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HDAC Inhibitors as Anticancer Agents

05372

University of Pittsburgh researchers have developed a series of chromane-based hydroxamic acids that have been demonstrated to be potent and selective HDAC inhibitors with potential use as novel anticancer and anti-neurodegenerative agents.

· Entirely novel set of histone deacetylase inhibitors.

, Topacio, A. Z., Sannino, S., Brodsky, J. L., & Wipf, P.

Chemistry

2020-05-19

Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D

02314

Protein kinase D (PKD) is a member of a novel family of serine/threonine kinases that regulate fundamental cellular processes.

Chemistry

2010-10-06

Novel Thiadiazines as Heat Shock Protein Modulators and Anti-Huntington Disease Therapeutic Agents

05177

Using iterative alkylations, saponifications, and coupling reactions, Dr. Wipf and his team were able to synthesize novel thiadiazines in which the core heterocycle could be selectively functionalized.

... com/patent/US20230131668A1. Related Publication(s). Terrab, L., & Wipf, P. (2020). Hsp70 and the Unfolded Protein Response as a Challenging Drug Target and an Inspiration for Probe Molecule Development.

Chemistry

2019-11-20

p97 ATPase Inhibitors for Cancer and Neurodegneration