Complex Coacervate for Controlled Release
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Ophthalmology
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The gel allows for controlled release of treatment for DED, requiring less applications, and has the potential to improve regimen compliance, allowing for direct treatment of the underlying cause of DED. Integrating these peptides into a coacervate gel leads to controlled, sustained release of medication into the eye and could provide a novel treatment approach for DED and other eye diseases. In all three studies the eye surface was improved back to baseline, whereas the control groups demonstrated continued damage to the eye surface.
Controlled release of ciprofloxacin and ceftriaxone from a single ototopical administration of antibiotic-loaded polymer microspheres and thermoresponsive gel. Modification of the polymer microparticle could regulate the timeframe over which a therapeutic agent is released. The microparticle can be tailored to control slow release of the therapeutic agent.
The researchers developed a controlled delivery system to locally release SAHA and present preliminary data suggesting its potential to prevent ocular tissue damage, enhance FoxP3 expression (a Treg marker), and reduce the pro-inflammatory environment in DED. This is a novel controlled release drug delivery system. Researchers at Pitt are exploring a novel approach to the treatment of inflammatory eye diseases, particularly dry eye disease (DED), using a controlled drug delivery system.
- 4Therapeutic Modality
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- 4Drug Delivery / Formulation
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- 5Oncology
- 4Ophthalmology
- 2Cardiovascular
- 2Musculoskeletal
- 2Neuroscience
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- 2Conjunctivitis
- 2Dry eye syndrome
- 1Age-related macular degeneration
- 1Glaucoma
- 1Keratitis
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- 1Life Science
- 1Peptide
- 1Platform Technology
- 1Polymer
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- 1Alan Wells
- 1Daewon Park
- 1Morgan Dileo
- 1Steven Little
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- 1Bioengineering
- 1Engr-Dept Chairperson's Office
- 1Med-Ophthalmology
- 1Med-Pathology
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- 2Steven R. Little
- 2Yadong Wang
- 1Alan H. Wells
- 1Daewon Park
- 1Joel Steven Schuman
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