Automated 3D OCT Vessel Segmentation Framework for Precise Retinal Blood Vessel Mapping01998Automated 3D SD-OCT vessel segmentation fuses 2D fundus and 3D OCT cues for robust retinal vessel mapping and early disease detection.Technology TypeMedical DeviceTechnology SubtypeDiagnostic ImagingTherapeutic AreasOphthalmologyTherapeutic IndicationsGlaucomaTagsMicroscopyLead InventorJuan XuDepartmentMed-OphthalmologyAll Tech InnovatorsHiroshi IshikawaJoel Steven SchumanDavid TolliverDate Submitted2009-05-11
Dipeptidyl Peptidase-4 (DPP4) Inhibitors for Inhibiting Posterior Capsular Opacification07055DPP4 inhibitors delivered locally prevent posterior capsular opacification by blocking TGF-β–driven EMT in lens cells.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasOphthalmologyTherapeutic IndicationsCataractsTagsAgingDrug RepurposingLead InventorKun Che ChangDepartmentMed-OphthalmologyAll Tech InnovatorsKun Che ChangChi-Yu ChenPei-Kang LiuTechnology Readiness Level4. Pre-clinical developmentDate Submitted2025-01-31CollectionsRegenerative Medicine
Automated OCT-Based Tissue Screening System06669Automated OCT tissue screening with deep learning for label-free, high-throughput, quantitative 3-D tissue analysis and drug screening.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasOphthalmologyTagsMicroscopyMachine learningPlatform TechnologyLead InventorShaohua PiDepartmentMed-OphthalmologyAll Tech InnovatorsYuanyuan ChenShaohua PiJose Alain SahelTechnology Readiness Level4. Prototype testing and refinementDate Submitted2024-03-06
pTol2- fTyrp1- Enhanced Green Fluorescent Protein05098Engineered Tol2-based plasmid drives cell-specific EGFP in zebrafish melanophores for stable, real-time visualization.Technology TypeLife Science Research ToolLead InventorXiangyun WeiDepartmentMed-OphthalmologyAll Tech InnovatorsXiangyun WeiDate Submitted2019-08-23
Novel Repair and Regeneration Therapy for Glaucoma07246AAV-Ina overexpression promotes retinal ganglion cell survival and axon regeneration, offering neuroprotection for glaucoma with regeneration potential.Technology TypeTherapeutic ModalityTherapeutic AreasNeuroscienceOphthalmologyTherapeutic IndicationsGlaucomaTagsDrug Discovery - TargetLife ScienceLead InventorKun Che ChangDepartmentMed-OphthalmologyAll Tech InnovatorsKun Che ChangChi-Yu ChenDate Submitted2025-07-11
Plasmin-Enhanced Transplantation of Retinal Ganglion Cells via Internal Limiting Membrane Digestion07056Plasmin digests the retinal ILM to improve donor retinal ganglion cell transplantation, boosting survival without inflammation.Technology TypeLife Science Research ToolTechnology SubtypeProteinTherapeutic AreasOphthalmologyTherapeutic IndicationsOtherLead InventorKun Che ChangDepartmentMed-OphthalmologyAll Tech InnovatorsKun Che ChangDimitrios StavropoulosDate Submitted2025-01-31
Anti-Inflammatory Biotherapeutics for Eye Wound06908Engineered eye bacteria deliver IL-10 to corneal wounds, accelerating healing with a novel, low-maintenance ocular therapy.Technology TypeTherapeutic ModalityTechnology SubtypeProteinTherapeutic AreasOphthalmologyTherapeutic IndicationsOcular hypertensionTagsLife ScienceLead InventorAnthony St LegerDepartmentMed-OphthalmologyAll Tech InnovatorsJackie Lynn ShaneAnthony J. St LegerDate Submitted2024-09-30CollectionsRegenerative Medicine
Novel Genetically Encoded Nanoparticles05910Genetically encoded nanoparticles target and protect cells, enabling precision antibacterial, anticancer therapies and radiation shielding.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasInfectious DiseaseOncologyLead InventorOr ShemeshDepartmentMed-OphthalmologyAll Tech InnovatorsOr ShemeshDate Submitted2021-12-06
A Neuromorphic Brain Decoding Method for Brain-Machine Interfaces05119Neuromorphic BMI decoding uses precise spike-time dynamics, outperforming rate coding to accurately infer intended hand movements.Technology TypeMedical DeviceTechnology SubtypeRehab or Assistive Medical DeviceTherapeutic AreasNeuroscienceTherapeutic IndicationsOtherTagsHuman performanceLead InventorBenjamin BenosmanDepartmentMed-OphthalmologyAll Tech InnovatorsHimanshu AkolkarBenjamin BenosmanAndrew B. SchwartzDate Submitted2019-09-24
Comparing OCT Scans from Baseline and Follow Up06320New OCT/OCTA 3D change-mapping algorithm compares baseline vs. follow-up scans without layer segmentation, enabling earlier retinal disease insight.Technology TypeMedical DeviceTechnology SubtypeDiagnostic ImagingTherapeutic AreasOphthalmologyLead InventorShaohua PiDepartmentMed-OphthalmologyAll Tech InnovatorsShaohua PiBingjie WangDate Submitted2023-02-28
Deep Learning System for Noise-Free Optical Coherence Tomography (OCT) Imaging without Clean Training Data06607Dual-scan, noise-free OCT denoising via Sub2Full: train on two noisy scans to reveal fine retinal structures without clean data.Technology TypeDigital HealthTechnology SubtypeHealthcare DataTherapeutic AreasOphthalmologyTherapeutic IndicationsDiabetic retinopathyTagsArtificial intelligence (AI)MicroscopyMachine learningLead InventorShaohua PiDepartmentMed-OphthalmologyAll Tech InnovatorsShaohua PiLingyun WangTechnology Readiness Level5. Advanced prototype validationDate Submitted2024-01-10CollectionsHealthcare AI
TriaGel: Comprehensive Gel Eye Dressing to Revolutionize Ocular First Aid04068TriaGel: a rapid, injectable ocular gel that stabilizes injuries, delivers anti-inflammatories, reduces complications and costs.Technology TypeEngineering TechnologyTechnology SubtypeIndustrial BiotechTherapeutic AreasIntensive CareOphthalmologyTagsRegenerative medicineMaterial ScienceLead InventorMorgan DileoDepartmentMed-OphthalmologyAll Tech InnovatorsMorgan Virginia DileoJenny YuDate Submitted2016-11-07CollectionsRegenerative Medicine
Novel Treatment for Posterior Capsulation06621GDF-15 blocks EMT to prevent posterior capsular opacification, potentially reducing recurrent surgeries and vision loss.Technology TypeTherapeutic ModalityTechnology SubtypeProteinTherapeutic AreasOphthalmologyTherapeutic IndicationsCataractsLead InventorKun Che ChangDepartmentMed-OphthalmologyAll Tech InnovatorsKun Che ChangChi-Yu ChenShining WangTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2024-01-31CollectionsRegenerative Medicine
Novel Methods for Treating Glaucoma06441Laser-irradiation photomodulates ocular tissue mechanics to stiffen or soften sclera, boosting glaucoma resilience without viruses.Technology TypeTherapeutic ModalityTechnology SubtypeOther Therapeutic ModalityTherapeutic AreasOphthalmologyTherapeutic IndicationsGlaucomaLead InventorIan SigalDepartmentMed-OphthalmologyAll Tech InnovatorsPo-Yi LeeIan Alejandro SigalTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2023-06-27
Noninvasive & Long-Acting Thermoresponsive Hydrogel for Sustained Ocular Drug Delivery02867Noninvasive, thermoresponsive ocular gel with drug-loaded microparticles enables month-long, drop-free sustained eye treatment.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOphthalmologyTherapeutic IndicationsOtherGlaucomaDry eye syndromeLead InventorMorgan DileoDepartmentMed-OphthalmologyAll Tech InnovatorsAnthony CuginiMorgan Virginia DileoSteven R. LittleTechnology Readiness Level4. Pre-clinical developmentDate Submitted2012-08-14
High-Precision Vision Restoration Using Soma-Targeted Optogenetics06357Soma-targeted opsins enable single-cell-resolution retinal activation, improving high-acuity vision with reduced cross-activation for restoration.Technology TypeTherapeutic ModalityTechnology SubtypeProteinTherapeutic AreasOphthalmologyTherapeutic IndicationsRetinitis pigmentosa (RP)Diabetic retinopathyAge-related macular degenerationLead InventorOr ShemeshDepartmentMed-OphthalmologyAll Tech InnovatorsPururav RamakrishnaOr ShemeshDate Submitted2023-03-21
Optimizing Corneal Stem Cell Therapy: Quality Screening for Enhanced Regenerative Outcomes06002Quality-controlled corneal stem cells selected by regenerative indicators enhance healing potential and consistency in scar treatment.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - Stem CellTherapeutic AreasOphthalmologyLead InventorHin-Fai YamDepartmentMed-OphthalmologyAll Tech InnovatorsIsabelle BilligDeepinder K. Dhaliwal M.D.Yiqin DuTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2022-04-13CollectionsCell & Gene TherapyRegenerative Medicine
Optical Coherence Tomography (OCT) Image Enhancement03534Virtual averaging accelerates OCT scanning by 80%, producing frame-averaged-quality images from rapid, nonframe-averaged data.Technology TypeMedical DeviceTechnology SubtypeDiagnostic ImagingTherapeutic AreasOphthalmologyLead InventorHiroshi IshikawaDepartmentMed-OphthalmologyAll Tech InnovatorsChieh-Li ChenHiroshi IshikawaJoel Steven SchumanDate Submitted2015-03-04
Image Registration for the Analysis of Fixational Eye Movement05074Synthetic-reference registration extracts fine-scale fixational eye movements from noisy, artifacted SLO frames for robust high-resolution diagnostics.Technology TypeDiagnostic/AssayTechnology SubtypeOther Diagnostic/AssayTherapeutic AreasOphthalmologyLead InventorEthan RossiDepartmentMed-OphthalmologyAll Tech InnovatorsEthan A. RossiMin ZhangDate Submitted2019-08-02
Delivery of Biological Drugs to Epithelia04508Anchoring domains bind wet epithelia to prevent washout, enabling extended delivery of biologics to eyes, lungs, and mucosal tissues.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasRespiratoryOphthalmologyTherapeutic IndicationsChronic Obstructive Pulmonary Disease (COPD)AsthmaDry eye syndromeLead InventorRobert ShanksDepartmentMed-OphthalmologyAll Tech InnovatorsJes K. KlarlundRobert Michael Queen ShanksTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2018-02-15CollectionsWomen's & Reproductive Health
Thermoresponsive Hydrogel Containing Polymer Microparticles for Controlled Drug Delivery to the Ear03810Single-dose, thermoresponsive ear gel with PLGA microspheres for 14-day ciprofloxacin release and lidocaine.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtolaryngologyTagsPolymerPlatform TechnologyLead InventorMorgan DileoDepartmentMed-OphthalmologyAll Tech InnovatorsLiza Anna BrukMorgan Virginia DileoSteven R. LittleDate Submitted2016-01-26
Non-contact OCT Imaging and Analysis System for 3D Visualization and Monitoring of Limbal Palisades02412Non-contact 3D OCT maps Palisades of Vogt for limbal stem cell niche profiling, disease monitoring, and donor assessment.Technology TypeMedical DeviceTechnology SubtypeDiagnostic ImagingTherapeutic AreasOphthalmologyLead InventorKira LathropDepartmentMed-OphthalmologyAll Tech InnovatorsLawrence E. Kagemann JrKira L. LathropJoel Steven SchumanDate Submitted2011-02-22
Innovative Screening Device for Early Detection of Retinal Ischemia in Diabetics00900A non-invasive pupillography device quantitatively detects retinal ischemia in diabetics, enabling quick primary-care screening and monitoring.Technology TypeDiagnostic/AssayTechnology SubtypeOther Diagnostic/AssayTherapeutic AreasOphthalmologyTherapeutic IndicationsDiabetic retinopathyLead InventorMichael GorinDepartmentMed-OphthalmologyAll Tech InnovatorsMichael B. GorinDate Submitted2004-01-22
A Novel Method of Visualizing Three-Dimensional Image Datasets01481New 3D imaging visualization adapts to tissue curvature, reducing artifacts across MRI, CT, ultrasound, and OCT for accurate clinical insight.Technology TypeDigital HealthTechnology SubtypeHealthcare DataTherapeutic AreasOphthalmologyLead InventorHiroshi IshikawaDepartmentMed-OphthalmologyAll Tech InnovatorsHiroshi IshikawaJoel Steven SchumanDate Submitted2007-04-16
Novel Autologus Serum Insert for Dry Eye Disease06434Autologous serum ocular insert stabilizes, daily-delivery dry eye treatment; longer shelf-life, fewer administrations than eyedrops.Technology TypeMedical DeviceTherapeutic AreasOphthalmologyTherapeutic IndicationsDry eye syndromeLead InventorMorgan DileoDepartmentMed-OphthalmologyAll Tech InnovatorsMorgan Virginia DileoVishal JhanjiTechnology Readiness Level3. Prototype developmentDate Submitted2023-06-19
Automated SD-OCT Optic Nerve Head Assessment System for Disc and Cup Segmentation and Glaucoma Classification01627Automated SD-OCT ONH system segments disc/cup, quantifies metrics, and classifies glaucoma via a trained shape model.Technology TypeDigital HealthTechnology SubtypeClinical Decision SupportTherapeutic AreasOphthalmologyTherapeutic IndicationsGlaucomaLead InventorHiroshi IshikawaDepartmentMed-OphthalmologyAll Tech InnovatorsHiroshi IshikawaJoel Steven SchumanChaim-Gadi WollsteinDate Submitted2008-01-17
Mapping of Internal Features on En-Face Imagery03453Bidirectional OCT-to-map system creates 3D ocular maps integrating SSADA, pseudo-coloring, and functional metrics for MIGS planning.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceLead InventorLawrence KagemannDepartmentMed-OphthalmologyAll Tech InnovatorsLawrence E. Kagemann JrSayoko Eileen MoroiJoel Steven SchumanDate Submitted2014-11-20
Topical Ethyl Pyruvate for Eye Scar Prevention01536Ethyl pyruvate as a safe, topical anti-scarring treatment for corneal injuries and post-surgery healing.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasDermatologyOphthalmologyLead InventorNirmala Sundar RajDepartmentMed-OphthalmologyAll Tech InnovatorsJames L. FunderburghJoel Steven SchumanNirmala Sundar RajTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2007-07-17CollectionsRegenerative Medicine
Susceptibility Genes for Age-Related Maculopathy (ARM) on Chromosome 10q2601066Identifies ARM risk via PLEKHA1 and LOC387715 variations on chromosome 10q26; enables predictive assays and arrays.Technology TypeDiagnostic/AssayTechnology SubtypeBiomarkerTherapeutic AreasOphthalmologyTherapeutic IndicationsAge-related macular degenerationLead InventorMichael GorinDepartmentMed-OphthalmologyAll Tech InnovatorsYvette Perry ConleyRobert E. Ferrell Ph.D.Michael B. GorinDate Submitted2005-03-15
Cross-dimensional OCT Registration for Aligning 2D Scans with 3D Volumes across Devices01633Cross-Device OCT alignment enables 2D-3D registration across time and platforms, preserving history and reducing variability.Technology TypeMedical DeviceTechnology SubtypeDiagnostic ImagingTherapeutic AreasOphthalmologyLead InventorHiroshi IshikawaDepartmentMed-OphthalmologyAll Tech InnovatorsHiroshi IshikawaJongsick S. KimJoel Steven SchumanDate Submitted2008-02-04
Novel Vector for Making Transgenic Animals for Genetic Regulation01151A cell-specific, inducible transgenic RNAi system downregulates target genes temporally, reducing developmental artifacts across species.Technology TypeLife Science Research ToolTechnology SubtypeAnimal ModelLead InventorXiangyun WeiDepartmentMed-OphthalmologyAll Tech InnovatorsXiangyun WeiJian ZouDate Submitted2005-09-07
