Biomaterial

Targeted Nanoparticle Therapy for Brain Repair: Harnessing Memory T Cells for Endogenous Neuroregeneration and Neuroimmune Homeostasis

07316

Targeted brain nanoparticles reprogram memory T cells to foster neuroprotection, reduce neuroinflammation, and promote endogenous CNS repair.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Multiple Sclerosis (MS)
Alzheimer's Disease
Tags: Biomaterial
Autoimmune
Polymer
Lead Inventor: Swaminathan Iyer
Department: Med-Pathology
All Tech Innovators: Swaminathan Smita Iyer
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2025-08-29
Collections: Regenerative Medicine

Regenerative Topical Therapy for Cold-Induced Skin Injury: A Field-Ready Solution to Prevent Necrosis and Amputation

07296

Hydrogel HA-Metformin topical therapy regenerates frostbitten skin, restores architecture, reduces necrosis risk, deployable field-ready.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Dermatology
Tags: Biomaterial
Polymer
Regenerative medicine
Lead Inventor: James Wang
Department: Med-Orthopedic Surgery
All Tech Innovators: James Huicong Wang
Jianying Zhang
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2025-08-19
Collections: Regenerative Medicine

On-Demand Reversible Hydrogel Adhesive: Visible-Light Bonding and Rapid UV-Triggered Debonding

07190

Dual-wavelength hydrogel glue bonds with visible light, debonds rapidly under UV via ONB cleavage, enabling on-demand, non-invasive removal.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Therapeutic Areas: Intensive Care
Tags: Biomaterial
Polymer
Lead Inventor: Wei Zhang
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Huaming Wang
Wei Zhang
Technology Readiness Level: 3. Prototype development
Date Submitted: 2025-05-21

Innovative Magnesium-Based Therapy for Periodontal Disease

06460

Mg-based anti-inflammatory therapy uses Mg-PLGA nanoparticles/fibers to treat periodontal disease and aid bone regeneration.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Dental
Tags: Biomaterial
Lead Inventor: Jin Gao
Department: Dent Med-Periodontics/Preventive Dentistry
All Tech Innovators: Jin Gao
Charles S. Sfeir
Date Submitted: 2023-07-17

Silk-Iron Packaged Extracellular Vesicles

06360

Silk-iron packaged extracellular vesicles guide regenerative, cell-free therapy for abdominal aortic aneurysm by delivering elastin/collagen factors.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Tags: Biomaterial
Regenerative medicine
Lead Inventor: Ande Marini
Department: Bioengineering
All Tech Innovators: Mostafa M. Bedewy
Ande Xiaojie Marini
Golnaz Najaf Tomaraei
Date Submitted: 2023-03-23
Collections: Regenerative Medicine
Cardiometabolic

AI-Driven Bioreactor for Long-Term Ex Vivo Human Tissue Perfusion and Research

06260

AI-driven bioreactor extends ex vivo human tissue viability to weeks, enabling AI-monitored, high-fidelity drug testing and research.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Dermatology
Oncology
Tags: Biomaterial
Artificial intelligence (AI)
Platform Technology
Lead Inventor: Asim Ejaz
Department: Med-Plastic Surgery
All Tech Innovators: Jose Arellano
Asim Ejaz
Yusuf Surucu
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2023-01-08
Collections: Healthcare AI

A Flexible Wireless Sensor Embedded Intravaginal ring (IVR) for On-Demand Electroresponsive Release of Anti-Sexually Transmitted Infection

06042

Flexible wireless IVR detects vaginal cues and electrically releases anti-STI agents on demand for targeted prevention.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Infectious Disease
Therapeutic Indications: HIV
Tags: Biomaterial
Sustainability
Sensor
Lead Inventor: Seungil Kim
Department: Bioengineering
All Tech Innovators: Emmanuel A. Ho
Seungil Kim
Yongkuk Lee
Date Submitted: 2022-05-31
Collections: Women's & Reproductive Health

Novel Device for Coating Medical Conduits

06000

RegenCoat coats nerve conduits with uniform micro/nano particles for precise, biodegradable regenerative drug delivery in nerve repair.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Rehabilitation/Mobility
Neuroscience
Tags: Biomaterial
Coating
Regenerative medicine
Lead Inventor: Caroline Fedor
Department: Med-Plastic Surgery
All Tech Innovators: Fuat Baris Bengur
Caroline Nadia Fedor
Kacey Gribbin Marra
Technology Readiness Level: 3. Prototype development
Date Submitted: 2022-04-10
Collections: Regenerative Medicine

Novel Treatment for Dry Eye Disease

05988

IL-4 eye drops target inflammation and goblet cell dysfunction in dry eye disease, aiming for lasting tear film stability.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Immunology
Ophthalmology
Tags: Biomaterial
Lead Inventor: Alexis Nolfi
Department: Office of the SVC and Provost
All Tech Innovators: Bryan Nicklaus Brown
Vishal Jhanji
Mangesh Kulkarni
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-03-18

BioBulwark: Implants with Biofilm-Resistant Coating to Prevent Bacterial Infection

05459

BioBulwark coats implants with vertically oriented graphene to destroy biofilms, preventing infections without harming human cells.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Cardiovascular
Infectious Disease
Tags: Biomaterial
Coating
Lead Inventor: Eric Shaker
Department: Med-Medicine
All Tech Innovators: Rui Liang
Eric Shaker
Technology Readiness Level: 1. Concept development
Date Submitted: 2020-07-27
Collections: Cardiometabolic

Scaffold-Free Nerve Conduit Comprising Cells, Secretome, and Endogenous Aligned Extracellular Matrix

05228

Scaffold-free, autologous dental pulp stem cell conduit uses aligned extracellular matrix and secretome to accelerate facial nerve repair.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Rehabilitation/Mobility
Neuroscience
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Fatima Syed
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Fatima N. Syed
Date Submitted: 2020-01-21
Collections: Regenerative Medicine

Use of Specific Phages for the Treatment of Non-Tuberculosis Mycobacterial Infections

05095

Phage therapy targets drug-resistant non-tuberculous Mycobacteria, enabling rapid, strain-specific treatment with minimal resistance and side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Bacteriophage
Therapeutic Areas: Respiratory
Infectious Disease
Tags: Biomaterial
Lead Inventor: Graham Hatfull
Department: Distinguished Faculty-Dietrich School of Arts and Sciences
All Tech Innovators: Rebekah Marie Dedrick
Carlos Andres Guerrero
Graham F. Hatfull
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-08-20

Ovarian ECM Derivatives for Women's Health Applications

04945

Bioengineered ovarian ECM hydrogel enables rapid follicle delivery to restore fertility and endocrine function after chemotherapy.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Reproductive Health
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Michael Buckenmeyer
Department: Bioengineering
All Tech Innovators: Bryan Nicklaus Brown
Michael Joseph Buckenmeyer
Kyle E. Orwig
Date Submitted: 2019-04-06
Collections: Regenerative Medicine
Women's & Reproductive Health

Using Nanoparticles to Stabilize and Preserve the Bioactivity of Proteins and Peptides

04961

Silica nanoparticle textures stabilize surface-bound proteins, enabling dry storage, broader biosensor and implant applications.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Other
Tags: Biomaterial
Coating
Platform Technology
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Xinyan Cui
Kevin M. Woeppel
Date Submitted: 2019-04-17

Nanoparticle Dopants for Conducting Polymers

04941

Nanoparticle-doped PEDOT lowers impedance, boosts charge injection and drug loading for improved neural interfaces.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Neuroscience
Tags: Biomaterial
Coating
Polymer
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Xinyan Cui
Kevin M. Woeppel
Date Submitted: 2019-04-03
Collections: Regenerative Medicine
Cardiometabolic

Endovascular Orifice Detection Device (EOrD)

04938

Endovascular Orifice Detection Device enables in situ fenestration for AAAs using EM guidance, reducing wait times and costs.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Cardiovascular
Tags: Biomaterial
Minimally invasive
Lead Inventor: Mohammad Eslami
Department: Bioengineering
All Tech Innovators: Timothy K. Chung
Mohammad Hamed Eslami
David A. Vorp Ph.D.
Technology Readiness Level: 3. Prototype development
Date Submitted: 2019-04-01
Collections: Cardiometabolic

Biodegradable Magnesium-Based Tenting Devices for Vertical Alveolar Ridge Regeneration

04795

Biodegradable magnesium ridge screws with tunable resorption for vertical augmentation, delivering growth factors and reducing second surgery.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Dental
Tags: Biomaterial
Lead Inventor: Charles Sfeir
Department: Dent Med-Periodontics/Preventive Dentistry
All Tech Innovators: Andrew J. Brown
Charles S. Sfeir
Date Submitted: 2018-10-29
Collections: Regenerative Medicine

Port Thermometer

04733

A wireless port-attached thermometer provides continuous, non-invasive fever monitoring for mediport patients, alerting caregivers in real time.

Technology Type: Medical Device
Technology Subtype: Monitoring Medical Device
Therapeutic Areas: Infectious Disease
Oncology
Tags: Biomaterial
Lead Inventor: Deirdre Nolfi-Donegan
Department: Med-Pediatrics
All Tech Innovators: Michael Sivan Landau
Quyen Le Ngoc Nguyen
Deirdre S. Nolfi-Donegan
Technology Readiness Level: 2. Initial proof-of-concept (PoC)
Date Submitted: 2018-09-18

Functional Poly(Hydrosiloxane)-Based Microbial Nanoculture Systems

04723

Functional PDMS-based microbial nanocultures enhance permeability and mechanical strength for safer, in-situ microbial studies.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Therapeutic Areas: Immunology
Tags: Biomaterial
Platform Technology
Lead Inventor: Tagbo Niepa
Department: Chem/Petroleum Engineering
All Tech Innovators: Shanna-Leigh Davidson
Tagbo Herman Roland Niepa
Date Submitted: 2018-08-29

Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells

04531

Magnetic delivery and hydrogel fixation of adipose-derived stem cells enable minimally invasive, localized AAA treatment and broader applications.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: David Vorp
Department: Bioengineering
All Tech Innovators: Yogev Baruch
Kory James Blose
Timothy K. Chung
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2018-03-05
Collections: Regenerative Medicine

Nitrix: A Biomaterial Bandage for Closing Chronic Wounds

04182

Nitrix: a low-cost ECM biomaterial bandage that reduces inflammation, boosts antioxidants/angiogenesis, and accelerates chronic wound healing.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Intensive Care
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Samuel LoPresti
Department: Bioengineering
All Tech Innovators: Bryan Nicklaus Brown
Samuel Traxler LoPresti
Date Submitted: 2017-03-06
Collections: Regenerative Medicine

Regenerative Ligament Repair Therapy

04487

Cell-free ACL/PCL ECM extracts drive stem cell tenogenic differentiation, enabling regenerative ligament and dental repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Riccardo Gottardi
All Tech Innovators: Riccardo Luca Gottardi
Shinsuke Kihara
Benjamin Burke Rothrauff
Date Submitted: 2018-01-17
Collections: Regenerative Medicine

Highly Configurable Vagus Nerve Bioelectronic Device Approach to Modulate Inflammation/Immunity and Control Cancer

04256

Vagus nerve bioelectronic implant personalizes cancer therapy by modulating inflammation, boosting immunotherapy effectiveness, with fewer side effects.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Oncology
Neuroscience
Therapeutic Indications: Glioblastoma
Tags: Biomaterial
Autoimmune
Immuno-oncology
Lead Inventor: Charles Horn
Department: Med-Medicine
All Tech Innovators: Christopher J. Bettinger
Gary Keith Fedder
Charles C. Horn
Technology Readiness Level: 3. Prototype development
Date Submitted: 2017-05-22
Collections: Regenerative Medicine

Self-Assembled Coatings for Magnesium Implants

04203

Self-assembling anticorrosive organosilane coating slows magnesium implant degradation, enabling drug delivery and improved biocompatibility.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Musculoskeletal
Dental
Tags: Biomaterial
Coating
Tissue engineering
Lead Inventor: Elia Beniash
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Elia Beniash
Avinash Jagannath Patil
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2017-04-04

Programmable Platform for the Assembly of New Biomaterials

04187

Programmable peptide-oligonucleotide chimeras enable tunable, morphologically responsive hybrid materials with dual peptide/nucleic acid features.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Tags: Biomaterial
Lead Inventor: Nathaniel Rosi
Department: Distinguished Faculty-Dietrich School of Arts and Sciences
All Tech Innovators: Andrea David Merg
SonBinh T. Nguyen
Nathaniel L. Rosi
Date Submitted: 2017-03-08

Hybrid Scaffolds for Bone Defect Regeneration

04114

Hybrid Mg alloy–polymer/DBM scaffold enables osteogenic bone regeneration for critical-sized defects, reducing grafting risks.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Regenerative medicine
Life Science
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Yingqi Chen
Vesselin N. Shanov
William R. Wagner PhD
Date Submitted: 2016-12-12
Collections: Regenerative Medicine

VitaCapsule: A Synthetic Hydrogel for Supporting Human Stem Cells

04045

VitaCapsule: a low-cost synthetic peptide-conjugated hydrogel boosting single-cell hPSC viability for scalable 2D/3D biomanufacturing.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Tags: Biomaterial
Regenerative medicine
Platform Technology
Lead Inventor: Thomas Richardson
Department: All Temps
All Tech Innovators: Ipsita Banerjee
Prashant N. Kumta
Thomas Charles Richardson
Date Submitted: 2016-10-12
Collections: Regenerative Medicine

A Biodegradable, Antioxidant, Thermally Responsive Injectable Hydrogel for Treatment of Ischemic Cardiomyopathy

04039

Thermally gelling, MRI-visible, biodegradable hydrogel with covalently bonded antioxidants for injectable ischemic cardiomyopathy therapy.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Hypertrophic cardiomyopathy
Dialated cardiomyopathy
Tags: Biomaterial
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Yasumoto Matsumura
Murugesan Velayutham
William R. Wagner PhD
Date Submitted: 2016-10-04
Collections: Cardiometabolic

A Biodegradable, Porous, Thermally Responsive Injectable Hydrogel as Soft Tissue Defect Filler

04040

Biodegradable, injectable hydrogel with in situ gelation, porosity, ECM cues, and rapid tissue regeneration for soft-tissue repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Hong Bin Jiang
Hideyoshi Sato
Date Submitted: 2016-10-04
Collections: Regenerative Medicine

A Shear-thinning Hydrogel That Extends In Vivo Bioactivity of Therapeutic Proteins

03988

Injectable, shear-thinning hydrogel using silicate nanoplatelets and heparin enables rapid, tunable, Bioactive protein delivery and biodegrades in 8 weeks.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Yadong Wang
Department: Bioengineering
All Tech Innovators: Xiaochu Ding
Jin Gao
Yadong Wang
Date Submitted: 2016-07-07
Collections: Regenerative Medicine

An Expandable Percutaneous Venous Cannula for Use in Extracorporeal Cardiopulmonary Support

03884

Expandable single‑cannula ECMO device conforming to atrial anatomy for complete, low‑occlusion venous drainage via percutaneous deployment

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Respiratory
Cardiovascular
Tags: Biomaterial
Polymer
Lead Inventor: Antonio DAmore
Department: Med-Surgery
All Tech Innovators: Vinay Badhwar
Antonio DAmore
Daniel T. McKeel
Date Submitted: 2016-04-04
Collections: Cardiometabolic

Layer Up: Drug-Eluting Coating for Implantable Devices and Biomaterials

03741

Layer Up coats implants with anti-inflammatory drug release to reduce rejection and improve long-term integration across biomaterials.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Biomaterial
Coating
Platform Technology
Lead Inventor: Daniel Hachim
Department: Bioengineering Department
All Tech Innovators: Bryan Nicklaus Brown
Daniel Hachim
Date Submitted: 2015-10-05

Esophocclude: Making Emergency Care Safer

03742

Esophocclude: a swallowed pill that temporarily blocks the esophagus to prevent aspiration during emergencies and surgery.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Otolaryngology
Tags: Biomaterial
Lead Inventor: Philip Carullo
Department: UHCP0-GME â€“ Residency
All Tech Innovators: Philip Carullo
Youngjae Jae Chun
Date Submitted: 2015-10-06
Collections: Women's & Reproductive Health

Biomimetic Fibrous Hydrogel Scaffolds Promote Biomineralization

03610

Injectable biomimetic fibrous hydrogel scaffolds self-assemble electrostatically to guide bone-like mineralization and drug delivery.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Tissue engineering
Lead Inventor: Shilpa Sant
Department: Department of Pharmaceutical Sciences
All Tech Innovators: Shilpa Sant
Date Submitted: 2015-05-11

Resorbable Magnesium Hardware for Bone Fractures

03562

Biodegradable magnesium bone fixation hardware strengthens healing and resorbs, reducing need for removal and surgeries.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Vijay S. Gorantla
Dae Ho Hong
Date Submitted: 2015-03-24
Collections: Regenerative Medicine

TracheoMag

03396

Biodegradable magnesium-lithium airway stent with ultra-ductility, enabling natural healing and reduced need for removal.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Surgery
Respiratory
Tags: Biomaterial
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Oleg Velikokhatnyi
Jingyao Wu
Date Submitted: 2014-09-09
Collections: Regenerative Medicine

Self-Assembled Coatings for Magnesium Implants

03377

Self-assembled anticorrosive organosilane coatings slow magnesium implant degradation, enabling drug delivery and improved biocompatibility.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Other
Tags: Biomaterial
Coating
Regenerative medicine
Lead Inventor: Elia Beniash
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Elia Beniash
Date Submitted: 2014-08-11
Collections: Regenerative Medicine

Superelastic, Bioabsorbable Endovascular Devices

03179

Superelastic, mostly-biodegradable endovascular scaffold that self-expands with temperature, offers temporary support, then safely resorbs.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Tags: Biomaterial
Tissue engineering
Lead Inventor: Young Chun
Department: Industrial Engineering
All Tech Innovators: Youngjae Jae Chun
Xinzhu Gu
William R. Wagner PhD
Date Submitted: 2013-11-22
Collections: Regenerative Medicine
Cardiometabolic

Injectable Thermoresponsive Hydrogel For Sustained Drug Release and Enhanced Cell therapy

03044

Thermoresponsive injectable hydrogel enables sustained protein/drug release, antioxidative cell support, and tissue regeneration scaffolds.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Neuroscience
Tags: Biomaterial
Lead Inventor: Yadong Wang
Department: Bioengineering
All Tech Innovators: Martin Oudega
Yadong Wang
Date Submitted: 2013-05-02

Corrosion-Resistant, Bioactive Coatings for Magnesium -Based Medical Devices

03014

Bioactive PEM coatings yield corrosion resistance, improved biocompatibility, and controlled biomolecule delivery for magnesium-based implants.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Dental
Musculoskeletal
Tags: Biomaterial
Coating
Polymer
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Sangeetha Kunjukunju
Boeun Lee
Date Submitted: 2013-04-01

Degradable Osteosensor: Novel Degradable CNT-based Impedimetric Biosensors for Bone Marker Detection

03000

Degradable CNT-based impedimetric sensor detects bone resorption markers; biodegradable, home-use osteosense enables in vivo monitoring.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Immunology
Musculoskeletal
Therapeutic Indications: Rheumatoid arthritis
Osteoporosis
Bone metabolism
Tags: Biomaterial
Aging
Coating
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Mitali S. Patil
Madhumati Ramanathan
Technology Readiness Level: 3. Prototype development
Date Submitted: 2013-03-04
Collections: Regenerative Medicine
Women's & Reproductive Health

Advanced Electrospinning for Regenerative Biomaterials

02919

New PGS electrospun fibers blended with carriers yield suturable, strong, tunable, ECM-mimicking vascular grafts and nerve guides.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Eric Jeffries
Department: Bioengineering
All Tech Innovators: Eric M. Jeffries
Yadong Wang
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2012-10-23
Collections: Regenerative Medicine

Revolutionary Biodegradable Iron Alloys for Advanced Medical Implants

02903

Biodegradable iron alloys engineered to safely corrode in vivo, providing resorbable, strong implants matched to healing timelines.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Tags: Biomaterial
Precision medicine
Surgery
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Sung Jae Chung
Moni Kanchan Datta
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2012-09-27
Collections: Regenerative Medicine

Bio-Inspired Nanocomposites for Advanced Bone and Tissue Regeneration

02778

Bio-inspired bone/dentin nanocomposites using multiphosphorylated peptides for integrated organic-inorganic regeneration and osteogenesis.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Intensive Care
Musculoskeletal
Therapeutic Indications: Trauma
Osteogenesis Imperfecta
Bone metabolism
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Elia Beniash
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Elia Beniash
Charles S. Sfeir
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2012-05-25
Collections: Regenerative Medicine

ResMag: A Resorbable Magnesium Alloy for Medical Applications

02522

ResMag: a biodegradable magnesium alloy matching bone properties, enabling resorbable orthopedic implants with safe, controlled degradation. 15 words.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Regenerative medicine
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Dae Ho Hong
Prashant N. Kumta
Date Submitted: 2011-07-14
Collections: Regenerative Medicine

A Novel Biohybrid Composite Scaffold

02205

Elastic biohybrid scaffold combining ECM gel and electrospun elastomer fibers for improved integration and support.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Biomaterial
Tissue engineering
Lead Inventor: Yi Hong
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Ryotaro Hashizume
Yi Hong
Date Submitted: 2010-04-27
Collections: Regenerative Medicine

Biodegradable Electrospun Scaffolds for Enhanced Tissue Repair and Cellular Infiltration

02170

Biodegradable wet-electrospun scaffolds enhance tissue repair with bioactive, integrated fibers for superior cellular infiltration and mechanics.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Biomaterial
Polymer
Tissue engineering
Lead Inventor: Yi Hong
All Tech Innovators: Nicholas J. Amoroso
Kazuro Lee Fujimoto
Ryotaro Hashizume
Date Submitted: 2010-03-22
Collections: Regenerative Medicine

Acellular Central Nervous System (Spinal Cord)-Derived Product for Tissue Engineering and Regenerative Therapies

01915

Acellular porcine spinal cord scaffold supports neuronal growth; injectable, lyophilizable CNS biomaterial for regenerative therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Neuroscience
Tags: Biomaterial
Tissue engineering
Lead Inventor: Alan Boruch
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Alan V. Boruch
Date Submitted: 2009-02-05

Novel Nanostructured Smart Injectable Bone Cements for Bone Regeneration

01918

Smart injectable calcium phosphate bone cement carries proteins, DNA, cells, and drugs; enables rapid, porous, 3D-printed, regenerative bone repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Osteoporosis
Bone metabolism
Tags: Biomaterial
Aging
Regenerative medicine
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Abhijit Roy
Charles S. Sfeir
Date Submitted: 2009-02-13
Collections: Regenerative Medicine
Women's & Reproductive Health

Novel Peptides for Tissue Reconstruction

01877

Synthetic peptides recruit patient progenitor cells to injury sites, enabling targeted tissue healing without stem cell harvesting.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Stephen Badylak
Department: Med-Surgery
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Stephen Tottey
Date Submitted: 2008-11-26
Collections: Regenerative Medicine