Regenerative medicine

Regenerative Topical Therapy for Cold-Induced Skin Injury: A Field-Ready Solution to Prevent Necrosis and Amputation

07296

Hydrogel HA-Metformin topical therapy regenerates frostbitten skin, restores architecture, reduces necrosis risk, deployable field-ready.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Dermatology
Tags: Regenerative medicine
Biomaterial
Polymer
Lead Inventor: James Wang
Department: Med-Orthopedic Surgery
All Tech Innovators: James Huicong Wang
Jianying Zhang
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2025-08-19
Collections: Regenerative Medicine

Innovative 3D Bioprinting for Primary and iPSC-Derived Organoids

06820

3D bioprinting platform fabricates viable primary and iPSC-derived organoids in porous hydrogel for drug testing.

Technology Type: Engineering Technology
Technology Subtype: Other Engineering Technology
Therapeutic Areas: Other
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Miranda Poklar
Department: Chem/Petroleum Engineering
All Tech Innovators: Ipsita Banerjee
Yong Fan
Prashant N. Kumta
Date Submitted: 2024-07-24
Collections: Regenerative Medicine

Targeted Nanoparticle Therapy for Brain Repair: Harnessing Memory T Cells for Endogenous Neuroregeneration and Neuroimmune Homeostasis

07316

Targeted brain nanoparticles reprogram memory T cells to foster neuroprotection, reduce neuroinflammation, and promote endogenous CNS repair.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Multiple Sclerosis (MS)
Alzheimer's Disease
Tags: Regenerative medicine
Autoimmune
Biomaterial
Lead Inventor: Swaminathan Iyer
Department: Med-Pathology
All Tech Innovators: Swaminathan Smita Iyer
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2025-08-29
Collections: Regenerative Medicine

A Novel Platform for Enhanced Inner Ear Drug Delivery and Gene Therapy

07230

Exosome-based inner ear drug delivery platform enhances RWM traversal, enabling sustained, versatile loading of drugs and gene therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Otolaryngology
Therapeutic Indications: Hearing Loss
Tags: Regenerative medicine
Platform Technology
Lead Inventor: Adele Moatti
Department: Med-Otolaryngology
All Tech Innovators: Adele Moatti
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-06-23
Collections: Regenerative Medicine

Targeting Cardiomyocyte Endoreplication to Prevent Hypertrophic Cardiomyopathy

07132

Inhibits PCNA-POLD1 interactions via p21 to curb cardiomyocyte endoreplication, preventing hypertrophic cardiomyopathy progression.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Hypertrophic cardiomyopathy
Tags: Regenerative medicine
Genetics
Platform Technology
Lead Inventor: Jason Becker
Department: Med-Medicine
All Tech Innovators: Jason Robert Becker
Soumojit Pal
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-03-30
Collections: Cell & Gene Therapy
Regenerative Medicine
Cardiometabolic

Silk-Iron Packaged Extracellular Vesicles

06360

Silk-iron packaged extracellular vesicles guide regenerative, cell-free therapy for abdominal aortic aneurysm by delivering elastin/collagen factors.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Tags: Regenerative medicine
Biomaterial
Lead Inventor: Ande Marini
Department: Bioengineering
All Tech Innovators: Mostafa M. Bedewy
Ande Xiaojie Marini
Golnaz Najaf Tomaraei
Date Submitted: 2023-03-23
Collections: Regenerative Medicine
Cardiometabolic

Novel Device for Coating Medical Conduits

06000

RegenCoat coats nerve conduits with uniform micro/nano particles for precise, biodegradable regenerative drug delivery in nerve repair.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Rehabilitation/Mobility
Neuroscience
Tags: Regenerative medicine
Biomaterial
Coating
Lead Inventor: Caroline Fedor
Department: Med-Plastic Surgery
All Tech Innovators: Fuat Baris Bengur
Caroline Nadia Fedor
Kacey Gribbin Marra
Technology Readiness Level: 3. Prototype development
Date Submitted: 2022-04-10
Collections: Regenerative Medicine

Novel Approach to Bone Regeneration

06099

Activates skeletal stem cells to regenerate bone endogenously, using mechanical suture expansion and niclosamide-based stimulation.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Dental
Musculoskeletal
Therapeutic Indications: Osteoporosis
Tags: Regenerative medicine
Lead Inventor: Giuseppe Intini
Department: Dent Med-Periodontics/Preventive Dentistry
All Tech Innovators: Xue Hui Geng
Giuseppe Intini
Luigi Mancinelli
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-07-13
Collections: Regenerative Medicine
Women's & Reproductive Health

Novel Approach to Treatment of Osteoarthritis

05840

Enhancing estrogen receptor-α in cartilage reverses osteoarthritis damage; potential ERα-targeted therapies emerge with RAD001 and Urolithin A.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Aging
Tissue engineering
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Hang Lin
Ning Wang
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-10-13
Collections: Regenerative Medicine

Novel Hepatocyte Growth Factor Receptor Agonist

05468

A humanized MET agonist META4 restores HGF-MET signaling, promoting tissue regeneration and potential therapies for liver disease and AMD.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Hepatology
Ophthalmology
Therapeutic Indications: Other
Non-alcoholic steatohepatitis (NASH)
Diabetic retinopathy
Tags: Regenerative medicine
Lead Inventor: Abdolreza Zarnegar
Department: Med-Pathology
All Tech Innovators: Abdolreza Zarnegar
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-08-05
Collections: Regenerative Medicine
Cardiometabolic

Stimulation of Angiogenesis with miRNA as Protection Against Acute Kidney Injury

05448

Therapeutic miRNA approach promotes kidney angiogenesis to protect against acute kidney injury and ischemia-reperfusion damage.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Nephrology
Tags: Regenerative medicine
Lead Inventor: Sunder Lucas
Department: Med-Pediatrics
All Tech Innovators: Takuto Chiba
Jacqueline Ho
Sunder Sims Lucas
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-07-16
Collections: Cell & Gene Therapy
Regenerative Medicine

Scaffold-Free Nerve Conduit Comprising Cells, Secretome, and Endogenous Aligned Extracellular Matrix

05228

Scaffold-free, autologous dental pulp stem cell conduit uses aligned extracellular matrix and secretome to accelerate facial nerve repair.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Rehabilitation/Mobility
Neuroscience
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Fatima Syed
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Fatima N. Syed
Date Submitted: 2020-01-21
Collections: Regenerative Medicine

Ovarian ECM Derivatives for Women's Health Applications

04945

Bioengineered ovarian ECM hydrogel enables rapid follicle delivery to restore fertility and endocrine function after chemotherapy.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Reproductive Health
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Michael Buckenmeyer
Department: Bioengineering
All Tech Innovators: Bryan Nicklaus Brown
Michael Joseph Buckenmeyer
Kyle E. Orwig
Date Submitted: 2019-04-06
Collections: Regenerative Medicine
Women's & Reproductive Health

Nanoparticle Dopants for Conducting Polymers

04941

Nanoparticle-doped PEDOT lowers impedance, boosts charge injection and drug loading for improved neural interfaces.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Neuroscience
Tags: Regenerative medicine
Biomaterial
Coating
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Xinyan Cui
Kevin M. Woeppel
Date Submitted: 2019-04-03
Collections: Regenerative Medicine
Cardiometabolic

Regenerative Ligament Repair Therapy

04487

Cell-free ACL/PCL ECM extracts drive stem cell tenogenic differentiation, enabling regenerative ligament and dental repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Riccardo Gottardi
All Tech Innovators: Riccardo Luca Gottardi
Shinsuke Kihara
Benjamin Burke Rothrauff
Date Submitted: 2018-01-17
Collections: Regenerative Medicine

Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells

04531

Magnetic delivery and hydrogel fixation of adipose-derived stem cells enable minimally invasive, localized AAA treatment and broader applications.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: David Vorp
Department: Bioengineering
All Tech Innovators: Yogev Baruch
Kory James Blose
Timothy K. Chung
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2018-03-05
Collections: Regenerative Medicine

Scaffold-Free Cell Sheet for Nerve Repair

04482

Scaffold-free dental stem cell sheets deliver neurotrophic factors locally to accelerate nerve regeneration and motor recovery.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Tags: Regenerative medicine
Tissue engineering
Surgery
Lead Inventor: Fatima Syed
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Fatima N. Syed
Date Submitted: 2018-01-12
Collections: Regenerative Medicine

Improved Preclinical Models for Osteoarthritis

04384

3D human micro-joint chip (mJoint) models multifactorial osteoarthritis to test disease-modifying medications with patient-relevant tissues.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Aging
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Peter Alexander
Riccardo Luca Gottardi
Hang Lin
Date Submitted: 2017-09-26
Collections: Regenerative Medicine

Highly Configurable Vagus Nerve Bioelectronic Device Approach to Modulate Inflammation/Immunity and Control Cancer

04256

Vagus nerve bioelectronic implant personalizes cancer therapy by modulating inflammation, boosting immunotherapy effectiveness, with fewer side effects.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Oncology
Neuroscience
Therapeutic Indications: Glioblastoma
Tags: Regenerative medicine
Autoimmune
Biomaterial
Lead Inventor: Charles Horn
Department: Med-Medicine
All Tech Innovators: Christopher J. Bettinger
Gary Keith Fedder
Charles C. Horn
Technology Readiness Level: 3. Prototype development
Date Submitted: 2017-05-22
Collections: Regenerative Medicine

Nitrix: A Biomaterial Bandage for Closing Chronic Wounds

04182

Nitrix: a low-cost ECM biomaterial bandage that reduces inflammation, boosts antioxidants/angiogenesis, and accelerates chronic wound healing.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Intensive Care
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Samuel LoPresti
Department: Bioengineering
All Tech Innovators: Bryan Nicklaus Brown
Samuel Traxler LoPresti
Date Submitted: 2017-03-06
Collections: Regenerative Medicine

Hybrid Scaffolds for Bone Defect Regeneration

04114

Hybrid Mg alloy–polymer/DBM scaffold enables osteogenic bone regeneration for critical-sized defects, reducing grafting risks.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Biomaterial
Life Science
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Yingqi Chen
Vesselin N. Shanov
William R. Wagner PhD
Date Submitted: 2016-12-12
Collections: Regenerative Medicine

A Biodegradable, Porous, Thermally Responsive Injectable Hydrogel as Soft Tissue Defect Filler

04040

Biodegradable, injectable hydrogel with in situ gelation, porosity, ECM cues, and rapid tissue regeneration for soft-tissue repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Hong Bin Jiang
Hideyoshi Sato
Date Submitted: 2016-10-04
Collections: Regenerative Medicine

TriaGel: Comprehensive Gel Eye Dressing to Revolutionize Ocular First Aid

04068

TriaGel: a rapid, injectable ocular gel that stabilizes injuries, delivers anti-inflammatories, reduces complications and costs.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Intensive Care
Ophthalmology
Tags: Regenerative medicine
Material Science
Lead Inventor: Morgan Dileo
Department: Med-Ophthalmology
All Tech Innovators: Morgan Virginia Dileo
Jenny Yu
Date Submitted: 2016-11-07
Collections: Regenerative Medicine

ResMag: A Resorbable Magnesium Alloy for Medical Applications

04049

Biodegradable magnesium alloy implants matching bone elasticity reduce metastasis risk and need for removal surgeries.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Material Science
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Dae Ho Hong
Prashant N. Kumta
Date Submitted: 2016-10-18
Collections: Regenerative Medicine

VitaCapsule: A Synthetic Hydrogel for Supporting Human Stem Cells

04045

VitaCapsule: a low-cost synthetic peptide-conjugated hydrogel boosting single-cell hPSC viability for scalable 2D/3D biomanufacturing.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Tags: Regenerative medicine
Biomaterial
Platform Technology
Lead Inventor: Thomas Richardson
Department: All Temps
All Tech Innovators: Ipsita Banerjee
Prashant N. Kumta
Thomas Charles Richardson
Date Submitted: 2016-10-12
Collections: Regenerative Medicine

Ultrasound-Guided Rete Testis Injection/Aspiration Device

04016

Ultrasound-guided, non-surgical rete testis access device enables targeted injections/aspirations, reducing biopsies for azoospermia therapy.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Other
Reproductive Health
Therapeutic Indications: Male genitourinary
Infertility
Tags: Regenerative medicine
Minimally invasive
Lead Inventor: Kyle Orwig
Department: Med-OB-Gyn & Reproductive Science
All Tech Innovators: Brian Peter Hermann
Kyle E. Orwig
Date Submitted: 2016-08-29
Collections: Regenerative Medicine
Women's & Reproductive Health

A Shear-thinning Hydrogel That Extends In Vivo Bioactivity of Therapeutic Proteins

03988

Injectable, shear-thinning hydrogel using silicate nanoplatelets and heparin enables rapid, tunable, Bioactive protein delivery and biodegrades in 8 weeks.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Yadong Wang
Department: Bioengineering
All Tech Innovators: Xiaochu Ding
Jin Gao
Yadong Wang
Date Submitted: 2016-07-07
Collections: Regenerative Medicine

Regeneration of Epiphyseal Growth Plate

03828

Hydrogel-encapsulated stem cells and growth factors morph cartilage-like growth plate tissue, enabling regeneration and deformity prevention.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Dental
Tags: Regenerative medicine
Tissue engineering
Life Science
Lead Inventor: Juan Taboas
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Jingming Chen
Juan M. Taboas
Date Submitted: 2016-02-10
Collections: Regenerative Medicine

Novel Biomimetic Rotated Plywood Motifs as Scaffolds for Bone Tissue Engineering

03778

Biomimetic rotated plywood bone scaffolds via binder-jet 3D printing; data-driven, multi-material, enhanced strength, tailored implants.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Tissue engineering
Surgery
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Gary Zhengbo Yu
Date Submitted: 2015-11-27
Collections: Regenerative Medicine

Resorbable Magnesium Hardware for Bone Fractures

03562

Biodegradable magnesium bone fixation hardware strengthens healing and resorbs, reducing need for removal and surgeries.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Vijay S. Gorantla
Dae Ho Hong
Date Submitted: 2015-03-24
Collections: Regenerative Medicine

Fertilized Chicken Eggs: A Novel Platform for Cancer and Regenerative Medicine Research

03087

Fertilized chicken eggs offer a non-immunogenic, in vivo microenvironment to study human cancer growth, EMT, regeneration, and drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Tags: Regenerative medicine
Immuno-oncology
Immunology
Lead Inventor: Vera Donnenberg
Department: Med-Cardiothoracic Surgery
All Tech Innovators: Albert D. Donnenberg
Vera Svobodova Donnenberg
Technology Readiness Level: 3. Prototype development
Date Submitted: 2013-07-03
Collections: Regenerative Medicine

Stem Cell-Based Technologies for Avian Skeletal Tissue Engineering and Regeneration

03360

Light-activated, 3D-printed avian stem cell scaffolds enable precise bone/cartilage repair with antibacterial protection.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - Stem Cell
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Rocky Tuan
Department: Med-Orthopedic Surgery
All Tech Innovators: Rocky Sung Chi Tuan
Date Submitted: 2014-07-07
Collections: Cell & Gene Therapy
Regenerative Medicine

Self-Assembled Coatings for Magnesium Implants

03377

Self-assembled anticorrosive organosilane coatings slow magnesium implant degradation, enabling drug delivery and improved biocompatibility.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Other
Tags: Regenerative medicine
Biomaterial
Coating
Lead Inventor: Elia Beniash
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Elia Beniash
Date Submitted: 2014-08-11
Collections: Regenerative Medicine

Controlled Release Microparticle Platform for Localized Prevention of Tissue Calcification and Ossification

03248

PLGA microparticles deliver BMP receptor inhibitor locally to prevent tissue calcification with sustained, customizable release.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Sports medicine
Tissue engineering
Lead Inventor: Riccardo Gottardi
All Tech Innovators: Peter Alexander
Patrick A. Bianconi
Riccardo Luca Gottardi
Date Submitted: 2014-02-17
Collections: Regenerative Medicine

Hybrid Additive Manufacturing and Electrospinning for Fabricating Vascularized Biodegradable Tissue Scaffolds

03187

Hybrid 3D printing and electrospinning create biodegradable, porous, vascularized tissue scaffolds with programmable microchannels.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Yadong Wang
Department: Bioengineering
All Tech Innovators: James Henry Clampffer III
Eric M. Jeffries
Yadong Wang
Date Submitted: 2013-12-04
Collections: Regenerative Medicine

Advanced Electrospinning for Regenerative Biomaterials

02919

New PGS electrospun fibers blended with carriers yield suturable, strong, tunable, ECM-mimicking vascular grafts and nerve guides.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Eric Jeffries
Department: Bioengineering
All Tech Innovators: Eric M. Jeffries
Yadong Wang
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2012-10-23
Collections: Regenerative Medicine

New Biometric Coating for Neural Implants Improves Outcomes

03008

A neural implant coating using the L1 neural adhesion molecule boosts recording quality and longevity, reducing tissue reaction.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Epilepsy
Tags: Regenerative medicine
Coating
Tissue engineering
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Erdrin Azemi
Xinyan Cui
Carl F. Lagenaur
Date Submitted: 2013-03-28
Collections: Regenerative Medicine

Degradable Osteosensor: Novel Degradable CNT-based Impedimetric Biosensors for Bone Marker Detection

03000

Degradable CNT-based impedimetric sensor detects bone resorption markers; biodegradable, home-use osteosense enables in vivo monitoring.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Immunology
Musculoskeletal
Therapeutic Indications: Rheumatoid arthritis
Osteoporosis
Bone metabolism
Tags: Regenerative medicine
Aging
Biomaterial
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Mitali S. Patil
Madhumati Ramanathan
Technology Readiness Level: 3. Prototype development
Date Submitted: 2013-03-04
Collections: Regenerative Medicine
Women's & Reproductive Health

Bio-Inspired Nanocomposites for Advanced Bone and Tissue Regeneration

02778

Bio-inspired bone/dentin nanocomposites using multiphosphorylated peptides for integrated organic-inorganic regeneration and osteogenesis.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Intensive Care
Musculoskeletal
Therapeutic Indications: Trauma
Osteogenesis Imperfecta
Bone metabolism
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Elia Beniash
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Elia Beniash
Charles S. Sfeir
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2012-05-25
Collections: Regenerative Medicine

ResMag: A Resorbable Magnesium Alloy for Medical Applications

02522

ResMag: a biodegradable magnesium alloy matching bone properties, enabling resorbable orthopedic implants with safe, controlled degradation. 15 words.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Biomaterial
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Dae Ho Hong
Prashant N. Kumta
Date Submitted: 2011-07-14
Collections: Regenerative Medicine

Low Passage Mesenchymal Stem Cell Cell Bank from Cadaveric Vertebral Bodies

02247

Cadaver vertebra-derived MSC bank enables rapid, large-scale expansion in bioreactors, reducing chromosomal risks and passage.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Immunology
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Albert Donnenberg
Department: Med-Medicine
All Tech Innovators: Albert D. Donnenberg
Ludovic Zimmerlin
Date Submitted: 2010-06-09
Collections: Regenerative Medicine

Cell Programming Device Via Covalent Bonding or Ionic Bonding

02066

A patient-sourced fluid is treated on immobilized surfaces with covalently or ionically bound agents to modify cells, then returned.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Oncology
Cardiovascular
Therapeutic Indications: Atherosclerotic disease
Tags: Regenerative medicine
Platform Technology
Lead Inventor: John Kellum
Department: Med-Critical Care Medicine
All Tech Innovators: William J. Federspiel
John A. Kellum Jr
Kai Singbartl
Date Submitted: 2009-08-29
Collections: Regenerative Medicine
Cardiometabolic

Novel Nanostructured Smart Injectable Bone Cements for Bone Regeneration

01918

Smart injectable calcium phosphate bone cement carries proteins, DNA, cells, and drugs; enables rapid, porous, 3D-printed, regenerative bone repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Osteoporosis
Bone metabolism
Tags: Regenerative medicine
Aging
Biomaterial
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Abhijit Roy
Charles S. Sfeir
Date Submitted: 2009-02-13
Collections: Regenerative Medicine
Women's & Reproductive Health

Novel Peptides for Tissue Reconstruction

01877

Synthetic peptides recruit patient progenitor cells to injury sites, enabling targeted tissue healing without stem cell harvesting.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Stephen Badylak
Department: Med-Surgery
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Stephen Tottey
Date Submitted: 2008-11-26
Collections: Regenerative Medicine

Tracking Cell-Based Therapeutics in the Body with Microbubbles

01857

Ultrasound-visible microbubbles enable safe, noninvasive tracking of injected stem cells in patients, aiding trials and treatment decisions.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Hematology
Oncology
Tags: Regenerative medicine
Polymer
Platform Technology
Lead Inventor: Flordeliza Villanueva
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Wenjin Cui
Andrew Robert Fisher
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2008-10-24
Collections: Regenerative Medicine

Thermoresponsive, Biodegradable, Elastomeric Material

01315

Biodegradable, thermoresponsive hydrogel that is injectable, ultra-flexible, and shapes with temperature for tissue engineering and drug delivery.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Jianjun Guan
William R. Wagner PhD
Date Submitted: 2006-09-14
Collections: Regenerative Medicine

Modeling Wound Healing

01265

Agent-based in silico wound-healing model simulates inflammation, tissue damage, and therapies for personalized clinical predictions.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Therapeutic Areas: Intensive Care
Immunology
Therapeutic Indications: Trauma
Tags: Regenerative medicine
Immuno-oncology
Lead Inventor: Yoram Vodovotz
Department: Med-Surgery
All Tech Innovators: Gilles Clermont
Patricia Ann Hebda Ph.D.
Yee Key Li
Date Submitted: 2006-05-10
Collections: Regenerative Medicine

Biohybrid Elastomeric Scaffolds for Wound Healing and Tissue Regeneration

01174

Biohybrid elastomeric scaffolds merge synthetic and biological polymers to enhance wound healing and tissue regeneration.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Donald O. Freytes MSBME
Thomas W. Gilbert
Date Submitted: 2005-11-16
Collections: Regenerative Medicine

Cellular Biobandage: A ‘Smart’ Gel for Wound Healing

01062

Smart, antimicrobial, fast-curing gel with mesenchymal cells to rapidly seal wounds, inhibit inflammation, and boost healing.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Tags: Regenerative medicine
Polymer
Tissue engineering
Lead Inventor: Eric Beckman
Department: Chem/Petroleum Engineering
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Eric J. Beckman
Donald O. Freytes MSBME
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2005-03-07
Collections: Regenerative Medicine

Vacuum Seeding Rotational Device

00985

Vacuum-rotational seeding rapidly coats porous tubular grafts with uniform, high-density cells for ready-to-use tissue-engineered vessels.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Cardiovascular
Tags: Regenerative medicine
Tissue engineering
Plastic Surgery
Lead Inventor
All Tech Innovators: Alejandro Nieponice
Lorenzo Soletti
David A. Vorp Ph.D.
Date Submitted: 2004-08-19
Collections: Regenerative Medicine
Cardiometabolic