Therapeutic Areas

Cardiovascular

Novel Continuous Monitoring of Cardiac Health

06979

New PPG-to-ECG model enables accurate, continuous blood pressure monitoring via wearable signals, lowering clinical barriers.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Cardiovascular
Tags: Machine learning
Cardiology
Cardiovascular Disease
Lead Inventor: Pengfei Zhou
Department: SCI-Informatics and Networked Systems
All Tech Innovators: Hui Ji
Pengfei Zhou
Date Submitted: 2024-11-19
Collections: Cardiometabolic

Machine Learning-Based Cardiovascular Risk Prediction Tool for Personalized 10-Year CVD Estimates in Midlife Women

07148

ML-driven, female-specific CVD risk tool using SWAN data; personalized 10-year estimates via R Shiny, improved accuracy.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Therapeutic Areas: Cardiovascular
Lead Inventor: Ziyuan Wang
Department: GSPH-Epidemiology
All Tech Innovators: Samar Riyad El Khoudary Abushaban
Ziyuan Wang
Date Submitted: 2025-04-11
Collections: Cardiometabolic
Women's & Reproductive Health

Post-Cardiac Arrest Classification Mobile and Web App

06035

Real-time PCAC scoring app for bedside cardiac arrest patients, improving outcomes, workflow, and cross-center comparisons.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Other
Lead Inventor: Ankur Doshi
Department: Med-Emergency Medicine
All Tech Innovators: Gabriel Lucas Diamond
Ankur Ashok Doshi
Date Submitted: 2022-05-19
Collections: Cardiometabolic

AI-Powered Precision Stroke Care

07112

AI-driven NeuroSmart: real-time, personalized acute ischemic stroke decisions via scalable ML, integrating EHR data, dashboards, and telestroke.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Stroke
Tags: Artificial intelligence (AI)
Machine learning
Algorithm
Lead Inventor: Mohamed Doheim
Department: Med-Neurology
All Tech Innovators: Mohamed Doheim
Raul Gomes Nogueira
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-03-07
Collections: Cardiometabolic
Healthcare AI

Personalized Prevention of Intraoperative Hypotension

05611

Personalized intraoperative blood pressure targets predict IOH risk, enabling real-time MAP targets to prevent hypotension.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Other
Tags: Precision medicine
Algorithm
Surgery
Lead Inventor: Michael Schnetz
Department: Med-Anesthesiology and Perioperative Medicine
All Tech Innovators: David J. Danks
Aman Mahajan
Michael Schnetz
Date Submitted: 2021-02-08
Collections: Cardiometabolic

Novel Therapy for Chondrocyte Aging and Osteoarthritis

07004

GATA4-targeting small molecule HCA42027 may restore aged chondrocyte repair, offering a potential disease-modifying OA therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Musculoskeletal
Therapeutic Indications: Heart failure
Atherosclerotic disease
Osteoarthritis
Tags: Drug Discovery - Target
Life Science
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Olivia Bartholomew
Kate Li
Hang Lin
Date Submitted: 2024-12-11
Collections: Cardiometabolic

Advanced Laser-Assisted Fabrication of Mesoporous, Compliance-Matched, and Drug-Eluting Vascular Grafts

06824

Laser-assisted, mesoporous, drug-eluting vascular grafts with compliance matching; controlled porosity, improved patency, ready for testing.

Technology Type: Engineering Technology
Technology Subtype: Other Engineering Technology
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Other
Atherosclerotic disease
Tags: Cardiovascular Disease
Engineering
Therapeutic Medical Device
Lead Inventor: Jonathan Vande Geest
Department: Bioengineering
All Tech Innovators: Ali Behrangzade
Xuanyu Min
Tiffany Alexandra Moreno
Date Submitted: 2024-07-26
Collections: Cardiometabolic

Handheld Oscillating Device of Vascular Interventions

06595

A handheld ERM-driven torquing device eases guidewire navigation in vascular interventions, lowering trauma risk and costs.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Atherosclerotic disease
Lead Inventor: Catalin Toma
Department: Med-Medicine
All Tech Innovators: Jared D. Romeo
Catalin Toma
Date Submitted: 2023-12-13
Collections: Cardiometabolic

Proactive AI System for Real-Time Prediction and Management of Anesthesia-Induced Hypotension

06579

Proactive AI predicts anesthesia-induced hypotension in real time and suggests actionable therapies via reinforcement learning.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Other
Tags: Artificial intelligence (AI)
Machine learning
Precision medicine
Lead Inventor: Harikesh Subramanian
Department: Med-Anesthesiology and Perioperative Medicine
All Tech Innovators: Harikesh Subramanian
Shyam Visweswaran
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2023-11-29
Collections: Cardiometabolic
Healthcare AI

AI for Vascular Calcification Risk Assessment

06541

AI-driven vascular calcification phenotyping classifies risk, enabling targeted, faster MACE prediction and personalized treatment.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Atherosclerotic disease
Tags: Cardiology
Clinical Decision Support
Life Science
Lead Inventor: Mehdi Ramezanpour Koomleh
Department: Mechanical Engineering and Materials Science
All Tech Innovators: Mehdi Ramezanpour Koomleh
Anne M. Robertson
Date Submitted: 2023-10-12
Collections: Cardiometabolic
Healthcare AI

Hypoplastic Left Heart Syndrome - Novel Mouse Model

05362

CRISPR-validated mouse model replicates HLHS heart defects for drug, device, and gene-therapy development.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Cardiovascular
Lead Inventor: Cecilia Lo
Department: Med-Pediatrics
All Tech Innovators: Cecilia Wen Ya Lo
Date Submitted: 2020-05-15
Collections: Cardiometabolic

Novel Small-Diameter Vascular Graft for Tissue Engineering

04295

Three-layer, bio-inspired 2–3 mm TEVGs mimic coronary arteries, combining ES, cECM, and TIPS for scalable grafts.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Lead Inventor: Antonio DAmore
Department: Med-Surgery
All Tech Innovators: Antonio DAmore
Matteo Solazzo
William R. Wagner PhD
Date Submitted: 2017-06-14
Collections: Cardiometabolic

Neuroprotective Peptide in Acute Ischemic Injury

05442

A brain-penetrant peptide (TAT-DP-2) disrupts Kv2.1 clusters to prevent delayed neuronal death after stroke.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Cardiovascular
Neuroscience
Therapeutic Indications: Stroke
Other
Lead Inventor: Elias Aizenman
Department: Med-Neurobiology
All Tech Innovators: Elias Aizenman
Jason Arnold Justice
Anthony John Schulien
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-07-09
Collections: Cardiometabolic

Targeting Cardiomyocyte Endoreplication to Prevent Hypertrophic Cardiomyopathy

07132

Inhibits PCNA-POLD1 interactions via p21 to curb cardiomyocyte endoreplication, preventing hypertrophic cardiomyopathy progression.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Hypertrophic cardiomyopathy
Tags: Genetics
Regenerative medicine
Platform Technology
Lead Inventor: Jason Becker
Department: Med-Medicine
All Tech Innovators: Jason Robert Becker
Soumojit Pal
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-03-30
Collections: Cell & Gene Therapy
Regenerative Medicine
Cardiometabolic

Next-generation smart cardiovascular stents with wireless diagnostic functionality

06187

Wirelessly monitored, self-powered metamaterial stents diagnose restenosis and occlusion in real time without external power.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Lead Inventor: Amir Alavi
Department: Civil & Environmental Engineering
All Tech Innovators: Amir Alavi
Date Submitted: 2022-10-18
Collections: Regenerative Medicine
Cardiometabolic

Nitro-fatty Acids for Treating Aortic Aneurysm

05302

Nitro-oleic acid (nitro-fatty acid) shows promise halting abdominal aortic aneurysm progression via anti-inflammatory effects.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Other
Lead Inventor: Francisco Schopfer
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Yuqing Eugene Chen
Bruce A. Freeman
Francisco Jose Schopfer PhD
Date Submitted: 2020-04-13
Collections: Cardiometabolic

Near Real-Time Composite Pulmonary Vascular Impedance Software

05304

Near real-time PVZ spectrum tool with FFT from pressure/flow data, giving comprehensive, bedside right-heart afterload insights.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Heart failure
Lead Inventor: Timothy Bachman
Department: Med-Medicine
All Tech Innovators: Timothy Nicholas Bachman
Marc Alan Simon
Date Submitted: 2020-04-13
Collections: Cardiometabolic

Hands-Free Display Focus System with Mixed Reality

06862

Hands-free mixed-reality display streams computer data as holograms, enabling untethered, focused task work with gestures.

Technology Type: Engineering Technology
Therapeutic Areas: Cardiovascular
Tags: Surgery
Engineering
Lead Inventor: Griffin Hurt
Department: Graduate Studies-Dietrich School of Arts and Sciences
All Tech Innovators: Edward Gregory Andrews
Jacob Biehl
Griffin James Hurt
Date Submitted: 2024-09-04
Collections: Cardiometabolic

System and Method for Assessment of Stroke Patients and Personalized Rehabilitation

05401

A data-driven system uses wearable data and machine learning to assess stroke severity and tailor at-home, patient-specific rehab.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Cardiovascular
Central Nervous System
Therapeutic Indications: Stroke
Tags: Human performance
Machine learning
Lead Inventor: Amit Sethi
Department: SHRS-Occupational Therapy
All Tech Innovators: Marcus C. Allen
William W. Clark
Amit Sethi
Date Submitted: 2020-06-03
Collections: Cardiometabolic

Fully Human Fab and VH Antibody Binding to PLA2G7

06870

Fully human antibodies block PLA2G7 to reduce inflammation, with potential anti-aging and cancer therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - Bispecific
Therapeutic Areas: Cardiovascular
Oncology
Therapeutic Indications: Stroke
Atherosclerotic disease
Tags: Aging
Lead Inventor: Seungmin Shin
Department: Med-Medicine
All Tech Innovators: Dimiter Stanchev Dimitrov
Wei Li
John W. Mellors
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2024-09-09
Collections: Cardiometabolic

Laser-Textured Grooves for Accelerated Endothelialization

06847

Laser-textured grooves on CoCr stents boost endothelialization up to 10x, enhancing safety, biocompatibility, and performance.

Technology Type: Engineering Technology
Technology Subtype: Other Engineering Technology
Therapeutic Areas: Cardiovascular
Lead Inventor: Young Chun
Department: Industrial Engineering
All Tech Innovators: Youngjae Jae Chun
Mohamed Samir Mohamed Ibrahim
Date Submitted: 2024-08-22
Collections: Regenerative Medicine
Cardiometabolic

Innovative Gene Therapy for Heart Disease: p21 Overexpression in Cardiomyocytes

06708

AAV9-delivered p21 overexpression in cardiomyocytes reduces hypertrophic remodeling and improves diastolic function in mouse models.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - AAV
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Hypertrophic cardiomyopathy
Lead Inventor: Jason Becker
Department: Med-Medicine
All Tech Innovators: Jason Robert Becker
Soumojit Pal
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2024-04-03
Collections: Cell & Gene Therapy
Cardiometabolic

Innovative Arterial Pulsation System for Superior Hemocompatibility in Endovascular Devices

06612

Piezoelectric pulsation enhances endovascular hemocompatibility via continuous, in-situ surface modification, reducing thrombosis risk.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Atherosclerotic disease
Myocardial infarction
Acute coronary syndrome
Lead Inventor: Young Chun
Department: Industrial Engineering
All Tech Innovators: Youngjae Jae Chun
Mohamed Samir Mohamed Ibrahim
Sang Ho Ye
Date Submitted: 2024-01-14
Collections: Cardiometabolic

Virtual Health Coach Bridges Rural Cardiovascular Care Gaps

06539

A rural-focused virtual health coach delivers empathic, personalized cardiovascular coaching with home monitoring integration for chronic disease.

Technology Type: Digital Health
Technology Subtype: Other Digital Health
Therapeutic Areas: Cardiovascular
Endocrinology and Metabolic Diseases
Therapeutic Indications: Pulmonary arterial hypertension (PAH)
Diabetes
Lead Inventor: Jared Magnani
Department: Med-Medicine
All Tech Innovators: Brian Kaleida
Jared William Magnani
Date Submitted: 2023-10-10
Collections: Cardiometabolic

A Novel Treatment Target for Pulmonary Hypertension

05987

A non-coding SNV in KMT2E links HIF-driven epigenetic changes to pulmonary hypertension, suggesting targeted diagnostics and one-off therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Pulmonary arterial hypertension (PAH)
Lead Inventor: Stephen Chan
Department: Med-Medicine
All Tech Innovators: Stephen Yu-Wah Chan MD, PhD
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-03-17
Collections: Cardiometabolic

Nanoparticle Dopants for Conducting Polymers

04941

Nanoparticle-doped PEDOT lowers impedance, boosts charge injection and drug loading for improved neural interfaces.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Neuroscience
Tags: Biomaterial
Coating
Polymer
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Xinyan Cui
Kevin M. Woeppel
Date Submitted: 2019-04-03
Collections: Regenerative Medicine
Cardiometabolic

Ex-Vivo Adult Heart Perfusion System

04903

A prototype ex-vivo heart perfusion system rehabilitates donor hearts, enabling ventricular testing, rehab, and research for transplantation.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Cardiovascular
Lead Inventor: Christopher Sciortino
Department: Med-Cardiothoracic Surgery
All Tech Innovators: Christopher Michael Sciortino
Date Submitted: 2019-02-25
Collections: Cardiometabolic

Novel Activators of AMP-activated Protein Kinase

03887

New nanomolar small molecules block AMPK ubiquitination, stabilizing and activating AMPK to treat metabolic, inflammatory, and cancer disorders.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Endocrinology and Metabolic Diseases
Tags: Aging
Lead Inventor: Beibei Chen
Department: Med-Medicine
All Tech Innovators: Beibei Chen
Yuan Liu
Rama K. Mallampalli
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2016-04-05
Collections: Cardiometabolic

Extracellular Matrix of Primitive Animal Species

03728

Zebrafish heart ECM promotes mammalian heart repair via NRG1-ErbB2 signaling, improving function and reducing infarct size.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Myocardial infarction
Lead Inventor: Yadong Wang
Department: Bioengineering
All Tech Innovators: William Chen
Yadong Wang
Date Submitted: 2015-09-19
Collections: Regenerative Medicine
Cardiometabolic

E-mag System for Rapid Cannulation of Fenestrated Endovascular Grafts

04371

Electromagnetically guided cannulation device (E-mag) speeds fenestrated graft wiring, reduces radiation and contrast exposure during aortic repair.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Cardiovascular
Tags: Surgery
Lead Inventor: Bryan Tillman
Department: Med-Surgery
All Tech Innovators: Youngjae Jae Chun
Catherine C. Go
Bryan W. Tillman
Date Submitted: 2017-09-13
Collections: Cardiometabolic

Automatic Early-Onset Free Flap Failure Detection

04241

Automated, early-detection system reduces free flap failure false positives to ~10%, eliminating expert reliance and enabling implantable monitoring.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Musculoskeletal
Tags: Artificial intelligence (AI)
Machine learning
Material Science
Lead Inventor: Michael Rothfuss
Department: All Temps
All Tech Innovators: Murat Akcakaya
Michael Lawrence Gimbel
Michael A. Rothfuss
Technology Readiness Level: 3. Prototype development
Date Submitted: 2017-05-10
Collections: Cardiometabolic
Healthcare AI

A Novel Customizable Implantable Cranial Device

05740

A sub-scalp, flexible brain–computer implant with wireless control, EEG monitoring, and medication reservoir for enhanced DBS.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Neuroscience
Therapeutic Indications: Parkinson's Disease
Multiple Sclerosis (MS)
Stroke
Tags: Brain-computer interface
Lead Inventor: Joseph Rubin
Department: Med-Plastic Surgery
All Tech Innovators: Joseph Peter Rubin
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2021-06-24
Collections: Cardiometabolic

Novel Nitro-Fatty Acid Microbubbles for Targeted Therapy

05003

Targeted ultrasound-triggered nitro-fatty acid microbubbles enable localized, enhanced delivery for cardiovascular therapy and imaging.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Intensive Care
Lead Inventor: Gary Yu
Department: Bioengineering
All Tech Innovators: Xucai Chen
Marco Fazzari
Bruce A. Freeman
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-06-14
Collections: Cardiometabolic

A Biodegradable, Antioxidant, Thermally Responsive Injectable Hydrogel for Treatment of Ischemic Cardiomyopathy

04039

Thermally gelling, MRI-visible, biodegradable hydrogel with covalently bonded antioxidants for injectable ischemic cardiomyopathy therapy.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Hypertrophic cardiomyopathy
Dialated cardiomyopathy
Tags: Biomaterial
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Yasumoto Matsumura
Murugesan Velayutham
William R. Wagner PhD
Date Submitted: 2016-10-04
Collections: Cardiometabolic

Nanoparticles to Treat Coronary Arterial Calcification

06198

Nanoparticle-delivered sodium thiosulfate selectively dissolves arterial plaque calcium, reducing rupture risk and side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Atherosclerotic disease
Lead Inventor: Brittany Rodriguez
Department: Graduate Studies-Dietrich School of Arts and Sciences
All Tech Innovators: Brittany Renee Rodriguez
David A. Vorp Ph.D.
Justin Sol Weinbaum
Date Submitted: 2022-10-26
Collections: Cardiometabolic

Pfn1 as a Novel Therapeutic Target for Atherosclerosis

06880

Pfn1 inhibitors block actin interaction, offering a novel anti-atherosclerosis approach with anti-angiogenic potential.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Atherosclerotic disease
Lead Inventor: David Gau
Department: Med-Pathology
All Tech Innovators: David Martin Gau
Abigail Gondringer
Donna Huryn
Date Submitted: 2024-09-17
Collections: Cardiometabolic

iHeart: Injectable Hydrogel for Enhancing or Attracting Regulatory T-Cells

06482

Injectable hydrogel releases CCL22 to recruit regulatory T cells, reducing reperfusion injury after myocardial infarction.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Myocardial infarction
Lead Inventor: Matthew Borrelli
Department: Chem/Petroleum Engineering
All Tech Innovators: Matthew Andrew Borrelli
Jason Burdick
Steven R. Little
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-08-15
Collections: Cell & Gene Therapy
Cardiometabolic

Novel Strategy to Prevent Cardiomyopathy

06477

Targeting MDM2 to prevent left ventricular hypertrophy and microvascular dysfunction, potentially halting hypertrophic cardiomyopathy progression.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Cardiovascular
Lead Inventor: Jason Becker
Department: Med-Medicine
All Tech Innovators: Jason Robert Becker
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-08-08
Collections: Cardiometabolic

Novel Nitro Nitrate Lipid Intermediates that Mediate Nitrosating and Alkylating Reactions

03996

Nitro-nitrate-lipid intermediates act as versatile NO donors, offering vasodilation with dual nitrosating/alkylating actions for CVD therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Lead Inventor: Marco Fazzari
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Marco Fazzari
Bruce A. Freeman
Francisco Jose Schopfer PhD
Date Submitted: 2016-07-19
Collections: Cardiometabolic

Dual Lumen Intravascular Ultrasound Catheter

06009

A miniaturized dual-lumen IVUS catheter enables real-time imaging-guided true lumen reentry in chronic total occlusions.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Myocardial infarction
Atherosclerotic disease
Lead Inventor: Catalin Toma
Department: Med-Medicine
All Tech Innovators: Catalin Toma
Technology Readiness Level: 2. Initial proof-of-concept (PoC)
Date Submitted: 2022-04-20
Collections: Cardiometabolic

A Novel Approach for Multi-Parameter Hemodynamic Monitoring

05507

Smart cuff with smart algorithms enables noninvasive BP, CO, EF monitoring from an arm cuff—enhanced hemodynamic insights.

Technology Type: Medical Device
Technology Subtype: Monitoring Medical Device
Therapeutic Areas: Cardiovascular
Lead Inventor: Ramakrishna Mukkamala
Department: Bioengineering
All Tech Innovators: Jin-Oh Hahn
Aman Mahajan
Ramakrishna Mukkamala
Date Submitted: 2020-09-17
Collections: Cardiometabolic

Ultrasound-Mediated Treatment of Microvascular Obstruction Using tPA-Labeled Microbubbles

04611

Ultrasound-triggered tPA-labeled microbubbles disrupt microthrombi, enhancing thrombolysis to improve microvascular patency in CAD.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Lead Inventor: John Pacella
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Stephen D'Auria
John J. Pacella
Date Submitted: 2018-04-30
Collections: Cardiometabolic

Selective Targeting of Cardiomyocytes

06346

Cardiomyocyte-targeted AAV-PKG1 therapy boosts heart function, promising selective treatment for heart failure with reduced off-target effects.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Heart failure
Dialated cardiomyopathy
Lead Inventor: Jason Becker
Department: Med-Medicine
All Tech Innovators: Jason Robert Becker
Soumojit Pal
Date Submitted: 2023-03-07
Collections: Cardiometabolic

Using STAT5 Inhibitors for the Treatment of Cardiovascular Calcification

05857

STAT5 inhibitors halt cardiovascular calcification by disrupting RUNX2-driven osteogenesis in valve and vascular cells.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Musculoskeletal
Lead Inventor: Cynthia St Hilaire
Department: Med-Medicine
All Tech Innovators: Rolando A. Cuevas
Cynthia L. St Hilaire
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-10-27
Collections: Cardiometabolic

Small Molecule Inhibitor Therapy to Prevent Aneurysm Formation, Growth, and Rupture

05390

Small molecule inhibitors block CXCL7-CXCR1/2 inflammation to prevent cerebral aneurysm formation, growth, and rupture.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Neuroscience
Lead Inventor: Robert Friedlander
Department: Med-Neurological Surgery
All Tech Innovators: Michael P. D'Angelo
Robert Max Friedlander
Wendy Fellows Mayle
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2020-05-30
Collections: Regenerative Medicine
Cardiometabolic

An Organ Perfusion Stent for Transplant Organ Recovery

03146

An endovascular dual-chamber stent perfuses abdominal organs during cardiac death, preserving organs for transplantation without harming the donor.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Cardiovascular
Lead Inventor: Bryan Tillman
Department: Med-Surgery
All Tech Innovators: Amit D. Tevar
Bryan W. Tillman
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2013-10-13
Collections: Cardiometabolic

An integrated ultrasound and mechanical testing system for mapping 3D tissue mechanics and fiber architecture.

02986

Integrated ultrasound-mechanical tester maps 3D tissue mechanics and fiber architecture in opaque, thick samples without extensive prep.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Cardiovascular
Tags: Cardiovascular Disease
Diagnostic Imaging
Lead Inventor: Kang Kim
Department: Bioengineering
All Tech Innovators: Kang Kim
Choon Hwai Yap
Date Submitted: 2013-02-18
Collections: Cardiometabolic

Biodegradable Polyester Urethane Urea Cardiac Patch

01261

Biodegradable elastomeric PEUU cardiac patch grows with patient, reduces remodeling, and supports host tissue integration and recovery.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Cardiovascular
Tags: Biomaterial
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Kazuro Lee Fujimoto
Jianjun Guan
Bradley B. Keller
Date Submitted: 2006-05-04
Collections: Regenerative Medicine
Cardiometabolic

Biocarpet biodegradable device for vascular disease

05505

Biodegradable, flexible biocarpet device for targeted drug delivery in peripheral arteries; thermoforms in situ, reduces restenosis risk.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Lead Inventor: Jonathan Vande Geest
Department: Bioengineering
All Tech Innovators: John J. Pacella
Jonathan P. Vande Geest
William R. Wagner PhD
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2020-09-14
Collections: Cardiometabolic

Endovascular Orifice Detection Device (EOrD)

04938

Endovascular Orifice Detection Device enables in situ fenestration for AAAs using EM guidance, reducing wait times and costs.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Cardiovascular
Tags: Biomaterial
Minimally invasive
Lead Inventor: Mohammad Eslami
Department: Bioengineering
All Tech Innovators: Timothy K. Chung
Mohammad Hamed Eslami
David A. Vorp Ph.D.
Technology Readiness Level: 3. Prototype development
Date Submitted: 2019-04-01
Collections: Cardiometabolic