Regenerative medicine

54 results

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Regenerative Topical Therapy for Cold-Induced Skin Injury: A Field-Ready Solution to Prevent Necrosis and Amputation

07296

Hydrogel HA-Metformin topical therapy accelerates frostbite healing, restores skin adnexa, reduces inflammation, and lowers amputation risk.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Dermatology
Tags: Regenerative medicine
Biomaterial
Polymer
Lead Inventor: James Wang
Department: Med-Orthopedic Surgery
All Tech Innovators: James Huicong Wang
Jianying Zhang
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2025-08-19
Collections: Regenerative Medicine

Biodegradable Polymer Conduits for Controlled and Sustained Drug Delivery

07365

Biodegradable PLGA/PLA nerve conduits with double-walled microspheres enable 60+ day, controlled drug release for enhanced regeneration.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Tags: Regenerative medicine
Biomaterial
Polymer
Lead Inventor: Kacey Marra
Department: Med-Plastic Surgery
All Tech Innovators: Dzana Katana
Kacey Gribbin Marra
Technology Readiness Level: 3. Prototype development
Date Submitted: 2025-10-06
Collections: Regenerative Medicine
Healthcare AI

Novel Wound Management System

07495

A sealed regenerative wound chamber converts avascular substrates to vascularized graft-ready tissue in vivo, enabling allograft support.

Tags: Regenerative medicine
Surgery
Life Science
Lead Inventor: Mario Solari
Department: Med-Plastic Surgery
All Tech Innovators: Armin Aryannejad
Fuat Baris Bengur
Chiaki Komatsu
Date Submitted: 2026-02-23
Collections: Regenerative Medicine

Microparticle-Based Regulatory T Cell Recruitment for Muscle Regeneration

07174

Recruit Treg-evoked immune modulation via PLGA/PEG microparticles releasing CCL22 to enhance acute muscle regeneration.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Sports medicine
Tissue engineering
Lead Inventor: Matthew Borrelli
Department: Chem/Petroleum Engineering
All Tech Innovators: Matthew Andrew Borrelli
Steven R. Little
Heth Turnquist
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-05-05
Collections: Cell & Gene Therapy
Regenerative Medicine

Innovative 3D Bioprinting for Primary and iPSC-Derived Organoids

06820

3D bioprinting platform creates functional primary and iPSC-derived organoids in alginate-methylcellulose hydrogel for personalized tissue applications.

Technology Type: Engineering Technology
Technology Subtype: Other Engineering Technology
Therapeutic Areas: Other
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Miranda Poklar
Department: Chem/Petroleum Engineering
All Tech Innovators: Ipsita Banerjee
Yong Fan
Prashant N. Kumta
Date Submitted: 2024-07-24

Targeted Nanoparticle Therapy for Brain Repair: Harnessing Memory T Cells for Endogenous Neuroregeneration and Neuroimmune Homeostasis

07316

Targeted brain nanoparticles reprogram memory T cells to foster neuroprotection, reduce inflammation, and promote endogenous CNS repair.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Multiple Sclerosis (MS)
Alzheimer's Disease
Tags: Regenerative medicine
Autoimmune
Biomaterial
Lead Inventor: Swaminathan Iyer
Department: Med-Pathology
All Tech Innovators: Swaminathan Smita Iyer
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2025-08-29
Collections: Regenerative Medicine

A Novel Platform for Enhanced Inner Ear Drug Delivery and Gene Therapy

07230

Exosome-based inner ear drug delivery platform enhances RWM traversal, enabling sustained, versatile loading of drugs and gene therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Otolaryngology
Therapeutic Indications: Hearing Loss
Tags: Regenerative medicine
Platform Technology
Lead Inventor: Adele Moatti
Department: Med-Otolaryngology
All Tech Innovators: Adele Moatti
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-06-23
Collections: Regenerative Medicine

Targeting Cardiomyocyte Endoreplication to Prevent Hypertrophic Cardiomyopathy

07132

Inhibits PCNA-POLD1 interactions via p21 to curb cardiomyocyte endoreplication, preventing hypertrophic cardiomyopathy progression.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Hypertrophic cardiomyopathy
Tags: Regenerative medicine
Genetics
Platform Technology
Lead Inventor: Jason Becker
Department: Med-Medicine
All Tech Innovators: Jason Robert Becker
Soumojit Pal
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-03-30
Collections: Cell & Gene Therapy
Cardiometabolic

Silk-Iron Packaged Extracellular Vesicles

06360

Silk-iron packaged extracellular vesicles guide regenerative, cell-free therapy for abdominal aortic aneurysm by delivering elastin/collagen factors.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Tags: Regenerative medicine
Biomaterial
Lead Inventor: Ande Marini
Department: Bioengineering
All Tech Innovators: Mostafa M. Bedewy
Ande Xiaojie Marini
Golnaz Najaf Tomaraei
Date Submitted: 2023-03-23
Collections: Regenerative Medicine
Cardiometabolic

Novel Device for Coating Medical Conduits

06000

RegenCoat coats nerve conduits with uniform micro/nano particles for precise, biodegradable regenerative drug delivery in nerve repair.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Rehabilitation/Mobility
Neuroscience
Tags: Regenerative medicine
Biomaterial
Coating
Lead Inventor: Caroline Fedor
Department: Med-Plastic Surgery
All Tech Innovators: Fuat Baris Bengur
Caroline Nadia Fedor
Kacey Gribbin Marra
Technology Readiness Level: 3. Prototype development
Date Submitted: 2022-04-10

Novel Approach to Bone Regeneration

06099

Activates skeletal stem cells to regenerate bone endogenously, using mechanical suture expansion and niclosamide-based stimulation.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Dental
Musculoskeletal
Therapeutic Indications: Osteoporosis
Tags: Regenerative medicine
Lead Inventor: Giuseppe Intini
Department: Dent Med-Periodontics/Preventive Dentistry
All Tech Innovators: Xue Hui Geng
Giuseppe Intini
Luigi Mancinelli
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-07-13
Collections: Women's & Reproductive Health

Novel Approach to Treatment of Osteoarthritis

05840

Enhancing estrogen receptor-α in cartilage reverses osteoarthritis damage; potential ERα-targeted therapies emerge with RAD001 and Urolithin A.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Aging
Tissue engineering
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Hang Lin
Ning Wang
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-10-13

Novel Hepatocyte Growth Factor Receptor Agonist

05468

A humanized MET agonist META4 restores HGF-MET signaling, promoting tissue regeneration and potential therapies for liver disease and AMD.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Hepatology
Ophthalmology
Therapeutic Indications: Other
Non-alcoholic steatohepatitis (NASH)
Diabetic retinopathy
Tags: Regenerative medicine
Lead Inventor: Abdolreza Zarnegar
Department: Med-Pathology
All Tech Innovators: Abdolreza Zarnegar
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-08-05
Collections: Regenerative Medicine
Cardiometabolic

Stimulation of Angiogenesis with miRNA as Protection Against Acute Kidney Injury

05448

Therapeutic miRNA approach promotes kidney angiogenesis to protect against acute kidney injury and ischemia-reperfusion damage.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Nephrology
Tags: Regenerative medicine
Lead Inventor: Sunder Lucas
Department: Med-Pediatrics
All Tech Innovators: Takuto Chiba
Jacqueline Ho
Sunder Sims Lucas
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-07-16
Collections: Cell & Gene Therapy

Scaffold-Free Nerve Conduit Comprising Cells, Secretome, and Endogenous Aligned Extracellular Matrix

05228

Scaffold-free, autologous dental pulp stem cell conduit uses aligned extracellular matrix and secretome to accelerate facial nerve repair.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Rehabilitation/Mobility
Neuroscience
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Fatima Syed
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Fatima N. Syed
Date Submitted: 2020-01-21

Ovarian ECM Derivatives for Women's Health Applications

04945

Bioengineered ovarian ECM hydrogel enables rapid follicle delivery to restore fertility and endocrine function after chemotherapy.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Reproductive Health
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Michael Buckenmeyer
Department: Bioengineering
All Tech Innovators: Bryan Nicklaus Brown
Michael Joseph Buckenmeyer
Kyle E. Orwig
Date Submitted: 2019-04-06
Collections: Women's & Reproductive Health

Nanoparticle Dopants for Conducting Polymers

04941

Nanoparticle-doped PEDOT lowers impedance, boosts charge injection and drug loading for improved neural interfaces.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Neuroscience
Tags: Regenerative medicine
Biomaterial
Coating
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Xinyan Cui
Kevin M. Woeppel
Date Submitted: 2019-04-03
Collections: Cardiometabolic

Regenerative Ligament Repair Therapy

04487

Soluble ACL/PCL extracellular matrix extracts promote stem cell proliferation and tenogenic differentiation, enabling regenerative ligament therapies.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Riccardo Gottardi
All Tech Innovators: Riccardo Luca Gottardi
Shinsuke Kihara
Benjamin Burke Rothrauff
Date Submitted: 2018-01-17

Automated Dip-Coating Platform for Fabricating Resorbable Nerve Guide Constructs

04805

Automated dip-coating platform creates multi-layer, biodegradable nerve guides with embedded particles for reproducible peripheral nerve repair.

Technology Type: Life Science Research Tool
Therapeutic Areas: Neuroscience
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Benjamin Schilling
Department: Bioengineering
All Tech Innovators: Kacey Gribbin Marra
Alexander James Repko
Benjamin Schilling
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2018-11-06

Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells

04531

Magnetic-assisted hydrogel fixation delivers adipose-derived stem cells to target sites, enabling minimally invasive, localized therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: David Vorp
Department: Bioengineering
All Tech Innovators: Yogev Baruch
Kory James Blose
Timothy K. Chung
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2018-03-05

Scaffold-Free Cell Sheet for Nerve Repair

04482

Scaffold-free dental stem cell sheets deliver neurotrophic factors locally to accelerate nerve regeneration and motor recovery.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Tags: Regenerative medicine
Tissue engineering
Surgery
Lead Inventor: Fatima Syed
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Fatima N. Syed
Date Submitted: 2018-01-12
Collections: Regenerative Medicine

Improved Preclinical Models for Osteoarthritis

04384

3D human micro-joint chip (mJoint) models multifactorial osteoarthritis to test disease-modifying medications with patient-relevant tissues.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Aging
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Peter Alexander
Riccardo Luca Gottardi
Hang Lin
Date Submitted: 2017-09-26

Highly Configurable Vagus Nerve Bioelectronic Device Approach to Modulate Inflammation/Immunity and Control Cancer

04256

Vagus nerve bioelectronic implant personalizes cancer therapy by modulating inflammation, boosting immunotherapy effectiveness, with fewer side effects.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Oncology
Neuroscience
Therapeutic Indications: Glioblastoma
Tags: Regenerative medicine
Autoimmune
Biomaterial
Lead Inventor: Charles Horn
Department: Med-Medicine
All Tech Innovators: Christopher J. Bettinger
Gary Keith Fedder
Charles C. Horn
Technology Readiness Level: 3. Prototype development
Date Submitted: 2017-05-22

Nitrix: A Biomaterial Bandage for Closing Chronic Wounds

04182

Nitrix: a low-cost ECM biomaterial bandage that boosts antioxidant, anti-inflammatory, and angiogenic healing for chronic wounds.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Intensive Care
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Samuel LoPresti
Department: Bioengineering
All Tech Innovators: Bryan Nicklaus Brown
Samuel Traxler LoPresti
Date Submitted: 2017-03-06
Collections: Regenerative Medicine

Hybrid Scaffolds for Bone Defect Regeneration

04114

Hybrid Mg-doped scaffold with polymer/DBM supports osteogenic bone regeneration for critical-sized defects, enabling safer, scaffold-guided repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Biomaterial
Life Science
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Yingqi Chen
Vesselin N. Shanov
William R. Wagner PhD
Date Submitted: 2016-12-12
Collections: Regenerative Medicine

A Biodegradable, Porous, Thermally Responsive Injectable Hydrogel as Soft Tissue Defect Filler

04040

Biodegradable, injectable hydrogel with in situ gelation, porosity, ECM cues, and rapid tissue regeneration for soft-tissue repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Hong Bin Jiang
Hideyoshi Sato
Date Submitted: 2016-10-04
Collections: Regenerative Medicine

TriaGel: Comprehensive Gel Eye Dressing to Revolutionize Ocular First Aid

04068

TriaGel—a thermoresponsive, injectable gel for immediate ocular injury care, reducing inflammation, cost, and recovery time.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Intensive Care
Ophthalmology
Tags: Regenerative medicine
Material Science
Lead Inventor: Morgan Dileo
Department: Med-Ophthalmology
All Tech Innovators: Morgan Virginia Dileo
Jenny Yu
Date Submitted: 2016-11-07
Collections: Regenerative Medicine

ResMag: A Resorbable Magnesium Alloy for Medical Applications

04049

Biodegradable magnesium alloy implants matching bone elasticity reduce metastasis risk and need for removal surgeries.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Material Science
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Dae Ho Hong
Prashant N. Kumta
Date Submitted: 2016-10-18
Collections: Regenerative Medicine

VitaCapsule: A Synthetic Hydrogel for Supporting Human Stem Cells

04045

VitaCapsule: a low-cost, animal-free hydrogel that enhances single-cell hPSC viability for 2D/3D expansion and scalable biomanufacturing.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Tags: Regenerative medicine
Biomaterial
Platform Technology
Lead Inventor: Thomas Richardson
Department: All Temps
All Tech Innovators: Ipsita Banerjee
Prashant N. Kumta
Thomas Charles Richardson
Date Submitted: 2016-10-12

Ultrasound-Guided Rete Testis Injection/Aspiration Device

04016

Ultrasound-guided, non-surgical rete testis injection/aspiration device enables targeted delivery of therapies with single, minimal procedures.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Other
Reproductive Health
Therapeutic Indications: Male genitourinary
Infertility
Tags: Regenerative medicine
Minimally invasive
Lead Inventor: Kyle Orwig
Department: Med-OB-Gyn & Reproductive Science
All Tech Innovators: Brian Peter Hermann
Kyle E. Orwig
Date Submitted: 2016-08-29
Collections: Women's & Reproductive Health

A Shear-thinning Hydrogel That Extends In Vivo Bioactivity of Therapeutic Proteins

03988

Injectable, shear-thinning hydrogel using silicate nanoplatelets and heparin enables rapid, tunable, Bioactive protein delivery and biodegrades in 8 weeks.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Yadong Wang
Department: Bioengineering
All Tech Innovators: Xiaochu Ding
Jin Gao
Yadong Wang
Date Submitted: 2016-07-07
Collections: Regenerative Medicine

Regeneration of Epiphyseal Growth Plate

03828

Hydrogel-MSC scaffolds with cytokines and microparticles direct chondrogenesis, regenerating growth plate tissue to prevent deformities in children.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Dental
Tags: Regenerative medicine
Tissue engineering
Life Science
Lead Inventor: Juan Taboas
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Jingming Chen
Juan M. Taboas
Date Submitted: 2016-02-10

Novel Biomimetic Rotated Plywood Motifs as Scaffolds for Bone Tissue Engineering

03778

Biomimetic rotated plywood bone scaffolds via binder-jet 3D printing; data-driven, multi-material, enhanced strength, tailored implants.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Tissue engineering
Surgery
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Gary Zhengbo Yu
Date Submitted: 2015-11-27

Method of Making Trabecular Bone in vitro

03691

Efficient in vitro trabecular bone generation from modified mesenchymal stem cells enables implants, osteoporosis treatment, and dental grafts.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Aging
Biomaterial
Lead Inventor: Harry Blair
Department: Med-Pathology
All Tech Innovators: Harry Colbert Blair
Quitterie Larrouture
Deborah J. Nelson
Date Submitted: 2015-07-31
Collections: Women's & Reproductive Health

Resorbable Magnesium Hardware for Bone Fractures

03562

Biodegradable magnesium bone fixation hardware matches strength, promotes bone growth, and eliminates removal surgeries through gradual resorption.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Vijay S. Gorantla
Dae Ho Hong
Date Submitted: 2015-03-24
Collections: Regenerative Medicine

Fertilized Chicken Eggs: A Novel Platform for Cancer and Regenerative Medicine Research

03087

Fertilized chicken eggs offer a non-immunogenic, in vivo microenvironment to study human cancer growth, EMT, regeneration, and drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Tags: Regenerative medicine
Immuno-oncology
Immunology
Lead Inventor: Vera Donnenberg
Department: Med-Cardiothoracic Surgery
All Tech Innovators: Albert D. Donnenberg
Vera Svobodova Donnenberg
Technology Readiness Level: 3. Prototype development
Date Submitted: 2013-07-03

Stem Cell-Based Technologies for Avian Skeletal Tissue Engineering and Regeneration

03360

Light-activated, 3D-printed avian stem cell scaffolds enable precise bone/cartilage repair with antibacterial protection.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - Stem Cell
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Rocky Tuan
Department: Med-Orthopedic Surgery
All Tech Innovators: Rocky Sung Chi Tuan
Date Submitted: 2014-07-07
Collections: Cell & Gene Therapy
Regenerative Medicine

Self-Assembled Coatings for Magnesium Implants

03377

Self-assembled anticorrosive organosilane coatings slow magnesium implant degradation, enabling drug delivery and improved biocompatibility.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Other
Tags: Regenerative medicine
Biomaterial
Coating
Lead Inventor: Elia Beniash
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Elia Beniash
Date Submitted: 2014-08-11

Controlled Release Microparticle Platform for Localized Prevention of Tissue Calcification and Ossification

03248

PLGA microparticles deliver BMP receptor inhibitor locally to prevent tissue calcification with sustained, customizable release.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Sports medicine
Tissue engineering
Lead Inventor: Riccardo Gottardi
All Tech Innovators: Peter Alexander
Patrick A. Bianconi
Riccardo Luca Gottardi
Date Submitted: 2014-02-17

Hybrid Additive Manufacturing and Electrospinning for Fabricating Vascularized Biodegradable Tissue Scaffolds

03187

Hybrid 3D printing and electrospinning create biodegradable, porous, vascularized tissue scaffolds with programmable microchannels.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Yadong Wang
Department: Bioengineering
All Tech Innovators: James Henry Clampffer III
Eric M. Jeffries
Yadong Wang
Date Submitted: 2013-12-04

Advanced Electrospinning for Regenerative Biomaterials

02919

Novel electrospun PGS biomaterials blends yield suturable, tough, elastic vascular grafts, nerve guides, and regenerative scaffolds.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Eric Jeffries
Department: Bioengineering
All Tech Innovators: Eric M. Jeffries
Yadong Wang
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2012-10-23

New Biometric Coating for Neural Implants Improves Outcomes

03008

Neural implants gain lasting accuracy via L1 coating, boosting neuron adherence, reducing glial response, and sustaining high-quality signals.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Epilepsy
Tags: Regenerative medicine
Coating
Tissue engineering
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Erdrin Azemi
Xinyan Cui
Carl F. Lagenaur
Date Submitted: 2013-03-28

Degradable Osteosensor: Novel Degradable CNT-based Impedimetric Biosensors for Bone Marker Detection

03000

Degradable CNT-based impedimetric sensor detects bone resorption markers; biodegradable, home-use osteosense enables in vivo monitoring.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Immunology
Musculoskeletal
Therapeutic Indications: Rheumatoid arthritis
Osteoporosis
Bone metabolism
Tags: Regenerative medicine
Aging
Biomaterial
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Mitali S. Patil
Madhumati Ramanathan
Technology Readiness Level: 3. Prototype development
Date Submitted: 2013-03-04
Collections: Women's & Reproductive Health

Bio-Inspired Nanocomposites for Advanced Bone and Tissue Regeneration

02778

Bio-inspired bone/dentin nanocomposites using multiphosphorylated peptides for integrated organic-inorganic regeneration and osteogenesis.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Intensive Care
Musculoskeletal
Therapeutic Indications: Trauma
Osteogenesis Imperfecta
Bone metabolism
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Elia Beniash
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Elia Beniash
Charles S. Sfeir
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2012-05-25
Collections: Regenerative Medicine

ResMag: A Resorbable Magnesium Alloy for Medical Applications

02522

Bio-absorbable magnesium alloy ResMag matches bone mechanics, degrades safely, enhances cell viability for orthopedic implants.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Biomaterial
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Dae Ho Hong
Prashant N. Kumta
Date Submitted: 2011-07-14
Collections: Regenerative Medicine

Low Passage Mesenchymal Stem Cell Cell Bank from Cadaveric Vertebral Bodies

02247

Cadaver vertebra-derived MSC bank enables rapid, large-scale expansion in bioreactors, reducing chromosomal risks and passage.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Immunology
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Albert Donnenberg
Department: Med-Medicine
All Tech Innovators: Albert D. Donnenberg
Ludovic Zimmerlin
Date Submitted: 2010-06-09

Novel Nanostructured Smart Injectable Bone Cements for Bone Regeneration

01918

Smart injectable calcium phosphate bone cement carries proteins, DNA, cells, and drugs; enables rapid, porous, 3D-printed, regenerative bone repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Osteoporosis
Bone metabolism
Tags: Regenerative medicine
Aging
Biomaterial
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Abhijit Roy
Charles S. Sfeir
Date Submitted: 2009-02-13
Collections: Women's & Reproductive Health

Novel Peptides for Tissue Reconstruction

01877

Synthetic peptides recruit patient progenitor cells to injury sites, enabling targeted tissue healing without stem cell harvesting.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: Stephen Badylak
Department: Med-Surgery
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Stephen Tottey
Date Submitted: 2008-11-26
Collections: Regenerative Medicine

Tracking Cell-Based Therapeutics in the Body with Microbubbles

01857

Ultrasound-visible microbubbles enable safe, noninvasive tracking of injected stem cells in patients, aiding trials and treatment decisions.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Hematology
Oncology
Tags: Regenerative medicine
Polymer
Platform Technology
Lead Inventor: Flordeliza Villanueva
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Wenjin Cui
Andrew Robert Fisher
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2008-10-24

Thermoresponsive, Biodegradable, Elastomeric Material

01315

Biodegradable, thermoresponsive hydrogel that is injectable, ultra-flexible, and shapes with temperature for tissue engineering and drug delivery.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Regenerative medicine
Biomaterial
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Jianjun Guan
William R. Wagner PhD
Date Submitted: 2006-09-14
Collections: Regenerative Medicine