Uridine Diphosphate Compounds as Mobilizers of Hematopoietic Progenitor Cells
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The natural course of aging, as well as the progression of several degenerative diseases, closely correlates with a loss of adult stem cell quantity and function. Injecting muscle-derived stem cells harvested from young mice can recover the loss of stem cell proliferation and function observed in older mice, and in addition to anti-aging applications, mice with simulated Hutchinson-Gilford progeria syndrome significantly extended lifespan and improved health after stem cell injection. This technology is a therapeutic method of administering autologous or allogenic stem cells isolated from younger donors in order to restore or rejuvenate adult stem cell function.
The top 360 compounds were further tested in a cell-based NAD+.
• Improved Performance of Regulatory T Cells in vivo. Previous research demonstrated that CAR T cells with a more oxidative phenotype persisted longer in vivo persistence were more effective in targeting leukemia cells. When applied to CAR T cells during the ex vivo expansion phase, the oxidative metabolism of these cells increased without negatively impacting cell growth.