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Platelet-rich plasma (PRP) is an emerging biological tool for musculoskeletal tissue healing. The abundance of autologous growth factors in PRP and ease with which it can be obtained gives it a significant advantage over other potential therapies. - Critical-sized calvarial defect. Treatment of CSBD remains a clinical challenge and there is a great need to develop safe and effective treatments to encourage bone regeneration to heal these factures. In vitro experiments confirmed the mesh could promote osteogenic differentiation of bone marrow stem cells. This dual approach of promoting tissue regeneration while mitigating infection risks offers a significant advancement over traditional repair methods, paving the way for more effective treatment options in avian skeletal medicine. - Enhances regeneration by combining avian mesenchymal stem cells with advanced biomaterials for bone and cartilage formation. - Enables precise, customizable skeletal tissue repair through photopolymerizable hydrogel scaffolds and in situ crosslinking. 
