Technology Subtype

Cell Line

46 results

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Proprietary AML Cell Lines: Best-in-Class Models for High-Throughput Drug Screening and Target Validation

07140

Engineered AML cell lines with constitutive Fgr/Hck activation enable ultra-sensitive HTS, target validation, and combination therapy testing.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Leukemia
Tags: Genetics
Drug Repurposing
Synthetic Biology
Lead Inventor: Thomas Smithgall
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Thomas E. Smithgall
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2025-04-04

Integrated 3D Brain Organoids for Modeling the Blood-Brain Barrier and Neurological Disease Mechanisms

06972

Integrated 3D brain organoids recreate the blood-brain barrier for long-term neurodegenerative/viral research and safer drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Alzheimer's Disease
Lead Inventor: Velpandi Ayyavoo
Department: GSPH-Infectious Diseases & Microbiology
All Tech Innovators: Velpandi Ayyavoo
Roberta Souza Dos Reis
Sathish Selvam
Date Submitted: 2024-11-12

Development of WCRC-25, an Invasive Lobular Carcinoma Cell Line

06163

A new ER-negative invasive lobular carcinoma cell line with CDH1, FOXA1, CTCF, BRCA2, TP53 mutations for drug testing and precision oncology.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Steffi Oesterreich
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Adrian Vincent Lee
Steffi Oesterreich
Date Submitted: 2022-09-14
Collections: Women's & Reproductive Health

Novel Patient-Derived Assembloid Model Accelerates Immunotherapy Development for Difficult-to-Treat Cancers

06922

Patient-derived assembloid with tumor-immune co-cultures accelerates immunotherapy/vaccine development for hard-to-treat head and neck cancers.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Immunology
Oncology
Therapeutic Indications: Solid tumor
Tags: Immuno-oncology
Tissue engineering
Platform Technology
Lead Inventor: Riyue Bao
Department: Med-Medicine
All Tech Innovators: Riyue Bao
Jason J. Luke
Technology Readiness Level: 3. Prototype development
Date Submitted: 2024-10-16

Madin Darby Canine Kidney (MDCK) Cells Expressing the Epithelial Na+ Channel (ENaC)

01434

MDCK cells engineered with mouse ENaC subunits enable study of channel biosynthesis, trafficking, and inhibitor screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Nephrology
Lead Inventor: Thomas Kleyman
Department: Med-Medicine
All Tech Innovators: James B. Bruns
Rebecca P. Hughey Ph.D.
Thomas Ralph Kleyman
Date Submitted: 2007-02-03

Novel Research Model for Liver Dysfunction

06810

Researchers create TM6SF2-167K iPSC-derived liver cells to model MASLD, enabling target discovery and therapy screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Hepatology
Therapeutic Indications: Cirrhosis
Tags: Drug Discovery - Target
Life Science
Lead Inventor: Alejandro Soto Gutierrez
Department: Med-Pathology
All Tech Innovators: Lanuza Alaby Pinheiro Alaby Pinheiro Faccioli
Rodrigo Machado Florentino
Alejandro Soto Gutierrez
Date Submitted: 2024-07-17
Collections: Cardiometabolic

Novel Immortal Antibody Secreting Cell Lines

06101

Immortal antibody-secreting ovarian cancer plasma cell lines enable target discovery, biomarker development, and potential immunotherapy.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ovarian cancer
Lead Inventor: Anda Vlad
Department: Med-OB-Gyn & Reproductive Science
All Tech Innovators: Robert Page Edwards
Anda Mioara Vlad
Lixin Zhang
Date Submitted: 2022-07-13
Collections: Women's & Reproductive Health

Models of DNA Mismatch Repair Deficiency (Including Panc02 and 4T1)

05503

CRISPR MLH1 knockout creates MSI murine cancer models to study immunogenicity, apoptosis, and immunotherapy in vivo.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Lead Inventor: Lin Zhang
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2020-09-11

Superecliptic pHluorin (SEP)-PTH Receptor (SEP-PTHR) Stable Cells

04806

SEP-PTHR stable cells enable real-time, pH-controlled visualization of PTH receptor trafficking, internalization, and recycling.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Peter Friedman
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Peter Andrew Friedman
Date Submitted: 2018-11-09

Anti-HLA-A mAbs LGIII-147.4.1 and Hybridoma Cell Line

01827

Monoclonal antibody LGIII-147.4.1 targets HLA-A2, enabling selective immune recognition for research tools and MHC studies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Immunology
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-04

Methods and Reagents of Conversion of Bacterial Strain into Gateway Compatible

00996

Converts any bacterial strain to Gateway compatibility, enabling tailored genotypes, resistance, stability, and transformation traits.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Darren Wolfe
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Joseph C. Glorioso III
Darren Paul Wolfe
Date Submitted: 2004-10-13

Novel Pipette Tip Design Encapsulates Cells to Co-Culture 96 or 384

04138

BioActivator: encapsulated hepatocytes on pipette tips enable on-demand bioactivation for HTS/co-culture in 96–1536-well plates.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Other
Lead Inventor: Lawrence Vernetti
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Lawrence A. Vernetti
Date Submitted: 2017-01-27

Lab-on-Chip Manipulating and Detecting Nanometer Scale Particles Using 3D Integrated Circuits

01477

3D integrated circuits enable precise dielectrophoretic manipulation and rapid detection of nanometer-scale particles and viruses.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Donald Chiarulli
Department: Electrical and Computer Engineering
All Tech Innovators: Donald M. Chiarulli
Samuel J. Dickerson
Steven P. Levitan
Date Submitted: 2007-04-12

Caspase-3 Knockout Colon Cancer Cells

03687

Caspase-3 knockout HCT116 cells via AAV targeting offer a unique, reliable cancer apoptosis model for drug screening and research.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Lead Inventor: Jian Yu
Department: Med-Pathology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2015-07-30

Tumor Cell–Derived Endothelial Cell Platform for Modeling and Targeting Tumor Angiogenesis

02265

Tumor-derived endothelial cells enable stable tumor angiogenesis modeling and targeted anti-angiogenic therapy screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Lead Inventor: Edward Prochownik
Department: Med-Pediatrics
All Tech Innovators: Edward V. Prochownik MD, PhD
Date Submitted: 2010-07-13

PUMA Gene and p53 Binding Site Knockout Cell Lines for Cancer Research

02384

PUMA p53 site knockout cell lines enable focused study of PUMA-mediated apoptosis in cancer research, via AAV-targeted deletions.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Tags: Immuno-oncology
Drug Discovery - Target
Lead Inventor: Lin Zhang
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Jian Yu
Lin Zhang
Technology Readiness Level: 3. Prototype development
Date Submitted: 2011-01-14

Anti-Beta 2-Microglobulin (beta 2-mu) MoAb NAMB-1 and Hybridoma Cell Line

01818

Monoclonal antibody NAMB-1 targets beta-2 microglobulin in HLA Class I molecules, enabling immune interaction studies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-03

Positive Albumin: Enhancing Recombinant Protein Secretion and Purification in Mammalian Cell Lines

04342

Engineered positively charged mutant albumin enhances secretion and enables cation-exchange purification of recombinant proteins.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Troy Krzysiak
Department: Med-Structural Biology
All Tech Innovators: Angela M. Gronenborn
Troy C. Krzysiak
Technology Readiness Level: 3. Prototype development
Date Submitted: 2017-08-04

A Pain-enabled in vitro System for Studying Pain Mechanisms and Developing Treatments

05994

Pain-enabled human joint chip models OA pain using innervated synovium for mechanism study and drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Osteoarthritis
Pain
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Michael S. Gold
Hang Lin
Rocky Sung Chi Tuan
Date Submitted: 2022-03-28

Genetically Engineered MCF-7 Cells for pin1-driven Breast Cancer Cell Cycle Research

05275

Engineered MCF-7 cells overexpress Pin1 to study breast cancer cell cycle regulation and screen targeted therapies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Shivendra Singh
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Shivendra V. Singh
Date Submitted: 2020-03-11
Collections: Women's & Reproductive Health

FADD Knockout Colon Cancer Cells

03688

AAV-targeted FADD knockout colon cancer cells provide a precise, apoptosis-resistant model for cancer research and drug testing.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Lead Inventor: Jian Yu
Department: Med-Pathology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2015-07-30

PCI-13 Human Oral Squamous Cell Carcinoma Cell Line

05480

A reproducible human oral squamous cell carcinoma cell line for drug screening, cancer biology, biomarkers, and personalized therapies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Theresa Whiteside
Department: Med-Pathology
All Tech Innovators: Theresa L. Whiteside
Date Submitted: 2020-08-14

MLKL KO Cell Lines

06488

MLKL knockout HT29 and L929 cell lines enable precise necroptosis research, drug screening, and preclinical testing.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Yi-Nan Gong
Department: Med-Immunology
All Tech Innovators: Yi-Nan Gong
Date Submitted: 2023-08-22

Anti-ICAM-1 mAb VF27-516 and Hybridoma Cell Line

01829

Monoclonal antibody VF27-516 targets ICAM-1, aiding leukocyte-endothelial interactions research; potential Rhinovirus binding blocker.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-15

Anti-HLA-DR, -DQ and -DP Beta Chains mAb LGII-612.14 and Hybridoma Cell Line

01817

Monoclonal antibody LGII-612.14 targets HLA-DR, -DQ, -DP beta chains; useful research tool for MHC class II studies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-03

Modular, Micro-fluiidic Bioreactor for 3D Multi-tissue Cultures

03088

Modular microfluidic bioreactor enables 3D multi-tissue cultures with precise fluid control, mechanics, and high-throughput drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Rocky Tuan
Department: Med-Orthopedic Surgery
All Tech Innovators: Peter Alexander
Riccardo Luca Gottardi
Hang Lin
Date Submitted: 2013-07-05

Anti-alpha(v) mAb TP36.1 and Hybridoma Cell Line

01822

Anti-alpha(v) antibody TP36.1 targets human Integrin alpha-5 (αV/CD49e), enabling research tools and hybridoma cell line development.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-03

Flag-p73 Knockin Colon Cancer Cells

03689

Triple-Flag tagged HCT116 cells enable specific TAp73 detection, aiding DNA damage, drug response, and cancer biology research.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Lead Inventor: Jian Yu
Department: Med-Pathology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2015-07-30

Human Colorectal Cancer Stem Cell Line: A Novel Platform for Therapeutics and Research

02640

Novel human colon cancer stem cell lines (Tu-12/21/22) enable in vitro/in vivo drug screening and tumor modeling for therapeutics.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Tags: Immuno-oncology
Drug Development
Immunology
Lead Inventor: Eric Lagasse
Department: Med-Pathology
All Tech Innovators: Eric Lagasse
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2011-12-02

Enhanced Immunogenic Murine Tumor Cell Lines

05240

Engineered murine tumor lines express active IL-33, boosting CD8+ T/NK activation to halt tumor growth and study immunotherapy.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Tags: Genetics
Immuno-oncology
Lead Inventor: Binfeng Lu
Department: Med-Immunology
All Tech Innovators: Xin Gao
Gang Li
Binfeng Lu
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2020-02-06

Beclin-1 Knockin Colon Cancer Cells

03685

Beclin-1 knockin HCT116 cells reveal autophagy-apoptosis balance, caspase-8 cleavage resistance, aiding cancer drug resistance research.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Lead Inventor: Jian Yu
Department: Med-Pathology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2015-07-30

Bioreactor for Physiologic Loading of Epithelialized Hollow Organs

02411

A bioreactor cyclically distends epithelialized hollow organs, delivering luminal pressure and controlled flow to support multi-tissue growth.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Tags: Tissue engineering
Lead Inventor: Thomas Gilbert
Department: Bioengineering
All Tech Innovators: Thomas W. Gilbert
Mark Juhas
Nathaniel Thomas Remlinger
Date Submitted: 2011-02-21

Anti-Alpha(v) Beta 3 mAb VF27-312 and Hybridoma Cell Line

01824

Monoclonal antibody VF27-312 targets human integrin αVβ3, implicated in tumor angiogenesis; offered as a research tool with hybridoma line.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-04

Immortalized Breast Cancer Stem Cell Lines for Continuous Self-renewal and Targeted Drug Screening

01687

Reproducible, GFP-labeled breast cancer stem cells maintained by promoter-driven self-renewal enable scalable, targeted drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Edward Prochownik
Department: Med-Pediatrics
All Tech Innovators: Edward V. Prochownik MD, PhD
Date Submitted: 2008-04-04
Collections: Women's & Reproductive Health

Anti-Alpha(v) Beta 3 mAb Play a Role in Tumor-Induced Angiogenesis

01823

Anti-αvβ3 antibody therapy impacts tumor-driven angiogenesis by blocking integrin-mediated blood vessel formation.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-03

Bid Knockout Colon Cancer Cells

03686

Complete BID-null colon cancer cell models (with FADD loss) for studying apoptosis, drug resistance, and anticancer efficacy.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Lead Inventor: Jian Yu
Department: Med-Pathology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2015-07-30

Putative Cancer Stem Cells (CSCs) from Mouse Mammary Tumor

02465

Isolation of putative mouse mammary cancer stem cells via retinol signaling to reveal stemness; potential for translational oncology research.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Tags: Women's Health
Lead Inventor: Jaspal Khillan
Department: Med-Immunology
All Tech Innovators: Jaspal S. Khillan
Qingde Wang
Date Submitted: 2011-04-19
Collections: Women's & Reproductive Health

Low Passage Mesenchymal Stem Cell Cell Bank from Cadaveric Vertebral Bodies

02247

Cadaver vertebra-derived MSC bank enables rapid, large-scale expansion in bioreactors, reducing chromosomal risks and passage.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Immunology
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Albert Donnenberg
Department: Med-Medicine
All Tech Innovators: Albert D. Donnenberg
Ludovic Zimmerlin
Date Submitted: 2010-06-09

Monoclonal Antibody Technology for Sensitive ICAM-1 Detection Preserving Cell Adhesion

01825

Non-disruptive ICAM-1 monoclonal antibody detects lesions with preserved adhesion, boosting immunohistochemistry, western blotting, and imaging.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-04

Genetically Defined Murine Ovarian Cancer Cell Lines for Advanced Research

03711

Mouse ovarian cancer cell lines with defined Kras/Pten mutations and human MUC1, enabling targeted immunotherapy and in vivo modeling.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ovarian cancer
Lead Inventor: Anda Vlad
Department: Med-OB-Gyn & Reproductive Science
All Tech Innovators: Anda Mioara Vlad
Lixin Zhang
Date Submitted: 2015-09-01
Collections: Women's & Reproductive Health

SOP for Collection and Establishment of Tissue from the Head and Neck Region In Vitro and In Vivo

02623

A standardized method to harvest, culture, and propagate head and neck tissue in vitro and in vivo for research.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Otolaryngology
Lead Inventor: Sufi Thomas
Department: Med-Otolaryngology
All Tech Innovators: Jennifer Rubin Grandis M.D.
Sufi Mary Thomas
Sarah Elizabeth Wheeler
Date Submitted: 2011-11-17

Anti-alpha(v) mAb VF33-ST100 and Hybridoma Cell Line

01821

Anti-αV (CD49e) targeting mAb VF33-ST100 for Integrin αV-5; supports research tool use with hybridoma line.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-03

Differentiation of Pluripotent Stem Cells Into 3D Lung Tissue

03682

3D lung tissue from pluripotent stem cells enables multi-lineage, self-organizing lung models for realistic development, disease, and toxicology studies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Respiratory
Lead Inventor: Diane Carlisle
Department: Med-Neurological Surgery
All Tech Innovators: Diane L. Carlisle
Date Submitted: 2015-07-30

Engineered Cell Line Platform for Studying Herpes Simplex Virus Immediate-Early Protein Functions

04312

Engineered FO6 cell line enables controlled HSV protein expression for reproducible viral gene regulation studies and drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Lead Inventor: Neal DeLuca
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Neal DeLuca
Date Submitted: 2017-07-11

Anti-HLA-A2,B17 MAb HO-2 and Hybridoma Cell Line

01820

HO-2 monoclonal antibody targets human HLA-A2 and B17; useful as a research tool for MHC class I studies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-03

Monoclonal Antibody and Hybridoma Platform for Sensitive HLA-B27 and Alloantigen Detection

01828

Highly specific monoclonal antibody detects HLA-B27 and related alloantigens with ultra-sensitive, versatile double-determinant immunoassay.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Soldano Ferrone
Department: Department of Surgery
All Tech Innovators: Soldano Ferrone
Date Submitted: 2008-09-04