Related Technologies - University of Pittsburgh

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Small Molecule Inhibitor Therapy to Prevent Aneurysm Formation, Growth, and Rupture

05390

New research shows that small molecule inhibitors targeting the platelet-driven CXCL7-CXCR1/2 inflammatory pathway can be used to prevent cerebral aneurysm formation and rupture.

· Preventing the formation, growth, and rupture of cerebral aneurysms.

In vivo data, including cytokine arrays and ELISA data from a hypertensive mouse model of intracranial aneurysm formation; electron microscopy of aneurysm samples, cytokine arrays of aneurysm samples, and blood samples from human patients with aneurysms, and in silico computational data for pathway discovery from the above cytokine arrays.

Therapeutic Modality

Small Molecule

Cardiovascular Neuroscience

Small molecule

Robert Friedlander

Med-Neurological Surgery

2020-05-30

Delivery of Antagonists and Agonists for Immune Modulation

06543

University of Pittsburgh researchers have developed a novel delivery formulation for small molecules to manipulate the adenosine triphosphate (ATP)/Adenosine (Ado) signaling axis.

Controlled release of these small molecules could reduce the need for repetitive administration of medication, reduce inflammation, and enhance patient quality of life.

Using microparticle-based controlled release systems, an antagonist for an ATP receptor and/or agonists for Ado receptors can be delivered over a period of days to weeks, leading to reduced inflammation.

Therapeutic Modality

Drug Delivery / Formulation

Immunology

Elizabeth Bentley

Bioengineering

2023-10-17

Zwitterionic Polysiloxane-Urethane Urea Copolymers for Preventing Protein and Platelet Adhesion

04958

It can be synthesized via hydrosilylation of vinyl-terminated poly(dialkylsiloxane) with a diallyl sulfobetaine macromer using platinum or ruthenium catalysts, or by copolymerizing a PDMS diol, a diisocyanate, a tertiary amine alkyl diol, and a PDMS diamine followed by post-functionalization with cyclic sulfonates.

The technology employs polysiloxane elastomers and poly(urethane urea) copolymers functionalized with sulfobetaine (zwitterionic) side chains to resist nonspecific protein and platelet adhesion.

The dual synthetic routes enable tailoring of polymer composition and processing options, while the poly(urethane urea) segments impart additional strength and versatility, making this platform uniquely suited for next-generation blood-compatible medical devices.

Engineering Technology

Material Science

Sang Ho Ye

Bioengineering

2019-04-15

Cyclic Adenosine Monophosphates for Reducing the Formation of Adhesions