CRISPR-crafted mouse model of rare TPI deficiency enables mechanistic studies and therapeutic exploration for this childhood neurodegenerative disorder.
Non-genetic mouse model mimics immunotherapy irAEs across gut, liver, skin via diet/microbiome changes; versatile, human-relevant, safe for KO systems.
OptoTAU enables light-controlled visualization of tau behavior in living cells, aiding discovery of modifiers to prevent tau-related dementia. (21 words)
Precise, bead-dissected nanoseeds standardize protein crystallization, boosting reproducibility, crystal quality, and throughput for challenging targets.
