University of Pittsburgh

p97 ATPase Inhibitors for Cancer and Neurodegneration

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Using iterative alkylations, saponifications, and coupling reactions, Dr. Wipf and his team were able to synthesize novel thiadiazines in which the core heterocycle could be selectively functionalized.
... com/patent/US20230131668A1. Related Publication(s). Terrab, L., & Wipf, P. (2020). Hsp70 and the Unfolded Protein Response as a Challenging Drug Target and an Inspiration for Probe Molecule Development.
, Topacio, A. Z., Sannino, S., Brodsky, J. L., & Wipf, P.
, Epperly, M. W., Greenberger, J. S., Bayır, H., Wipf, P., & Clark, R. S. B.