Microneedle Array Delivery of Adenovirus Vectored Vaccines05297Microneedle arrays deliver adenovirus-vectored vaccines into skin, boosting immunogenicity and enabling universal, adjuvant-enhanced vaccination.Technology TypeTherapeutic ModalityTechnology SubtypeVaccine - Viral VectorTherapeutic AreasInfectious DiseaseDermatologyLead InventorLouis FaloDepartmentMed-DermatologyAll Tech InnovatorsGeza ErdosLouis D. Falo JrAndrea A. Gambotto M.D.Date Submitted2020-04-08
Novel Influenza D Virus Vaccine Strategy06964Single-cycle M-null IDV vaccine prompts strong immunity without disease, offering cross-species protection for cattle, swine, and humans.Technology TypeTherapeutic ModalityTechnology SubtypeVaccine - subunit, recombinant, polysaccharide, or conjugateTherapeutic AreasInfectious DiseaseTherapeutic IndicationsInfluenzaTagsLife ScienceLead InventorSuresh V KuchipudiDepartmentGSPH-Infectious Diseases & MicrobiologyAll Tech InnovatorsSuresh V KuchipudiSanthamani RamasamyDate Submitted2024-11-08
Novel Prediction Method of Dominant Viral Strains06246A data-driven epidemiological model rapidly predicts dominant viral strains from genomic data to guide vaccine design.Technology TypeDigital HealthTechnology SubtypeHealthcare DeliveryTherapeutic AreasInfectious DiseaseTherapeutic IndicationsInfluenzaCovid-19Lead InventorJohn BartonDepartmentMed-Computational and Systems BiologyAll Tech InnovatorsJohn Paul BartonDate Submitted2022-12-09
Bacteriophage Cocktail to Treat Achromobacter06380Five phages form a cocktail to broaden Achromobacter targeting, offering personalized, antibiotic-sparing therapy potential.Technology TypeTherapeutic ModalityTechnology SubtypeBacteriophageTherapeutic AreasInfectious DiseaseRespiratoryTherapeutic IndicationsOtherLead InventorDaria Van TyneDepartmentMed-MedicineAll Tech InnovatorsGhady HaidarDaria N. Van TyneTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2023-04-20
PROTAC treatment for HIV06285PROTACs selectively degrade HIV Nef, restoring immune recognition and suppressing HIV replication, aiming for reservoir clearance.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasInfectious DiseaseLead InventorThomas SmithgallDepartmentMed-Microbiology and Molecular GeneticsAll Tech InnovatorsLori Ann Emert-SedlakAllen B. ReitzThomas E. SmithgallTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2023-02-06
Innovative Small Molecule for Zika Virus Neutralization06214CZV1-1: first nonpeptide Zika neutralization surrogate enabling highly specific, room-temperature diagnostics and research tools.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasInfectious DiseaseTherapeutic IndicationsZikaLead InventorDonald BurkeDepartmentGSPH-EpidemiologyAll Tech InnovatorsDonald S. BurkePriscila Mayrelle Da Silva CastanhaErnesto Torres De Azeved Marques JrDate Submitted2022-11-14CollectionsWomen's & Reproductive Health
Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-205391Multivalent nanobody cocktails deliver ultra-highly potent, breath-stable SARS-CoV-2 neutralization, enabling rapid, inhalable therapeutic options.Technology TypeTherapeutic ModalityTechnology SubtypeVaccine - subunit, recombinant, polysaccharide, or conjugateTherapeutic AreasInfectious DiseaseLead InventorYi ShiDepartmentMed-Cell BiologyAll Tech InnovatorsYi ShiYufei XiangTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2020-05-30
Novel Therapy for Sepsis07388A novel polypeptide YPD-203 targets sepsis-induced cytokine surges, reducing organ damage and improving survival in animal models.Technology TypeTherapeutic ModalityTechnology SubtypePeptideTherapeutic AreasInfectious DiseaseTherapeutic IndicationsSepsisTagsPeptideDrug Discovery - TargetLife ScienceLead InventorYuanpu DiAll Tech InnovatorsYuanpu DiDate Submitted2025-10-24
Novel Nucleotide Prodrugs to Target Oxidative Stress05934Targeted oxidative-stress-activated nucleotide prodrugs release active nucleotides in diseased tissue, enabling safer cancer/antiviral therapies.Technology TypeTherapeutic ModalityTechnology SubtypeGene Therapy - DNATherapeutic AreasInfectious DiseaseOncologyLead InventorPaul FloreancigDepartmentChemistryAll Tech InnovatorsAlexander DeitersPaul Edward FloreancigBrittany M. KlootwykDate Submitted2022-01-05CollectionsCell & Gene Therapy
Novel Neutralizing Nanobodies for Coronavirus Diseases05802Pan-sarbecovirus nanobodies enable inhalable, stable, cost-effective COVID-19 and related coronavirus neutralization across variants.Technology TypeTherapeutic ModalityTechnology SubtypeOther Therapeutic ModalityTherapeutic AreasInfectious DiseaseTherapeutic IndicationsOtherCovid-19Lead InventorYi ShiDepartmentMed-Cell BiologyAll Tech InnovatorsYi ShiYufei XiangDate Submitted2021-09-06
Insertion Unique to SARS-CoV-2 Exhibits Superantigenic Characteristics05404SARS-CoV-2 spike contains a unique superantigen-like site; monoclonal antibodies may block MIS-C, cytokine storms, and entry.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Discovery - TargetTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorIvet BaharDepartmentBiochemistry and Cell BiologyAll Tech InnovatorsMoshe Arditi MDIvet BaharHongying ChengDate Submitted2020-06-05
A Novel Mechanism for Disrupting Biofilms and Combating Antimicrobial Resistance07134Disrupts bacterial biofilms by targeting wall teichoic acid with WLBU2; low-probability resistance via membrane potential changes.Technology TypeTherapeutic ModalityTechnology SubtypePeptideTherapeutic AreasInfectious DiseaseTagsCoatingDrug Discovery - TargetLead InventorKenneth UrishDepartmentMed-Orthopedic SurgeryAll Tech InnovatorsUmit AkbeyVaughn Scott CooperKenneth L. Urish JrTechnology Readiness Level4. Pre-clinical developmentDate Submitted2025-04-02
Device for Collecting Exhaled Aerosols During Mechanical Ventilation06109Non-invasive device collects exhaled aerosols from ventilated patients for frequent VAP monitoring and rapid pathogen detection.Technology TypeMedical DeviceTechnology SubtypeMonitoring Medical DeviceTherapeutic AreasInfectious DiseaseRespiratoryTherapeutic IndicationsOtherTagsMinimally invasiveLead InventorTimothy CorcoranDepartmentMed-MedicineAll Tech InnovatorsTimothy E. CorcoranSteven George Kefalos IIRutuja Amar KulkarniTechnology Readiness Level4. Prototype testing and refinementDate Submitted2022-07-25
Use of Specific Phages for the Treatment of Non-Tuberculosis Mycobacterial Infections05095Phage therapy targets drug-resistant non-tuberculous Mycobacteria, enabling rapid, strain-specific treatment with minimal resistance and side effects.Technology TypeTherapeutic ModalityTechnology SubtypeBacteriophageTherapeutic AreasInfectious DiseaseRespiratoryTagsBiomaterialLead InventorGraham HatfullDepartmentDistinguished Faculty-Dietrich School of Arts and SciencesAll Tech InnovatorsRebekah Marie DedrickCarlos Andres GuerreroGraham F. HatfullTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2019-08-20
Whole Genome Sequencing Analytic Pipeline for Healthcare Associated Transmission05332Whole-genome sequencing plus ML and EHRs enables real-time hospital outbreak detection and targeted infection control.Technology TypeDigital HealthTechnology SubtypeHealthcare DeliveryTherapeutic AreasInfectious DiseaseLead InventorLee HarrisonDepartmentMed-MedicineAll Tech InnovatorsArtur Wladyslaw DubrawskiLee H. HarrisonDate Submitted2020-05-01CollectionsHealthcare AI
Universal Vaccine for SARS-CoV-2 (COVID 19)05356Universal vaccine approach targets SARS-CoV-2 RdRp activation motif, potentially halting replication across coronaviruses.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorPatrick MooreDepartmentMed-PathologyAll Tech InnovatorsYuan ChangPatrick S. MooreMasahiro ShudaDate Submitted2020-05-13
Fully Human Fabs Binding to the CD94/NKG2A Heterodimer05650Fully human antibodies block CD94/NKG2A, restoring NK and CD8+ T cell activity against cancer and HIV.Technology TypeTherapeutic ModalityTechnology SubtypeAntibody - FabTherapeutic AreasInfectious DiseaseOncologyTherapeutic IndicationsHIVLung Cancer - Non-Small CellTagsImmuno-oncologyLead InventorDimiter DimitrovAll Tech InnovatorsDusan BaekDimiter Stanchev DimitrovYae Jin KimTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2021-03-23CollectionsWomen's & Reproductive Health
Next-Generation Long-Lasting Soluble CD4-D1 Domains as HIV Entry Inhibitors06603Engineered soluble CD4-D1 variant offers long-lasting HIV entry inhibition with enhanced stability, MHC II avoidance, and broad neutralization.Technology TypeTherapeutic ModalityTechnology SubtypeAntibody - BispecificTherapeutic AreasInfectious DiseaseTherapeutic IndicationsHIVLead InventorWei LiDepartmentMed-MedicineAll Tech InnovatorsXiaojie ChuJana Lynn JacobsWei LiTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2024-01-08CollectionsWomen's & Reproductive Health
Novel Genetically Encoded Nanoparticles05910Genetically encoded nanoparticles target and protect cells, enabling precision antibacterial, anticancer therapies and radiation shielding.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasInfectious DiseaseOncologyLead InventorOr ShemeshDepartmentMed-OphthalmologyAll Tech InnovatorsOr ShemeshDate Submitted2021-12-06
Novel Llama Nanobody to Treat HIV-106827Humanized llama nanobody 4E2 neutralizes diverse HIV-1 strains, offering a potential long-term, low-immunogenic therapy.Technology TypeTherapeutic ModalityTechnology SubtypeAntibody - mAbTherapeutic AreasInfectious DiseaseImmunologyTherapeutic IndicationsHIVTagsDrug Discovery - TargetLife ScienceLead InventorWei LiDepartmentMed-MedicineAll Tech InnovatorsZhiwei FengMargaret Grace HinesWei LiDate Submitted2024-07-26CollectionsWomen's & Reproductive HealthHealthcare AI
Novel Design of Cationic Antimicrobial Peptides06604Novel linear-amphipathic antimicrobial peptides with stabilized disulfide cycles offer potent activity and reduced toxicity against resistant pathogens.Technology TypeTherapeutic ModalityTechnology SubtypePeptideTherapeutic AreasInfectious DiseaseTherapeutic IndicationsStreptococcusTagsLife ScienceLead InventorBerthony DeslouchesDepartmentGSPH-Environmental/Occupational HealthAll Tech InnovatorsBerthony DeslouchesDate Submitted2024-01-08
Novel Approach to Study Human Respiratory Tracts06098New combined synthetic sputum–epithelial co-culture model better mimics human respiratory tract biofilms, enhancing antimicrobial research.Technology TypeLife Science Research ToolTechnology SubtypeOther Life Science Research ToolTherapeutic AreasInfectious DiseaseRespiratoryTherapeutic IndicationsOtherLead InventorJennifer BombergerDepartmentDepartment of Microbiology and ImmunologyAll Tech InnovatorsJennifer M. BombergerAnanya KapurDate Submitted2022-07-13
Enema-Based Prophylaxis for HIV and Other STIs05760Enema-delivered TFV and Q-Griffithsin offer topical PrEP for HIV/STI prevention, aiming to improve adherence among MSM.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasInfectious DiseaseTherapeutic IndicationsHIVLead InventorLisa RohanDepartmentPharm-Pharmaceutical ScienceAll Tech InnovatorsLisa Cencia RohanXin TongDate Submitted2021-07-14CollectionsWomen's & Reproductive Health
Epstein-Barr Circular RNA as a Novel Biomarker of EBV-Related Cancers04470Stable EBV circBART circular RNAs enable rapid, low-cost, reliable cancer detection and early diagnosis in diverse tumors.Technology TypeDiagnostic/AssayTechnology SubtypeIn vitro DiagnosticTherapeutic AreasInfectious DiseaseOncologyTherapeutic IndicationsLymphomaHerpesLead InventorPatrick MooreDepartmentMed-PathologyAll Tech InnovatorsYuan ChangPatrick S. MooreTuna ToptanDate Submitted2018-01-02
Fighting Lethal Inflammation with ALK Inhibitors04364ALK inhibitors block ALK-STING-driven inflammation to treat lethal sepsis and other autoimmune conditions.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Discovery - TargetTherapeutic AreasInfectious DiseaseTherapeutic IndicationsSepsisLead InventorDao Lin TangDepartmentDepartment of SurgeryAll Tech InnovatorsTimothy R. BilliarDao Lin TangLing ZengTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2017-09-05
Next-Generation Viral Entry Inhibitors: Synthetic ApoE Polypeptides for the Treatment and Prevention of Hepatitis C02380Synthetic ApoE peptides block HCV entry/replication, offering resistance-reducing antiviral therapy with dual action and delivery potential.Technology TypeTherapeutic ModalityTechnology SubtypePeptideTherapeutic AreasInfectious DiseaseTherapeutic IndicationsHepatitis BTagsPlatform TechnologyLead InventorTianyi WangDepartmentGSPH-Infectious Diseases & MicrobiologyAll Tech InnovatorsDaping Fan M.D., Ph.D.Shufeng Liu Ph.D.Tianyi Wang Ph.D.Technology Readiness Level4. Pre-clinical developmentDate Submitted2011-01-11
Human Monoclonal Antibodies against SARS-CoV-205259Neutralizing human monoclonal antibodies target SARS-CoV-2 spike RBD, blocking entry or directing infected-cell killing.Technology TypeTherapeutic ModalityTechnology SubtypeAntibody - mAbTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorDimiter DimitrovAll Tech InnovatorsChuan ChenDimiter Stanchev DimitrovDontcho V. JelevTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2020-02-26
Cationic Peptides for Treatment of Drug-Resistant Cancer and Infections05214Rationally engineered cationic peptides offer multiple in vivo therapeutics for drug-resistant cancer and infections, with reduced toxicity.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Discovery - TargetTherapeutic AreasInfectious DiseaseOncologyTagsAlgorithmLead InventorBerthony DeslouchesDepartmentGSPH-Environmental/Occupational HealthAll Tech InnovatorsBerthony DeslouchesTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2020-01-06
Novel Peptide Antibiotics in Treating Drug Resistant Microbial Infection04006Engineered antimicrobial peptides rapidly kill multidrug-resistant bacteria and biofilms with low toxicity, promising safer alternative therapies.Technology TypeTherapeutic ModalityTechnology SubtypePeptideTherapeutic AreasInfectious DiseaseLead InventorYuanpu DiAll Tech InnovatorsBerthony DeslouchesYuanpu DiDate Submitted2016-08-05
Enzyme Inhibitor Promotes Anticancer Immune Response05716Enzyme ALDH1A inhibitor boosts antitumor immunity, enhances vaccine efficacy, and improves tumor control in hard-to-treat cancers.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasInfectious DiseaseOncologyTagsImmuno-oncologyLead InventorRonald BuckanovichDepartmentMed-MedicineAll Tech InnovatorsRonald J. BuckanovichAnda Mioara VladTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2021-06-08CollectionsWomen's & Reproductive Health
Thermogel-extended Release Microsphere Based Delivery to the Paranasal Sinuses05299Thermogel-PLGA microspheres deliver four-week, localized mometasone furoate to paranasal sinuses post-surgery.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasInfectious DiseaseLead InventorAndrea SchillingDepartmentChemical and Petroleum EngineeringAll Tech InnovatorsStella LeeSteven R. LittleAndrea Leigh SchillingDate Submitted2020-04-10
Novel Biomarker to Detect CMV T Cell Immunity04855KLRG1-based assay predicts CMV T cell immunity in transplant patients, enabling targeted antiviral therapy.Technology TypeDiagnostic/AssayTechnology SubtypeBiomarkerTherapeutic AreasInfectious DiseaseImmunologyLead InventorJohn McDyerDepartmentMed-MedicineAll Tech InnovatorsAkihiko HojiJohn Francis McDyerIulia-Dana PopescuDate Submitted2019-01-09
Novel Transcriptional Signature for Chlamydial PID03188Novel gene-expression biomarkers enable low-cost, minimally invasive detection of asymptomatic chlamydial PID and endometritis.Technology TypeDiagnostic/AssayTechnology SubtypeIn vitro DiagnosticTherapeutic AreasInfectious DiseaseReproductive HealthTagsAutoimmuneLead InventorCatherine O'ConnellDepartmentPediatricsAll Tech InnovatorsLee Antoinette DarvilleCatherine Mary O'ConnellXiaojing ZhengDate Submitted2013-12-06CollectionsWomen's & Reproductive Health
Phamerator01741Phamerator visualizes bacteriophage genome relationships, comparing gene content to reveal evolutionary patterns across phage genomes.Technology TypeLife Science Research ToolTechnology SubtypeBioinformaticsTherapeutic AreasInfectious DiseaseTagsGeneticsLead InventorSteven CresawnDepartmentBiological SciencesAll Tech InnovatorsMatthew W. BogelSteven G. CresawnGraham F. HatfullDate Submitted2008-05-29
Novel Treatment Approach for Seasonal Influenza04073Novel antisense oligonucleotides target conserved influenza RNA regions, offering a potential universal treatment beyond vaccines.Technology TypeTherapeutic ModalityTechnology SubtypeGene Therapy - RNATherapeutic AreasInfectious DiseaseTherapeutic IndicationsInfluenzaLead InventorSeema LakdawalaDepartmentMed-Microbiology and Molecular GeneticsAll Tech InnovatorsSeema S. LakdawalaNara LeeDate Submitted2016-11-08CollectionsCell & Gene Therapy
Non-Replicating SARS-CoV-2 for Safer Research06926Replication-defective SARS-CoV-2 enables safer, BSL-2 research; single-cycle, reporter-enabled tools for vaccines and therapies.Technology TypeLife Science Research ToolTechnology SubtypeNucleic AcidTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19TagsLife ScienceLead InventorZandrea AmbroseDepartmentMed-Microbiology and Molecular GeneticsAll Tech InnovatorsZandrea AmbroseHannah Leah FischerChristopher J. KlineDate Submitted2024-10-16
A Flexible Wireless Sensor Embedded Intravaginal ring (IVR) for On-Demand Electroresponsive Release of Anti-Sexually Transmitted Infection06042Flexible wireless IVR detects vaginal cues and electrically releases anti-STI agents on demand for targeted prevention.Technology TypeMedical DeviceTechnology SubtypeRehab or Assistive Medical DeviceTherapeutic AreasInfectious DiseaseTherapeutic IndicationsHIVTagsBiomaterialSustainabilitySensorLead InventorSeungil KimDepartmentBioengineeringAll Tech InnovatorsEmmanuel A. HoSeungil KimYongkuk LeeDate Submitted2022-05-31CollectionsWomen's & Reproductive Health
Novel Approach to Overcome Biofouling in Biosensors05784Two-electrode correction boosts label-free biosensor accuracy by separating biofouling from target signals for rapid, multi-analyte detection.Technology TypeDiagnostic/AssayTechnology SubtypeOther Diagnostic/AssayTherapeutic AreasInfectious DiseaseLead InventorPrashant KumtaDepartmentBioengineeringAll Tech InnovatorsMoni Kanchan DattaPrashant N. KumtaSangeetha KunjukunjuDate Submitted2021-08-16
A Novel Vaginal Film Platform for Sustained Drug Delivery05770Sustained-release vaginal film co-delivers HIV prevention and contraception, enabling monthly dosing and multi-actives compatibility.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasInfectious DiseaseReproductive HealthTherapeutic IndicationsHIVGynecological disorderObstetricsLead InventorLisa RohanDepartmentPharm-Pharmaceutical ScienceAll Tech InnovatorsPrithivirajan DurairajanSravan Kumar PatelLisa Cencia RohanTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2021-07-23CollectionsWomen's & Reproductive Health
Small Molecule Antagonists of HIV Nef Function02843Small molecule inhibitors block HIV Nef function, offering potential combination therapies to reduce resistance and toxicity.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasInfectious DiseaseTherapeutic IndicationsHIVLead InventorThomas SmithgallDepartmentMed-Microbiology and Molecular GeneticsAll Tech InnovatorsBilly W. DayLori Ann Emert-SedlakPrema Chandrasekhar IyerDate Submitted2012-07-25CollectionsWomen's & Reproductive Health
Novel Antiviral Therapy for H5N1 Influenza07141Novel antiviral peptide targets H5N1 HA, enabling nasal/aerosol delivery; broad clade activity and pandemic preparedness potential.Technology TypeTherapeutic ModalityTechnology SubtypePeptideTherapeutic AreasInfectious DiseaseTagsLife ScienceLead InventorSuresh V KuchipudiDepartmentGSPH-Infectious Diseases & MicrobiologyAll Tech InnovatorsSuresh V KuchipudiDate Submitted2025-04-06
Novel Treatment Approach for Antibiotic Resistance in Bacterial Pathogens Gram-Negative05667Novel cationic peptide WLBU2 exploits restrictive mutation pathways in Gram-negative bacteria, reducing resistance emergence.Technology TypeTherapeutic ModalityTechnology SubtypePeptideTherapeutic AreasInfectious DiseaseLead InventorVaughn CooperDepartmentMed-Microbiology and Molecular GeneticsAll Tech InnovatorsVaughn Scott CooperAlfonso Santos LopezTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2021-04-13
Use of Immunomodulatory DNA for the Treatment of Diseases of Systemic Sepsis01448TLR9-activated CpG-DNA modulates innate immunity to dampen TLR4 signaling, reducing NEC severity and intestinal inflammation.Technology TypeTherapeutic ModalityTechnology SubtypeOther Therapeutic ModalityTherapeutic AreasInfectious DiseaseGastroenterologyTherapeutic IndicationsSepsisOtherLead InventorDavid HackamDepartmentPediatric SurgeryAll Tech InnovatorsSteven C. GribarDavid Joel HackamDate Submitted2007-02-20
Tenofovir Spray Drying Sachet Enema Powder Formulation for HIV Prevention05906Spray-dried tenofovir sachet enema powder improves HIV prevention accessibility, manufacturability, and user acceptance over liquid formulations.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasInfectious DiseaseTherapeutic IndicationsHIVLead InventorLisa RohanDepartmentPharm-Pharmaceutical ScienceAll Tech InnovatorsChristina BagiaCraig HendrixLisa Cencia RohanDate Submitted2021-12-03CollectionsWomen's & Reproductive Health
Rapid Detection of Recent Flavivirus Infections Using IgG3 Anti-NS103819IgG3-NS1 flavivirus assay detects recent infections within two weeks, reducing cross-reactivity across-bearing platforms (ELISA/Luminex).Technology TypeDiagnostic/AssayTechnology SubtypeBiomarkerTherapeutic AreasInfectious DiseaseTherapeutic IndicationsOtherLead InventorErnesto MarquesDepartmentGSPH-Infectious Diseases & MicrobiologyAll Tech InnovatorsErnesto Torres De Azeved Marques JrEduardo NascimentoDate Submitted2016-02-02
Reversing Fosfomycin Resistance04054A small-molecule inhibitor ANY1 blocks FosA, reversing fosfomycin resistance and restoring efficacy against multidrug-resistant Gram-negative bacteria.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasInfectious DiseaseTherapeutic IndicationsOtherLead InventorNicolas Sluis-CremerDepartmentMed-MedicineAll Tech InnovatorsYohei DoiNicolas Paul Sluis-CremerAdam Daniel TomichTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2016-10-19
Novel Metabolomic Markers in Sepsis and Pneumonia02808Metabolomic profiling links sepsis/pneumonia outcomes to distinct biomarkers, revealing early pathways and candidate survival markers.Technology TypeDiagnostic/AssayTechnology SubtypeBiomarkerTherapeutic AreasInfectious DiseaseRespiratoryTherapeutic IndicationsSepsisPneumococcalLead InventorChristopher SeymourDepartmentMed-Critical Care MedicineAll Tech InnovatorsJohn A. Kellum JrChristopher W. SeymourDate Submitted2012-06-12
Antibodies to Detect TAT-C1aB (CM-EA1) in Biological Fluids06516Dual-antibody sandwich ELISA detects intact TAT-C1aB fusion peptide in fluids, enabling precise pharmacokinetics and adaptable sensing.Technology TypeLife Science Research ToolTechnology SubtypeProteinTherapeutic AreasInfectious DiseaseTherapeutic IndicationsHIVTagsAntibody - mAbLead InventorBradley MolyneauxDepartmentMed-NeurologyAll Tech InnovatorsElias AizenmanBradley J. MolyneauxDate Submitted2023-09-22CollectionsWomen's & Reproductive Health
Rapid Diagnostic Tool for Tuberculosis06426A fast, affordable TB diagnostic using SWCNT FET sensors detects MTB antigen 85B in minutes at fg/mL sensitivity.Technology TypeDiagnostic/AssayTechnology SubtypeIn vitro DiagnosticTherapeutic AreasInfectious DiseaseTagsIn Vitro DiagnosticLife SciencePublic HealthLead InventorAlexander StarDepartmentChemistryAll Tech InnovatorsMichael R. ShurinAlexander StarJieyu WangDate Submitted2023-06-09
Rapid COVID-19 Antigen Test05627Rapid, five-minute COVID-19 antigen test using sc-SWCNT FETs for rapid, accessible, point-of-care detection.Technology TypeDiagnostic/AssayTechnology SubtypeIn vitro DiagnosticTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorAlexander StarDepartmentChemistryAll Tech InnovatorsWenting ShaoMichael R. ShurinAlexander StarDate Submitted2021-03-04
