Therapeutic Areas

Mental and Behavioral Health

RU SATED: A Self-Report Instrument for Measuring Sleep Health

06027

RU SATED: a validated self-report tool assessing multiple sleep-health dimensions for clinical use and research applications.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Sleep disorder
Lead Inventor: Daniel Buysse
Department: Med-Psychiatry
All Tech Innovators: Daniel J. Buysse
Date Submitted: 2022-05-13

Prophetic Algorithm Boosts Prognostic Accuracy in High-Risk Psychiatric Populations

07157

A sparse, interpretable ML method (SCORE) predicts trajectory-based psychiatric risk, improving early intervention and resource efficiency.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Mental and Behavioral Health
Tags: Artificial intelligence (AI)
Machine learning
Precision medicine
Lead Inventor: Eric Strobl
Department: Med-Biomedical Informatics
All Tech Innovators: Eric Von Strobl
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2025-04-22
Collections: Healthcare AI

Flourish: Digital Mental Health Chatbot Platform Offering Tailored Support to Underserved Youth Experiencing Online Victimization

07110

Flourish: a tailored, secure SMS/web chatbot delivering evidence-based, youth-centered online victimization support with high usability.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Candice Biernesser
Department: Med-Psychiatry
All Tech Innovators: Candice Leeann Biernesser
David A. Brent
Tina R. Goldstein
Date Submitted: 2025-03-07

Restorative Neurophysiology: A System for Re-achieving Previous Neurological States

07059

Restores a personalized prior brain state using baseline EEG and adaptive TACS, enabling non-invasive, closed-loop neural restoration.

Technology Type: Medical Device
Therapeutic Areas: Mental and Behavioral Health
Neuroscience
Therapeutic Indications: Depression
Tags: Precision medicine
Brain-computer interface
Lead Inventor: Greg Siegle
Department: Med-Psychiatry
All Tech Innovators: Greg Jeremy Siegle Ph.D.
Technology Readiness Level: 3. Prototype development
Date Submitted: 2025-02-04

Teaching Videos to Aid Care of Aggressive Patients

06386

Teaching videos train nursing students to de-escalate aggressive patients, boosting self-efficacy and compassionate care skills.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Mental and Behavioral Health
Tags: Education Technology
Lead Inventor: Melissa Harlan
Department: Nurs-Acute and Tertiary Care
All Tech Innovators: Victor Ross Bench
Melissa D. Harlan
Linda Kathryn Kelly
Date Submitted: 2023-04-24

CM4StUD: Transforming Contingency Management for Addiction Treatment

06055

Open-source CM4StUD cuts contingency management costs, scales addiction treatment, and enables global, remote program participation.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: James Latronica
Department: Med-Psychiatry
All Tech Innovators: Ilana Hull
James Robert Latronica
Date Submitted: 2022-06-16

Opioid Use Disorder Medication Training Program for Health Professionals

06869

Comprehensive FDA‑MOUD training for primary care pros, boosting OUD treatment quality, engagement, and outcomes with case worker roles.

Technology Type: Other
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Opiod use disorder
Lead Inventor: Heather Santa
Department: Med-Medicine
All Tech Innovators: Heather Marie Santa
Date Submitted: 2024-09-06

Rapid Electrochemical Screen for Illicit Drugs

06703

Automated 96-sensor electrolyte-gated FET platform rapidly screens illicit drugs with high-throughput, streamlined lab workflows.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Alexander Star
Department: Chemistry
All Tech Innovators: Zhengru Liu
Alexander Star
Date Submitted: 2024-03-27

Resilience and Engagement Playbook

06868

A practical, evidence-based guide for boosting resilience and engagement in graduate students and employees across academia and industry.

Technology Type: Other
Therapeutic Areas: Mental and Behavioral Health
Tags: Education Technology
Lead Inventor: Ann Sinsheimer
Department: Law-Faculty
All Tech Innovators: Leo Omid Schumann
Ann Margaret Sinsheimer
Ciara Louise Willett
Date Submitted: 2024-09-06

Engaging Together for Healthy Relationships

06061

Interactive ETHR tool educates parents and adolescents in primary care to prevent adolescent relationship abuse.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Maya Ragavan
Department: Med-Pediatrics
All Tech Innovators: Joseph Amodei
Erin Mickievicz
Elizabeth Miller
Date Submitted: 2022-06-22

Novel Class Therapeutic Psychedelics

05753

Novel clavine psychedelics: total synthesis enables SAR-driven development of non-hallucinogenic, CNS-targeting therapeutic candidates.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Depression
Lead Inventor: Peter Wipf
Department: Chemistry
All Tech Innovators: Ethan James Pazur
Nikhil Rushi Tasker
Peter Wipf
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-07-02

Context-Aware AI: Personalized Healthcare Recommendations Driven by Physiological Sensors

06906

Sensor-in-the-loop AI: uses real-time physiological data to refine prompts, delivering empathetic, personalized health guidance.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Insomnia
Sleep disorder
Anxiety
Tags: Artificial intelligence (AI)
Machine learning
Personalized Medicine
Lead Inventor: Longfei Shangguan
Department: SCI-Computer Science
All Tech Innovators: Zhiwei Ren
Longfei Shangguan
Technology Readiness Level: 3. Prototype development
Date Submitted: 2024-09-29
Collections: Healthcare AI

Innovative Naloxone-Administering Patch for Rapid Opioid Overdose Response

06741

A patch that detects lactate to trigger naloxone delivery via microneedles, enabling rapid, wearable overdose intervention.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Trent Emerick
Department: Med-Anesthesiology and Perioperative Medicine
All Tech Innovators: Trent D. Emerick
Alexander Star
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2024-05-08

Healthcare Provider for LGBTQIA

05602

Online LGBTQIA+ health-competence training for providers, built from stakeholder input to improve respectful care and reduce disparities.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Mental and Behavioral Health
Tags: Education Technology
Lead Inventor: Brenda Cassidy
Department: Nurs-Health Promotion & Development
All Tech Innovators: Betty Jean Braxter
Brenda Lee Cassidy
Andrea F.R. Fischl
Date Submitted: 2021-01-26

Flexible Micro-Interconnect for Brain Implants

05737

Ultra-flexible, hermetically sealed micro-interconnect cable for brain implants; 100–200 leads to connect electrode arrays to processing devices.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Mental and Behavioral Health
Neuroscience
Lead Inventor: Andrew Schwartz
Department: Med-Neurobiology
All Tech Innovators: Andrew B. Schwartz
Technology Readiness Level: 2. Initial proof-of-concept (PoC)
Date Submitted: 2021-06-22

A Paradigm Shift in the Treatment of Sleep Apnea

05707

A non-invasive inflatable pillow (AHT-CLiP) adjusts head tilt to open airways during sleep, using breath-sound feedback.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Mental and Behavioral Health
Respiratory
Therapeutic Indications: Sleep disorder
Tags: Consumer
Lead Inventor: Kirill Kiselyov
Department: Biological Sciences
All Tech Innovators: Ata Murat Kaynar
Kirill Igorevich Kiselyov
Technology Readiness Level: 3. Prototype development
Date Submitted: 2021-05-27

Upregulation of NMDA Receptor Function by a GluN2A/ZnT1-directed Peptide

05075

Peptide disrupts ZnT1-GluN2A interaction to boost NMDA receptor signaling, offering potential schizophrenia therapy for NMDA hypofunction.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Mental and Behavioral Health
Neuroscience
Therapeutic Indications: Other
Schizophrenia
Lead Inventor: Elias Aizenman
Department: Med-Neurobiology
All Tech Innovators: Elias Aizenman
Athanassios Tzounopoulos
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2019-08-02

The Likelihood of Diagnosis Index (LODI) Standalone Software Program

02735

Probability-based mental health diagnoses via Bayesian weighting, enhancing accuracy, confidence, EHR integration, and decision support.

Technology Type: Digital Health
Technology Subtype: Other Digital Health
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Oliver Lindhiem
Department: Med-Psychiatry
All Tech Innovators: Damion Grasso
Oliver James Lindhiem
Date Submitted: 2012-04-03

Use It! mHealth System

04327

mHealth platform with parent-child apps, clinician portal, real-time coaching, time-stamped diaries, gamified rewards, secure messaging, remote monitoring.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Other
Lead Inventor: Oliver Lindhiem
Department: Med-Psychiatry
All Tech Innovators: David J. Kolko
Oliver James Lindhiem
Bambang Parmanto
Date Submitted: 2017-07-13

Behavioral Modulation Using Smell

06401

Olfactory cues modulate behavior to curb addictions, via a portable platform integrated with smartphone apps and multi-odor modules.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Michael Sayette
Department: Distinguished Faculty-Dietrich School of Arts and Sciences
All Tech Innovators: Michael Businelle
Rachel S. Herz
Michael A. Sayette
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2023-05-08

Interpersonal Psychotherapy for Bereavement in Communities of Color

05773

Culturally adapted interpersonal psychotherapy for bereavement in Black communities, training paraprofessionals to improve grief outcomes.

Technology Type: Therapeutic Modality
Technology Subtype: Other Therapeutic Modality
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Other
Lead Inventor: Laura Dietz
Department: SHRS-Counseling and Behavioral Health
All Tech Innovators: Laura J. Dietz
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-07-27

Apathy Evaluation Scale (AES): A Standardized Tool for Measuring Lack of Motivation in Adults and the Elderly

05180

AES is a validated 18-item tool measuring motivation deficits (apathy) across behavioral, cognitive, and emotional domains.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Robert Marin
Department: Med-Psychiatry
All Tech Innovators: Robert S. Marin
Date Submitted: 2019-11-22

SmartCAT: Smartphone Enhanced Child Anxiety Treatment

04271

SmartCAT pairs a smartphone app with clinician-supported CBT for pediatric anxiety, boosting recovery, cutting sessions, and costs.

Technology Type: Digital Health
Technology Subtype: Digital Therapeutic
Therapeutic Areas: Mental and Behavioral Health
Tags: Consumer
Pediatrics
Lead Inventor: Jennifer Silk
Department: Psychology
All Tech Innovators: Oliver James Lindhiem
Bambang Parmanto
Igede Wira Pramana
Date Submitted: 2017-05-26

Adjunctive Treatment with Withania Somnifera to Treat Symptoms of Schizophrenia

04142

Ashwagandha adjunct to antipsychotics may alleviate negative, general, and stress symptoms in schizophrenia with mild side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Schizophrenia
Lead Inventor: Kadiamada Chengappa
Department: Med-Psychiatry
All Tech Innovators: Kadiamada N. Chengappa
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2017-01-29

TIPS: Smartphone-Based Training for ADHD

07201

Smartphone-m health app TIPS delivers personalized, real-time ADHD strategies to curb symptoms and risky drinking behaviors.

Technology Type: Digital Health
Technology Subtype: Other Digital Health
Therapeutic Areas: Mental and Behavioral Health
Tags: Life Science
Lead Inventor: Traci Kennedy
Department: Med-Psychiatry
All Tech Innovators: Traci M. Kennedy
Date Submitted: 2025-05-31

Empowering Postpartum Care: BIMF - A Patient-Centered Approach to Assessing Maternal Functioning

02094

BIMF: a 20-item, patient-centered postpartum tool assessing seven functional domains to guide care beyond depression screens.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Depression
Tags: Women's Health
Lead Inventor: Jennifer Barkin
Department: Med-Psychiatry
All Tech Innovators: Jennifer Lynn Barkin
Date Submitted: 2009-10-20
Collections: Women's & Reproductive Health

Screening Wizard: Enhancing Decision Support for Adolescent Mental Health

05576

Screening Wizard aids PCPs in adolescent depression/suicidality care by reconciling adolescent-parent reports and guiding evidence-based treatment.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Oliver Lindhiem
Department: Med-Psychiatry
All Tech Innovators: David A. Brent
Oliver James Lindhiem
Ana Radovic-Stakic
Date Submitted: 2020-12-28

Pupillary Predictor of Treatment Outcome for Affective Disorders

02473

Predicts treatment response for affective disorders from pupillary responses in standard eye images, including webcams, via stimuli.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Depression
Bipolar
Lead Inventor: Greg Siegle
Department: Med-Psychiatry
All Tech Innovators: Greg Jeremy Siegle Ph.D.
Date Submitted: 2011-05-04

PTSD-specific Sleep Quality Assessment Addendum for Capturing Trauma-related Sleep Disturbances

02238

PTSD-tailored PSQI addendum captures trauma-specific sleep disturbances, integrating with standard scoring for precise assessment and tracking.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Anne Germain
Department: Med-Psychiatry
All Tech Innovators: Daniel J. Buysse
Anne Germain
M Katherine Shear
Date Submitted: 2010-06-01

GABAA-R Alpha 4 KO Mice

01699

Engineered GABAA-R alpha4 floxed mice enable tissue-specific exon 3 deletion via Cre, aiding neurological and behavior studies.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Mental and Behavioral Health
Neuroscience
Therapeutic Indications: Autism spectrum disorder (ASD)
Lead Inventor: Gregg Homanics
Department: Med-Anesthesiology and Perioperative Medicine
All Tech Innovators: Gregg E. Homanics PhD
Date Submitted: 2008-04-16

Progressive Youth Fitness Curriculum for Developing Physical Literacy and Promoting Lifelong Health

07238

Develops foundational physical literacy in grades 3-5 through integrated fitness, inclusive UDL design, and progressive daily skill progressions.

Technology Type: Other
Technology Subtype: Other Subtype
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Laura Hunt
Department: Falk School
All Tech Innovators: Laura Anne Hunt
Date Submitted: 2025-07-01

A Mouse Model of Chronic Inflammatory Pain with Co-Morbid Depression and Anxiety

04436

Integrated mouse model links chronic inflammatory pain with depression/anxiety, enabling sex-specific, bidirectional pain-mood mechanism studies.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Mental and Behavioral Health
Neuroscience
Therapeutic Indications: Depression
Anxiety
Pain
Lead Inventor: Marianne Seney
Department: Med-Psychiatry
All Tech Innovators: Andrea G. Gillman
Marianne Louise Seney
Ajay D. Wasan
Date Submitted: 2017-11-15

Pittsburgh Insomnia Rating Scale (PIRS)

02570

A free, 20-item, self-administered insomnia scale measuring nightly symptoms and daytime impact with prorated scoring for missing data.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Insomnia
Lead Inventor: Douglas Moul
Department: Med-Psychiatry
All Tech Innovators: Douglas Edward Moul
Date Submitted: 2011-09-20

A Brief Behavioral Sleep Treatment for Improving Insomnia Outcomes in Older Adults

02930

Two-session nurse-led behavioral insomnia program for older adults: brief, scalable, nonpharmacologic, durable sleep gains.

Technology Type: Other
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Sleep disorder
Tags: Education Technology
Lead Inventor: Timothy Monk
Department: Med-Psychiatry
All Tech Innovators: Daniel J. Buysse
Anne Germain
Timothy H. Monk
Date Submitted: 2012-11-06

A Novel Use of Angiotensin II AT1 Receptor Antagonists for the Treatment of Insomnia

02562

Angiotensin II AT1 antagonists (candesartan) as targeted, non-sedative insomnia treatment with dual hypertension benefit.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Sleep disorder
Insomnia
Tags: Drug Repurposing
Lead Inventor: Georgina Cano
Department: Neuroscience
All Tech Innovators: Georgina Cano
Alan F. Sved
Date Submitted: 2011-09-13

iMHere 2.0: Advanced Tele-Wellness Support System for Chronic Condition Management

04151

iMHere 2.0 is a modular cross-platform mHealth system enabling real-time, personalized tele-wellness for chronic condition self-management.

Technology Type: Digital Health
Technology Subtype: Digital Therapeutic
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Bambang Parmanto
Department: SHRS-Health Information Management
All Tech Innovators: Brad E. Dicianno
Andrea Dawn Fairman
Haomin Hu
Date Submitted: 2017-02-06

Pittsburgh Insomnia Rating Scale

02569

Automated 3D OCT-based glaucoma screening with robust ONH segmentation, quantitative disc/cup metrics, and PDM classification.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Insomnia
Lead Inventor: Douglas Moul
Department: Med-Psychiatry
All Tech Innovators: Douglas Edward Moul
Date Submitted: 2011-09-20

Discovery of Mood and Therapeutic Genes in a Depression Model

01659

Identification of depression-related gene changes in UCMS mice reversed by antidepressants; reveals targets and mechanisms for mood disorder therapies.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Mental and Behavioral Health
Therapeutic Indications: Depression
Tags: Genetics
Drug Discovery - Target
Lead Inventor: Etienne Sibille
Department: Med-Psychiatry
All Tech Innovators: Catherine Belzung
Guy Griebel
Samuel Leman
Date Submitted: 2008-03-02

Text to Connect (T2C): Enhancing Mental Health Self-Efficacy for College Students

05564

Text to Connect uses automated, tailored text prompts and peer video psychoeducation to boost college students' mental health self-efficacy.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Tina Goldstein
Department: Med-Psychiatry
All Tech Innovators: Tina R. Goldstein
Brian Paul Suffoletto MD
Date Submitted: 2020-11-25

ClockWork : For Better Health and Well-Being

04674

ClockWork aligns sleep, light exposure, eating, and activity to circadian timing using coaching and digital tracking.

Technology Type: Therapeutic Modality
Technology Subtype: Other Therapeutic Modality
Therapeutic Areas: Mental and Behavioral Health
Lead Inventor: Daniel Buysse
Department: Med-Psychiatry
All Tech Innovators: Daniel J. Buysse
Rachel Pearl Kolko Conlon
Peter Lloyd Franzen
Date Submitted: 2018-07-03