fold, enabling rapid, scalable exosome production for therapies and research.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Theresa Whiteside
Department: Med-Pathology
All Tech Innovators: Edwin Kerry Jackson
Nils Ludwig
Theresa L. Whiteside
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-05-19

Nanoparticle Dopants for Conducting Polymers

04941

Nanoparticle-doped PEDOT lowers impedance, boosts charge injection and drug loading for improved neural interfaces.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Neuroscience
Tags: Platform Technology
Biomaterial
Coating
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Xinyan Cui
Kevin M. Woeppel
Date Submitted: 2019-04-03
Collections: Regenerative Medicine
Cardiometabolic

Using Nanoparticles to Stabilize and Preserve the Bioactivity of Proteins and Peptides

04961

Silica nanoparticle textures stabilize surface-bound proteins, enabling dry storage, broader biosensor and implant applications.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Other
Tags: Platform Technology
Biomaterial
Coating
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Xinyan Cui
Kevin M. Woeppel
Date Submitted: 2019-04-17

Functional Poly(Hydrosiloxane)-Based Microbial Nanoculture Systems

04723

Functional PDMS-based microbial nanocultures enhance permeability and mechanical strength for safer, in-situ microbial studies.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Therapeutic Areas: Immunology
Tags: Platform Technology
Biomaterial
Lead Inventor: Tagbo Niepa
Department: Chem/Petroleum Engineering
All Tech Innovators: Shanna-Leigh Davidson
Tagbo Herman Roland Niepa
Date Submitted: 2018-08-29

Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells

04531

Magnetic delivery and hydrogel fixation of adipose-derived stem cells enable minimally invasive, localized AAA treatment and broader applications.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Biomaterial
Regenerative medicine
Lead Inventor: David Vorp
Department: Bioengineering
All Tech Innovators: Yogev Baruch
Kory James Blose
Timothy K. Chung
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2018-03-05
Collections: Regenerative Medicine

DataDigger: A Quick, Flexible Search Engine for Biomarker Data

04527

DataDigger: flexible, cloud-capable tool for multi-file biomarker data search and SNP-based patient subset querying.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Therapeutic Areas: Oncology
Other
Tags: Platform Technology
Lead Inventor: Yoram Vodovotz
Department: Med-Surgery
All Tech Innovators: Fayten Kathryn El-Dehaibi
Qi Mi
Yoram Vodovotz
Date Submitted: 2018-02-23

Humanized Animal Models for Advanced Antibody Production

04301

Humanized mice cultivate human immune responses to produce monoclonal antibodies, enabling safer, more efficacious human antibody therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Moses Bility
Department: GSPH-Infectious Diseases & Microbiology
All Tech Innovators: Moses Turkle Bility
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2017-06-21

Ultra-Stable Distributed Fiber Optic Sensor for High-Resolution, High-Temperature Monitoring

04137

Ultra-stable, high-temperature distributed fiber sensor with nanograting-enhanced Rayleigh scattering for 1 mm resolution.

Technology Type: Engineering Technology
Technology Subtype: Sensor
Tags: Platform Technology
Sustainability
Lead Inventor: Peng Chen
Department: Electrical and Computer Engineering
All Tech Innovators: Michael Paul Buric
Peng Kevin Chen
Rongzhang Chen
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2017-01-25

Optogenetic Induction of Neurodegenerative Disease Pathologies

04130

Blue-light induced fusion proteins trigger controllable TDP-43/alpha-synuclein/Tau aggregation, modeling neurodegeneration for high-throughput screening.

Technology Type: Life Science Research Tool
Technology Subtype: Nucleic Acid
Therapeutic Areas: Neuroscience
Therapeutic Indications: Amyotrophic lateral sclerosis (ALS)
Alzheimer's Disease
Tags: Platform Technology
Aging
Genetics
Lead Inventor: Christopher Donnelly
Department: Med-Neurobiology
All Tech Innovators: Christopher James Donnelly
Jacob R. Mann
Date Submitted: 2017-01-15

VitaCapsule: A Synthetic Hydrogel for Supporting Human Stem Cells

04045

VitaCapsule: a low-cost synthetic peptide-conjugated hydrogel boosting single-cell hPSC viability for scalable 2D/3D biomanufacturing.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Tags: Platform Technology
Biomaterial
Regenerative medicine
Lead Inventor: Thomas Richardson
Department: All Temps
All Tech Innovators: Ipsita Banerjee
Prashant N. Kumta
Thomas Charles Richardson
Date Submitted: 2016-10-12
Collections: Regenerative Medicine

Boryl Ethers as Oxidatively-Triggered Drug Delivery Vehicles

03939

Oxidative-stress-triggered α-boryl ether prodrugs release non-toxic ketone/aldehyde cargos selectively in diseased cells.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Paul Floreancig
Department: Chemistry
All Tech Innovators: Alexander Deiters
Paul Edward Floreancig
Ramsey D. Hanna
Date Submitted: 2016-05-13

Protection and Delivery of Multiple Therapeutic Proteins

03836

Coacervate delivery system extends protein half-lives to weeks using platelet-rich plasma, enhancing wound healing and tissue repair.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Daniel Long
Department: Bioengineering
All Tech Innovators: Eric M. Jeffries
Noah R. Johnson
Daniel Ward Long
Date Submitted: 2016-02-25
Collections: Regenerative Medicine

Thermoresponsive Hydrogel Containing Polymer Microparticles for Controlled Drug Delivery to the Ear

03810

Single-dose, thermoresponsive ear gel with PLGA microspheres for 14-day ciprofloxacin release and lidocaine.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Otolaryngology
Tags: Platform Technology
Polymer
Lead Inventor: Morgan Dileo
Department: Med-Ophthalmology
All Tech Innovators: Liza Anna Bruk
Morgan Virginia Dileo
Steven R. Little
Date Submitted: 2016-01-26

Layer Up: Drug-Eluting Coating for Implantable Devices and Biomaterials

03741

Layer Up coats implants with anti-inflammatory drug release to reduce rejection and improve long-term integration across biomaterials.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Platform Technology
Biomaterial
Coating
Lead Inventor: Daniel Hachim
Department: Bioengineering Department
All Tech Innovators: Bryan Nicklaus Brown
Daniel Hachim
Date Submitted: 2015-10-05

Biodegradable Poly(Ester Amide) Elastomers

03590

Biodegradable poly(ester amide) elastomers: solvent-free, tunable, biocompatible scaffolds for soft tissue engineering and drug delivery.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Tags: Platform Technology
Polymer
Lead Inventor: Shilpa Sant
Department: Department of Pharmaceutical Sciences
All Tech Innovators: Shilpa Sant
Vinayak Sant
Date Submitted: 2015-04-20
Collections: Regenerative Medicine

Light-Activated CRISPR/Cas9: Precise Control over Gene Editing

03547

Light-activated CRISPR/Cas9 enables spatially, temporally precise gene editing, reducing off-target effects with light control.

Technology Type: Life Science Research Tool
Technology Subtype: Nucleic Acid
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Alexander Deiters
Department: Distinguished Faculty-Dietrich School of Arts and Sciences
All Tech Innovators: Aravind Asokan
Erin Borchardt
Alexander Deiters
Date Submitted: 2015-03-11

Synthetic Enveloped Virus as a Systemically Deliverable Therapy

03499

Biomimetic synthetic enveloped virus delivers targeted, systemic viral therapies with pH-triggered release and enhanced persistence.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Stephen Thorne
Department: Med-Cell Biology
All Tech Innovators: Song Li
Stephen Howard Thorne
Date Submitted: 2015-01-26

Colorimetric Chemodosimeter for Palladium

03416

A low-cost, on-site colorimetric palladium detector with autonomous halting/restart, rivaling ICP methods in sensitivity.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Tags: Platform Technology
Material Science
Lead Inventor: Kazunori Koide
Department: Chemistry
All Tech Innovators: Xiaodong Bu
Junyong Jo
Kazunori Koide
Date Submitted: 2014-10-04

Self-Assembled Coatings for Magnesium Implants

03377

Self-assembled anticorrosive organosilane coatings slow magnesium implant degradation, enabling drug delivery and improved biocompatibility.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Other
Tags: Platform Technology
Biomaterial
Coating
Lead Inventor: Elia Beniash
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Elia Beniash
Date Submitted: 2014-08-11
Collections: Regenerative Medicine

Controlled Release Microparticle Platform for Localized Prevention of Tissue Calcification and Ossification

03248

PLGA microparticles deliver BMP receptor inhibitor locally to prevent tissue calcification with sustained, customizable release.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Musculoskeletal
Tags: Platform Technology
Regenerative medicine
Sports medicine
Lead Inventor: Riccardo Gottardi
All Tech Innovators: Peter Alexander
Patrick A. Bianconi
Riccardo Luca Gottardi
Date Submitted: 2014-02-17
Collections: Regenerative Medicine

Temperature-Assisted On-Column Focusing in Liquid Chromatography

03289

Temperature-Assisted On-Column Focusing enhances small-column LC by cooling sections to concentrate samples, improving efficiency and reducing waste.

Technology Type: Engineering Technology
Technology Subtype: Chemical
Tags: Platform Technology
Coating
Material Science
Lead Inventor: Stephen Weber
Department: Chemistry
All Tech Innovators: Stephen Robert Groskreutz
Stephen G. Weber
Technology Readiness Level: 3. Prototype development
Date Submitted: 2014-04-03

A Novel Peptide Mediated Intravesical Drug Delivery

03150

Peptide-mediated intravesical delivery uses a protamine carrier to deliver therapeutic oligonucleotides directly into the bladder.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Tags: Platform Technology
Lead Inventor: Pradeep Tyagi
Department: Med-Urology
All Tech Innovators: Mahendra Pratap Kashyap
Pradeep Tyagi
Naoki Yoshimura M.D., Ph.D.
Date Submitted: 2013-10-18

Corrosion-Resistant, Bioactive Coatings for Magnesium -Based Medical Devices

03014

Bioactive PEM coatings yield corrosion resistance, improved biocompatibility, and controlled biomolecule delivery for magnesium-based implants.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Dental
Musculoskeletal
Tags: Platform Technology
Biomaterial
Coating
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Sangeetha Kunjukunju
Boeun Lee
Date Submitted: 2013-04-01

Advanced Electrospinning for Regenerative Biomaterials

02919

New PGS electrospun fibers blended with carriers yield suturable, strong, tunable, ECM-mimicking vascular grafts and nerve guides.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Tags: Platform Technology
Biomaterial
Regenerative medicine
Lead Inventor: Eric Jeffries
Department: Bioengineering
All Tech Innovators: Eric M. Jeffries
Yadong Wang
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2012-10-23
Collections: Regenerative Medicine

A Mechanistic Approach for the Development and Use of Surfactants Containing Drug-Interactive Domains

02645

Tailored surfactants with drug-interactive interfaces enable stable, efficient delivery of moderately hydrophobic drugs.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Oncology
Tags: Platform Technology
Coating
Lead Inventor: Xiang Gao
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Michael W. Epperly Ph.D.
Xiang Gao
Joel S. Greenberger M.D.
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2011-12-06

Evidence-Based Driving Assessment: A System for Objective Evaluation and Training

02557

A sensor-driven, objective on-road driving assessment translating evaluator interventions into quantifiable data for licensing and training.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Tags: Platform Technology
Human performance
Algorithm
Lead Inventor: Nahom Beyene
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Nahom Minassie Beyene
Rory A. Cooper Ph.D.
Amy Karas Lane
Date Submitted: 2011-09-06

Electroosmotic Convection-Enhanced Delivery System

02482

Electroosmosis-driven, programmable drug delivery via porous tissue with directed, backflow-free transport, enabling precise tumor targeting.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Therapeutic Areas: Oncology
Tags: Platform Technology
Material Science
Lead Inventor: Stephen Weber
Department: Chemistry
All Tech Innovators: Amir H. Faraji
Yifat Guy
Stephen G. Weber
Date Submitted: 2011-05-13

Next-Generation Viral Entry Inhibitors: Synthetic ApoE Polypeptides for the Treatment and Prevention of Hepatitis C

02380

Synthetic ApoE peptides block HCV entry/replication, offering resistance-reducing antiviral therapy with dual action and delivery potential.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Infectious Disease
Therapeutic Indications: Hepatitis B
Tags: Platform Technology
Lead Inventor: Tianyi Wang
Department: GSPH-Infectious Diseases & Microbiology
All Tech Innovators: Daping Fan M.D., Ph.D.
Shufeng Liu Ph.D.
Tianyi Wang Ph.D.
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2011-01-11