Department

Med-Pediatrics

Hypoplastic Left Heart Syndrome - Novel Mouse Model

05362

CRISPR-validated mouse model replicates HLHS heart defects for drug, device, and gene-therapy development.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Cardiovascular
Lead Inventor: Cecilia Lo
Department: Med-Pediatrics
All Tech Innovators: Cecilia Wen Ya Lo
Date Submitted: 2020-05-15
Collections: Cardiometabolic

Smartphone-based Ultrasonic Respiratory Evaluation

05314

Smartphone ultrasonic respiratory tool (SURe) enables at-home, non-invasive lung function monitoring via built-in mic/speaker.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Respiratory
Lead Inventor: Wei Chen
Department: Med-Pediatrics
All Tech Innovators: Wei Chen
Erick Forno
Wei Gao
Date Submitted: 2020-04-21

Novel Peptide Therapy to Halt the Progression of Chronic and Acute Kidney Disease

07203

HMMR-inhibiting peptides block HA signaling, halting AKI and CKD progression by reducing fibrosis, inflammation, and ERK/mTOR signaling.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Nephrology
Therapeutic Indications: Chronic Kidney Disease (CKD)
Acute Kidney Injury (AKI)
Tags: Autoimmune
Precision medicine
Critical Care
Lead Inventor: Rannar Airik
Department: Med-Pediatrics
All Tech Innovators: Rannar Airik
Merlin Airik
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2025-06-04
Collections: Cardiometabolic

Biomarkers for Diagnosis of Ear and Sinus Infections

07147

A nasal biomarker (IL-1a) plus symptom scores enables precise pediatric bacterial sinusitis diagnosis and antibiotic stewardship.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Otolaryngology
Tags: Biomarker
Clinical Decision Support
Life Science
Lead Inventor: Nader Shaikh
Department: Med-Pediatrics
All Tech Innovators: Nader Shaikh
Date Submitted: 2025-04-11

4D Oxy-Wavelet MRI for Monitoring Mitochondrial Function

06288

Non-invasive 4D Oxy-wavelet MRI tracks mitochondrial function via BOLD, revealing oxygen balance and tissue health in vivo.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Endocrinology and Metabolic Diseases
Therapeutic Indications: Other
Mitochondrial Disease
Tags: Pediatrics
Rare disease
Diagnostic Imaging
Lead Inventor: Yijen Wu
Department: Med-Pediatrics
All Tech Innovators: Anthony G. Christodoulou
Devin Raine Everaldo Cortes
Yijen Wu
Date Submitted: 2023-02-13
Collections: Rare Diseases
Cardiometabolic

Stimulation of Angiogenesis with miRNA as Protection Against Acute Kidney Injury

05448

Therapeutic miRNA approach promotes kidney angiogenesis to protect against acute kidney injury and ischemia-reperfusion damage.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Nephrology
Tags: Regenerative medicine
Lead Inventor: Sunder Lucas
Department: Med-Pediatrics
All Tech Innovators: Takuto Chiba
Jacqueline Ho
Sunder Sims Lucas
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-07-16
Collections: Cell & Gene Therapy
Regenerative Medicine

Antioxidant Therapy for Treating Propionic and Methylmalonic Acidemia

05544

Mitochondria-targeted antioxidants offer a non-invasive therapy to lower reactive oxygen, mitigating damage in propionic and methylmalonic acidemia.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Other
Mitochondrial Disease
Tags: Pediatrics
Rare disease
Lead Inventor: Gerard Vockley
Department: Med-Pediatrics
All Tech Innovators: Gerard Vockley
Peter Wipf
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-10-30
Collections: Rare Diseases
Cardiometabolic

Driving Oxidative Metabolism in Therapeutic T Cells through Overexpression of AMPK

05496

Boosts AMPK-driven oxidative metabolism in T cells to enhance persistence and efficacy of CAR-T and related therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - Lentivirus
Therapeutic Areas: Oncology
Therapeutic Indications: Chronic Myeloid Leukemia (CML)
Chronic Lymphocytic Leukemia (CLL)
Acute Myeloid Leukemia (AML)
Lead Inventor: Craig Byersdorfer
Department: Med-Pediatrics
All Tech Innovators: Craig Alan Byersdorfer
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-08-26
Collections: Cell & Gene Therapy

Gene Therapy for Prader-Willi Syndrome

06241

A multi-gene Prader-Willi gene therapy using a minigene AAV vector to encode up to eight PWS genes for potential treatment.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - AAV
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Prader-Willi Syndrome
Tags: Platform Technology
Lead Inventor: Robert Nicholls
Department: Med-Pediatrics
All Tech Innovators: Robert David Nicholls
Date Submitted: 2022-12-06
Collections: Cell & Gene Therapy
Cardiometabolic

Engaging Together for Healthy Relationships

06061

Interactive ETHR tool educates parents and adolescents in primary care to prevent adolescent relationship abuse.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Maya Ragavan
Department: Med-Pediatrics
All Tech Innovators: Joseph Amodei
Erin Mickievicz
Elizabeth Miller
Date Submitted: 2022-06-22

Polyclonal IgY Immunoassay for Ultra-sensitive Detection of Neuregulin 1 Isoforms

04322

Ultra-sensitive IgY-based ELISA detects multiple Neuregulin 1 isoforms (100 pg/mL), enabling precise cardiovascular biomarker monitoring.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Lead Inventor: Bernhard Kuhn
Department: Med-Pediatrics
All Tech Innovators: Bernhard Kuhn
Date Submitted: 2017-07-12

Enhancing the Activity of Cancer-targeting Immune Cells

06446

AMPK agonist c991 boosts oxidative T cell metabolism during CAR T preparation, enhancing anti-leukemia efficacy in vivo.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Oncology
Therapeutic Indications: Chronic Myeloid Leukemia (CML)
Chronic Lymphocytic Leukemia (CLL)
Acute Myeloid Leukemia (AML)
Lead Inventor: Craig Byersdorfer
Department: Med-Pediatrics
All Tech Innovators: Erica Braverman
Craig Alan Byersdorfer
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-07-02

FSTL-1: a Novel Target for Inflammation

01185

FSTL-1 is a novel proinflammatory target in arthritis; blocking it may reduce inflammation with new therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Immunology
Therapeutic Indications: Rheumatoid arthritis
Inflammation - General
Lead Inventor: Raphael Hirsch
Department: Med-Pediatrics
All Tech Innovators: Raphael Hirsch
Anthony D. Marinov
Takakao Miyamae
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2005-11-29

Novel 4D MRI Method for In Utero Imaging

05257

Innovative 4D MRI combines high-frame-rate cMRI and fMRI with reconstruction software to image fetal and placental development in utero.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Reproductive Health
Therapeutic Indications: Obstetrics
Tags: Diagnostic Imaging
Life Science
Lead Inventor: Yijen Wu
Department: Med-Pediatrics
All Tech Innovators: Anthony G. Christodoulou
Yijen Wu
Date Submitted: 2020-02-25
Collections: Women's & Reproductive Health

Early Warning System for Preventing Necrotizing Enterocolitis (NEC) in Preterm Infants

05327

AI-driven NEC risk predictor for preterm infants using stool microbiome data, clinical features, enabling early intervention. 132 characters

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Gastroenterology
Therapeutic Indications: Other
Tags: Machine learning
Lead Inventor: Thomas Hooven
Department: Med-Pediatrics
All Tech Innovators: Thomas Hooven
Yun Chao Lin
Ansaf Salleb-Aouissi
Date Submitted: 2020-04-29
Collections: Healthcare AI

AOM-SOS Version 5.0: Enhanced Psychometric Scale for Acute Otitis Media

04070

Enhanced AOM-SOS 5.0: six-point pediatric otitis media symptom scale with improved reliability for clinical use and research.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Otolaryngology
Therapeutic Indications: Other
Lead Inventor: Nader Shaikh
Department: Med-Pediatrics
All Tech Innovators: Alejandro Hoberman
Jack L. Paradise
Nader Shaikh
Date Submitted: 2016-11-07

MicFly: Rapid, Single-Cell Phenotyping and Absolute Quantification of Bacterial Microbiota

06270

MicFly integrates surface antibody binding with HCR-based DNA/RNA identity in single bacteria via flow cytometry for absolute quantification.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Immunology
Gastroenterology
Therapeutic Indications: Inflammatory bowel disease
Inflammation - General
Chrohn's Disease
Tags: Pediatrics
Precision medicine
Critical Care
Lead Inventor: Timothy Hand
Department: Med-Pediatrics
All Tech Innovators: Darryl A. Abbott
William H. DePas
Timothy Wesley Hand
Date Submitted: 2023-01-23

Novel Therapeutic Target for Rare Neurological Disease

06177

Discovery of GEMIN5-related neurodevelopmental syndrome; SMN upregulation as a potential gene therapy target for neurological diseases.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Therapeutic Indications: Spinal muscular atrophy (SMA)
Other
Tags: Genetics
Pediatrics
Rare disease
Lead Inventor: Udai Pandey
Department: Med-Pediatrics
All Tech Innovators: Tyler R. Fortuna
Sukhleen Kour
Udai Bhan Pandey
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2022-10-05
Collections: Rare Diseases

Database of Pediatric Kidney Scans for AI Projects

05280

Pediatric kidney scan database with triple-radiologist readings and clinical data enables AI to diagnose and tailor treatments.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Nephrology
Tags: Artificial intelligence (AI)
Clinical Decision Support
Life Science
Lead Inventor: Nader Shaikh
Department: Med-Pediatrics
All Tech Innovators: Nader Shaikh
Date Submitted: 2020-03-19
Collections: Healthcare AI

Synergistic Gene Therapy and Stem Cell Transplant for Comprehensive Krabbe Disease Treatment

04044

Synergistic stem cell transplant and gene therapy delivers GALC systemically, treating CNS and PNS Krabbe disease comprehensively.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - AAV
Therapeutic Areas: Neuroscience
Tags: Pediatrics
Rare disease
Lead Inventor: Maria Escolar
Department: Med-Pediatrics
All Tech Innovators: Maria Luisa Escolar
Paul Szabolcs
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2016-10-10
Collections: Cell & Gene Therapy
Rare Diseases

Tumor Cell–Derived Endothelial Cell Platform for Modeling and Targeting Tumor Angiogenesis

02265

Tumor-derived endothelial cells enable stable tumor angiogenesis modeling and targeted anti-angiogenic therapy screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Lead Inventor: Edward Prochownik
Department: Med-Pediatrics
All Tech Innovators: Edward V. Prochownik MD, PhD
Date Submitted: 2010-07-13

Immune Boost from a Tiny Fraction of a Cord Blood Transplant Graft

05418

Immune-boosting, delayed infusion of 3–5% cord blood enhances T cell recovery in reduced-intensity HSCT for non-malignant pediatric disorders.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Hematology
Tags: Pediatrics
Rare disease
Lead Inventor: Paul Szabolcs
Department: Med-Pediatrics
All Tech Innovators: Paul Szabolcs
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-06-11
Collections: Cell & Gene Therapy
Rare Diseases

Novel Immune-Stimulating Virus for Cancer Therapy

05986

Engineered rrVSV-G selectively targets HER2-positive cancers, boosting immunotherapy with tumor-specific oncolytic viral action.

Technology Type: Therapeutic Modality
Technology Subtype: Oncolytic Virus
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Ira Bergman
Department: Med-Pediatrics
All Tech Innovators: Ira Bergman
Yanhua Gao
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-03-16
Collections: Women's & Reproductive Health

Development of Monoclonal Antibodies to the Nonstructural Proteins of Chikungunya Virus

04665

Advanced monoclonal antibodies target each chikungunya nsP, enabling precise replication studies, broader assays, and antiviral research.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Tags: Antibody - mAb
Lead Inventor: Terence Dermody
Department: Med-Pediatrics
All Tech Innovators: Terence Shawn Dermody
Adaeze Ogochukwu Izuogu
Laurie Anne Silva
Date Submitted: 2018-06-20

Ribosomal Protein-Based Diagnostic and Prognostic Test for Cancer

04267

AI-driven RP transcript patterns diagnose cancer types and predict patient survival, guiding personalized treatment decisions.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Oncology
Lead Inventor: Edward Prochownik
Department: Med-Pediatrics
All Tech Innovators: James Matthew Dolezal
Edward V. Prochownik MD, PhD
Date Submitted: 2017-05-24
Collections: Women's & Reproductive Health
Healthcare AI

Diagnostic for Preventing Necrotizing Enterocolitis (NEC)

04771

Breast milk IgA-based bacterial array predicts NEC prevention potential, guiding donor milk selection to reduce infant risk.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Womens Health
Infectious Disease
Therapeutic Indications: Other
Tags: Pediatrics
Lead Inventor: Timothy Hand
Department: Med-Pediatrics
All Tech Innovators: Kathyayini Parlakoti Gopalakrishna
Timothy Wesley Hand
Michael Jason Morowitz
Date Submitted: 2018-10-15
Collections: Women's & Reproductive Health

Validation of a Multiplex Biomarker Panel for Detection of Abusive Head Trauma in Well-Appearing Children

02655

Rapid, automated four-biomarker blood test (BIBIS) with multivariate scoring detects abusive head trauma in children quickly.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Intensive Care
Therapeutic Indications: Trauma
Tags: Pediatrics
Lead Inventor: Rachel Berger
Department: Med-Pediatrics
All Tech Innovators: Rachel Pardes Berger
Patrick M. Kochanek M.D.
Shlomo Ta'asan
Date Submitted: 2012-01-05

Automated High-Content Live Animal Drug Screening Using C. elegans

01366

Automated C. elegans–based live-animal drug screening platform enables high-content, high-throughput in vivo discovery for neurodegenerative diseases.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Hepatology
Therapeutic Indications: Cirrhosis
Tags: Microscopy
Platform Technology
Lead Inventor: Gary Silverman
Department: Med-Pediatrics
All Tech Innovators: Stephen Chongoh Pak
David Hirsch Perlmutter MD
Gary A. Silverman
Date Submitted: 2006-10-18
Collections: Cardiometabolic

Personalized Nephrotic Syndrome Treatment: A Novel Organotypic Human Kidney Culture System

03358

Personalized ex vivo kidney organoid model tailors nephrotic syndrome treatment, predicting response and minimizing toxicity.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Nephrology
Therapeutic Indications: Nephrosis
Tags: Personalized Medicine
Clinical Decision Support
Drug Development
Lead Inventor: Agnieszka Swiatecka-Urban
Department: Med-Pediatrics
All Tech Innovators: Agnieszka Swiatecka-Urban
Technology Readiness Level: 2. Initial proof-of-concept (PoC)
Date Submitted: 2014-07-03
Collections: Cardiometabolic

Linked Bivalent Small Molecule Inhibitors for Inhibiting c-Myc-Driven Tumor Growth

01847

Linked bivalent inhibitors double-lock c-Myc-Max, delivering high-affinity, selective cancer suppression at low doses.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Oncology
Lead Inventor: Edward Prochownik
Department: Med-Pediatrics
All Tech Innovators: Ariele Viacava Follis
Steven J. Metallo
Edward V. Prochownik MD, PhD
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2008-10-07

Immortalized Breast Cancer Stem Cell Lines for Continuous Self-renewal and Targeted Drug Screening

01687

Reproducible, GFP-labeled breast cancer stem cells maintained by promoter-driven self-renewal enable scalable, targeted drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Edward Prochownik
Department: Med-Pediatrics
All Tech Innovators: Edward V. Prochownik MD, PhD
Date Submitted: 2008-04-04
Collections: Women's & Reproductive Health

Tailored Research Ethics Training and Certification for Community Partners

03326

CPRET offers IRB-approved, PI-led, tailored ethics training for community partners in CBPR, strengthening ethical human-subject research.

Technology Type: Other
Tags: Education Technology
Lead Inventor: Elizabeth Miller
Department: Med-Pediatrics
All Tech Innovators: Jean Marie Barone
Maria Catrina Diestro Jaime
Elizabeth Miller
Date Submitted: 2014-05-23

Anti-Phospho Forkhead Box O6 (FoxO6) Antibody

02711

FoxO6 integrates insulin signaling to control hepatic gluconeogenesis, revealing targets to curb excessive glucose production in insulin resistance.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Hepatology
Lead Inventor: Hengjiang Dong
Department: Med-Pediatrics
All Tech Innovators: Hengjiang Dong
Date Submitted: 2012-03-06

Port Thermometer

04733

A wireless port-attached thermometer provides continuous, non-invasive fever monitoring for mediport patients, alerting caregivers in real time.

Technology Type: Medical Device
Technology Subtype: Monitoring Medical Device
Therapeutic Areas: Infectious Disease
Oncology
Tags: Biomaterial
Lead Inventor: Deirdre Nolfi-Donegan
Department: Med-Pediatrics
All Tech Innovators: Michael Sivan Landau
Quyen Le Ngoc Nguyen
Deirdre S. Nolfi-Donegan
Technology Readiness Level: 2. Initial proof-of-concept (PoC)
Date Submitted: 2018-09-18

UTICalc: Tool to Predict Urinary Tract Infection Risk

03350

UTICalc predicts pediatric UTI risk (2–23 months) to guide urine testing, reducing invasive procedures and delays.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Urology
Lead Inventor: Nader Shaikh
Department: Med-Pediatrics
All Tech Innovators: Nader Shaikh
Timothy R. Shope
Date Submitted: 2014-06-23

Treatment of Medium Chain Acyl-CoA Dehydrogenase Deficiency

02591

Novel therapy stabilizes mutant MCAD enzyme in MCADD using phenylbutyryl-CoA, boosting fatty acid oxidation and patient outcomes.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Metabolic Disease
Tags: Drug Development
Life Science
Pediatric Medicine
Lead Inventor: Al-Walid Mohsen
Department: Med-Pediatrics
All Tech Innovators: Al-Walid A. Mohsen
Gerard Vockley
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2011-10-12

Orenstein-I-GERQ Survey Instrument

00770

A standardized, dual-tool infant GERD assessment balancing rich context with a 13-item quick scale for longitudinal, precise care.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Gastroenterology
Therapeutic Indications: Reflux
Lead Inventor: Susan Orenstein
Department: Med-Pediatrics
All Tech Innovators: Susan R. Orenstein
Date Submitted: 2002-11-06

Novel Treatments for Mitochondrial Disorders

03999

Personalized, pathway-targeted therapies for mitochondrial disorders by downstream enzyme inhibition; expands beyond diet management.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Other
Lead Inventor: Al-Walid Mohsen
Department: Med-Pediatrics
All Tech Innovators: Al-Walid A. Mohsen
Gerard Vockley
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2016-07-29
Collections: Cardiometabolic