Therapeutic Areas

Neuroscience

AI-Driven Precision Dosing and Survival Analytics for Personalized Brain Radiosurgery

07224

AI-driven personalized brain radiosurgery doses with survival analytics; real-time guardrails, offline decision support, rapid prognostic predictions.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Neuroscience
Oncology
Therapeutic Indications: Brain cancer - Other
Glioblastoma
Solid tumor
Tags: Artificial intelligence (AI)
Machine learning
Surgery
Lead Inventor: Jheremy S. Reyes
All Tech Innovators: Constantinos George Hadjipanayis
L Dade Lunsford
Ajay Niranjan
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-06-16
Collections: Healthcare AI

Novel Diagnostic Biomarker for Alzheimer's Disease

06770

Ultrasensitive CSF assay detects early pre-tangle soluble tau assemblies, enabling earlier Alzheimer’s diagnosis and targeted therapies.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Lead Inventor: Thomas Karikari
Department: Med-Psychiatry
All Tech Innovators: Eric E. Abrahamson
Milos Dragan Ikonomovic MD
Thomas K. Karikari
Date Submitted: 2024-06-10

Heterocyclic Compounds for Imaging Aggregated Tau

06319

New indole-based PET radiotracers selectively image 4R-tau tauopathies (PSP, CBD), aiding early diagnosis and therapy monitoring.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Tags: Diagnostic Imaging
Life Science
Lead Inventor: Jeffrey Stehouwer
Department: Med-Radiology
All Tech Innovators: Thomas Graham
Robert H. Mach
Chester A. Mathis Jr., Ph.D.
Date Submitted: 2023-02-28

Extracorporeal Human Brain Perfusion Platform

06814

Ex vivo human brain perfusion platform enables live brain tissue stimulation, recording, and analysis under near-physiological conditions.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Neuroscience
Tags: Brain-computer interface
Life Science
Lead Inventor: Pascal Zinn
Department: Med-Neurological Surgery
All Tech Innovators: Pascal Oliver Zinn
Date Submitted: 2024-07-19

Novel Biomarker Tools for Tauopathies

06769

New tau-targeting antibodies enable blood tests for early tauopathies, offering noninvasive diagnosis and treatment insight.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Lead Inventor: Thomas Karikari
Department: Med-Psychiatry
All Tech Innovators: Thomas K. Karikari
Xuemei Zeng
Date Submitted: 2024-06-06

Automated Tool for Infant Facial Action Unit Detection

05739

Infant AFAR automates infant facial action unit detection, enabling real-time, cross-age AU analysis with CNN-based accuracy.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Neuroscience
Lead Inventor: Itir Onal Ertugrul
Department: Psychology
All Tech Innovators: Amy Ahn
Maneesh Bilalpur
Jeffrey F. Cohn
Date Submitted: 2021-06-23

Novel Classification System for Temporal Lobe SEEG Explorations

06813

New SEEG classification standard for temporal lobe epilepsy standardizes implant coordinates, boosts planning, accuracy, and seizure outcomes.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Lead Inventor: Arka Mallela
Department: Med-Neurological Surgery
All Tech Innovators: Thandar Aung
Jorge A. Gonzalez-Martinez
Arka Narayana Mallela
Date Submitted: 2024-07-18

Innovative Low-Profile Deployable and Retrievable Epidural Lead Array System for Pain Management

06614

Ultra-thin, deployable epidural lead array enables safer, retrievable spinal cord stimulation with larger contact area for pain.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Pain
Lead Inventor: Trent Emerick
Department: Med-Anesthesiology and Perioperative Medicine
All Tech Innovators: Hassan Beheshti Seresht
Gaurav Chauhan
Youngjae Jae Chun
Date Submitted: 2024-01-17

Biased GPCR Ligands as a Therapeutic Intervention Strategy for Alzheimer's Disease

06184

Biased GPCR ligands selectively block β-arrestin signaling, reduce amyloid pathology, and preserve safety in Alzheimer's models.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Lead Inventor: Amantha Thathiah
Department: Med-Neurobiology
All Tech Innovators: Yunhong Huang
Amantha Thathiah
Date Submitted: 2022-10-05

Optogenetic Induction of Neurodegenerative Disease Pathologies

04130

Blue-light induced fusion proteins trigger controllable TDP-43/alpha-synuclein/Tau aggregation, modeling neurodegeneration for high-throughput screening.

Technology Type: Life Science Research Tool
Technology Subtype: Nucleic Acid
Therapeutic Areas: Neuroscience
Therapeutic Indications: Amyotrophic lateral sclerosis (ALS)
Alzheimer's Disease
Tags: Aging
Genetics
Platform Technology
Lead Inventor: Christopher Donnelly
Department: Med-Neurobiology
All Tech Innovators: Christopher James Donnelly
Jacob R. Mann
Date Submitted: 2017-01-15

Restorative Neurophysiology: A System for Re-achieving Previous Neurological States

07059

Restores a personalized prior brain state using baseline EEG and adaptive TACS, enabling non-invasive, closed-loop neural restoration.

Technology Type: Medical Device
Therapeutic Areas: Neuroscience
Mental and Behavioral Health
Therapeutic Indications: Depression
Tags: Precision medicine
Brain-computer interface
Lead Inventor: Greg Siegle
Department: Med-Psychiatry
All Tech Innovators: Greg Jeremy Siegle Ph.D.
Technology Readiness Level: 3. Prototype development
Date Submitted: 2025-02-04

Bait Oligonucleotides to Prevent TDP-43 Associated Neurodegeneration

06987

Dual-acting RNA chaperones (24–48 nt) prevent and dissolve TDP-43/FUS aggregates, restoring function and reducing neurodegeneration.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Amyotrophic lateral sclerosis (ALS)
Alzheimer's Disease
Lead Inventor: Christopher Donnelly
Department: Med-Neurobiology
All Tech Innovators: Christopher James Donnelly
James Shorter
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2024-11-30
Collections: Cell & Gene Therapy

High-Density Micro-Invasive Array for Brain Monitoring

06812

High-density, dissolvable carbon fiber brain electrodes enable simultaneous neurochemical and electrical recording and stimulation for deep structures.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Tags: Implantable Medical Device
Life Science
Lead Inventor: Helen Schwerdt
Department: Bioengineering
All Tech Innovators: Shreya Mahajan
Helen Schwerdt
Ritesh Shrivastav
Date Submitted: 2024-07-18

Streamlined Resource–Efficient Assay for Amyloid-β

06792

A streamlined IP-MS assay uses a common buffer to quantify plasma amyloid-β biomarkers, enabling affordable, noninvasive AD monitoring.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Tags: In Vitro Diagnostic
Life Science
Lead Inventor: Thomas Karikari
Department: Med-Psychiatry
All Tech Innovators: Yijun Chen
Thomas K. Karikari
Nathan A. Yates
Date Submitted: 2024-07-05

Dual Modality Micro-Invasive Neural Probes for Simultaneous Neurochemical and Electrophysiological In Deep Brain Structures

06771

Dual-modality micro-invasive neural probes measure electrophysiology and neurochemistry across deep brain regions with micro-scale carbon fiber probes.

Technology Type: Medical Device
Technology Subtype: Monitoring Medical Device
Therapeutic Areas: Neuroscience
Lead Inventor: Helen Schwerdt
Department: Bioengineering
All Tech Innovators: Usamma Amjad
Jiwon Choi
Helen Schwerdt
Date Submitted: 2024-06-10

Novel Approach to Detect Skull or Other Bone Failure in Fixation

06751

Acoustic-emission skull clamp monitoring detects bone microcracking in real time, preventing injury and clamp slippage during neurosurgery.

Technology Type: Medical Device
Technology Subtype: Monitoring Medical Device
Therapeutic Areas: Neuroscience
Lead Inventor: Andrew Bunger
Department: Civil & Environmental Engineering
All Tech Innovators: Andrew P. Bunger
Charles Clemenes Hager
William Harbert
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2024-05-16

Novel Research Tool to Study TDP-43 Dysfunction

06637

RNA biosensor CUTS-1 detects TDP-43 loss-of-function cells via cryptic exon–driven EGFP, enabling targeted therapy and tracking disease.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Lead Inventor: Christopher Donnelly
Department: Med-Neurobiology
All Tech Innovators: Christopher James Donnelly
Date Submitted: 2024-02-08
Collections: Cell & Gene Therapy

Restoring Sensation: Cutting-Edge Skin Reprogramming to Combat Diabetic Nerve Damage

06619

Skin-to-Schwann-like reprogramming via TNT delivers ASK factors, restoring sensation and promoting nerve repair in diabetic neuropathy.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - DNA
Therapeutic Areas: Neuroscience
Tags: Genetics
Lead Inventor: Chandan Sen
Department: Med-Surgery
All Tech Innovators: Raghunath Reddy Raghunath Bommana
Savita Khanna
Ravichand Palakurti
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2024-01-29
Collections: Cell & Gene Therapy

Novel Use of Metformin to Treat Musculoskeletal Injury

06416

Metformin advances tendon healing by reducing fibrosis and inflammation, promoting angiogenesis for safer, cost-effective tendinopathy treatment.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Neuroscience
Musculoskeletal
Lead Inventor: James Wang
Department: Med-Orthopedic Surgery
All Tech Innovators: James Huicong Wang
Jianying Zhang
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-05-23
Collections: Regenerative Medicine

Novel Approach to Reverse Cerebral Cortex Decline

06081

Proteins linked to aging spine loss identified; 10 drugs may protect cognition, slowing dementia by preserving dendritic spines.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Therapeutic Indications: Dementia
Alzheimer's Disease
Tags: Aging
Drug Repurposing
Lead Inventor: Robert Sweet
Department: Med-Psychiatry
All Tech Innovators: Peihao Fan
Joshua Michael Krivinko
Matthew Luke MacDonald
Date Submitted: 2022-06-30

A Genetically Engineered Mouse Model of Inflammatory Brain Injury

05385

CRISPR-edited mouse model replicates Aicardi-Goutières neuroinflammation for drug screening, target validation, and biomarker discovery.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Neuroscience
Lead Inventor: Qingde Wang
Department: Med-Surgery
All Tech Innovators: Xinfeng Guo
Qingde Wang
Date Submitted: 2020-05-28

Skin Screw Electrodes for Recording and Physical Stability

04146

Skin screw electrodes securely anchor to skin with shallow teeth, enabling stable, comfortable, fast-recording EEG/EMG interfaces.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Neuroscience
Lead Inventor: Mingui Sun
Department: Med-Neurological Surgery
All Tech Innovators: Wenyan Jia
Robert J. Sclabassi M.D., Ph.D.
Mingui Sun Ph.D.
Date Submitted: 2017-02-01

Novel Repair and Regeneration Therapy for Glaucoma

07246

AAV-Ina overexpression promotes retinal ganglion cell survival and axon regeneration, offering neuroprotection for glaucoma with regeneration potential.

Technology Type: Therapeutic Modality
Therapeutic Areas: Neuroscience
Ophthalmology
Therapeutic Indications: Glaucoma
Tags: Drug Discovery - Target
Life Science
Lead Inventor: Kun Che Chang
Department: Med-Ophthalmology
All Tech Innovators: Kun Che Chang
Chi-Yu Chen
Date Submitted: 2025-07-11

Neuroprotective Peptide in Acute Ischemic Injury

05442

A brain-penetrant peptide (TAT-DP-2) disrupts Kv2.1 clusters to prevent delayed neuronal death after stroke.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Neuroscience
Cardiovascular
Therapeutic Indications: Stroke
Other
Lead Inventor: Elias Aizenman
Department: Med-Neurobiology
All Tech Innovators: Elias Aizenman
Jason Arnold Justice
Anthony John Schulien
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-07-09
Collections: Cardiometabolic

Integrated 3D Brain Organoids for Modeling the Blood-Brain Barrier and Neurological Disease Mechanisms

06972

Integrated 3D brain organoids recreate the blood-brain barrier for long-term neurodegenerative/viral research and safer drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Alzheimer's Disease
Lead Inventor: Velpandi Ayyavoo
Department: GSPH-Infectious Diseases & Microbiology
All Tech Innovators: Velpandi Ayyavoo
Roberta Souza Dos Reis
Sathish Selvam
Date Submitted: 2024-11-12

Transient-based click decoding for brain-computer interface cursor emulation

05761

Transient-based click decoding boosts iBCI cursor control with onset/offset neural transients, 10x accuracy gain, enabling robust click-and-drag.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Neuroscience
Musculoskeletal
Therapeutic Indications: Other
Lead Inventor: Brian Dekleva
Department: Med-Physical Medicine & Rehabilitation
All Tech Innovators: Jennifer Lynn Collinger
Brian M. Dekleva
Technology Readiness Level: 3. Prototype development
Date Submitted: 2021-07-14

A Novel Approach to Treating Autoimmune Diseases by Modulating Immune Cell Proliferation

07129

Inhibits PIKFYVE to boost Treg cells, lowering Th17-driven autoimmunity and restoring immune balance.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Immunology
Therapeutic Indications: Multiple Sclerosis (MS)
Autoimmune encephalitis (AIE)
Tags: Autoimmune
Platform Technology
Personalized Medicine
Lead Inventor: William Hawse
Department: Med-Immunology
All Tech Innovators: William F. Hawse
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-03-27

HART: Health App Review Tool

07091

HART tailors health app recommendations for ADRD patients via four-domain assessment, guiding clinicians, patients, and caregivers.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Neuroscience
Therapeutic Indications: Dementia
Alzheimer's Disease
Tags: Clinical Decision Support
Life Science
Lead Inventor: Julie Faieta
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Yong Kyung Choi
Julie Marie Faieta
Haomin Hu
Date Submitted: 2025-02-24

OptoTAU: A Novel Tool for Visualizing and Studying TAU

06409

OptoTAU enables light-controlled visualization of tau behavior in living cells, aiding discovery of modifiers to prevent tau-related dementia. (21 words)

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Neuroscience
Therapeutic Indications: Dementia
Alzheimer's Disease
Lead Inventor: Amantha Thathiah
Department: Med-Neurobiology
All Tech Innovators: Amantha Thathiah
Xin Zhang
Date Submitted: 2023-05-15
Collections: Rare Diseases

4D Oxy-Wavelet MRI for Monitoring Mitochondrial Function

06288

Non-invasive 4D Oxy-wavelet MRI tracks mitochondrial function via BOLD, revealing oxygen balance and tissue health in vivo.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Endocrinology and Metabolic Diseases
Therapeutic Indications: Other
Mitochondrial Disease
Tags: Pediatrics
Rare disease
Diagnostic Imaging
Lead Inventor: Yijen Wu
Department: Med-Pediatrics
All Tech Innovators: Anthony G. Christodoulou
Devin Raine Everaldo Cortes
Yijen Wu
Date Submitted: 2023-02-13
Collections: Rare Diseases
Cardiometabolic

Magneto-Vibrational Therapy for Phantom Limb Pain

07142

Non-invasive magnetically driven vibration therapy for phantom limb pain, compatible with prosthetic sockets; adjustable, patent-pending.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Pain
Tags: Prosthetics
Lead Inventor: Goeran Fiedler
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Aiden Chinwalla
Goeran Fiedler
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-04-07

iAChSnFR-BTX: A Novel Optical Probe to Monitor Neurotransmitter Release

06606

Novel optical probe iAChSnFR-BTX enables single-vesicle, real-time acetylcholine release imaging via irreversible toxin binding across species.

Technology Type: Life Science Research Tool
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Lead Inventor: Stephen Meriney
Department: Neuroscience
All Tech Innovators: Yomna Badawi
Stephen D. Meriney
Date Submitted: 2024-01-09

Deep Brain Stimulation of the Pulvinar for the Treatment of Posterior Quadrant Epilepsy

06581

Pulvinar deep brain stimulation offers a subcortical, adjustable, potentially safer option for refractory posterior quadrant epilepsy.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Epilepsy
Lead Inventor: Elvira Pirondini
Department: Med-Physical Medicine & Rehabilitation
All Tech Innovators: Arianna Damiani
Jorge A. Gonzalez-Martinez
Elvira Pirondini
Date Submitted: 2023-12-01

Novel Treatment for Retinitis Pigmentosa

06383

Pyrvinium targets NS LLPS to restore proteostasis, preserve retinal structure, and may treat retinitis pigmentosa and proteinopathies.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Neuroscience
Ophthalmology
Therapeutic Indications: Parkinson's Disease
Alzheimer's Disease
Retinitis pigmentosa (RP)
Tags: Life Science
Lead Inventor: Bokai Zhu
Department: Med-Medicine
All Tech Innovators: Yuanyuan Chen
William A. Dion
Bokai Zhu
Date Submitted: 2023-04-23

Novel Glycine Receptor Modulators for Analgesia

04250

Glycine receptor modulators offer THC-like analgesia without psychoactivity, enabling opioid-sparing pain relief and inflammation targeting.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Neuroscience
Lead Inventor: Yan Xu
Department: Med-Anesthesiology and Perioperative Medicine
All Tech Innovators: Pei Tang
Marta Megan Wells
Yan Xu
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2017-05-17

Biosensors for the Detection of Brain Injury

04031

Antibody-aptamer biosensor detects tau in blood via electrochemical impedance, enabling rapid, portable TBI/ND biomarker diagnosis.

Technology Type: Engineering Technology
Technology Subtype: Sensor
Therapeutic Areas: Neuroscience
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Robert L. Kormos
Prashant N. Kumta
David O. Okonkwo
Date Submitted: 2016-09-23

Use of Deep Brain Stimulation to Treat Seizures

06088

Deep brain stimulation in motor thalamus offers seizure suppression without resection, via targeted neurostimulation and neuromodulation.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Epilepsy
Tags: Pediatrics
Brain-computer interface
Lead Inventor: Arianna Damiani
Department: Bioengineering
All Tech Innovators: Marco Capogrosso
Arianna Damiani
Jorge A. Gonzalez-Martinez
Date Submitted: 2022-07-01

Whole Genome Sequencing Analytic Pipeline for Healthcare Associated Transmission

05346

EDS-HAT fuses whole-genome sequencing, ML, and EHRs to detect, map, and prevent hospital outbreaks in real time.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Neuroscience
Lead Inventor: Xiangqun Xie
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Xiangqun Xie
Ying Xue
Date Submitted: 2020-05-08

Novel Treatment for Phantom Limb Pain

05033

Vibration-enabled prosthetic liners deliver non-invasive phantom limb pain relief, controlled via wireless vibro-motors for home use.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Pain
Tags: Prosthetics
Lead Inventor: Brianna Perry
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Goeran Fiedler
Brianna Perry
Kevin Charles Quinn
Date Submitted: 2019-06-24

TDP-43 Targeting Antibodies for Diagnosing Neurodegenerative Diseases

07105

Antibody-based TDP-43 detection enables early, non-invasive diagnosis of AD, ALS, PD, and related neurodegenerative diseases.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Amyotrophic lateral sclerosis (ALS)
Alzheimer's Disease
Tags: In Vitro Diagnostic
Lead Inventor: Thomas Karikari
Department: Med-Psychiatry
All Tech Innovators: Thomas K. Karikari
Xuemei Zeng
Date Submitted: 2025-03-04

Innovative Deep Brain Stimulation for Upper-Limb Motor Control and Speech Recovery

06571

Targeted motor-thalamus DBS boosts motor cortex excitability to improve upper-limb movement and speech after brain injury.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Lead Inventor: Elvira Pirondini
Department: Med-Physical Medicine & Rehabilitation
All Tech Innovators: Donald James Crammond
Arianna Damiani
Jorge A. Gonzalez-Martinez
Date Submitted: 2023-11-16

Novel Approach to Modulate Neural Activity

05653

AM-HF neuromodulation induces asynchronous neural firing to enhance sensory feedback in prosthetics and reduce FES fatigue.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Neuroscience
Lead Inventor: Beatrice Barra
Department: Physical Medicine & Rehabilitation
All Tech Innovators: Beatrice Barra
Marco Capogrosso
Lee Erik Bartholomew Fisher
Date Submitted: 2021-03-30

The Minister’s Cat – A Memory Game for Aphasia

05639

Aphasia-friendly memory card game—The Minister’s Cat—boosts speech, memory, and social engagement for PwA.

Technology Type: Digital Health
Technology Subtype: Digital Therapeutic
Therapeutic Areas: Neuroscience
Therapeutic Indications: Other
Tags: Life Science
Lead Inventor: William Evans
Department: SHRS-Commu Science & Disorders
All Tech Innovators: Meguey Baker
William Streicher Evans
Kathryn Hymes
Date Submitted: 2021-03-16

A Neuromorphic Brain Decoding Method for Brain-Machine Interfaces

05119

Neuromorphic BMI decoding uses precise spike-time dynamics, outperforming rate coding to accurately infer intended hand movements.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Other
Tags: Human performance
Lead Inventor: Benjamin Benosman
Department: Med-Ophthalmology
All Tech Innovators: Himanshu Akolkar
Benjamin Benosman
Andrew B. Schwartz
Date Submitted: 2019-09-24

Nanoparticle Dopants for Conducting Polymers

04941

Nanoparticle-doped PEDOT lowers impedance, boosts charge injection and drug loading for improved neural interfaces.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Cardiovascular
Tags: Biomaterial
Coating
Polymer
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Xinyan Cui
Kevin M. Woeppel
Date Submitted: 2019-04-03
Collections: Regenerative Medicine
Cardiometabolic

VASFAS (Ventriculoamniotic Shunt for Fetal Aqueductal Stenosis)

04909

Ultra-flexible ventriculoamniotic shunt with nitinol anchors; safer, self-expanding CSF drainage for fetal hydrocephalus today.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Lead Inventor: Young Chun
Department: Industrial Engineering
All Tech Innovators: Youngjae Jae Chun
Stephen Paul Emery
Stephanie Greene
Date Submitted: 2019-03-02

Novel Method to Treat PACS1 and PACS2 Syndromes

04682

HDAC6 inhibitors like tubacin reverse cellular defects in PACS1/2 syndromes, offering a promising preclinical therapy path.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Lead Inventor: Gary Thomas
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Gary Thomas
Laurel Thomas
Sabrina Villar Pazos
Date Submitted: 2018-07-13

Preparation-free Electrode with Conducting Polymer/Hydrogel

01360

Preparation-free, MRI-compatible skin electrode using conducting polymer hydrogel enables quick EEG/ECG, comfortable, low-cost, and high-density sensing.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Other
Multiple Sclerosis (MS)
Migraine
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Xinyan Cui
Date Submitted: 2006-10-08

Novel Treatment for Eye Disorders

05703

Monoclonal antibody blocks Lipocalin-2 to curb retinal inflammation and dry AMD progression, offering a preventive therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Neuroscience
Ophthalmology
Therapeutic Indications: Stargardt Disease
Diabetic retinopathy
Age-related macular degeneration
Lead Inventor: Debasish Sinha
Department: Department of Ophthalmology
All Tech Innovators: Sayan Ghosh
Urvi Gupta
Stacey Hose
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-05-26

PET Imaging Agents for Aggregated Tau in the Brain

06483

Novel 4R-tau PET radiotracers: photostable, high affinity to 4R-tau, enabling early PSP/CBD diagnosis and progression tracking.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Therapeutic Indications: Other
Progressive supranuclear palsy
Alzheimer's Disease
Lead Inventor: Chester Mathis
Department: Med-Radiology
All Tech Innovators: Chester A. Mathis Jr., Ph.D.
Jeffrey S. Stehouwer
Date Submitted: 2023-08-16