Cyclic Adenosine Monophosphates for Reducing the Formation of Adhesions

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Small Molecule Inhibitor Therapy to Prevent Aneurysm Formation, Growth, and Rupture
05390
New research shows that small molecule inhibitors targeting the platelet-driven CXCL7-CXCR1/2 inflammatory pathway can be used to prevent cerebral aneurysm formation and rupture.
· Preventing the formation, growth, and rupture of cerebral aneurysms.
In vivo data, including cytokine arrays and ELISA data from a hypertensive mouse model of intracranial aneurysm formation; electron microscopy of aneurysm samples, cytokine arrays of aneurysm samples, and blood samples from human patients with aneurysms, and in silico computational data for pathway discovery from the above cytokine arrays.
Therapeutic Modality
Small Molecule
CardiovascularNeuroscience
Small molecule
Robert Friedlander
Med-Neurological Surgery
2020-05-30
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        Tissue engineering
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        Regenerative medicine
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    • Lead Inventor
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        Robert Friedlander
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        Kamil W. Nowicki
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        Michael P. D'Angelo
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        Robert Max Friedlander
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        Wendy Fellows Mayle
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