Innovative 3D Bioprinting for Primary and iPSC-Derived Organoids068203D bioprinting platform fabricates viable primary and iPSC-derived organoids in porous hydrogel for drug testing.Technology TypeEngineering TechnologyTechnology SubtypeOther Engineering TechnologyTherapeutic AreasOtherTagsTissue engineeringRegenerative medicineLead InventorMiranda PoklarDepartmentChem/Petroleum EngineeringAll Tech InnovatorsIpsita BanerjeeYong FanPrashant N. KumtaDate Submitted2024-07-24CollectionsRegenerative Medicine
Novel Patient-Derived Assembloid Model Accelerates Immunotherapy Development for Difficult-to-Treat Cancers06922Patient-derived assembloid with tumor-immune co-cultures accelerates immunotherapy/vaccine development for hard-to-treat head and neck cancers.Technology TypeLife Science Research ToolTechnology SubtypeCell LineTherapeutic AreasImmunologyOncologyTherapeutic IndicationsSolid tumorTagsTissue engineeringImmuno-oncologyPlatform TechnologyLead InventorRiyue BaoDepartmentMed-MedicineAll Tech InnovatorsRiyue BaoJason J. LukeTechnology Readiness Level3. Prototype developmentDate Submitted2024-10-16
Novel Maxillo-Mandibular Measurement Tool05982A handheld, disposable/reusable tool accurately measures pediatric alveolar overjet for craniofacial assessment and surgical planning.Technology TypeMedical DeviceTechnology SubtypeOther Medical DeviceTherapeutic AreasSurgeryDentalTagsTissue engineeringPediatricsLead InventorJesse GoldsteinDepartmentMed-Plastic SurgeryAll Tech InnovatorsJustin BeirigerJesse A. GoldsteinTechnology Readiness Level3. Prototype developmentDate Submitted2022-03-10
Novel Approach to Treatment of Osteoarthritis05840Enhancing estrogen receptor-α in cartilage reverses osteoarthritis damage; potential ERα-targeted therapies emerge with RAD001 and Urolithin A.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasMusculoskeletalTagsTissue engineeringAgingRegenerative medicineLead InventorHang LinDepartmentMed-Orthopedic SurgeryAll Tech InnovatorsHang LinNing WangTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2021-10-13CollectionsRegenerative Medicine
Scaffold-Free Nerve Conduit Comprising Cells, Secretome, and Endogenous Aligned Extracellular Matrix05228Scaffold-free, autologous dental pulp stem cell conduit uses aligned extracellular matrix and secretome to accelerate facial nerve repair.Technology TypeMedical DeviceTechnology SubtypeRehab or Assistive Medical DeviceTherapeutic AreasRehabilitation/MobilityNeuroscienceTagsTissue engineeringBiomaterialRegenerative medicineLead InventorFatima SyedDepartmentDent Med-Oral and Craniofacial SciencesAll Tech InnovatorsFatima N. SyedDate Submitted2020-01-21CollectionsRegenerative Medicine
Nanoparticle Dopants for Conducting Polymers04941Nanoparticle-doped PEDOT lowers impedance, boosts charge injection and drug loading for improved neural interfaces.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasCardiovascularNeuroscienceTagsTissue engineeringBiomaterialCoatingLead InventorXinyan CuiDepartmentBioengineeringAll Tech InnovatorsXinyan CuiKevin M. WoeppelDate Submitted2019-04-03CollectionsRegenerative MedicineCardiometabolic
Ovarian ECM Derivatives for Women's Health Applications04945Bioengineered ovarian ECM hydrogel enables rapid follicle delivery to restore fertility and endocrine function after chemotherapy.Technology TypeEngineering TechnologyTechnology SubtypeIndustrial BiotechTherapeutic AreasReproductive HealthTagsTissue engineeringBiomaterialRegenerative medicineLead InventorMichael BuckenmeyerDepartmentBioengineeringAll Tech InnovatorsBryan Nicklaus BrownMichael Joseph BuckenmeyerKyle E. OrwigDate Submitted2019-04-06CollectionsRegenerative MedicineWomen's & Reproductive Health
Novel Processing Method and Apparatus for Micro-Structured Rope-Like Material04694Continuous mandrel-less electrospun ropes with tunable diameter and fiber orientation for regenerative tendon, nerve, and suture applications.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasMusculoskeletalTagsTissue engineeringPolymerLead InventorAntonio DAmoreDepartmentMed-SurgeryAll Tech InnovatorsAntonio DAmoreDaniel T. McKeelWilliam R. Wagner PhDDate Submitted2018-07-30CollectionsRegenerative Medicine
Scaffold-Free Cell Sheet for Nerve Repair04482Scaffold-free dental stem cell sheets deliver neurotrophic factors locally to accelerate nerve regeneration and motor recovery.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasNeuroscienceTagsTissue engineeringRegenerative medicineSurgeryLead InventorFatima SyedDepartmentDent Med-Oral and Craniofacial SciencesAll Tech InnovatorsFatima N. SyedDate Submitted2018-01-12CollectionsRegenerative Medicine
Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells04531Magnetic delivery and hydrogel fixation of adipose-derived stem cells enable minimally invasive, localized AAA treatment and broader applications.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtherTagsTissue engineeringBiomaterialRegenerative medicineLead InventorDavid VorpDepartmentBioengineeringAll Tech InnovatorsYogev BaruchKory James BloseTimothy K. ChungTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2018-03-05CollectionsRegenerative Medicine
Regenerative Ligament Repair Therapy04487Cell-free ACL/PCL ECM extracts drive stem cell tenogenic differentiation, enabling regenerative ligament and dental repair.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasMusculoskeletalTagsTissue engineeringBiomaterialRegenerative medicineLead InventorRiccardo GottardiAll Tech InnovatorsRiccardo Luca GottardiShinsuke KiharaBenjamin Burke RothrauffDate Submitted2018-01-17CollectionsRegenerative Medicine
Novel Biomimetic Rotated Plywood Motifs as Scaffolds for Bone Tissue Engineering03778Biomimetic rotated plywood bone scaffolds via binder-jet 3D printing; data-driven, multi-material, enhanced strength, tailored implants.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasMusculoskeletalTagsTissue engineeringRegenerative medicineSurgeryLead InventorPrashant KumtaDepartmentBioengineeringAll Tech InnovatorsPrashant N. KumtaGary Zhengbo YuDate Submitted2015-11-27CollectionsRegenerative Medicine
Self-Assembled Coatings for Magnesium Implants04203Self-assembling anticorrosive organosilane coating slows magnesium implant degradation, enabling drug delivery and improved biocompatibility.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasMusculoskeletalDentalTagsTissue engineeringBiomaterialCoatingLead InventorElia BeniashDepartmentDent Med-Oral and Craniofacial SciencesAll Tech InnovatorsElia BeniashAvinash Jagannath PatilTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2017-04-04
Nitrix: A Biomaterial Bandage for Closing Chronic Wounds04182Nitrix: a low-cost ECM biomaterial bandage that reduces inflammation, boosts antioxidants/angiogenesis, and accelerates chronic wound healing.Technology TypeEngineering TechnologyTechnology SubtypeIndustrial BiotechTherapeutic AreasIntensive CareTagsTissue engineeringBiomaterialRegenerative medicineLead InventorSamuel LoPrestiDepartmentBioengineeringAll Tech InnovatorsBryan Nicklaus BrownSamuel Traxler LoPrestiDate Submitted2017-03-06CollectionsRegenerative Medicine
A Biodegradable, Porous, Thermally Responsive Injectable Hydrogel as Soft Tissue Defect Filler04040Biodegradable, injectable hydrogel with in situ gelation, porosity, ECM cues, and rapid tissue regeneration for soft-tissue repair.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTagsTissue engineeringBiomaterialRegenerative medicineLead InventorWilliam WagnerDepartmentBioengineeringAll Tech InnovatorsStephen Francis Badylak DVM, PhD, MDHong Bin JiangHideyoshi SatoDate Submitted2016-10-04CollectionsRegenerative Medicine
A Shear-thinning Hydrogel That Extends In Vivo Bioactivity of Therapeutic Proteins03988Injectable, shear-thinning hydrogel using silicate nanoplatelets and heparin enables rapid, tunable, Bioactive protein delivery and biodegrades in 8 weeks.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTagsTissue engineeringBiomaterialRegenerative medicineLead InventorYadong WangDepartmentBioengineeringAll Tech InnovatorsXiaochu DingJin GaoYadong WangDate Submitted2016-07-07CollectionsRegenerative Medicine
Regeneration of Epiphyseal Growth Plate03828Hydrogel-encapsulated stem cells and growth factors morph cartilage-like growth plate tissue, enabling regeneration and deformity prevention.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasDentalTagsTissue engineeringRegenerative medicineLife ScienceLead InventorJuan TaboasDepartmentDent Med-Oral and Craniofacial SciencesAll Tech InnovatorsJingming ChenJuan M. TaboasDate Submitted2016-02-10CollectionsRegenerative Medicine
Stem Cell-Based Technologies for Avian Skeletal Tissue Engineering and Regeneration03360Light-activated, 3D-printed avian stem cell scaffolds enable precise bone/cartilage repair with antibacterial protection.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - Stem CellTherapeutic AreasMusculoskeletalTagsTissue engineeringRegenerative medicineLead InventorRocky TuanDepartmentMed-Orthopedic SurgeryAll Tech InnovatorsRocky Sung Chi TuanDate Submitted2014-07-07CollectionsCell & Gene TherapyRegenerative Medicine
Biomimetic Fibrous Hydrogel Scaffolds Promote Biomineralization03610Injectable biomimetic fibrous hydrogel scaffolds self-assemble electrostatically to guide bone-like mineralization and drug delivery.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasMusculoskeletalTagsTissue engineeringBiomaterialLead InventorShilpa SantDepartmentDepartment of Pharmaceutical SciencesAll Tech InnovatorsShilpa SantDate Submitted2015-05-11
Resorbable Magnesium Hardware for Bone Fractures03562Biodegradable magnesium bone fixation hardware strengthens healing and resorbs, reducing need for removal and surgeries.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasMusculoskeletalTagsTissue engineeringBiomaterialRegenerative medicineLead InventorPrashant KumtaDepartmentBioengineeringAll Tech InnovatorsDa-Tren ChouVijay S. GorantlaDae Ho HongDate Submitted2015-03-24CollectionsRegenerative Medicine
Self-Assembled Coatings for Magnesium Implants03377Self-assembled anticorrosive organosilane coatings slow magnesium implant degradation, enabling drug delivery and improved biocompatibility.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasMusculoskeletalTherapeutic IndicationsOtherTagsTissue engineeringBiomaterialCoatingLead InventorElia BeniashDepartmentDent Med-Oral and Craniofacial SciencesAll Tech InnovatorsElia BeniashDate Submitted2014-08-11CollectionsRegenerative Medicine
Controlled Release Microparticle Platform for Localized Prevention of Tissue Calcification and Ossification03248PLGA microparticles deliver BMP receptor inhibitor locally to prevent tissue calcification with sustained, customizable release.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasMusculoskeletalTagsTissue engineeringRegenerative medicineSports medicineLead InventorRiccardo GottardiAll Tech InnovatorsPeter AlexanderPatrick A. BianconiRiccardo Luca GottardiDate Submitted2014-02-17CollectionsRegenerative Medicine
Hybrid Additive Manufacturing and Electrospinning for Fabricating Vascularized Biodegradable Tissue Scaffolds03187Hybrid 3D printing and electrospinning create biodegradable, porous, vascularized tissue scaffolds with programmable microchannels.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTagsTissue engineeringRegenerative medicineLead InventorYadong WangDepartmentBioengineeringAll Tech InnovatorsJames Henry Clampffer IIIEric M. JeffriesYadong WangDate Submitted2013-12-04CollectionsRegenerative Medicine
Superelastic, Bioabsorbable Endovascular Devices03179Superelastic, mostly-biodegradable endovascular scaffold that self-expands with temperature, offers temporary support, then safely resorbs.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasCardiovascularTagsTissue engineeringBiomaterialLead InventorYoung ChunDepartmentIndustrial EngineeringAll Tech InnovatorsYoungjae Jae ChunXinzhu GuWilliam R. Wagner PhDDate Submitted2013-11-22CollectionsRegenerative MedicineCardiometabolic
New Biometric Coating for Neural Implants Improves Outcomes03008A neural implant coating using the L1 neural adhesion molecule boosts recording quality and longevity, reducing tissue reaction.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasNeuroscienceTherapeutic IndicationsParkinson's DiseaseEpilepsyTagsTissue engineeringCoatingRegenerative medicineLead InventorXinyan CuiDepartmentBioengineeringAll Tech InnovatorsErdrin AzemiXinyan CuiCarl F. LagenaurDate Submitted2013-03-28CollectionsRegenerative Medicine
Corrosion-Resistant, Bioactive Coatings for Magnesium -Based Medical Devices03014Bioactive PEM coatings yield corrosion resistance, improved biocompatibility, and controlled biomolecule delivery for magnesium-based implants.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasDentalMusculoskeletalTagsTissue engineeringBiomaterialCoatingLead InventorPrashant KumtaDepartmentBioengineeringAll Tech InnovatorsPrashant N. KumtaSangeetha KunjukunjuBoeun LeeDate Submitted2013-04-01
Degradable Osteosensor: Novel Degradable CNT-based Impedimetric Biosensors for Bone Marker Detection03000Degradable CNT-based impedimetric sensor detects bone resorption markers; biodegradable, home-use osteosense enables in vivo monitoring.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasImmunologyMusculoskeletalTherapeutic IndicationsRheumatoid arthritisOsteoporosisBone metabolismTagsTissue engineeringAgingBiomaterialLead InventorPrashant KumtaDepartmentBioengineeringAll Tech InnovatorsPrashant N. KumtaMitali S. PatilMadhumati RamanathanTechnology Readiness Level3. Prototype developmentDate Submitted2013-03-04CollectionsRegenerative MedicineWomen's & Reproductive Health
Advanced Electrospinning for Regenerative Biomaterials02919New PGS electrospun fibers blended with carriers yield suturable, strong, tunable, ECM-mimicking vascular grafts and nerve guides.Technology TypeEngineering TechnologyTechnology SubtypeMaterial ScienceTagsTissue engineeringBiomaterialRegenerative medicineLead InventorEric JeffriesDepartmentBioengineeringAll Tech InnovatorsEric M. JeffriesYadong WangTechnology Readiness Level4. Prototype testing and refinementDate Submitted2012-10-23CollectionsRegenerative Medicine
Bio-Inspired Nanocomposites for Advanced Bone and Tissue Regeneration02778Bio-inspired bone/dentin nanocomposites using multiphosphorylated peptides for integrated organic-inorganic regeneration and osteogenesis.Technology TypeTherapeutic ModalityTechnology SubtypePeptideTherapeutic AreasIntensive CareMusculoskeletalTherapeutic IndicationsTraumaOsteogenesis ImperfectaBone metabolismTagsTissue engineeringBiomaterialRegenerative medicineLead InventorElia BeniashDepartmentDent Med-Oral and Craniofacial SciencesAll Tech InnovatorsElia BeniashCharles S. SfeirTechnology Readiness Level5. Drug candidate createdDate Submitted2012-05-25CollectionsRegenerative Medicine
Revolutionary Perfusion Solution for Extended Organ Preservation and Improved Transplant Outcomes02777Oxygenated acellular hemoglobin perfusate preserves organs longer at sub‑normothermia, improving transplant viability and function.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTagsTissue engineeringSurgeryLead InventorPaulo FontesDepartmentMed-SurgeryAll Tech InnovatorsPaulo Artur Chaves FontesDate Submitted2012-05-24
Bioreactor for Physiologic Loading of Epithelialized Hollow Organs02411A bioreactor cyclically distends epithelialized hollow organs, delivering luminal pressure and controlled flow to support multi-tissue growth.Technology TypeLife Science Research ToolTechnology SubtypeCell LineTagsTissue engineeringLead InventorThomas GilbertDepartmentBioengineeringAll Tech InnovatorsThomas W. GilbertMark JuhasNathaniel Thomas RemlingerDate Submitted2011-02-21
Low Passage Mesenchymal Stem Cell Cell Bank from Cadaveric Vertebral Bodies02247Cadaver vertebra-derived MSC bank enables rapid, large-scale expansion in bioreactors, reducing chromosomal risks and passage.Technology TypeLife Science Research ToolTechnology SubtypeCell LineTherapeutic AreasImmunologyTagsTissue engineeringRegenerative medicineLead InventorAlbert DonnenbergDepartmentMed-MedicineAll Tech InnovatorsAlbert D. DonnenbergLudovic ZimmerlinDate Submitted2010-06-09CollectionsRegenerative Medicine
Biodegradable Electrospun Scaffolds for Enhanced Tissue Repair and Cellular Infiltration02170Biodegradable wet-electrospun scaffolds enhance tissue repair with bioactive, integrated fibers for superior cellular infiltration and mechanics.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTagsTissue engineeringBiomaterialPolymerLead InventorYi HongAll Tech InnovatorsNicholas J. AmorosoKazuro Lee FujimotoRyotaro HashizumeDate Submitted2010-03-22CollectionsRegenerative Medicine
A Novel Biohybrid Composite Scaffold02205Elastic biohybrid scaffold combining ECM gel and electrospun elastomer fibers for improved integration and support.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTagsTissue engineeringBiomaterialLead InventorYi HongAll Tech InnovatorsStephen Francis Badylak DVM, PhD, MDRyotaro HashizumeYi HongDate Submitted2010-04-27CollectionsRegenerative Medicine
Acellular Central Nervous System (Spinal Cord)-Derived Product for Tissue Engineering and Regenerative Therapies01915Acellular porcine spinal cord scaffold supports neuronal growth; injectable, lyophilizable CNS biomaterial for regenerative therapy.Technology TypeTherapeutic ModalityTechnology SubtypeProteinTherapeutic AreasNeuroscienceTagsTissue engineeringBiomaterialLead InventorAlan BoruchDepartmentMed-Pharmacology and Chemical BiologyAll Tech InnovatorsAlan V. BoruchDate Submitted2009-02-05
Novel Nanostructured Smart Injectable Bone Cements for Bone Regeneration01918Smart injectable calcium phosphate bone cement carries proteins, DNA, cells, and drugs; enables rapid, porous, 3D-printed, regenerative bone repair.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasMusculoskeletalTherapeutic IndicationsOsteoporosisBone metabolismTagsTissue engineeringAgingBiomaterialLead InventorPrashant KumtaDepartmentBioengineeringAll Tech InnovatorsPrashant N. KumtaAbhijit RoyCharles S. SfeirDate Submitted2009-02-13CollectionsRegenerative MedicineWomen's & Reproductive Health
Novel Peptides for Tissue Reconstruction01877Synthetic peptides recruit patient progenitor cells to injury sites, enabling targeted tissue healing without stem cell harvesting.Technology TypeTherapeutic ModalityTechnology SubtypePeptideTagsTissue engineeringBiomaterialRegenerative medicineLead InventorStephen BadylakDepartmentMed-SurgeryAll Tech InnovatorsStephen Francis Badylak DVM, PhD, MDStephen TotteyDate Submitted2008-11-26CollectionsRegenerative Medicine
Thermoresponsive, Biodegradable, Elastomeric Material01315Biodegradable, thermoresponsive hydrogel that is injectable, ultra-flexible, and shapes with temperature for tissue engineering and drug delivery.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTagsTissue engineeringBiomaterialRegenerative medicineLead InventorWilliam WagnerDepartmentBioengineeringAll Tech InnovatorsJianjun GuanWilliam R. Wagner PhDDate Submitted2006-09-14CollectionsRegenerative Medicine
Biodegradable Polyester Urethane Urea Cardiac Patch01261Biodegradable elastomeric PEUU cardiac patch grows with patient, reduces remodeling, and supports host tissue integration and recovery.Technology TypeMedical DeviceTechnology SubtypeTherapeutic Medical DeviceTherapeutic AreasCardiovascularTagsTissue engineeringBiomaterialLead InventorWilliam WagnerDepartmentBioengineeringAll Tech InnovatorsKazuro Lee FujimotoJianjun GuanBradley B. KellerDate Submitted2006-05-04CollectionsRegenerative MedicineCardiometabolic
Biohybrid Elastomeric Scaffolds for Wound Healing and Tissue Regeneration01174Biohybrid elastomeric scaffolds merge synthetic and biological polymers to enhance wound healing and tissue regeneration.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTagsTissue engineeringBiomaterialRegenerative medicineLead InventorWilliam WagnerDepartmentBioengineeringAll Tech InnovatorsStephen Francis Badylak DVM, PhD, MDDonald O. Freytes MSBMEThomas W. GilbertDate Submitted2005-11-16CollectionsRegenerative Medicine
Cellular Biobandage: A ‘Smart’ Gel for Wound Healing01062Smart, antimicrobial, fast-curing gel with mesenchymal cells to rapidly seal wounds, inhibit inflammation, and boost healing.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTagsTissue engineeringPolymerRegenerative medicineLead InventorEric BeckmanDepartmentChem/Petroleum EngineeringAll Tech InnovatorsStephen Francis Badylak DVM, PhD, MDEric J. BeckmanDonald O. Freytes MSBMETechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2005-03-07CollectionsRegenerative Medicine
Vacuum Seeding Rotational Device00985Vacuum-rotational seeding rapidly coats porous tubular grafts with uniform, high-density cells for ready-to-use tissue-engineered vessels.Technology TypeMedical DeviceTechnology SubtypeTherapeutic Medical DeviceTherapeutic AreasCardiovascularTagsTissue engineeringRegenerative medicinePlastic SurgeryLead Inventor All Tech InnovatorsAlejandro NieponiceLorenzo SolettiDavid A. Vorp Ph.D.Date Submitted2004-08-19CollectionsRegenerative MedicineCardiometabolic