Therapeutic Areas

Ophthalmology

49 results

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AAV Potentiator Polypeptides: Unlocking Deeper Tissue Penetration for Next-Generation Gene Therapy

07037

Potentiator polypeptides enhance AAV tissue penetration, enabling lower doses and broader gene therapy targets across tissues.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - AAV
Therapeutic Areas: Ophthalmology
Oncology
Therapeutic Indications: Other
Retinitis pigmentosa (RP)
Age-related macular degeneration
Tags: Genetics
Platform Technology
Lead Inventor: Miguel Betegon
Department: Med-Ophthalmology
All Tech Innovators: Miguel Betegon
Leah Caroline Thomas Byrne
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-01-20
Collections: Cell & Gene Therapy

Trabecular Meshwork Stem Cell Secretome for Treatment of Glaucoma

05099

Stem cell secretome from trabecular meshwork lowers intraocular pressure, preserves vision via non-invasive, scalable glaucoma treatment.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Lead Inventor: Yiqin Du
Department: Department of Ophthalmology
All Tech Innovators: Yiqin Du
Ajay Kumar
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-08-27
Collections: Regenerative Medicine

Automated 3D OCT Vessel Segmentation Framework for Precise Retinal Blood Vessel Mapping

01998

Automated 3D SD-OCT vessel segmentation fuses 2D fundus and 3D OCT cues for robust retinal vessel mapping and early disease detection.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Tags: Microscopy
Lead Inventor: Juan Xu
Department: Med-Ophthalmology
All Tech Innovators: Hiroshi Ishikawa
Joel Steven Schuman
David Tolliver
Date Submitted: 2009-05-11

Dipeptidyl Peptidase-4 (DPP4) Inhibitors for Inhibiting Posterior Capsular Opacification

07055

DPP4 inhibitors delivered locally prevent posterior capsular opacification by blocking TGF-β–driven EMT in lens cells.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Cataracts
Tags: Aging
Drug Repurposing
Lead Inventor: Kun Che Chang
Department: Med-Ophthalmology
All Tech Innovators: Kun Che Chang
Chi-Yu Chen
Pei-Kang Liu
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2025-01-31
Collections: Regenerative Medicine

Novel Glaucomatous Damage Prediction Tool

07016

AI-based OCT tool predicts mechanical nonlinearity and RNFL changes to forecast glaucoma risk and progression.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Lead Inventor: Timothy Chung
All Tech Innovators: Timothy K. Chung
John Danias
Jonathan P. Vande Geest
Date Submitted: 2024-12-26
Collections: Healthcare AI

Automated OCT-Based Tissue Screening System

06669

Automated OCT tissue screening with deep learning for label-free, high-throughput, quantitative 3-D tissue analysis and drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Ophthalmology
Tags: Microscopy
Machine learning
Platform Technology
Lead Inventor: Shaohua Pi
Department: Med-Ophthalmology
All Tech Innovators: Yuanyuan Chen
Shaohua Pi
Jose Alain Sahel
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2024-03-06

Novel Repair and Regeneration Therapy for Glaucoma

07246

AAV-Ina overexpression promotes retinal ganglion cell survival and axon regeneration, offering neuroprotection for glaucoma with regeneration potential.

Technology Type: Therapeutic Modality
Therapeutic Areas: Ophthalmology
Neuroscience
Therapeutic Indications: Glaucoma
Tags: Drug Discovery - Target
Life Science
Lead Inventor: Kun Che Chang
Department: Med-Ophthalmology
All Tech Innovators: Kun Che Chang
Chi-Yu Chen
Date Submitted: 2025-07-11

Plasmin-Enhanced Transplantation of Retinal Ganglion Cells via Internal Limiting Membrane Digestion

07056

Plasmin digests the retinal ILM to improve donor retinal ganglion cell transplantation, boosting survival without inflammation.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Other
Lead Inventor: Kun Che Chang
Department: Med-Ophthalmology
All Tech Innovators: Kun Che Chang
Dimitrios Stavropoulos
Date Submitted: 2025-01-31

Walk-N-Talk: An Accessible Speech Generation Device

06715

Walk-N-Talk: a lightweight, cane-attached speech device with tactile buttons, enabling independent communication for visually impaired, nonverbal users.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Ophthalmology
Lead Inventor: Brad Dicianno
Department: Med-Physical Medicine & Rehabilitation
All Tech Innovators: Brad E. Dicianno
Lisa Swanson Dove
Owen Flaugh
Date Submitted: 2024-04-12

Novel Treatment for Retinitis Pigmentosa

06383

Pyrvinium targets NS LLPS to restore proteostasis, preserve retinal structure, and may treat retinitis pigmentosa and proteinopathies.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Ophthalmology
Neuroscience
Therapeutic Indications: Parkinson's Disease
Alzheimer's Disease
Retinitis pigmentosa (RP)
Tags: Life Science
Lead Inventor: Bokai Zhu
Department: Med-Medicine
All Tech Innovators: Yuanyuan Chen
William A. Dion
Bokai Zhu
Date Submitted: 2023-04-23

CyteSolutions Lens: Drug-Eluting Contact Lens Technology

04712

CyteSolutions Lens enables days-long, low-dose, sustained drug delivery via a smart contact lens to treat dry eye inflammation.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Lead Inventor: Alexis Nolfi
Department: Office of the SVC and Provost
All Tech Innovators: Bryan Nicklaus Brown
Vishal Jhanji
Alexis Lauren Nolfi
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2018-08-17

SWeeTT: Solitary Wave-based easily-employable Trans-palpebral Tonometer

04573

SWeeTT enables easy, at-home, trans-palpebral intraocular pressure monitoring with daily data and clinician connectivity.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Ophthalmology
Lead Inventor: Piervincenzo Rizzo
Department: Civil & Environmental Engineering
All Tech Innovators: Amir Nasrollahi
Piervincenzo Rizzo
Date Submitted: 2018-03-31

Prevention of DED Utilizing a Histone/Protein Deacetylase Inhibitor (HDACi)

04403

HDAC inhibitor-loaded PLGA microspheres deliver targeted, long-term anti-inflammatory therapy for dry eye by boosting regulatory T cells.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Conjunctivitis
Dry eye syndrome
Uveitic macular edema (UME)
Lead Inventor: Steven Little
Department: Engr-Dept Chairperson's Office
All Tech Innovators: Steven R. Little
Michelle Lynn Ratay
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2017-10-09

Comparing OCT Scans from Baseline and Follow Up

06320

New OCT/OCTA 3D change-mapping algorithm compares baseline vs. follow-up scans without layer segmentation, enabling earlier retinal disease insight.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Lead Inventor: Shaohua Pi
Department: Med-Ophthalmology
All Tech Innovators: Shaohua Pi
Bingjie Wang
Date Submitted: 2023-02-28

Novel Treatment for Eye Disorders

05703

Monoclonal antibody blocks Lipocalin-2 to curb retinal inflammation and dry AMD progression, offering a preventive therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Ophthalmology
Neuroscience
Therapeutic Indications: Stargardt Disease
Diabetic retinopathy
Age-related macular degeneration
Lead Inventor: Debasish Sinha
Department: Department of Ophthalmology
All Tech Innovators: Sayan Ghosh
Urvi Gupta
Stacey Hose
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-05-26

Deep Learning System for Noise-Free Optical Coherence Tomography (OCT) Imaging without Clean Training Data

06607

Dual-scan, noise-free OCT denoising via Sub2Full: train on two noisy scans to reveal fine retinal structures without clean data.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Diabetic retinopathy
Tags: Artificial intelligence (AI)
Microscopy
Machine learning
Lead Inventor: Shaohua Pi
Department: Med-Ophthalmology
All Tech Innovators: Shaohua Pi
Lingyun Wang
Technology Readiness Level: 5. Advanced prototype validation
Date Submitted: 2024-01-10
Collections: Healthcare AI

Use of Stem Cell Secretome to Prevent Corneal Scarring

05943

CSSC secretome enables scarless corneal healing, dampening inflammation, preserving nerves, reducing transplant needs.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Other
Lead Inventor: Yiqin Du
Department: Department of Ophthalmology
All Tech Innovators: Yiqin Du
Ajay Kumar
Yunshu Li
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-01-20
Collections: Regenerative Medicine

Novel Treatment for Posterior Capsulation

06621

GDF-15 blocks EMT to prevent posterior capsular opacification, potentially reducing recurrent surgeries and vision loss.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Cataracts
Lead Inventor: Kun Che Chang
Department: Med-Ophthalmology
All Tech Innovators: Kun Che Chang
Chi-Yu Chen
Shining Wang
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2024-01-31
Collections: Regenerative Medicine

Personalized Assembloids as AMD Models

06978

Patient-specific 3D AMD model: hiPSC-derived retinal layers with a biomimetic Bruch’s membrane on a perfusable choroidal vasculature.

Technology Type: Life Science Research Tool
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Age-related macular degeneration
Tags: Life Science
Lead Inventor: Jonathan Vande Geest
Department: Bioengineering
All Tech Innovators: Jay Kumar Chhablani
Jincy Joy
Susana Isabel Morgado Mendes Antunes da>VF
Date Submitted: 2024-11-15

Novel Methods for Treating Glaucoma

06441

Laser-irradiation photomodulates ocular tissue mechanics to stiffen or soften sclera, boosting glaucoma resilience without viruses.

Technology Type: Therapeutic Modality
Technology Subtype: Other Therapeutic Modality
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Lead Inventor: Ian Sigal
Department: Med-Ophthalmology
All Tech Innovators: Po-Yi Lee
Ian Alejandro Sigal
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2023-06-27

Novel Hepatocyte Growth Factor Receptor Agonist

05468

A humanized MET agonist META4 restores HGF-MET signaling, promoting tissue regeneration and potential therapies for liver disease and AMD.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Ophthalmology
Hepatology
Therapeutic Indications: Other
Non-alcoholic steatohepatitis (NASH)
Diabetic retinopathy
Tags: Regenerative medicine
Lead Inventor: Abdolreza Zarnegar
Department: Med-Pathology
All Tech Innovators: Abdolreza Zarnegar
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-08-05
Collections: Regenerative Medicine
Cardiometabolic

High-Precision Vision Restoration Using Soma-Targeted Optogenetics

06357

Soma-targeted opsins enable high-acuity, single-cell retinal activation, reducing cross-activation for precise vision restoration.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Diabetic retinopathy
Retinitis pigmentosa (RP)
Age-related macular degeneration
Lead Inventor: Or Shemesh
Department: Med-Ophthalmology
All Tech Innovators: Pururav Ramakrishna
Or Shemesh
Date Submitted: 2023-03-21

Optimizing Corneal Stem Cell Therapy: Quality Screening for Enhanced Regenerative Outcomes

06002

Quality-controlled corneal stem cells selected by regenerative indicators enhance healing potential and consistency in scar treatment.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - Stem Cell
Therapeutic Areas: Ophthalmology
Lead Inventor: Hin-Fai Yam
Department: Med-Ophthalmology
All Tech Innovators: Isabelle Billig
Deepinder K. Dhaliwal M.D.
Yiqin Du
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-04-13
Collections: Cell & Gene Therapy
Regenerative Medicine

Profilin1-actin Interaction Inhibitor as a Novel Anti-Angiogenic Compound

05290

Profilin1–actin interaction inhibitor blocks tumor angiogenesis, offering a VEGF-resistance–bypassing RCC therapy with broad cancer potential.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Ophthalmology
Oncology
Therapeutic Indications: Diabetic retinopathy
Age-related macular degeneration
Tags: Platform Technology
Lead Inventor: Partha Roy
Department: Bioengineering
All Tech Innovators: Paul G. Francoeur
David Martin Gau
Abigail Gondringer
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-04-09

TriaGel: Comprehensive Gel Eye Dressing to Revolutionize Ocular First Aid

04068

TriaGel—a thermoresponsive, injectable gel for immediate ocular injury care, reducing inflammation, cost, and recovery time.

Technology Type: Engineering Technology
Technology Subtype: Industrial Biotech
Therapeutic Areas: Ophthalmology
Intensive Care
Tags: Regenerative medicine
Material Science
Lead Inventor: Morgan Dileo
Department: Med-Ophthalmology
All Tech Innovators: Morgan Virginia Dileo
Jenny Yu
Date Submitted: 2016-11-07
Collections: Regenerative Medicine

New Gene Therapy Concept Shows Promise in Treating Age-Related Macular Degeneration

05088

TFEB-based gene therapy rejuvenates retinal cells to slow dry AMD progression, with potential neurodegenerative benefits.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - AAV
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Other
Age-related macular degeneration
Lead Inventor: Debasish Sinha
Department: Department of Ophthalmology
All Tech Innovators: Leah Caroline Thomas Byrne
Sayan Ghosh
Stacey Hose
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-08-09
Collections: Cell & Gene Therapy

Optical Coherence Tomography (OCT) Image Enhancement

03534

Virtual averaging boosts OCT image quality from brief scans to near frame-averaged clarity, cutting scan time by 80%.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Lead Inventor: Hiroshi Ishikawa
Department: Med-Ophthalmology
All Tech Innovators: Chieh-Li Chen
Hiroshi Ishikawa
Joel Steven Schuman
Date Submitted: 2015-03-04

Biomimetic 3D-Printed Platform for Personalized Mechanotransduction and Disease Modeling in Glaucoma

07146

Biomimetic 3D-printed lamina cribrosa model for patient-specific glaucoma mechanotransduction, genomic shifts, and drug screening.

Technology Type: Life Science Research Tool
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Tags: Biomaterial
Tissue engineering
Platform Technology
Lead Inventor: Jonathan Vande Geest
Department: Bioengineering
All Tech Innovators: Ian P. Conner
Susana Isabel Morgado Mendes Antunes da>VF
Remi Jessica Shittu
Technology Readiness Level: 3. Prototype development
Date Submitted: 2025-04-10

Slow Drug Release for Ophthalmic Treatments

05610

Coacervate gel delivers CXCL10p peptide to the eye for sustained, tunable treatment of dry eye disease.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Dry eye syndrome
Tags: Life Science
Lead Inventor: Alan Wells
Department: Med-Pathology
All Tech Innovators: Shivalingappa Kottur Swamynathan
Yadong Wang
Alan H. Wells
Date Submitted: 2021-02-08

Image Registration for the Analysis of Fixational Eye Movement

05074

Synthetic-reference registration extracts fine-scale fixational eye movements from noisy, artifacted SLO frames for robust high-resolution diagnostics.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Ophthalmology
Lead Inventor: Ethan Rossi
Department: Med-Ophthalmology
All Tech Innovators: Ethan A. Rossi
Min Zhang
Date Submitted: 2019-08-02

Delivery of Biological Drugs to Epithelia

04508

Anchor-domain delivery keeps biologics on wet epithelia, boosting retention and treating mucosal inflammation directly (e.g., eye, respiratory).

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Respiratory
Therapeutic Indications: Asthma
Chronic Obstructive Pulmonary Disease (COPD)
Dry eye syndrome
Lead Inventor: Robert Shanks
Department: Med-Ophthalmology
All Tech Innovators: Jes K. Klarlund
Robert Michael Queen Shanks
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2018-02-15
Collections: Women's & Reproductive Health

Signal Normalization Among Multiple Optical Coherence Tomography Devices

03384

Device-independent OCT normalization standardizes cross-device images via resampling, denoising, histogram-based scaling for consistent comparisons.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Lead Inventor: Chieh-Li Chen
Department: Bioengineering
All Tech Innovators: Chieh-Li Chen
Hiroshi Ishikawa
Joel Steven Schuman
Date Submitted: 2014-08-18

Novel Treatment for Dry Eye Disease

05988

IL-4 eye drops target inflammation and goblet cell dysfunction in dry eye disease, aiming for lasting tear film stability.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Immunology
Tags: Biomaterial
Lead Inventor: Alexis Nolfi
Department: Office of the SVC and Provost
All Tech Innovators: Bryan Nicklaus Brown
Vishal Jhanji
Mangesh Kulkarni
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-03-18

Small-Molecule Stabilizers of TFEB for Local Ocular Delivery in Age-Related Retinal Disease

04690

Small-molecule GT300 activates TFEB via intravitreal delivery, boosting retinal lysosome autophagy to modulate dry AMD.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Geographic atrophy
Age-related macular degeneration
Lead Inventor: Beibei Chen
Department: Med-Medicine
All Tech Innovators: Beibei Chen
Toren Finkel
Yuan Liu
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2018-07-26

Non-contact OCT Imaging and Analysis System for 3D Visualization and Monitoring of Limbal Palisades

02412

Non-contact 3D OCT maps Palisades of Vogt for limbal stem cell niche profiling, disease monitoring, and donor assessment.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Lead Inventor: Kira Lathrop
Department: Med-Ophthalmology
All Tech Innovators: Lawrence E. Kagemann Jr
Kira L. Lathrop
Joel Steven Schuman
Date Submitted: 2011-02-22

A Novel Method of Visualizing Three-Dimensional Image Datasets

01481

New 3D imaging visualization adapts to tissue curvature, reducing artifacts across MRI, CT, ultrasound, and OCT for accurate clinical insight.

Technology Type: Digital Health
Technology Subtype: Healthcare Data
Therapeutic Areas: Ophthalmology
Lead Inventor: Hiroshi Ishikawa
Department: Med-Ophthalmology
All Tech Innovators: Hiroshi Ishikawa
Joel Steven Schuman
Date Submitted: 2007-04-16

Real-time Presentation Access Technology for the Blind

04020

Real-time, cloud-synced accessible PowerPoint slides for the blind via auto-presenter add-in, pub/sub, multi-device terminals.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Ophthalmology
Lead Inventor: Hyun Ka
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Hyun Wook Ka
Date Submitted: 2016-09-03

Novel Autologus Serum Insert for Dry Eye Disease

06434

Autologous serum ocular insert stabilizes, daily-delivery dry eye treatment; longer shelf-life, fewer administrations than eyedrops.

Technology Type: Medical Device
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Dry eye syndrome
Lead Inventor: Morgan Dileo
Department: Med-Ophthalmology
All Tech Innovators: Morgan Virginia Dileo
Vishal Jhanji
Technology Readiness Level: 3. Prototype development
Date Submitted: 2023-06-19

Reverse Thermal Gels for Ocular Drug Delivery

02138

Thermo-responsive, biodegradable reverse-thermal gel self-assembles at body temperature for targeted ocular drug delivery and tissue engineering.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Lead Inventor: Daewon Park
Department: Bioengineering
All Tech Innovators: Thomas R. Friberg M.S.,M.D.
Daewon Park
Yadong Wang
Date Submitted: 2010-01-21
Collections: Regenerative Medicine

Anti-Inflammatory Biotherapeutics for Eye Wound

06908

Engineered eye-colonizing bacteria deliver human IL-10 to corneal wounds, accelerating healing with sustained anti-inflammatory therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Ocular hypertension
Tags: Life Science
Lead Inventor: Anthony St Leger
Department: Med-Ophthalmology
All Tech Innovators: Jackie Lynn Shane
Anthony J. St Leger
Date Submitted: 2024-09-30
Collections: Regenerative Medicine

Biomimetic Drug Delivery of an Immunomodulatory Agent for the Treatment of Dry Eye Disease

03658

Biomimetic, controlled-release immunomodulatory microspheres recruit Tregs to treat inflammatory eye diseases at the source with safer, longer relief.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Dry eye syndrome
Lead Inventor: Michelle Ratay
Department: Bioengineering
All Tech Innovators: Stephen C. Balmert
Morgan Virginia Dileo
Andrew Jason Glowacki
Date Submitted: 2015-06-22

Automated SD-OCT Optic Nerve Head Assessment System for Disc and Cup Segmentation and Glaucoma Classification

01627

Automated SD-OCT ONH system segments disc/cup, quantifies metrics, and classifies glaucoma via a trained shape model.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Lead Inventor: Hiroshi Ishikawa
Department: Med-Ophthalmology
All Tech Innovators: Hiroshi Ishikawa
Joel Steven Schuman
Chaim-Gadi Wollstein
Date Submitted: 2008-01-17

Noninvasive & Long-Acting Thermoresponsive Hydrogel for Sustained Ocular Drug Delivery

02867

Thermoresponsive, drop-to-gel ocular hydrogel delivers month-long, noninvasive drug release via biodegradable microparticles.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Other
Glaucoma
Dry eye syndrome
Lead Inventor: Morgan Dileo
Department: Med-Ophthalmology
All Tech Innovators: Anthony Cugini
Morgan Virginia Dileo
Steven R. Little
Technology Readiness Level: 4. Pre-clinical development
Date Submitted: 2012-08-14

Using Trabecular Meshwork Stem Cells to Treat Glaucoma

02257

TM stem cells replenish trabecular meshwork, restore aqueous outflow, normalize IOP, offering cell-based glaucoma repair.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - Stem Cell
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Glaucoma
Lead Inventor: Yiqin Du
Department: Department of Ophthalmology
All Tech Innovators: Yiqin Du
James L. Funderburgh
Joel Steven Schuman
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2010-06-30
Collections: Cell & Gene Therapy

Portable Head-mounted Eye-tracking Device During Dizziness Episodes

01647

Portable, eye-tracking goggles with home dizziness monitoring, 60Hz infrared tracking, synchronized sensors, wireless data sharing for remote diagnosis.

Technology Type: Medical Device
Technology Subtype: Monitoring Medical Device
Therapeutic Areas: Ophthalmology
Tags: Consumer
Lead Inventor: Joseph Furman
Department: Med-Otolaryngology
All Tech Innovators: Joseph M. Furman
Mark S. Redfern
Date Submitted: 2008-02-18

Topical Ethyl Pyruvate for Eye Scar Prevention

01536

Ethyl pyruvate as a safe, topical anti-scarring treatment for corneal injuries and post-surgery healing.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Ophthalmology
Dermatology
Lead Inventor: Nirmala Sundar Raj
Department: Med-Ophthalmology
All Tech Innovators: James L. Funderburgh
Joel Steven Schuman
Nirmala Sundar Raj
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2007-07-17
Collections: Regenerative Medicine

Innovative Screening Device for Early Detection of Retinal Ischemia in Diabetics

00900

A non-invasive, non-mydriatic screening device quantifies retinal ischemia in diabetics via pupillography for early detection.

Technology Type: Diagnostic/Assay
Technology Subtype: Other Diagnostic/Assay
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Diabetic retinopathy
Lead Inventor: Michael Gorin
Department: Med-Ophthalmology
All Tech Innovators: Michael B. Gorin
Date Submitted: 2004-01-22

Susceptibility Genes for Age-Related Maculopathy (ARM) on Chromosome 10q26

01066

Identifies ARM risk via PLEKHA1 and LOC387715 variations on chromosome 10q26; enables predictive assays and arrays.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Age-related macular degeneration
Lead Inventor: Michael Gorin
Department: Med-Ophthalmology
All Tech Innovators: Yvette Perry Conley
Robert E. Ferrell Ph.D.
Michael B. Gorin
Date Submitted: 2005-03-15

Cross-dimensional OCT Registration for Aligning 2D Scans with 3D Volumes across Devices

01633

Cross-Device OCT alignment enables 2D-3D registration across time and platforms, preserving history and reducing variability.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Ophthalmology
Lead Inventor: Hiroshi Ishikawa
Department: Med-Ophthalmology
All Tech Innovators: Hiroshi Ishikawa
Jongsick S. Kim
Joel Steven Schuman
Date Submitted: 2008-02-04