T Cell Receptors Targeting Defective DNA Repair Proteins

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Novel Targeted Gene Therapy for Cancers

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Scientists from University of Pittsburgh have developed a novel approach to target cancer cells through the insertion of a “suicide gene” (HSV1-tk) into key gene fusion areas of the cancer genome.

• Creation of this unique breakpoint, present only in cancer tissue provides a target for therapeutic intervention which is less likely to result in drug resistance through gene mutation.

Scientists from University of Pittsburgh have developed a novel approach to target cancer cells through the insertion of a “suicide gene” (HSV1-tk) into key gene fusion areas of the cancer genome.

Therapeutic Modality

Gene Therapy - CRISPR

Oncology

Liver cancerProstate cancer

Jianhua Luo

Med-Pathology

2023-07-06

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