Therapeutic Areas

Musculoskeletal

Small Molecule Allosteric Modulators of Class B GPCRs in the PTHR and Method to Identify Them

05559

Structure-guided discovery yields four small-molecule negative allosteric modulators of PTHR, offering oral, targeted osteoporosis therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Musculoskeletal
Endocrinology and Metabolic Diseases
Lead Inventor: Ieva Sutkeviciute
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Ivet Bahar
Pemra Doruker
Jiyoung Lee
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-11-19
Collections: Cardiometabolic
Women's & Reproductive Health

Biomimetic Fibrous Hydrogel Scaffolds Promote Biomineralization

03610

Injectable biomimetic fibrous hydrogel scaffolds self-assemble electrostatically to guide bone-like mineralization and drug delivery.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Tissue engineering
Lead Inventor: Shilpa Sant
Department: Department of Pharmaceutical Sciences
All Tech Innovators: Shilpa Sant
Date Submitted: 2015-05-11

Novel Therapy for Chondrocyte Aging and Osteoarthritis

07004

GATA4-targeting small molecule HCA42027 may restore aged chondrocyte repair, offering a potential disease-modifying OA therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Musculoskeletal
Cardiovascular
Therapeutic Indications: Heart failure
Atherosclerotic disease
Osteoarthritis
Tags: Drug Discovery - Target
Life Science
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Olivia Bartholomew
Kate Li
Hang Lin
Date Submitted: 2024-12-11
Collections: Cardiometabolic

Biocompatible 3D Printed Artificial Muscles

06510

Biocompatible, 3D-printed, remotely powered artificial muscles (ALCE) enable wireless actuation for medical implants and devices.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Lead Inventor: Ravi Meenakshisundaram
Department: Industrial Engineering
All Tech Innovators: Abdullah Mohamed Reyad Is AboHussien
Sivakumar Irla
Ravi Shankar Meenakshisundaram
Technology Readiness Level: 3. Prototype development
Date Submitted: 2023-09-20

Innovative Magnesium-Based Therapy for Periodontal Disease

06460

Mg-based anti-inflammatory therapy uses Mg-PLGA nanoparticles/fibers to treat periodontal disease and aid bone regeneration.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Dental
Tags: Biomaterial
Lead Inventor: Jin Gao
Department: Dent Med-Periodontics/Preventive Dentistry
All Tech Innovators: Jin Gao
Charles S. Sfeir
Date Submitted: 2023-07-17

Novel Use of Metformin to Treat Musculoskeletal Injury

06416

Metformin advances tendon healing by reducing fibrosis and inflammation, promoting angiogenesis for safer, cost-effective tendinopathy treatment.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Musculoskeletal
Neuroscience
Lead Inventor: James Wang
Department: Med-Orthopedic Surgery
All Tech Innovators: James Huicong Wang
Jianying Zhang
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-05-23
Collections: Regenerative Medicine

Novel Hybrid Cushion for Pressure Injury Prevention

05647

Active permeable cushion uses air fluidization and coordinated backrest-seat support to reduce pressure injuries in high-risk users.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Musculoskeletal
Lead Inventor: Rory Cooper
Department: Med-Physical Medicine & Rehabilitation
All Tech Innovators: Rory A. Cooper Ph.D.
Rosemarie Cooper
Brad E. Dicianno
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2021-03-18

Secretome Mouse Model

05233

Secretome mouse reveals tissue-specific protein secretion in vivo, enabling biomarker discovery and insights into exercise-induced proteome changes.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Musculoskeletal
Lead Inventor: Toren Finkel
Department: Med-Medicine
All Tech Innovators: Toren Finkel
Jie Liu
Date Submitted: 2020-01-25

HIF1 Activators as Therapeutics for Triosephosphate Isomerase Deficiency (TPI Df)

07001

HIF1-activating triazines boost TPI expression, repurposing approved PHD inhibitors (e.g., vadadustat) for TPI deficiency.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Musculoskeletal
Lead Inventor: Michael Palladino
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Michael John Palladino
Andreas Vogt
Date Submitted: 2024-12-09

Transient-based click decoding for brain-computer interface cursor emulation

05761

Transient-based click decoding boosts iBCI cursor control with onset/offset neural transients, 10x accuracy gain, enabling robust click-and-drag.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Other
Lead Inventor: Brian Dekleva
Department: Med-Physical Medicine & Rehabilitation
All Tech Innovators: Jennifer Lynn Collinger
Brian M. Dekleva
Technology Readiness Level: 3. Prototype development
Date Submitted: 2021-07-14

High Throughput Mechanical Activation Device for Tissue Engineering

04397

High-throughput mechanical activation device for tissue engineering enabling individualized stimulation on 24–96 wells with controlled conditions.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Lead Inventor: Riccardo Gottardi
All Tech Innovators: Riccardo Luca Gottardi
Davide Marino
Rocky Sung Chi Tuan
Date Submitted: 2017-10-05

Novel Approach to Bone Regeneration

06099

Activates skeletal stem cells to regenerate bone endogenously, using mechanical suture expansion and niclosamide-based stimulation.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Musculoskeletal
Dental
Therapeutic Indications: Osteoporosis
Tags: Regenerative medicine
Lead Inventor: Giuseppe Intini
Department: Dent Med-Periodontics/Preventive Dentistry
All Tech Innovators: Xue Hui Geng
Giuseppe Intini
Luigi Mancinelli
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-07-13
Collections: Regenerative Medicine
Women's & Reproductive Health

Novel Processing Method and Apparatus for Micro-Structured Rope-Like Material

04694

Continuous mandrel-less electrospun ropes with tunable diameter and fiber orientation for regenerative tendon, nerve, and suture applications.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Polymer
Tissue engineering
Lead Inventor: Antonio DAmore
Department: Med-Surgery
All Tech Innovators: Antonio DAmore
Daniel T. McKeel
William R. Wagner PhD
Date Submitted: 2018-07-30
Collections: Regenerative Medicine

Innovative Docking System for Personal Mobility Devices

07069

A universal, motorized docking system for personal mobility devices securely locks to vehicle pins, reducing motion and clutter.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Musculoskeletal
Lead Inventor: Brandon Daveler
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Rory A. Cooper Ph.D.
Brandon Joseph Daveler
Jonathan Aaron Duvall
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-02-11

Novel Technique to Obtain 3D Kinematics

06054

Innovative dynamic-filter radiography enables 3D kinematics capture by moving with the subject, enhancing spinal biomechanics imaging.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Musculoskeletal
Lead Inventor: Tom Gale
Department: Med-Orthopedic Surgery
All Tech Innovators: William J. Anderst
Tom Gale
Date Submitted: 2022-06-14

Bio-Inspired Nanocomposites for Advanced Bone and Tissue Regeneration

02778

Bio-inspired bone/dentin nanocomposites using multiphosphorylated peptides for integrated organic-inorganic regeneration and osteogenesis.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Musculoskeletal
Intensive Care
Therapeutic Indications: Trauma
Osteogenesis Imperfecta
Bone metabolism
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Elia Beniash
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Elia Beniash
Charles S. Sfeir
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2012-05-25
Collections: Regenerative Medicine

Automatic Early-Onset Free Flap Failure Detection

04241

Automated, early-detection system reduces free flap failure false positives to ~10%, eliminating expert reliance and enabling implantable monitoring.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Cardiovascular
Tags: Artificial intelligence (AI)
Machine learning
Material Science
Lead Inventor: Michael Rothfuss
Department: All Temps
All Tech Innovators: Murat Akcakaya
Michael Lawrence Gimbel
Michael A. Rothfuss
Technology Readiness Level: 3. Prototype development
Date Submitted: 2017-05-10
Collections: Cardiometabolic
Healthcare AI

A Generalizable Brain-Computer Interface for Motor Function Restoration

05806

A versatile, calibration-free brain-computer interface enabling natural, rapid motor restoration across stroke, amputation, and injury.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Parkinson's Disease
Other
Lead Inventor: Sudarshan Sekhar
Department: Bioengineering
All Tech Innovators: Aaron P. Batista
Patrick J. Loughlin
Sudarshan Sekhar
Technology Readiness Level: 3. Prototype development
Date Submitted: 2021-09-09

Hybrid Scaffolds for Bone Defect Regeneration

04114

Hybrid Mg alloy–polymer/DBM scaffold enables osteogenic bone regeneration for critical-sized defects, reducing grafting risks.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Regenerative medicine
Life Science
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Yingqi Chen
Vesselin N. Shanov
William R. Wagner PhD
Date Submitted: 2016-12-12
Collections: Regenerative Medicine

MOVISU-FIT: Mobile Gait Training for Limb Loss

03821

MOVISU-FIT delivers real-time visual gait feedback via lightweight smart glasses for home and on-the-go prosthetic training.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Other
Tags: Human performance
Sports medicine
Lead Inventor: Krista Kutina
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Goeran Fiedler
Krista Lee Kutina
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2016-02-03

Method for Monitoring Tissue Parameter by Magnetic Resonance Imaging

03250

Spin-lock MRI isolates chemical-exchange signals to quantify proteoglycan content linearly, robust to T1/T2 variations, aiding tissue health assessment.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Pain
Osteoporosis
Lead Inventor: Wen Ling
Department: Med-Radiology
All Tech Innovators: Kyong Tae Bae
Tao Jin
Wen Ling
Date Submitted: 2014-02-19
Collections: Women's & Reproductive Health

Novel Approach for Cartilage Repair

05596

Wnt inhibitors with microfracture improve cartilage repair by promoting hyaline cartilage and reducing fibrosis, via targeted intra-articular delivery.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Other
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Hang Lin
Date Submitted: 2021-01-18
Collections: Regenerative Medicine

Tissue Customized Platelet-Rich Plasma for Optimized Skeletal Muscle, Cartilage, and Bone Healing

05535

Personalized PRP: tissue-targeted platelet-rich plasma via antibody-neutralized deleterious factors to enhance musculoskeletal healing.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Musculoskeletal
Lead Inventor: Hongshuai Li
Department: Orthopedics and Rehabilitation
All Tech Innovators: Hongshuai Li
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2020-10-19
Collections: Regenerative Medicine

Software for Pivot Shift 2.0 Test as a Research Tool

02559

PIVOT 2.0: an orthopedic surgery data tool with enhanced UI, offline capability, API data capture, and clinical trial integration.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Other
Lead Inventor: Volker Musahl
Department: Med-Orthopedic Surgery
All Tech Innovators: Mattias Ahlden
Freddie H. Fu
Yuichi Hoshino
Date Submitted: 2011-09-07

Controlled Release Microparticle Platform for Localized Prevention of Tissue Calcification and Ossification

03248

PLGA microparticles deliver BMP receptor inhibitor locally to prevent tissue calcification with sustained, customizable release.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Sports medicine
Tissue engineering
Lead Inventor: Riccardo Gottardi
All Tech Innovators: Peter Alexander
Patrick A. Bianconi
Riccardo Luca Gottardi
Date Submitted: 2014-02-17
Collections: Regenerative Medicine

Using STAT5 Inhibitors for the Treatment of Cardiovascular Calcification

05857

STAT5 inhibitors halt cardiovascular calcification by disrupting RUNX2-driven osteogenesis in valve and vascular cells.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Musculoskeletal
Cardiovascular
Lead Inventor: Cynthia St Hilaire
Department: Med-Medicine
All Tech Innovators: Rolando A. Cuevas
Cynthia L. St Hilaire
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-10-27
Collections: Cardiometabolic

Bioabsorbable Cranial Springs for Craniosynostosis

05146

Bioabsorbable PLGA cranial springs replace metal hardware for craniosynostosis, enabling dissolving, fewer surgeries and safer skull remodeling.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Dental
Tags: Pediatrics
Life Science
Lead Inventor: Jesse Goldstein
Department: Med-Plastic Surgery
All Tech Innovators: Justin Beiriger
yuxuan deng
Jesse A. Goldstein
Date Submitted: 2019-10-26

Novel Robotic Accessible Seated Workstation

05109

Robotic seated workstation enhances accessibility for disabled workers, offering full motion, postural support, and adaptable, shareable use.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Musculoskeletal
Lead Inventor: Rory Cooper
Department: Med-Physical Medicine & Rehabilitation
All Tech Innovators: Joshua D. Brown
Rory A. Cooper Ph.D.
Benjamin T. Gebrosky
Date Submitted: 2019-09-12

Resorbable Magnesium Hardware for Bone Fractures

03562

Biodegradable magnesium bone fixation hardware strengthens healing and resorbs, reducing need for removal and surgeries.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Vijay S. Gorantla
Dae Ho Hong
Date Submitted: 2015-03-24
Collections: Regenerative Medicine

Stem Cell-Based Technologies for Avian Skeletal Tissue Engineering and Regeneration

03360

Light-activated, 3D-printed avian stem cell scaffolds enable precise bone/cartilage repair with antibacterial protection.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - Stem Cell
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Tissue engineering
Lead Inventor: Rocky Tuan
Department: Med-Orthopedic Surgery
All Tech Innovators: Rocky Sung Chi Tuan
Date Submitted: 2014-07-07
Collections: Cell & Gene Therapy
Regenerative Medicine

Pittsburgh Performance Fatigability Index (PPFI) for Older Adults

05949

New wearable-based metric derives fatigability from wrist accelerometer data during a 400m walk, improving granularity and comparability.

Technology Type: Digital Health
Technology Subtype: Other Digital Health
Therapeutic Areas: Musculoskeletal
Lead Inventor: Nancy Glynn
Department: GSPH-Epidemiology
All Tech Innovators: Nancy W. Glynn
Yujia Qiao
Date Submitted: 2022-01-27

Regenerative Ligament Repair Therapy

04487

Cell-free ACL/PCL ECM extracts drive stem cell tenogenic differentiation, enabling regenerative ligament and dental repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: Riccardo Gottardi
All Tech Innovators: Riccardo Luca Gottardi
Shinsuke Kihara
Benjamin Burke Rothrauff
Date Submitted: 2018-01-17
Collections: Regenerative Medicine

Corrosion-Resistant, Bioactive Coatings for Magnesium -Based Medical Devices

03014

Bioactive PEM coatings yield corrosion resistance, improved biocompatibility, and controlled biomolecule delivery for magnesium-based implants.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Dental
Tags: Biomaterial
Coating
Polymer
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Sangeetha Kunjukunju
Boeun Lee
Date Submitted: 2013-04-01

A Pain-enabled in vitro System for Studying Pain Mechanisms and Developing Treatments

05994

Pain-enabled human joint chip models OA pain using innervated synovium for mechanism study and drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Osteoarthritis
Pain
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Michael S. Gold
Hang Lin
Rocky Sung Chi Tuan
Date Submitted: 2022-03-28

ResMag: A Resorbable Magnesium Alloy for Medical Applications

04049

Biodegradable magnesium alloy implants matching bone elasticity reduce metastasis risk and need for removal surgeries.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Material Science
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Dae Ho Hong
Prashant N. Kumta
Date Submitted: 2016-10-18
Collections: Regenerative Medicine

CRISPR Epigenetic Therapeutics for Pain Management

05378

CRISPR-based epigenetic modulation via HSV delivery targets pain genes, offering durable, non-DNA-changing pain relief therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - CRISPR
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Pain
Tags: Human performance
Sports medicine
Lead Inventor: Samira Kiani
Department: Med-Pathology
All Tech Innovators: Mo Reza Ebrahimkhani
Samira Kiani
Date Submitted: 2020-05-26
Collections: Cell & Gene Therapy

Compound Would Healing Technology Platform

04661

Decorin-based slow-release therapy reduces scarring and improves wound healing in preclinical mouse models via ECM/regulatory pathways.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Musculoskeletal
Lead Inventor: Alan Wells
Department: Med-Pathology
All Tech Innovators: Yadong Wang
Alan H. Wells
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2018-06-14
Collections: Regenerative Medicine

Mesenchymal Stem Cell Culture Method for Generating Implantable, Native-like Cartilage Tissue

04535

Engineered MSC-derived, scaffold-free, implantable cartilage with native-like stiffness, low hypertrophy, hypoxic growth, broad MSC compatibility.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - Stem Cell
Therapeutic Areas: Musculoskeletal
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Hang Lin
Rocky Sung Chi Tuan
Yuanheng Yang
Date Submitted: 2018-03-07
Collections: Cell & Gene Therapy

AccelMOTION

03723

AccelMOTION delivers rapid, objective, wearable-based injury assessment to optimize PT decisions, personalize goals, and track recovery.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Other
Tags: Aging
Consumer
Human performance
Lead Inventor: Timothy Sell
Department: Bioengineering
All Tech Innovators: Heather Marie Bansbach
Timothy Crawford Sell
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2015-09-11

Self-Assembled Coatings for Magnesium Implants

03377

Self-assembled anticorrosive organosilane coatings slow magnesium implant degradation, enabling drug delivery and improved biocompatibility.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Other
Tags: Biomaterial
Coating
Regenerative medicine
Lead Inventor: Elia Beniash
Department: Dent Med-Oral and Craniofacial Sciences
All Tech Innovators: Elia Beniash
Date Submitted: 2014-08-11
Collections: Regenerative Medicine

Magnesium Based Suture Anchor for Rotator Cuff Repair

03257

Biodegradable magnesium suture anchor with optimized threading for strong fixation, osteointegration, MRI-friendly imaging, eliminates removal surgery.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Therapeutic Indications: Other
Tags: Sports medicine
Surgery
Lead Inventor: Savio Woo
Department: Bioengineering
All Tech Innovators: Kwang Eun Kim
Jonquil R. Mau
Savio L Y Woo
Date Submitted: 2014-03-04
Collections: Regenerative Medicine

Powering Passive Implanted Sensors with Dynamics

03019

Passive implanted sensors powered wirelessly via touch-probe tech; enables RFID-like reading on bone/metal implants.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Lead Inventor: Marlin Mickle
Department: Electrical and Computer Engineering
All Tech Innovators: Kara Nicole-Simms Bocan
Marlin H. Mickle
Joshua R. Stachel
Date Submitted: 2013-04-04

ResMag: A Resorbable Magnesium Alloy for Medical Applications

02522

ResMag: a biodegradable magnesium alloy matching bone properties, enabling resorbable orthopedic implants with safe, controlled degradation. 15 words.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Regenerative medicine
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Da-Tren Chou
Dae Ho Hong
Prashant N. Kumta
Date Submitted: 2011-07-14
Collections: Regenerative Medicine

Approaches to Counteract Age-related Cognitive Decline

04454

Biomarkers from exercise reveal Klotho-linked cognitive benefits; exosome engineering enables targeted anti-aging brain-muscle therapies.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Musculoskeletal
Neuroscience
Tags: Aging
Lead Inventor: Fabrisia Ambrosio
Department: Department of Physical Medicine and Rehabilitation
All Tech Innovators: Fabrisia Ambrosio
Kirk I. Erickson
John M. Jakicic
Technology Readiness Level: 3. Development of test
Date Submitted: 2017-12-06

Beverage Can Straw Holder

05340

Compact, can-top straw holder insert aids sip stability for all users, easing drinking with canned beverages; prototype-ready.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Musculoskeletal
Lead Inventor: Alexandra Delazio
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: David M. Brienza Ph.D.
Alexandra Marie Delazio
Date Submitted: 2020-05-06

Revised Hip Tether Device

04791

Reversible bio-suture hip tether aims to stabilize dysplastic hips, reducing re-dislocations, surgeries, and recovery time.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Lead Inventor: Patrick Bosch
Department: Med-Orthopedic Surgery
All Tech Innovators: Patrick Peter Bosch
Technology Readiness Level: 3. Prototype development
Date Submitted: 2018-10-26

Novel Biomimetic Rotated Plywood Motifs as Scaffolds for Bone Tissue Engineering

03778

Biomimetic rotated plywood bone scaffolds via binder-jet 3D printing; data-driven, multi-material, enhanced strength, tailored implants.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Regenerative medicine
Tissue engineering
Surgery
Lead Inventor: Prashant Kumta
Department: Bioengineering
All Tech Innovators: Prashant N. Kumta
Gary Zhengbo Yu
Date Submitted: 2015-11-27
Collections: Regenerative Medicine

Accelerate Bone Healing Post-Irradiation with MMS350

03622

MMS350 accelerates radiation-related bone healing by scavenging hydroxyl radicals; water-soluble, orally deliverable, non-toxic in mice.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Musculoskeletal
Oncology
Therapeutic Indications: Bone metabolism
Lead Inventor: Michael Epperly
Department: Med-Radiation Oncology
All Tech Innovators: Michael W. Epperly Ph.D.
Julianne Glowacki Ph.D.
Joel S. Greenberger M.D.
Date Submitted: 2015-05-28
Collections: Regenerative Medicine

Adaptive Multi-Input Robotic Feeder for Enhanced Accessibility and Independence

03335

Adaptive multi-input robotic feeder aids independence for disabled users, combining iPad touchscreen and voice control for feeding.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Musculoskeletal
Lead Inventor: Jonathan Duvall
Department: Med-Physical Medicine & Rehabilitation
All Tech Innovators: Tianyang Chen
Jonathan Aaron Duvall
Eric Joseph Sinagra
Date Submitted: 2014-06-09

Advanced Functional Mobility Outcomes Registry and Predictive Analytics

03233

Predictive analytics migrate mobility device outcomes from standardized data to personalized, cost-reducing care and evidence-based device selection.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Musculoskeletal
Tags: Human performance
Lead Inventor: Mark Schmeler
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Margo B. Holm
Mark R. Schmeler
Date Submitted: 2014-02-07