p97 ATPase Inhibitors for Cancer and Neurodegneration

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NAMPT Inhibitors Exhibit Excellent Potency and ADME Properties
05522
University of Pittsburgh researchers have synthesized and tested a novel class of Nampt inhibitors in a current study, which shows that they have exhibited excellent potency and ADME properties.
· Nampt inhibitors show excellent ADME properties.
Therapeutic Modality
Small Molecule
ImmunologyOncology
AutoimmuneImmuno-oncologySmall molecule
Beibei Chen
Med-Medicine
2020-10-06
Novel Compounds to Inhibit TNF-Induced NF-κB Pathways
04864
Using a novel systems biology approach combining transcriptomics and structural analysis with live-cell imaging, two first-in-class protein-protein inhibitors (PPIs) have been identified and shown to selectively inhibit TNF-induced NF-κB inflammatory pathways.
Therapeutic Modality
Small Molecule
Immunology
Autoimmune
Carlos Camacho
Med-Computational and Systems Biology
2019-01-22
    • Technology Type
      • 2
        Therapeutic Modality
      • Add ...
    • Technology Subtype
      • 2
        Small Molecule
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    • Therapeutic Areas
      • 2
        Immunology
      • 1
        Oncology
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    • Therapeutic Indications
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    • Tags
      • 4
        Small molecule
      • 3
        Immuno-oncology
      • 3
        Aging
      • 2
        Autoimmune
      • 1
        Computational biology
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    • Lead Inventor
      • 1
        Beibei Chen
      • 1
        Carlos Camacho
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    • Department
      • 1
        Med-Computational and Systems Biology
      • 1
        Med-Medicine
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    • All Tech Innovators
      • 1
        Beibei Chen
      • 1
        Carlos Jaime Camacho
      • 1
        Robin E C Lee
      • 1
        Toren Finkel
      • 1
        Yuan Liu
      • Add ...
    • Date Submitted
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