Therapeutic Areas

Respiratory

EVOLV-Rx: Automated Decision Support for Eliminating Low-Value Clinical Practices

07182

Automated, cross-source detection of low-value prescribing to reduce harm; scalable decision support for providers, payers, and hospitals.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Respiratory
Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Chronic Obstructive Pulmonary Disease (COPD)
Tags: Aging
Algorithm
Personalized Medicine
Lead Inventor: Thomas Radomski
Department: Med-Medicine
All Tech Innovators: Thomas R. Radomski
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-05-12
Collections: Cardiometabolic

Bacteriophage Cocktail to Treat Achromobacter

06380

Five phages form a cocktail to broaden Achromobacter targeting, offering personalized, antibiotic-sparing therapy potential.

Technology Type: Therapeutic Modality
Technology Subtype: Bacteriophage
Therapeutic Areas: Respiratory
Infectious Disease
Therapeutic Indications: Other
Lead Inventor: Daria Van Tyne
Department: Med-Medicine
All Tech Innovators: Ghady Haidar
Daria N. Van Tyne
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2023-04-20

Lung-Targeting Peptide to Deliver Diagnostic and Therapeutic Targets to the Lung

05084

Lung-targeting cell-penetrating peptides enable higher-transduction delivery of diagnostics and therapies directly to lung tissue.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Therapeutic Indications: Chronic Obstructive Pulmonary Disease (COPD)
Asthma
Acute respiratory failure
Tags: Platform Technology
Lead Inventor: Maliha Zahid
All Tech Innovators: Maliha Zahid
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-08-07

NextGenET

04917

NextGenET: a cuff-less endotracheal tube reducing ventilator-associated pneumonia by ~50%, lowering costs and monitoring needs.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Respiratory
Otolaryngology
Lead Inventor: Carl Snyderman
Department: Med-Otolaryngology
All Tech Innovators: Maxwell Baxter
Garrett N. Coyan MD, MS
Nikki Cwalina
Date Submitted: 2019-03-10

Integrated AI and Sensing System for Pulmonary Disease Evaluation

06395

AI-enabled smartphone system (PTEase) remotely analyzes airway measurements for lung function and disease classification.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Respiratory
Lead Inventor: Wei Gao
Department: Electrical and Computer Engineering
All Tech Innovators: Wei Chen
Erick Forno
Wei Gao
Date Submitted: 2023-05-03
Collections: Healthcare AI

Smartphone-based Ultrasonic Respiratory Evaluation

05314

Smartphone ultrasonic respiratory tool (SURe) enables at-home, non-invasive lung function monitoring via built-in mic/speaker.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Respiratory
Lead Inventor: Wei Chen
Department: Med-Pediatrics
All Tech Innovators: Wei Chen
Erick Forno
Wei Gao
Date Submitted: 2020-04-21

Device for Collecting Exhaled Aerosols During Mechanical Ventilation

06109

Non-invasive device collects exhaled aerosols from ventilated patients for frequent VAP monitoring and rapid pathogen detection.

Technology Type: Medical Device
Technology Subtype: Monitoring Medical Device
Therapeutic Areas: Respiratory
Infectious Disease
Therapeutic Indications: Other
Tags: Minimally invasive
Lead Inventor: Timothy Corcoran
Department: Med-Medicine
All Tech Innovators: Timothy E. Corcoran
Steven George Kefalos II
Rutuja Amar Kulkarni
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2022-07-25

Use of Specific Phages for the Treatment of Non-Tuberculosis Mycobacterial Infections

05095

Phage therapy targets drug-resistant non-tuberculous Mycobacteria, enabling rapid, strain-specific treatment with minimal resistance and side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Bacteriophage
Therapeutic Areas: Respiratory
Infectious Disease
Tags: Biomaterial
Lead Inventor: Graham Hatfull
Department: Distinguished Faculty-Dietrich School of Arts and Sciences
All Tech Innovators: Rebekah Marie Dedrick
Carlos Andres Guerrero
Graham F. Hatfull
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-08-20

Non-Contrast CT to Detect Pulmonary Embolisms

06721

AI converts CTPA to non-contrast CT via CycleGAN, enabling early pulmonary embolism detection on NCCT scans.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Respiratory
Therapeutic Indications: Other
Lead Inventor: Jiantao Pu
Department: Med-Radiology
All Tech Innovators: Jiantao Pu
Date Submitted: 2024-04-17
Collections: Healthcare AI

Novel Approach to Study Human Respiratory Tracts

06098

New combined synthetic sputum–epithelial co-culture model better mimics human respiratory tract biofilms, enhancing antimicrobial research.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Respiratory
Infectious Disease
Therapeutic Indications: Other
Lead Inventor: Jennifer Bomberger
Department: Department of Microbiology and Immunology
All Tech Innovators: Jennifer M. Bomberger
Ananya Kapur
Date Submitted: 2022-07-13

Inhibition of Fgr Reduces Radiation-Induced Profibrotic Markers

05603

Inhibiting Fgr in senescent cells dampens profibrotic signals, potentially preventing radiation-induced pulmonary fibrosis (RIPF).

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Respiratory
Lead Inventor: Amitava Mukherjee
Department: Med-Radiation Oncology
All Tech Innovators: Michael W. Epperly Ph.D.
Joel S. Greenberger M.D.
Amitava Mukherjee
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-01-26

PULM-TREE: A New Tool for Lung Transplant Research

06143

PULM-TREE unifies lung transplant clinical and genetic data into a native-format, agile, searchable research platform.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Respiratory
Therapeutic Indications: Acute respiratory failure
Lead Inventor: John McDyer
Department: Med-Medicine
All Tech Innovators: Carlo John Iasella
John Francis McDyer
Melissa Irene Saul
Date Submitted: 2022-08-24

Intervention to Prevent Acute Lung Injury for Patients with Sickle Cell Disease

05721

Inhibits GSDMD signaling to reduce lung vaso-occlusion and acute chest syndrome in sickle cell disease, beyond P-selectin therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Respiratory
Hematology
Therapeutic Indications: Acute Chest Syndrome
Sickle cell disease
Other
Lead Inventor: Prithu Sundd
Department: VERSITI Blood Research Institute
All Tech Innovators: Prithu Sundd
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-06-10

A Paradigm Shift in the Treatment of Sleep Apnea

05707

A non-invasive inflatable pillow (AHT-CLiP) adjusts head tilt to open airways during sleep, using breath-sound feedback.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Respiratory
Mental and Behavioral Health
Therapeutic Indications: Sleep disorder
Tags: Consumer
Lead Inventor: Kirill Kiselyov
Department: Biological Sciences
All Tech Innovators: Ata Murat Kaynar
Kirill Igorevich Kiselyov
Technology Readiness Level: 3. Prototype development
Date Submitted: 2021-05-27

Novel Protein and Lipid Therapeutic Targets for Exacerbation-Prone Asthma

05414

Novel protein and lipid targets curb ferroptosis to prevent and treat exacerbation-prone asthma, addressing underlying causes.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Respiratory
Therapeutic Indications: Asthma
Lead Inventor: Sally Morganroth
Department: GSPH-Environmental/Occupational Health
All Tech Innovators: Hulya Bayir
Valerian E. Kagan PhD, DSc
Sally Ellen Morganroth
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2020-06-09

New Method of Microstreaming

06155

A new glass-driven acoustic streaming method creates strong, stable vortices on membranes to boost microfluidic gas exchange.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Therapeutic Areas: Respiratory
Lead Inventor: Sung Kwon Cho
Department: Mechanical Engineering and Materials Science
All Tech Innovators: Sung Kwon Cho
Anthony L. Mercader
Date Submitted: 2022-09-07

Modular Extracorporeal Pump and Fiber Cartridge System for Ambulatory Oxygenation and Carbon Dioxide Removal

04370

Modular ambulatory ECMO/CO2 removal system with quick-swap fiber cartridges, reusable base, low hemolysis, versatile flow ranges.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Respiratory
Lead Inventor: William Federspiel
Department: Bioengineering
All Tech Innovators: Gregory Burgreen
William J. Federspiel
Brian Joseph Frankowski
Date Submitted: 2017-09-13

An Expandable Percutaneous Venous Cannula for Use in Extracorporeal Cardiopulmonary Support

03884

Expandable single‑cannula ECMO device conforming to atrial anatomy for complete, low‑occlusion venous drainage via percutaneous deployment

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Respiratory
Cardiovascular
Tags: Biomaterial
Polymer
Lead Inventor: Antonio DAmore
Department: Med-Surgery
All Tech Innovators: Vinay Badhwar
Antonio DAmore
Daniel T. McKeel
Date Submitted: 2016-04-04
Collections: Cardiometabolic

Novel Method of Idiopathic Pulmonary Fibrosis (IPF) Detection

01838

Urine-based MMP activation peptide detection correlates with IPF, enabling earlier diagnosis and flare prediction via ELISA.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Respiratory
Therapeutic Indications: Pulmonary fibrosis
Lead Inventor: Tim Oury
Department: Med-Pathology
All Tech Innovators: Jan J. Enghild
Naftali Kaminski
Tim David Oury MD, PhD
Date Submitted: 2008-09-25

Novel Metabolomic Markers in Sepsis and Pneumonia

02808

Metabolomic profiling links sepsis/pneumonia outcomes to distinct biomarkers, revealing early pathways and candidate survival markers.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Respiratory
Infectious Disease
Therapeutic Indications: Sepsis
Pneumococcal
Lead Inventor: Christopher Seymour
Department: Med-Critical Care Medicine
All Tech Innovators: John A. Kellum Jr
Christopher W. Seymour
Date Submitted: 2012-06-12

Extracellular Matrix–derived Inhalation Therapy for Prevention and Treatment of Pulmonary Fibrosis

01851

ECM-derived inhalation therapy uses decellularized porcine tissues to deliver regenerative signals, suppressing pulmonary fibrosis in models.

Technology Type: Therapeutic Modality
Technology Subtype: Other Therapeutic Modality
Therapeutic Areas: Respiratory
Therapeutic Indications: Pulmonary fibrosis
Lead Inventor: Thomas Gilbert
Department: Bioengineering
All Tech Innovators: Thomas W. Gilbert
Michelle L. Manni
Tim David Oury MD, PhD
Date Submitted: 2008-10-10

A Novel Therapeutic Target and Clinical Marker for Pulmonary Arterial Hypertension

05010

SCUBE1 offers a target and noninvasive marker for diagnosing, monitoring, and treating pulmonary arterial hypertension.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Respiratory
Cardiovascular
Lead Inventor: Stephen Chan
Department: Med-Medicine
All Tech Innovators: Stephen Yu-Wah Chan MD, PhD
Wei Sun
Date Submitted: 2019-06-12
Collections: Cardiometabolic

Augmentation of Gas Exchange Using Oscillating Membrane and/or Bubbles for Artificial Lung and Other Gas Exchange Devices

03776

Oscillating membrane-bubble system boosts gas exchange via microstreaming, enhancing mass transfer in artificial lungs and devices.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Respiratory
Lead Inventor: Sung Kwon Cho
Department: Mechanical Engineering and Materials Science
All Tech Innovators: Sung Kwon Cho
Date Submitted: 2015-11-25

Epidural Spinal Cord Stimulation System for Improving Neurodegenerative Motor Functions

06717

Indirect sensory-nerve stimulation via epidural spinal cord system may improve breathing, speech, and swallowing in neurodegenerative disease.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Respiratory
Neuroscience
Therapeutic Indications: Spinal muscular atrophy (SMA)
Parkinson's Disease
Multiple Sclerosis (MS)
Lead Inventor: Daryl Fields
Department: Med-Surgery
All Tech Innovators: Daryl Fields
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2024-04-15

Treatment for Pediatric Bronchopulmonary Dysplasia

06694

Oral vamorolone may treat infant bronchopulmonary dysplasia safely, reducing long-term corticosteroid side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Therapeutic Indications: Other
Tags: Pediatrics
Life Science
Lead Inventor: Donald DeFranco
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Timothy Cole
Donald B. DeFranco
Nathalie El Khoury Juri
Date Submitted: 2024-03-19

Nanoparticle ROS-scavenger Intervention to Modulate Oxidative Stress and Immune Cells in Respiratory Syncytial Virus (RSV)

05932

Cerium oxide nanoparticles scavenging ROS show potential RSV therapy, reducing oxidative stress and boosting antiviral strategies.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Respiratory
Infectious Disease
Tags: Pediatrics
Lead Inventor: Shilpa Sant
Department: Department of Pharmaceutical Sciences
All Tech Innovators: Kerry McGarr Empey
Jessica L. Kosanovich
Akhil Pravinkumar Patel
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-01-04

Quantification of Disease Severity Using 2D X-Ray

05478

Novel CNN method quantifies thoracic disease extent from 2D X-rays, using 3D CT ground truth for accuracy.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Respiratory
Infectious Disease
Therapeutic Indications: Emphysema
Pneumococcal
Chronic Obstructive Pulmonary Disease (COPD)
Lead Inventor: Jiantao Pu
Department: Med-Radiology
All Tech Innovators: Jiantao Pu
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2020-08-12

Delivery of Biological Drugs to Epithelia

04508

Anchoring domains bind wet epithelia to prevent washout, enabling extended delivery of biologics to eyes, lungs, and mucosal tissues.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Ophthalmology
Therapeutic Indications: Chronic Obstructive Pulmonary Disease (COPD)
Asthma
Dry eye syndrome
Lead Inventor: Robert Shanks
Department: Med-Ophthalmology
All Tech Innovators: Jes K. Klarlund
Robert Michael Queen Shanks
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2018-02-15
Collections: Women's & Reproductive Health

Mouse Model of Corticosteroid Refractory Severe Asthma

02744

New mouse model mimics human corticosteroid-refractory severe asthma, enabling study of treatment-resistant airway disease.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Respiratory
Therapeutic Indications: Asthma
Lead Inventor: Anuradha Ray
Department: Med-Medicine
All Tech Innovators: Anupriya Khare
Christina Mae Zinger Morse
Timothy B. Oriss
Date Submitted: 2012-04-11

ModELAS: A Modular Extracorporeal Lung Assist System

05256

Wearable modular artificial lung offering long-term extracorporeal oxygenation and CO2 removal for ambulatory patients.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Respiratory
Tags: Life Science
Lead Inventor: Brian Frankowski
Department: Med-McGowan Inst Regenerative Med
All Tech Innovators: Brian Joseph Frankowski
Ryan A. Orizondo
Date Submitted: 2020-02-25

Engineered Receptors as Therapeutic Targets

02884

Engineered chloride channel receptors target peripheral pain via gene delivery, offering pH- or drug-activated analgesia.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Respiratory
Neuroscience
Therapeutic Indications: Asthma
Pain
Lead Inventor: Yan Xu
Department: Med-Anesthesiology and Perioperative Medicine
All Tech Innovators: Pei Tang
Tommy Stevens Tillman
Yan Xu
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2012-08-31

Novel Small Molecule FIEL1 Inhibitor in Inflammatory and Fibrotic Lung Injury

03443

Novel FIEL1 inhibitor reduces inflammation and fibrosis in lung injury models, offering IPF treatment potential and targeted TGFβ disruption.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Respiratory
Therapeutic Indications: Idiopathic pulmonary fibrosis (IBF)
Lead Inventor: Beibei Chen
Department: Med-Medicine
All Tech Innovators: Beibei Chen
Date Submitted: 2014-11-11

Protection from Chemical-Induced Acute Lung Injury

03070

PTEN-inhibitor-based therapy to protect against chemical-induced acute lung injury, focusing on phosphatase pathways for pulmonology.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Respiratory
Therapeutic Indications: Acute respiratory failure
Lead Inventor: George Leikauf
Department: GSPH-Environmental/Occupational Health
All Tech Innovators: George D. Leikauf
Date Submitted: 2013-06-07
Collections: Regenerative Medicine

FibroKine(TM) A Novel Inhaled Delivery of Peptides to Target Fibrosis

04496

Inhaled FibroKine peptides target lung fibrosis by CXCR3/TGF-β modulation, halting fibrosis with direct deep-lung delivery.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Therapeutic Indications: Idiopathic pulmonary fibrosis (IBF)
Tags: Drug Discovery - Target
Life Science
Thoracic Disease
Lead Inventor: Cecelia Yates-Binder
Department: Nurs-Nurse Anesthesia
All Tech Innovators: Timothy E. Corcoran
Jesse Jaynes
Zariel I. Johnson
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2018-01-22

Novel Treatment for Severe Asthma

04035

Targeting IRF5 to curb IFN-γ overexpression offers potential severe asthma therapy, boosting steroid response and reducing symptoms.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - DNA
Therapeutic Areas: Respiratory
Therapeutic Indications: Asthma
Lead Inventor: Anuradha Ray
Department: Med-Medicine
All Tech Innovators: Timothy B. Oriss
Anuradha Ray Ph.D.
Prabir Ray Ph.D.
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2016-10-03
Collections: Cell & Gene Therapy

Bagpipe Valve Bag Mask

05051

One-operator bag-valve mask redesign with neck strap mimics bagpipe handling, enabling full ventilation, reduced fatigue, faster emergency response.

Technology Type: Medical Device
Technology Subtype: Other Medical Device
Therapeutic Areas: Respiratory
Intensive Care
Lead Inventor: Travis Fernald
Department: Dent Med-Office of the Dean
All Tech Innovators: Travis Lux Fernald
Technology Readiness Level: 3. Prototype development
Date Submitted: 2019-07-07

TracheoMag

03396

Biodegradable magnesium-lithium airway stent with ultra-ductility, enabling natural healing and reduced need for removal.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Respiratory
Surgery
Tags: Biomaterial
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Oleg Velikokhatnyi
Jingyao Wu
Date Submitted: 2014-09-09
Collections: Regenerative Medicine

Compact Ambulatory Extracorporeal Lung Assist System

03644

A wearable, integrated pump-lung provides ambulatory respiratory support with efficient gas transfer and minimized blood damage.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Respiratory
Therapeutic Indications: Acute respiratory failure
Tags: Critical Care
Lead Inventor: Shalv Madhani
Department: Med-McGowan Inst Regenerative Med
All Tech Innovators: James F. Antaki
Gregory Burgreen
William J. Federspiel
Date Submitted: 2015-06-10

Treatment of Lung Disease with Novel Water-Soluble Adducts of Michael Acceptors

02941

Water-soluble inhalable Michael-acceptor adducts show antioxidant, anti-inflammatory lung protection with targeted, short systemic exposure.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Respiratory
Cardiovascular
Lead Inventor: Raju Reddy
Department: Med-Medicine
All Tech Innovators: Raju Cheruku Reddy
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2012-11-27
Collections: Cardiometabolic

A Wearable Respiratory Energy Harvester

04004

Breathing-powered wearable harvester converts chest motion to electricity and self-powered respiratory monitoring with adaptive designs.

Technology Type: Engineering Technology
Technology Subtype: Energy
Therapeutic Areas: Respiratory
Lead Inventor: Mingui Sun
Department: Med-Neurological Surgery
All Tech Innovators: Wenyan Jia
Mingui Sun Ph.D.
Paresh Manik Vasandani
Date Submitted: 2016-08-03

Advanced Pulmonary Treatment with Verteporfin and Glutaminase Inhibitors

04344

Targeted, controlled lung delivery of Verteporfin with glutaminase inhibitors via porous PLGA particles to treat pulmonary hypertension.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Lead Inventor: Abhinav Acharya
Department: Chem/Petroleum Engineering
All Tech Innovators: Abhinav Prakash Acharya
Stephen Yu-Wah Chan MD, PhD
Ashlee Chennicia Greene
Date Submitted: 2017-08-07

Light Refraction Imaging to Measure Liquid Volume

02316

Light refraction imaging enables noninvasive, high-throughput airway liquid volume measurement using standard lab cameras, matching confocal accuracy.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Respiratory
Lead Inventor: Michael Myerburg
Department: Med-Medicine
All Tech Innovators: Michael M. Myerburg
Date Submitted: 2010-10-06

L-PLUNC Monoclonal Antibody

03164

Targeted IgG1 antibody against LPLUNC1 to diagnose and modulate respiratory infections; validated for WB, ELISA, immunostaining.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Respiratory
Infectious Disease
Therapeutic Indications: Respiratory syncytial virus (RSV)
Pneumococcal
Lead Inventor: Yuanpu Di
All Tech Innovators: Yuanpu Di
Date Submitted: 2014-06-12

Differentiation of Pluripotent Stem Cells Into 3D Lung Tissue

03682

3D lung tissue from pluripotent stem cells enables multi-lineage, self-organizing lung models for realistic development, disease, and toxicology studies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Respiratory
Lead Inventor: Diane Carlisle
Department: Med-Neurological Surgery
All Tech Innovators: Diane L. Carlisle
Date Submitted: 2015-07-30

SUPPORT: Comprehensive Palliative Care for Advanced Lung Diseases

03576

Early, standardized palliative education empowering advanced lung disease patients with symptom, rehab, oxygen, and care-planning guidance.

Technology Type: Therapeutic Modality
Technology Subtype: Other Therapeutic Modality
Therapeutic Areas: Respiratory
Lead Inventor: Kathleen Lindell
All Tech Innovators: Kathleen Oare Lindell
Date Submitted: 2015-04-07

Dynamic Texture Analysis for Automated Clinical Diagnosis of Abnormal Respirator

03185

Automated diagnosis of abnormal ciliary motion via video-based dynamic texture analysis, decomposing motion into rotation and deformation.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Respiratory
Tags: Artificial intelligence (AI)
Algorithm
Lead Inventor: Srinivas Chennubhotla
Department: Med-Computational and Systems Biology
All Tech Innovators: Srinivas C. Chennubhotla
John R. Durkin
Richard John Bruce Francis
Date Submitted: 2013-12-02
Collections: Healthcare AI

Isolation and Purification of Soluble Receptor for Advanced Glycation End-Products (sRAGE) from Lung Tissue and Polyclonal Antibodies

01831

Purified, endotoxin-free soluble RAGE from bovine/murine lung tissue; scalable 20 mg from 500 g, enabling research tool use.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Respiratory
Lead Inventor: Tim Oury
Department: Med-Pathology
All Tech Innovators: Judson M. Englert
Tim David Oury MD, PhD
Date Submitted: 2008-09-08

Anti-Inflammatory Small Molecules for Treatment of Chronic Inflammatory Disorders

04731

New small-molecule NF-κB inhibitors target chronic inflammation (asthma, RA, IBD) and may aid aging and cancer therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Respiratory
Gastroenterology
Therapeutic Indications: Ulcerative Colitis
Asthma
Lead Inventor: Beibei Chen
Department: Med-Medicine
All Tech Innovators: Beibei Chen
Toren Finkel
Yuan Liu
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2018-09-10

Clearing the Lungs with Ciliogenesis: New Treatment for Asthma and COPD

03732

Notch inhibition with DAPT restores airway cilia, boosting clearance and potentially treating COPD, asthma, and related lung diseases.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Respiratory
Therapeutic Indications: Emphysema
Chronic Obstructive Pulmonary Disease (COPD)
Asthma
Lead Inventor: Maliha Zahid
All Tech Innovators: Cecilia Wen Ya Lo
Maliha Zahid
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2015-09-25