Intracranial or Intrathecal Device for the Targeted Removal of Cell-Free Hemoglobin from Cerebrospinal Fluid, Lymph, and/or Brain Parenchyma
Search text
About 24 results
(0.12 seconds)
Managing intracranial physiology is essential to achieving positive outcomes for patients with severe traumatic brain injury (TBI), intracranial hemorrhage (ICH), and acute hydrocephalus (AH). Knowledge of intracranial compliance, coupled with measurement of intracranial pressure (ICP), would greatly enhance physiologic monitoring, inform clinicians understanding of patient condition, and identify patients at risk for intracranial hypertension. The new ICP-PCI algorithm combines intracranial pressure (ICP) measurements with End tidal CO2 (EtCO2) information to compute intracranial compliance in real-time to help clinician decision-making when handling traumatic brain injuries and other acute neurointensive emergencies.
University of Pittsburgh researchers have developed innovative nitrosyl-heme formulations that combine nitric oxide (NO)-heme complexes with albumin and a thiol (e. The nitrosyl-heme formulations developed by the researchers involve the combination of NO-heme complexes with albumin and thiols. The formulations also have the potential to neutralize free heme associated with hemolysis and stabilize free-heme proteins.
The algorithm uses patient-specific data, including predicted body weight and fluid infusion rate, to optimize the fluid removal process. This invention is a decision-support tool designed to aid critical care practitioners in setting the rate of net fluid removal during continuous kidney replacement therapy. By providing a systematic approach, this tool could reduce complications like hypotension, cardiac arrhythmias, and fluid overload, ultimately improving patient survival.
- 12Medical Device
- 9Therapeutic Modality
- 2Engineering Technology
- 1Life Science Research Tool
- Add ...
- 5Surgical Medical Device
- 4Implantable Medical Device
- 3Small Molecule
- 2Material Science
- 1Antibody - scFV
- Add ...
- 10Neuroscience
- 9Cardiovascular
- 3Oncology
- 2Hematology
- 2Surgery
- Add ...
- 3Other
- 2Epilepsy
- 2Myocardial infarction
- 1Acute coronary syndrome
- 1Atherosclerotic disease
- Add ...
- 2Biomaterial
- 2Brain-computer interface
- 2Minimally invasive
- 2Pediatrics
- 2Platform Technology
- Add ...
- 2Travis Jackson
- 2Young Chun
- 1Alan Boruch
- 1Alexander Star
- 1Anthony DeMartino
- Add ...
- 3Bioengineering
- 2Chemistry
- 2Industrial Engineering
- 2Med-Critical Care Medicine
- 2Med-Neurological Surgery
- Add ...
- 2Jason J. Rose
- 2Jesus Tejero Bravo
- 2Mark Thomas Gladwin
- 2Patrick M. Kochanek M.D.
- 2Ryan A. Orizondo
- Add ...