Revolutionary Perfusion Solution for Extended Organ Preservation and Improved Transplant Outcomes02777Oxygenated acellular hemoglobin perfusate preserves organs longer at sub‑normothermia, improving transplant viability and function.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTagsTissue engineeringSurgeryLead InventorPaulo FontesDepartmentMed-SurgeryAll Tech InnovatorsPaulo Artur Chaves FontesDate Submitted2012-05-24
Vasculogenic Reprogramming for Diabetic Wound Healing and Ischemic Tissue Regeneration06874Vasculogenic reprogramming via Tissue Nanotransfection induces vasculogenic fibroblasts, boosting diabetic wound healing and ischemic tissue regeneration.Technology TypeTherapeutic ModalityTechnology SubtypeGene Therapy - DNATherapeutic AreasEndocrinology and Metabolic DiseasesTherapeutic IndicationsDiabetesLead InventorChandan SenDepartmentMed-SurgeryAll Tech InnovatorsSujit Kumar MohantySashwati RoyChandan SenTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2024-09-16CollectionsCell & Gene TherapyRegenerative MedicineCardiometabolic
Restoring Sensation: Cutting-Edge Skin Reprogramming to Combat Diabetic Nerve Damage06619Skin-to-Schwann-like reprogramming via TNT delivers ASK factors, restoring sensation and promoting nerve repair in diabetic neuropathy.Technology TypeTherapeutic ModalityTechnology SubtypeGene Therapy - DNATherapeutic AreasNeuroscienceTagsGeneticsLead InventorChandan SenDepartmentMed-SurgeryAll Tech InnovatorsRaghunath Reddy Raghunath BommanaSavita KhannaRavichand PalakurtiTechnology Readiness Level4. Pre-clinical developmentDate Submitted2024-01-29CollectionsCell & Gene Therapy
B Cell-Based Biomarker for Detecting Acute Renal Transplant Rejection06574A blood test using B cell markers and machine learning detects acute renal transplant rejection noninvasively with high accuracy.Technology TypeDiagnostic/AssayTechnology SubtypeBiomarkerTherapeutic AreasNephrologyImmunologyTherapeutic IndicationsOtherLead InventorDavid RothsteinDepartmentMed-SurgeryAll Tech InnovatorsAravind CherukuriDavid Mark RothsteinDate Submitted2023-11-27
A Genetically Engineered Mouse Model of Inflammatory Brain Injury05385CRISPR-edited mouse model replicates Aicardi-Goutières neuroinflammation for drug screening, target validation, and biomarker discovery.Technology TypeLife Science Research ToolTechnology SubtypeAnimal ModelTherapeutic AreasNeuroscienceLead InventorQingde WangDepartmentMed-SurgeryAll Tech InnovatorsXinfeng GuoQingde WangDate Submitted2020-05-28
Novel Small-Diameter Vascular Graft for Tissue Engineering04295Three-layer, bio-inspired 2–3 mm TEVGs mimic coronary arteries, combining ES, cECM, and TIPS for scalable grafts.Technology TypeMedical DeviceTechnology SubtypeImplantable Medical DeviceTherapeutic AreasCardiovascularLead InventorAntonio DAmoreDepartmentMed-SurgeryAll Tech InnovatorsAntonio DAmoreMatteo SolazzoWilliam R. Wagner PhDDate Submitted2017-06-14CollectionsCardiometabolic
Self-Powered Pulse Generator for Drug Delivery06632Self-powered, battery-free pulse generator delivers precise high-voltage electrical pulses for topical gene and drug delivery.Technology TypeMedical DeviceTechnology SubtypeTherapeutic Medical DeviceTagsMaterial ScienceLead InventorChandan SenDepartmentMed-SurgeryAll Tech InnovatorsSubhadip GhatakChandan SenYi XuanDate Submitted2024-02-06
Producing Tumor Infiltrating T Cells for Immunotherapy05193Rapid, scalable expansion of tumor-infiltrating γδ T cells enables MHC-independent, durable immunotherapy for solid tumors.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - T CellTherapeutic AreasOncologyTagsImmuno-oncologyLead InventorMichael LotzeDepartmentMed-SurgeryAll Tech InnovatorsMichael T. Lotze M.D.Pranav MurthyDate Submitted2019-12-07CollectionsCell & Gene Therapy
Novel Processing Method and Apparatus for Micro-Structured Rope-Like Material04694Continuous mandrel-less electrospun ropes with tunable diameter and fiber orientation for regenerative tendon, nerve, and suture applications.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasMusculoskeletalTagsPolymerTissue engineeringLead InventorAntonio DAmoreDepartmentMed-SurgeryAll Tech InnovatorsAntonio DAmoreDaniel T. McKeelWilliam R. Wagner PhDDate Submitted2018-07-30CollectionsRegenerative Medicine
Eomesodermin as a Biomarker for Allograft Rejection03456Eomesodermin as a noninvasive biomarker predicts transplant rejection risk by monitoring memory T cell activity to guide therapy.Technology TypeDiagnostic/AssayTechnology SubtypeBiomarkerTherapeutic AreasSurgeryImmunologyTherapeutic IndicationsOtherLead InventorMohamed EzzelarabDepartmentMed-SurgeryAll Tech InnovatorsMohamed Borhami EzzelarabAngus W. ThomsonDate Submitted2014-11-25
Universal CAR T Cells Supercharge Antibody-Drug Conjugates for Broad Oncology Applications06538Universal CAR T cells pair with antibody-drug conjugates to enhance targeting, broaden cancer applicability, and overcome resistance.Technology TypeTherapeutic ModalityTechnology SubtypeAntibody - mAbTherapeutic AreasOncologyLead InventorJason LohmuellerDepartmentMed-SurgeryAll Tech InnovatorsAlexander DeitersJason Jakob LohmuellerElisa RuffoDate Submitted2023-10-10
E-mag System for Rapid Cannulation of Fenestrated Endovascular Grafts04371Electromagnetically guided cannulation device (E-mag) speeds fenestrated graft wiring, reduces radiation and contrast exposure during aortic repair.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasCardiovascularTagsSurgeryLead InventorBryan TillmanDepartmentMed-SurgeryAll Tech InnovatorsYoungjae Jae ChunCatherine C. GoBryan W. TillmanDate Submitted2017-09-13CollectionsCardiometabolic
Epigenetic Enhancement of VEGF Therapy for Ischemic Tissue Revascularization06723Epigenetically enhance VEGF therapy for diabetic ischemic wounds via targeted demethylation, boosting revascularization and healing.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Discovery - TargetTherapeutic AreasDermatologyTherapeutic IndicationsOtherLead InventorNo Name Given KanhaiyaDepartmentMed-SurgeryAll Tech InnovatorsNo Name Given KanhaiyaChandan SenSumit Singh VermaDate Submitted2024-04-18CollectionsRegenerative Medicine
Novel Peptides for Tissue Reconstruction01877Synthetic peptides recruit patient progenitor cells to injury sites, enabling targeted tissue healing without stem cell harvesting.Technology TypeTherapeutic ModalityTechnology SubtypePeptideTagsBiomaterialRegenerative medicineTissue engineeringLead InventorStephen BadylakDepartmentMed-SurgeryAll Tech InnovatorsStephen Francis Badylak DVM, PhD, MDStephen TotteyDate Submitted2008-11-26CollectionsRegenerative Medicine
Novel Therapy to Prevent Organ Transplant Rejection06909WS6 inhibitor targets tissue-resident memory T cells, potentially preventing organ transplant rejection with reduced broad immunosuppression.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasImmunologyTherapeutic IndicationsOtherTagsDrug Discovery - TargetLife ScienceLead InventorKhodor Abou DayaDepartmentMed-SurgeryAll Tech InnovatorsKhodor Abou DayaDate Submitted2024-10-01
Gene Therapy Targeting Type 2 Diabetes05593Gene therapy silences smad2 to boost insulin secretion and β-cell function, potentially reversing diet-induced diabetes.Technology TypeTherapeutic ModalityTechnology SubtypeGene Therapy - RNATherapeutic AreasEndocrinology and Metabolic DiseasesTherapeutic IndicationsDiabetesLead InventorGeorge GittesDepartmentMed-SurgeryAll Tech InnovatorsGeorge K. GittesKrishna PrasadanTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2021-01-15CollectionsCell & Gene TherapyCardiometabolic
An Organ Perfusion Stent for Transplant Organ Recovery03146An endovascular dual-chamber stent perfuses abdominal organs during cardiac death, preserving organs for transplantation without harming the donor.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasCardiovascularLead InventorBryan TillmanDepartmentMed-SurgeryAll Tech InnovatorsAmit D. TevarBryan W. TillmanTechnology Readiness Level4. Prototype testing and refinementDate Submitted2013-10-13CollectionsCardiometabolic
Novel Therapy to Prevent Transplanted Organ Rejection (DCreg)05684Regulatory dendritic cells from donor liver perfusate enable immunosuppression withdrawal, reducing organ rejection risk.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - NK CellTherapeutic AreasNeuroscienceTagsPlatform TechnologySurgeryLife ScienceLead InventorAngus ThomsonDepartmentMed-SurgeryAll Tech InnovatorsEster BadamiPier Giulio ConaldiFadi G. Lakkis M.D.Technology Readiness Level6. IND-enabling studiesDate Submitted2021-04-30CollectionsCell & Gene Therapy
Augmenter of Liver Regeneration Knockout Mouse05045A hepatocyte-specific ALR knockout mouse models progressive liver disease, enabling preclinical NASH, fibrosis, and cancer research.Technology TypeLife Science Research ToolTechnology SubtypeAnimal ModelTherapeutic AreasHepatologyLead InventorChandrashekhar GandhiDepartmentMed-SurgeryAll Tech InnovatorsChandrashekhar R. GandhiDate Submitted2019-07-03
Innovative NO2-OA Release Platform for Enhanced Angiogenesis in Abdominal Wall Repair04294Nitro-oleic acid release from PECUU-ECM scaffolds enhances regional angiogenesis for improved abdominal wall repair and integration.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasGastroenterologyTherapeutic IndicationsOtherLead InventorAntonio DAmoreDepartmentMed-SurgeryAll Tech InnovatorsAntonio DAmoreMarco FazzariBruce A. FreemanDate Submitted2017-06-14CollectionsRegenerative Medicine
An Expandable Percutaneous Venous Cannula for Use in Extracorporeal Cardiopulmonary Support03884Expandable single‑cannula ECMO device conforming to atrial anatomy for complete, low‑occlusion venous drainage via percutaneous deploymentTechnology TypeMedical DeviceTechnology SubtypeTherapeutic Medical DeviceTherapeutic AreasRespiratoryCardiovascularTagsBiomaterialPolymerLead InventorAntonio DAmoreDepartmentMed-SurgeryAll Tech InnovatorsVinay BadhwarAntonio DAmoreDaniel T. McKeelDate Submitted2016-04-04CollectionsCardiometabolic
T Cell Receptors Targeting Mutations in RNA Splicing Factors04989Engineered TCRs target mutated RNA splicing factors across cancers, offering personalized immunotherapy with no reactivity to normal proteins.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - T CellTherapeutic AreasImmunologyOncologyTherapeutic IndicationsOcular/ uveal melanomaChronic Lymphocytic Leukemia (CLL)Ductal carcinoma (Breast cancer)TagsImmuno-oncologyLead InventorUdai KammulaDepartmentMed-SurgeryAll Tech InnovatorsChetana BhaskarlaUdai Shankar KammulaGhanshyam Singh YadavTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2019-05-10CollectionsCell & Gene TherapyWomen's & Reproductive Health
Mixed Radiographic Contrast Agent and Acetic Acid for Pancreatic Infusion06417Novel infusion blends acetic acid with radiographic contrast to ablate exocrine pancreas while preserving islets, enabling targeted therapy.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasHepatologyEndocrinology and Metabolic DiseasesTherapeutic IndicationsDiabetesLead InventorGeorge GittesDepartmentMed-SurgeryAll Tech InnovatorsGeorge K. GittesHannah Rinehardt MDTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2023-05-25CollectionsCardiometabolic
Whole Organ Therapeutic Ultrasound Delivery and Containment Device05903Whole-organ ultrasound device purges microthrombi in ex vivo liver perfusion to reduce ischemic cholangiopathy and boost transplant viability.Technology TypeTherapeutic ModalityTechnology SubtypeOther Therapeutic ModalityTherapeutic AreasHepatologyTherapeutic IndicationsOtherLead InventorChristopher HughesDepartmentMed-SurgeryAll Tech InnovatorsXucai ChenChristopher B. HughesYermek NigmetTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2021-12-01
Chemical Pancreatectomy Using Ethanol Infusion04181Endoscopic acetic acid infusion selectively ablates exocrine pancreas to relieve pancreatitis pain and preserve insulin.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasSurgeryEndocrinology and Metabolic DiseasesTagsAutoimmuneMinimally invasiveLead InventorGeorge GittesDepartmentMed-SurgeryAll Tech InnovatorsGeorge K. GittesDate Submitted2017-03-06CollectionsCardiometabolic
Compounds that Convert Acinar Cells into Insulin-Producing Beta Cells03854Compound converts pancreatic acinar cells into insulin-producing beta-like cells, normalizing glucose in diabetes models.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasEndocrinology and Metabolic DiseasesLead InventorFarzad EsniDepartmentMed-SurgeryAll Tech InnovatorsFarzad EsniTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2016-03-08CollectionsCardiometabolic
Distal Perfusion Device for Traumatic Aortic Injury and Complex Aortic Repair02991A portable distal perfusion device stabilizes traumatic torso injuries, preserves distal blood flow, and aids frontline hemorrhage control.Technology TypeMedical DeviceTechnology SubtypeSurgical Medical DeviceTherapeutic AreasCardiovascularLead InventorBryan TillmanDepartmentMed-SurgeryAll Tech InnovatorsBryan W. TillmanDate Submitted2013-02-25CollectionsCardiometabolic
Epidural Spinal Cord Stimulation System for Improving Neurodegenerative Motor Functions06717Indirect sensory-nerve stimulation via epidural spinal cord system may improve breathing, speech, and swallowing in neurodegenerative disease.Technology TypeMedical DeviceTechnology SubtypeTherapeutic Medical DeviceTherapeutic AreasRespiratoryNeuroscienceTherapeutic IndicationsSpinal muscular atrophy (SMA)Parkinson's DiseaseMultiple Sclerosis (MS)Lead InventorDaryl FieldsDepartmentMed-SurgeryAll Tech InnovatorsDaryl FieldsTechnology Readiness Level4. Prototype testing and refinementDate Submitted2024-04-15
SToPVTE: Screening to Prevent Venous Thromboembolism04936SToPVTE is an EHR-embedded CDSS predicting VTE risk over recovery, guiding personalized prophylaxis dosing and duration.Technology TypeDigital HealthTechnology SubtypeClinical Decision SupportTherapeutic AreasCardiovascularTagsMachine learningLead InventorMatthew NealDepartmentMed-SurgeryAll Tech InnovatorsSara Poorfarahani MyersMatthew D. NealDate Submitted2019-04-01CollectionsCardiometabolic
Targeted Immune Cell Therapy Using CCL22 Muteins for Enhanced Precision06493Precise immune cell targeting via CCL22 muteins and engineered CCR4 receptors, boosting therapy localization and reducing off-target effects.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationLead InventorHeth TurnquistDepartmentMed-SurgeryAll Tech InnovatorsStephen C. BalmertMatthew Andrew BorrelliSteven R. LittleDate Submitted2023-08-24
STopVTE: A Clinical Decision Support Tool to Accurately Predict and Prevent Postoperative VTE05160Dynamic EHR-based CDS (STopVTE) updates daily VTE risk, personalizes prevention, and reduces perioperative VTE and bleeding events.Technology TypeDigital HealthTechnology SubtypeClinical Decision SupportTherapeutic AreasCardiovascularTagsClinical Decision SupportLead InventorMatthew NealDepartmentMed-SurgeryAll Tech InnovatorsRobert HandzelSara Poorfarahani MyersMatthew D. NealTechnology Readiness Level3. Prototype developmentDate Submitted2019-11-05CollectionsCardiometabolic
Hydractinia RNA as a Research Tool04833RNA from Hydractinia enables new tools for stem cell, developmental, and regenerative research, linking animal genes to human biology.Technology TypeLife Science Research ToolTechnology SubtypeNucleic AcidTherapeutic AreasOtherLead InventorMatthew NicotraDepartmentMed-SurgeryAll Tech InnovatorsMatthew L. NicotraSteven M. SandersDate Submitted2018-12-07
Platform for Rapid Stratification of Trauma Patients04199A rapid, point-of-care biomarker platform stratifies trauma patients in 60–90 minutes, guiding personalized treatment.Technology TypeDiagnostic/AssayTechnology SubtypeBiomarkerTherapeutic AreasIntensive CareTherapeutic IndicationsTraumaLead InventorTimothy BilliarDepartmentMed-SurgeryAll Tech InnovatorsTimothy R. BilliarGregory M. ConstantineQi MiDate Submitted2017-03-23
Animal Model for Acute Liver Failure01977A monkey model simulates controllable acute liver failure via liver-directed radiation and mild hepatotoxic injury, aiding research.Technology TypeLife Science Research ToolTechnology SubtypeAnimal ModelTherapeutic AreasHepatologyTherapeutic IndicationsOtherLead InventorIra FoxDepartmentMed-SurgeryAll Tech InnovatorsIra Jacob FoxDate Submitted2009-04-16
Modeling Wound Healing01265Agent-based in silico wound-healing model simulates inflammation, tissue damage, and therapies for personalized clinical predictions.Technology TypeLife Science Research ToolTechnology SubtypeBioinformaticsTherapeutic AreasIntensive CareImmunologyTherapeutic IndicationsTraumaTagsImmuno-oncologyRegenerative medicineLead InventorYoram VodovotzDepartmentMed-SurgeryAll Tech InnovatorsGilles ClermontPatricia Ann Hebda Ph.D.Yee Key LiDate Submitted2006-05-10CollectionsRegenerative Medicine
Semapimod Inhibits the Expression of the Proapoptotic and Proinflammatory Proteins HMGB1, Bad, Bax and COX-201087Semapimod lowers intestinal HMGB1, Bad, Bax, COX-2 in NEC-prone rats, reducing injury and inflammation.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasGastroenterologyTherapeutic IndicationsOtherTagsDrug RepurposingLead InventorRuben ZamoraDepartmentMed-SurgeryAll Tech InnovatorsHenri R. FordRuben ZamoraDate Submitted2005-04-15
DataDigger: A Quick, Flexible Search Engine for Biomarker Data04527DataDigger: flexible, cloud-capable tool for multi-file biomarker data search and SNP-based patient subset querying.Technology TypeLife Science Research ToolTechnology SubtypeBioinformaticsTherapeutic AreasOncologyOtherTagsPlatform TechnologyLead InventorYoram VodovotzDepartmentMed-SurgeryAll Tech InnovatorsFayten Kathryn El-DehaibiQi MiYoram VodovotzDate Submitted2018-02-23
Rapid Response Preventative Vaccines for Zika Virus Outbreak04010Rapid Zika vaccine using skin-targeted microneedle delivery and recombinant E antigen to boost safety, potency, and distribution.Technology TypeTherapeutic ModalityTechnology SubtypeVaccine - subunit, recombinant, polysaccharide, or conjugateTherapeutic AreasNeuroscienceInfectious DiseaseTherapeutic IndicationsZikaLead InventorAndrea GambottoDepartmentMed-SurgeryAll Tech InnovatorsGeza ErdosLouis D. Falo JrAndrea A. Gambotto M.D.Technology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2016-08-16
T Cell Receptors Targeting Defective DNA Repair Proteins04988Engineered T cells express two TCRs targeting mutated DNA repair proteins, offering mutation-specific cancer immunotherapy.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - T CellTherapeutic AreasImmunologyOncologyTherapeutic IndicationsSolid tumorTagsImmuno-oncologyLead InventorUdai KammulaDepartmentMed-SurgeryAll Tech InnovatorsChetana BhaskarlaSmriti ChaurasiaUdai Shankar KammulaTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2019-05-10CollectionsCell & Gene TherapyWomen's & Reproductive Health
Comprehensive Electronic Cancer Support System for Symptom Management03102Web-based Comprehensive Electronic Cancer Support System combines collaborative care and care coordinators to reduce depression, pain, fatigue.Technology TypeDigital HealthTechnology SubtypeHealthcare DeliveryTherapeutic AreasOncologyLead InventorJennifer SteelDepartmentMed-SurgeryAll Tech InnovatorsJonathan P. GradyJonathan Michael SpringJennifer L. SteelDate Submitted2013-08-05
Mathematical Modeling of Inflammation Following Traumatic Brain Injury01869Personalized computational brain inflammation models from injury biomarkers to predict outcomes and guide targeted therapies.Technology TypeLife Science Research ToolTechnology SubtypeBioinformaticsTherapeutic AreasNeuroscienceTherapeutic IndicationsOtherLead InventorYoram VodovotzDepartmentMed-SurgeryAll Tech InnovatorsGregory M. ConstantineQi MiDavid O. OkonkwoDate Submitted2008-11-16CollectionsRegenerative Medicine
High-Mobility Group Box 1 Preconditioning Protects Against Liver Ischemia-Reperfusion Injury01186HMGB1 preconditioning primes liver defense, reducing inflammation and damage from ischemia-reperfusion injury in transplantation contexts.Technology TypeTherapeutic ModalityTechnology SubtypeProteinTherapeutic AreasHepatologyLead InventorAllan TsungDepartmentMed-SurgeryAll Tech InnovatorsTimothy R. BilliarMitchell Phillip Fink MDKevin J. Tracey MDTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2005-12-05
In Silico Strategies for Cancer Diagnosis and Therapy02026Agent-based liver cancer simulation predicting patient prognosis, modeling inflammation, fibrosis, aiding drug testing and digital pathology.Technology TypeDigital HealthTechnology SubtypeDigital TherapeuticTherapeutic AreasOncologyTherapeutic IndicationsHepatocellular carcinoma (HCC)Lead InventorYoram VodovotzDepartmentMed-SurgeryAll Tech InnovatorsJoyeeta Dutta MoscatoLiang-I KangQi MiDate Submitted2009-06-12
A Method to Characterize the Complete Fiber Network Topology of Planar Fibrous Tissues and Scaffolds02193Automated image-based tool fully characterizes engineered tissue fiber networks, detailing orientation, connectivity, intersections, density, and diameter.Technology TypeLife Science Research ToolTechnology SubtypeBioinformaticsTagsMicroscopyLead InventorAntonio DAmoreDepartmentMed-SurgeryAll Tech InnovatorsAntonio DAmoreMichael Steven Sacks Ph.D.William R. Wagner PhDDate Submitted2010-04-14