Department

Med-Pathology

Tumor Associated Antigen Burden Predicts Immune Checkpoint Blockade Benefit in Tumors with Low T Cell Exhaustion Signature and Low Neoantigen Burden

06265

TAB-based antigen burden with T cell exhaustion signatures predicts immune checkpoint blockade benefit beyond low TMB/PD-L1.

Technology Type: Digital Health
Technology Subtype: Clinical Trial Tool
Therapeutic Areas: Oncology
Lead Inventor: Xiaosong Wang
Department: Med-Pathology
All Tech Innovators: Xiaosong Wang
Date Submitted: 2023-01-12

UniConSig and CSEA: Innovative Algorithms for Gene Function and Pathway Analysis

04440

Novel UniConSig and CSEA algorithms deepen gene-function/pathway analysis, outperforming GSEA via concept-based enrichment. 15 words.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Therapeutic Areas: Oncology
Lead Inventor: Xiaosong Wang
Department: Med-Pathology
All Tech Innovators: Xu Chi
Xiaosong Wang
Date Submitted: 2017-11-21

Microsphere-Based Therapy for Reversing New-Onset Autoimmune Diabetes

01703

Innovative antisense-loaded microspheres reverses new-onset autoimmune diabetes by downregulating CD40/CD80/CD86, modulating dendritic cells.

Technology Type: Therapeutic Modality
Technology Subtype: Vaccine - subunit, recombinant, polysaccharide, or conjugate
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Lead Inventor: Nick Giannoukakis
Department: Med-Pathology
All Tech Innovators: Nick Giannoukakis
Massimo M. Trucco
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2008-04-17
Collections: Cardiometabolic

Stimulation of Exosome Secretion

04959

A potent stimulator boosts exosome secretion up to 24-fold, enabling rapid, scalable exosome production for therapies and research.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Other
Tags: Platform Technology
Lead Inventor: Theresa Whiteside
Department: Med-Pathology
All Tech Innovators: Edwin Kerry Jackson
Nils Ludwig
Theresa L. Whiteside
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-05-19

A Novel Therapeutic Biomarker for Metabolic Liver Disease

06324

Identifies PNPLA3 rs738409 variant driving MAFLD via ferroptosis; enables targeted therapies, screening, and safer liver transplantation.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Hepatology
Therapeutic Indications: End-Stage liver disease (ESLD)
Cirrhosis
Tags: Drug Discovery - Target
Life Science
Liver Disease
Lead Inventor: Alejandro Soto Gutierrez
Department: Med-Pathology
All Tech Innovators: Abhinav Achreja
Olamide Animasahun
Rodrigo Machado Florentino
Date Submitted: 2023-03-01
Collections: Cardiometabolic

RNA- and DNA-Based Assays for Predicting Paclitaxel Resistance in Triple Negative Breast Cancer

05224

RNA- and DNA-based assays identify a TNBC-specific fusion linked to paclitaxel resistance, enabling therapy pivots.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Xiaosong Wang
Department: Med-Pathology
All Tech Innovators: Xiaosong Wang
Date Submitted: 2020-01-17
Collections: Women's & Reproductive Health

Universal Vaccine for SARS-CoV-2 (COVID 19)

05356

Universal vaccine approach targets SARS-CoV-2 RdRp activation motif, potentially halting replication across coronaviruses.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Infectious Disease
Therapeutic Indications: Covid-19
Lead Inventor: Patrick Moore
Department: Med-Pathology
All Tech Innovators: Yuan Chang
Patrick S. Moore
Masahiro Shuda
Date Submitted: 2020-05-13

Novel Small Molecules for Inhibition of MALT1

05186

Innovative MALT1 inhibitors block both protease and scaffolding functions, expanding cancer and autoimmune therapy potential.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Immunology
Oncology
Tags: Autoimmune
Immuno-oncology
Lead Inventor: Peter Lucas
Department: Med-Pathology
All Tech Innovators: Beibei Chen
Dong Hu
Heejae Kang
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2019-11-30
Collections: Women's & Reproductive Health

Resolving Diagnostic Discrepancies in Multiple Myeloma Patients

04607

Magnetic bead-based depletion removes therapeutic monoclonal antibodies, reducing false positives in MM diagnostics and treatment monitoring.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Oncology
Hematology
Tags: Coating
Immuno-oncology
Lead Inventor: Sarah Wheeler
Department: Med-Pathology
All Tech Innovators: Li Liu
Michael R. Shurin
Sarah Elizabeth Wheeler
Date Submitted: 2018-04-26

Novel Research Model for Liver Dysfunction

06810

Researchers create TM6SF2-167K iPSC-derived liver cells to model MASLD, enabling target discovery and therapy screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Hepatology
Therapeutic Indications: Cirrhosis
Tags: Drug Discovery - Target
Life Science
Lead Inventor: Alejandro Soto Gutierrez
Department: Med-Pathology
All Tech Innovators: Lanuza Alaby Pinheiro Alaby Pinheiro Faccioli
Rodrigo Machado Florentino
Alejandro Soto Gutierrez
Date Submitted: 2024-07-17
Collections: Cardiometabolic

Novel Immunotherapy for Hepatocellular Carcinoma

06382

Novel mAb targets MAN2A1-FER–positive cancers (HCC, prostate, glioblastoma), slowing growth and metastasis via PDGFRA extracellular domain binding.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Oncology
Therapeutic Indications: Hepatocellular carcinoma (HCC)
Tags: Antibody - mAb
Drug Discovery - Target
Immunology
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Muhamuda Kader
Jianhua Luo
Yanping Yu
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-04-21
Collections: Women's & Reproductive Health

Transcriptome and Exome Analyses of Hepatocellular Carcinoma Reveal Patterns to Predict Cancer Recurrence in Liver Transplant Patients

05947

Integrated transcriptome-exome sequencing with ML (Random Forest, k-top scoring pairs) to predict HCC recurrence post-liver transplant. 126 chars

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Oncology
Therapeutic Indications: Hepatocellular carcinoma (HCC)
Tags: Machine learning
Personalized Medicine
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Shuchang Liu
Jianhua Luo
George Michalopoulos
Date Submitted: 2022-01-27

Epstein-Barr Circular RNA as a Novel Biomarker of EBV-Related Cancers

04470

Stable EBV circBART circular RNAs enable rapid, low-cost, reliable cancer detection and early diagnosis in diverse tumors.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Oncology
Infectious Disease
Therapeutic Indications: Lymphoma
Herpes
Lead Inventor: Patrick Moore
Department: Med-Pathology
All Tech Innovators: Yuan Chang
Patrick S. Moore
Tuna Toptan
Date Submitted: 2018-01-02

Flux Balance Analysis with Molecular Crowding

01517

A crowding-aware flux balance model predicting bacterial growth, substrate use, and metabolic reorganization under varying growth rates.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Tags: Algorithm
Lead Inventor: Zoltan Oltvai
Department: Med-Pathology
All Tech Innovators: Zoltan Nagy Oltvai
Alexei Vazquez
Date Submitted: 2007-06-07

Fusion Gene-Based Machine Learning Tool Enhances Prediction of Prostate Cancer Clinical Outcomes

06089

Fusion-gene based machine learning boosts prostate cancer recurrence predictions using 14 gene signatures across multiple cohorts.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Urology
Oncology
Therapeutic Indications: Prostate cancer / adenocarcinoma
Tags: Genetics
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Shuchang Liu
Jianhua Luo
George Michalopoulos
Date Submitted: 2022-07-01

Pfn1 as a Novel Therapeutic Target for Atherosclerosis

06880

Pfn1 inhibitors block actin interaction, offering a novel anti-atherosclerosis approach with anti-angiogenic potential.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Atherosclerotic disease
Lead Inventor: David Gau
Department: Med-Pathology
All Tech Innovators: David Martin Gau
Abigail Gondringer
Donna Huryn
Date Submitted: 2024-09-17
Collections: Cardiometabolic

Integral Genomic Signature (IGenSig) as a Research Tool

05571

Integral Genomic Signature (iGenSig) offers robust, interpretable multi-omics cancer modeling with cross-dataset accuracy and bias tolerance.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Therapeutic Areas: Oncology
Tags: Machine learning
Lead Inventor: Xiaosong Wang
Department: Med-Pathology
All Tech Innovators: Xiaosong Wang
Date Submitted: 2020-12-09
Collections: Healthcare AI

A Novel Neoplastic Fusion Transcript Predicts Sensitivity to the MEK Inhibitor Trametinib in More Aggressive and Metastatic Breast Cancers

05317

Fusion RAD51AP1-DYRK4 predicts trametinib sensitivity in aggressive/metastatic breast cancers, enabling targeted MEK inhibitor therapy.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Tags: Precision medicine
Personalized Medicine
Women's Health
Lead Inventor: Xiaosong Wang
Department: Med-Pathology
All Tech Innovators: Chia Chia Liu
Xiaosong Wang
Date Submitted: 2020-04-22
Collections: Women's & Reproductive Health

Integral Genomic Signature Analysis (iGenSig)

05154

White-box, multi-omics genomic signature predicts cancer therapy responses across datasets with high accuracy, robustness.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Therapeutic Areas: Oncology
Lead Inventor: Xiaosong Wang
Department: Med-Pathology
All Tech Innovators: Xiaosong Wang
Date Submitted: 2019-10-31
Collections: Healthcare AI

Mouse Monoclonal Antibody Specific for Merkel Cell Polyomavirus- Small T Antigen

02155

New mouse monoclonal antibody targets Merkel cell polyomavirus small T antigen, enabling precise MCC diagnosis and viral study.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Oncology
Therapeutic Indications: Melanoma
Lead Inventor: Yuan Chang
Department: Med-Pathology
All Tech Innovators: Yuan Chang
Patrick S. Moore
Date Submitted: 2010-02-23

Novel Therapy to Prevent Liver Disease

05722

Targeting ferroptosis to prevent PNPLA3 rs738409:G-linked liver cirrhosis, offering non-invasive therapy and reduced transplant need.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Hepatology
Therapeutic Indications: Non-alcoholic steatohepatitis (NASH)
Cirrhosis
Tags: Genetics
Lead Inventor: Alejandro Soto Gutierrez
Department: Med-Pathology
All Tech Innovators: Abhinav Achreja
Olamide Animasahun
Rodrigo Machado Florentino
Date Submitted: 2021-06-10
Collections: Cardiometabolic

Slow Drug Release for Ophthalmic Treatments

05610

Coacervate gel delivers CXCL10p peptide to the eye for slow, tunable dry eye treatment, reducing goblet cell loss.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Dry eye syndrome
Tags: Life Science
Lead Inventor: Alan Wells
Department: Med-Pathology
All Tech Innovators: Shivalingappa Kottur Swamynathan
Yadong Wang
Alan H. Wells
Date Submitted: 2021-02-08

Alpha-Parvin (Also Known as PARVA, Actopaxin, or CH-ILKBP) Monoclonal Antibodies

05420

Cross-species mouse monoclonal antibodies (1D4, 3B5) target alpha-parvin for immunoprecipitation, Western blotting, and signaling studies.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Oncology
Lead Inventor: Chuanyue Wu
Department: Med-Pathology
All Tech Innovators: Chuanyue Wu
Date Submitted: 2020-06-15

Advanced Methods for Diagnosing Prostate Cancer and Predicting Relapse

02406

CNV-based genome analysis predicts prostate cancer progression and relapse, enabling personalized diagnostics and targeted treatment planning.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Oncology
Therapeutic Indications: Prostate cancer / adenocarcinoma
Tags: Precision medicine
Clinical Decision Support
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Jianhua Luo
George Michalopoulos
Joel B. Nelson
Technology Readiness Level: 5. Analytical validation
Date Submitted: 2011-02-15

Hibernation-Inspired Protein Reverses Fatty Liver Disease and Obesity

07317

Hibernation-inspired siRNA therapy silences fetal liver SULT1C2 to reverse fatty liver disease, obesity, and insulin resistance.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Endocrinology and Metabolic Diseases
Hepatology
Therapeutic Indications: Obesity
Metabolic Associated Fatty Liver Disease (MAFLD)
Tags: Life Science
Lead Inventor: Alejandro Soto Gutierrez
Department: Med-Pathology
All Tech Innovators: Lanuza Alaby Pinheiro Alaby Pinheiro Faccioli
Bharat Bhushan
Rodrigo Machado Florentino
Date Submitted: 2025-08-29
Collections: Cell & Gene Therapy
Cardiometabolic

Novel Hepatocyte Growth Factor Receptor Agonist

05468

A humanized MET agonist META4 restores HGF-MET signaling, promoting tissue regeneration and potential therapies for liver disease and AMD.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Hepatology
Ophthalmology
Therapeutic Indications: Other
Non-alcoholic steatohepatitis (NASH)
Diabetic retinopathy
Tags: Regenerative medicine
Lead Inventor: Abdolreza Zarnegar
Department: Med-Pathology
All Tech Innovators: Abdolreza Zarnegar
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-08-05
Collections: Regenerative Medicine
Cardiometabolic

Caspase-3 Knockout Colon Cancer Cells

03687

Caspase-3 knockout HCT116 cells via AAV targeting offer a unique, reliable cancer apoptosis model for drug screening and research.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Lead Inventor: Jian Yu
Department: Med-Pathology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2015-07-30

New Test Can Predict Immunotherapy Responders for Broader Range of Cancers than Current Tools

06200

IGR burden helps predict immunotherapy responders beyond current TMB tools, aiding broader cancer types and low-TMB cases.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Oncology
Lead Inventor: Xiaosong Wang
Department: Med-Pathology
All Tech Innovators: Xiaosong Wang
Date Submitted: 2022-10-31
Collections: Women's & Reproductive Health

Engineering Human iPSC-Derived Livers in Rats for Advanced Liver Disease Treatment

04064

Engineered human iPSC-derived livers grown in rats offer scalable, patient-specific hepatocytes for transplantation and disease modeling.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - Stem Cell
Therapeutic Areas: Hepatology
Lead Inventor: Alejandro Soto Gutierrez
Department: Med-Pathology
All Tech Innovators: Eduardo Cervantes Cervantes Alvarez
Alexandra Sylvie Collin De L Hortet
Jorge Guzman Lepe
Date Submitted: 2016-11-02
Collections: Cell & Gene Therapy

Novel Method of Idiopathic Pulmonary Fibrosis (IPF) Detection

01838

Urine-based MMP activation peptide detection correlates with IPF, enabling earlier diagnosis and flare prediction via ELISA.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Respiratory
Therapeutic Indications: Pulmonary fibrosis
Lead Inventor: Tim Oury
Department: Med-Pathology
All Tech Innovators: Jan J. Enghild
Naftali Kaminski
Tim David Oury MD, PhD
Date Submitted: 2008-09-25

Targeted Nanoparticle Therapy for Brain Repair: Harnessing Memory T Cells for Endogenous Neuroregeneration and Neuroimmune Homeostasis

07316

Targeted brain nanoparticles reprogram memory T cells to foster neuroprotection, reduce neuroinflammation, and promote endogenous CNS repair.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Multiple Sclerosis (MS)
Alzheimer's Disease
Tags: Autoimmune
Biomaterial
Polymer
Lead Inventor: Swaminathan Iyer
Department: Med-Pathology
All Tech Innovators: Swaminathan Smita Iyer
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2025-08-29
Collections: Regenerative Medicine

Targeting Chromosomal Rearrangements for Cancer Treatment

03641

Targeting fusion gene-driven cancers with genome-editing therapies for precise, breakpoint-specific treatment and improved outcomes.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Hodgkin Lymphoma
Chronic Myeloid Leukemia (CML)
Chronic Lymphocytic Leukemia (CLL)
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Zhanghui Chen
Jianhua Luo
George Michalopoulos
Date Submitted: 2015-06-09
Collections: Women's & Reproductive Health

Dual-Action Kinase Modulators: A Novel Therapeutic Class for Cancer and Fibrotic Diseases

03268

Dual-action kinase modulators activate AMPK and inhibit EMT drivers (Hippo, Wnt, TGF-β), suppressing cancer and fibrosis.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Immunology
Oncology
Tags: Immuno-oncology
Lead Inventor: Abdelhadi Rebbaa
Department: Med-Pathology
All Tech Innovators: Sebastien Comesse
Adam Daich
Martin Lawson
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2014-03-12

Disrupting Hippo Signaling to Treat Cancer, Organ Fibrosis, and Neuropathic Pain

03007

Pan-EMT inhibitor C19 blocks Hippo/Wnt/TGF-β, suppressing cancer growth and potentially treating organ fibrosis and neuropathic pain.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Oncology
Lead Inventor: Abdelhadi Rebbaa
Department: Med-Pathology
All Tech Innovators: Robert Bryant Lettan II
Abdelhadi Rebbaa
Miguel Reyes Mugica
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2013-03-26

Rat Monoclonal Antibody to SARS CoV2 RdRp

05697

Novel rat monoclonal antibody targets SARS-CoV-2 RdRp, enabling multi-technique research, diagnostics, and drug discovery.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Infectious Disease
Therapeutic Indications: Covid-19
Lead Inventor: Patrick Moore
Department: Med-Pathology
All Tech Innovators: Yuan Chang
Patrick S. Moore
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-05-19

CRISPR Epigenetic Therapeutics for Pain Management

05378

CRISPR-based epigenetic modulation via HSV delivery targets pain genes, offering durable, non-DNA-changing pain relief therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - CRISPR
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Pain
Tags: Human performance
Sports medicine
Lead Inventor: Samira Kiani
Department: Med-Pathology
All Tech Innovators: Mo Reza Ebrahimkhani
Samira Kiani
Date Submitted: 2020-05-26
Collections: Cell & Gene Therapy

Compound Would Healing Technology Platform

04661

Decorin-based slow-release therapy reduces scarring and improves wound healing in preclinical mouse models via ECM/regulatory pathways.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Musculoskeletal
Lead Inventor: Alan Wells
Department: Med-Pathology
All Tech Innovators: Yadong Wang
Alan H. Wells
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2018-06-14
Collections: Regenerative Medicine

FADD Knockout Colon Cancer Cells

03688

AAV-targeted FADD knockout colon cancer cells provide a precise, apoptosis-resistant model for cancer research and drug testing.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Lead Inventor: Jian Yu
Department: Med-Pathology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2015-07-30

PCI-13 Human Oral Squamous Cell Carcinoma Cell Line

05480

A reproducible human oral squamous cell carcinoma cell line for drug screening, cancer biology, biomarkers, and personalized therapies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Theresa Whiteside
Department: Med-Pathology
All Tech Innovators: Theresa L. Whiteside
Date Submitted: 2020-08-14

Predicting Cancer Recurrence after Liver Transplant

05628

A genome-based machine-learning model predicts post-transplant HCC recurrence with over 80% accuracy to guide liver transplant decisions.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Hepatocellular carcinoma (HCC)
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Shuchang Liu
Jianhua Luo
George Michalopoulos
Date Submitted: 2021-03-06

Methods of Engineering Human-Hepatic Tissue for Gene Specific and Genome Wide Screening Phenotypes

03814

Engineered human iPS-derived liver tissue enables gene-specific and genome-wide screening for NASH, HCC, and drug discovery.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Hepatology
Lead Inventor: Alejandro Soto Gutierrez
Department: Med-Pathology
All Tech Innovators: Alexandra Sylvie Collin De L Hortet
Ira Jacob Fox
Ken Fukumitsu
Date Submitted: 2016-01-27

Flag-p73 Knockin Colon Cancer Cells

03689

Triple-Flag tagged HCT116 cells enable specific TAp73 detection, aiding DNA damage, drug response, and cancer biology research.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Lead Inventor: Jian Yu
Department: Med-Pathology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2015-07-30

Human Colorectal Cancer Stem Cell Line: A Novel Platform for Therapeutics and Research

02640

Novel human colon cancer stem cell lines (Tu-12/21/22) enable in vitro/in vivo drug screening and tumor modeling for therapeutics.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Tags: Immuno-oncology
Drug Development
Immunology
Lead Inventor: Eric Lagasse
Department: Med-Pathology
All Tech Innovators: Eric Lagasse
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2011-12-02

Novel Targeted Gene Therapy for Cancers

06452

Targeted HSV1-tk genome editing at cancer fusion breakpoints to induce tumor cell death, offering genotype-specific therapy potential.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - CRISPR
Therapeutic Areas: Oncology
Therapeutic Indications: Prostate cancer / adenocarcinoma
Hepatocellular carcinoma (HCC)
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Muhamuda Kader
Shuchang Liu
Jianhua Luo
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-07-06
Collections: Cell & Gene Therapy

Beclin-1 Knockin Colon Cancer Cells

03685

Beclin-1 knockin HCT116 cells reveal autophagy-apoptosis balance, caspase-8 cleavage resistance, aiding cancer drug resistance research.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Lead Inventor: Jian Yu
Department: Med-Pathology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2015-07-30

Innovative Leukocyte Genomic CNV Analysis for Predicting Prostate Cancer Outcomes

03651

Leukocyte CNV profiling predicts prostate cancer outcomes; improves recurrence risk accuracy when combined with Gleason, Nomogram, and fusion status.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Oncology
Therapeutic Indications: Prostate cancer / adenocarcinoma
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Shuchang Liu
Jianhua Luo
George Michalopoulos
Date Submitted: 2015-06-16

PINCH-2 Recombinant Protein

00724

Small molecule inhibitors disrupt c-Myc/Max interaction, reducing tumorigenicity and highlighting yeast-based PPI screening for cancer therapies.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Oncology
Lead Inventor: Chuanyue Wu
Department: Med-Pathology
All Tech Innovators: Chuanyue Wu
Date Submitted: 2002-06-19

Taqman qRT-PCR Test for Fusion Genes

04811

TaqMan qRT-PCR detects eight fusion genes, including degraded samples, with in vivo-validated, highly sensitive diagnostics.

Technology Type: Life Science Research Tool
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Jianhua Luo
Yanping Yu
Date Submitted: 2018-11-13

Bid Knockout Colon Cancer Cells

03686

Complete BID-null colon cancer cell models (with FADD loss) for studying apoptosis, drug resistance, and anticancer efficacy.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Colorectal cancer (CRC)
Lead Inventor: Jian Yu
Department: Med-Pathology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2015-07-30

Anti-Human and Mouse PTEN-Induced Kinase-1 (PINK1) Polyclonal Antibodies

01873

Antibody tooling targeting human/mouse PINK1 kinase loop to study mitophagy and Parkinson-related pathology.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Lead Inventor: Charleen Chu
Department: Med-Pathology
All Tech Innovators: Charleen T. Chu
Date Submitted: 2008-11-20