Novel FOXM1 Inhibitors to Assist Cancer Treatment
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What differentiates this technology is its specialized focus on Pin1 overexpression, making it a unique tool for understanding cell cycle regulation in cancer biology. The technology involves a genetically engineered MCF-7 breast cancer cell line that has been modified to overexpress the Pin1 protein, a key peptidyl-prolyl cis/trans isomerase important for cell cycle regulation. This cell model facilitates detailed investigations into the cellular mechanisms governing breast cancer progression and provides a platform for screening compounds that might affect cell cycle dynamics.
A novel cell line has been developed by using AAV gene targeting to effectively delete a segment of the FADD genomic locus in HCT116 colon cancer cells obtained from ATCC. Its unparalleled capability to completely disrupt FADD function provides an innovative platform to explore therapeutic resistance in cancer treatments, making it a valuable resource for both basic research and drug development applications. Its unparalleled capability to completely disrupt FADD function provides an innovative platform to explore therapeutic resistance in cancer treatments, making it a valuable resource for both basic research and drug development applications.
Applications. - Cancer drug screening platform. - Therapeutic resistance testing model.
- Facilitates in-depth investigations into BID and FADD mediated processes in colon cancer cells. This technology involves a series of modified HCT116 colon cancer cell lines in which the BID gene has been completely deleted from both chromosomes using AAV gene targeting. Two extensively characterized clones display these unique features, making them an exceptional model for studying apoptosis pathways and the interplay between intrinsic and extrinsic cell death mechanisms in cancer research.
- 16Therapeutic Modality
- 6Life Science Research Tool
- 2Diagnostic/Assay
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- 14Small Molecule
- 3Cell Line
- 2Biomarker
- 1Drug Discovery - Target
- 1Gene Therapy - CRISPR
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- 18Oncology
- 4Immunology
- 2Infectious Disease
- 2Neuroscience
- 1Nephrology
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- 4Breast cancer
- 3Colorectal cancer
- 2Inflammation - General
- 2Rheumatoid arthritis
- 1Chrohn's Disease
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- 3Autoimmune
- 2Immuno-oncology
- 2Small molecule
- 1Aging
- 1Computational biology
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- 3Jian Yu
- 2Beibei Chen
- 2Kazunori Koide
- 2Xiaosong Wang
- 1Abdelhadi Rebbaa
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- 9Med-Pathology
- 4Med-Medicine
- 3Pharm-Pharmaceutical Science
- 2Chemistry
- 2Med-Pharmacology and Chemical Biology
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- 4Beibei Chen
- 4Jian Yu
- 4Lin Zhang
- 2Kazunori Koide
- 2Rama K. Mallampalli
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