Using iterative alkylations, saponifications, and coupling reactions, Dr. Wipf and his team were able to synthesize novel thiadiazines in which the core heterocycle could be selectively functionalized. ... com/patent/US20230131668A1. Related Publication(s). Terrab, L., & Wipf, P. (2020). Hsp70 and the Unfolded Protein Response as a Challenging Drug Target and an Inspiration for Probe Molecule Development.